Human Chitinase 3-like 1/YKL-40 Antibody | R&D Systems AF2599 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Chitinase 3-like 1/YKL-40 Antibody

catalog :

AF2599

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; loading ...; fig 2b	Cubas N xfa xf1 ez L, Gil Perot xed n S, Castillo Villalba J, L xf3 pez V, Sol xed s Tarazona L, Gasqu xe9 Rubio R, et al. Potential Role of CHI3L1+ Astrocytes in Progression in MS. Neurol Neuroimmunol Neuroinflamm. 2021;8: pubmed publisher
	Jiang W, Zhu F, Xu H, Xu L, Li H, Yang X, et al. CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation. Sci Adv. 2023;9:eadg8148 pubmed publisher
	Li J, Jaiswal M, Chien J, Kozlenkov A, Jung J, Zhou P, et al. Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation. Nat Commun. 2023;14:5714 pubmed publisher
	Alves B, Peixoto J, Macedo S, Pinheiro J, Carvalho B, Soares P, et al. High VEGFA Expression Is Associated with Improved Progression-Free Survival after Bevacizumab Treatment in Recurrent Glioblastoma. Cancers (Basel). 2023;15: pubmed publisher
	Wei W, Wu Y, Chen D, Song Y, Xu G, Shi Q, et al. Proteomics profiling for the global and acetylated proteins of papillary thyroid cancers. Proteome Sci. 2023;21:6 pubmed publisher
	Qiu W, Xiao Z, Yang Y, Jiang L, Song S, Qi X, et al. USP10 deubiquitinates RUNX1 and promotes proneural-to-mesenchymal transition in glioblastoma. Cell Death Dis. 2023;14:207 pubmed publisher
	Huss A, Abdelhak A, Mayer B, Tumani H, M xfc ller H, Althaus K, et al. Association of Serum GFAP with Functional and Neurocognitive Outcome in Sporadic Small Vessel Disease. Biomedicines. 2022;10: pubmed publisher
	Hok A Hin Y, Hoozemans J, Hu W, Wouters D, Howell J, R xe1 bano A, et al. YKL-40 changes are not detected in post-mortem brain of patients with Alzheimer's disease and frontotemporal lobar degeneration. Alzheimers Res Ther. 2022;14:100 pubmed publisher
	Xiong S, Kumar A, Tian S, Taher E, Yang E, Kinchington P, et al. Stem cell transplantation rescued a primary open-angle glaucoma mouse model. elife. 2021;10: pubmed publisher
	Zhang S, Sousa A, Lin M, Iwano A, Jain R, Ma B, et al. Role of Chitinase 3-Like 1 Protein in the Pathogenesis of Hepatic Insulin Resistance in Nonalcoholic Fatty Liver Disease. Cells. 2021;10: pubmed publisher
	Salomon J, Piotrowska A, Matusiak Ł, Dziegiel P, Szepietowski J. Chitinase-3-like Protein 1 (YKL-40) Is Expressed in Lesional Skin in Hidradenitis Suppurativa. In Vivo. 2019;33:141-143 pubmed publisher
	Andrés Benito P, Dominguez R, Colomina M, Llorens F, Povedano M, Ferrer I. YKL40 in sporadic amyotrophic lateral sclerosis: cerebrospinal fluid levels as a prognosis marker of disease progression. Aging (Albany NY). 2018;10:2367-2382 pubmed publisher
	Querol Vilaseca M, Colom Cadena M, Pegueroles J, San Martín Paniello C, Clarimon J, Belbin O, et al. YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies. J Neuroinflammation. 2017;14:118 pubmed publisher
	Langley S, Willeit K, Didangelos A, Matic L, Skroblin P, Barallobre Barreiro J, et al. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques. J Clin Invest. 2017;127:1546-1560 pubmed publisher
	Kumagai E, Mano Y, Yoshio S, Shoji H, Sugiyama M, Korenaga M, et al. Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver disease. Sci Rep. 2016;6:35282 pubmed publisher

product information

master code :

AF2599

SKU :

AF2599

product name :

Human Chitinase 3-like 1/YKL-40 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Chitinase 3-like 1/YKL-40 Antibody from R&D Systems is a goat polyclonal antibody to Chitinase 3-like 1/YKL-40. This antibody reacts with human,mouse. The Human Chitinase 3-like 1/YKL-40 Antibody has been validated for the following applications: Immunohistochemistry,Flow Cytometry,Western Blot,Simple Western,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry.

target :

Chitinase 3-like 1/YKL-40

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Chitinase 3-like 1/YKL-40, Tyr22-Thr383, Accession # P36222

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse

specificity :

Detects human Chitinase 3-like 1/YKL-40 in direct ELISAs and Western blots. In direct ELISAs, approximately 15% cross-reactivity with recombinant mouse Chitinase 3-like 1/YKL-40 is observed.

gene symbol :

CHI3L1

top caption :

Detection of Human Chitinase 3-like 1 antibody by Western Blot.

accessionNumbers :

P36222

applications :

Immunohistochemistry,Flow Cytometry,Western Blot,Simple Western,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

499 USD

alt names :

AW208766, Brp39, Chi3l1, Chitinase 3 like 1, gp39, HCgp39, YKL-40

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage