| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry knockout validation; mouse; 1:500; loading ...; fig 1g
| Zin E, Han D, Tran J, Morisson Welch N, Visel M, Kuronen M, et al. Outcomes of progranulin gene therapy in the retina are dependent on time and route of delivery. Mol Ther Methods Clin Dev. 2021;22:40-51 pubmed publisher |
- immunohistochemistry; mouse; 1:100; fig 1a
| Takahashi K, Nakamura S, Otsu W, Shimazawa M, Hara H. Progranulin deficiency in Iba-1+ myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation. J Neuroinflammation. 2021;18:164 pubmed publisher |
| Takahashi H, Bhagwagar S, Nies S, Ye H, Han X, Chiasseu M, et al. Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase. Nat Commun. 2024;15:1434 pubmed publisher |
| He Y, Kaya I, Shariatgorji R, Lundkvist J, Wahlberg L, Nilsson A, et al. Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents. Nat Commun. 2023;14:5804 pubmed publisher |
| Feng T, Minevich G, Liu P, Qin H, Wozniak G, Pham J, et al. AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b-/-Grn-/- mice. iScience. 2023;26:107247 pubmed publisher |
| Anderson A, Tansey M. Loss of Progranulin Results in Increased Pan-Cathepsin Activity and Reduced LAMP1 Lysosomal Protein. bioRxiv. 2023;: pubmed publisher |
| Zhang T, Feng T, Wu K, Guo J, Nana A, Yang G, et al. Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination. Acta Neuropathol. 2023;146:97-119 pubmed publisher |
| DU H, Yang C, Nana A, Seeley W, Smolka M, Hu F. Progranulin inhibits phospholipase sPLA2-IIA to control neuroinflammation. bioRxiv. 2023;: pubmed publisher |
| Smith D, Niehoff M, Ling K, Jafar Nejad P, Rigo F, Farr S, et al. Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn R493X mouse model of frontotemporal dementia. PLoS ONE. 2023;18:e0282822 pubmed publisher |
| He Y, Zhang X, Flais I, Svenningsson P. Decreased Prosaposin and Progranulin in the Cingulate Cortex Are Associated with Schizophrenia Pathophysiology. Int J Mol Sci. 2022;23: pubmed publisher |
| Santos M, Paushter D, Zhang T, Wu X, Feng T, Lou J, et al. Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis. J Biol Chem. 2022;298:102348 pubmed publisher |
| Dedert C, Mishra V, Aggarwal G, Nguyen A, Xu F. Progranulin Preserves Autophagy Flux and Mitochondrial Function in Rat Cortical Neurons Under High Glucose Stress. Front Cell Neurosci. 2022;16:874258 pubmed publisher |
| DU H, Zhou X, Feng T, Hu F. Regulation of lysosomal trafficking of progranulin by sortilin and prosaposin. Brain Commun. 2022;4:fcab310 pubmed publisher |
| Zhang T, DU H, Santos M, Wu X, Pagan M, Trigiani L, et al. Differential regulation of progranulin derived granulin peptides. Mol Neurodegener. 2022;17:15 pubmed publisher |
| Devireddy S, Ferguson S. Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo. J Cell Biol. 2022;221: pubmed publisher |
| Takahashi K, Nakamura S, Shimazawa M, Hara H. Retinal Degeneration and Microglial Dynamics in Mature Progranulin-Deficient Mice. Int J Mol Sci. 2021;22: pubmed publisher |
| Dong T, Tejwani L, Jung Y, Kokubu H, Luttik K, Driessen T, et al. Microglia regulate brain progranulin levels through the endocytosis/lysosomal pathway. JCI Insight. 2021;6: pubmed publisher |
| DU H, Wong M, Zhang T, Santos M, Hsu C, Zhang J, et al. A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses. Life Sci Alliance. 2021;4: pubmed publisher |
| Frew J, Nygaard H. Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice. Acta Neuropathol Commun. 2021;9:57 pubmed publisher |
| Murakoshi M, Gohda T, Adachi E, Ichikawa S, Hagiwara S, Suzuki Y. Differential organ-specific inflammatory response to progranulin in high-fat diet-fed mice. Sci Rep. 2021;11:1194 pubmed publisher |
| Huang M, Modeste E, Dammer E, Merino P, Taylor G, Duong D, et al. Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations. Acta Neuropathol Commun. 2020;8:163 pubmed publisher |
| Lan Y, Li Z, Wang Z, Wang X, Wang G, Zhang J, et al. An Experimental Model of Neurodegenerative Disease Based on Porcine Hemagglutinating Encephalomyelitis Virus-Related Lysosomal Abnormalities. Mol Neurobiol. 2020;57:5299-5306 pubmed publisher |
| Feng T, Mai S, Roscoe J, Sheng R, Ullah M, Zhang J, et al. Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice. EMBO Rep. 2020;21:e50219 pubmed publisher |
| Sasaki T, Shimazawa M, Kanamori H, Yamada Y, Nishinaka A, Kuse Y, et al. Effects of progranulin on the pathological conditions in experimental myocardial infarction model. Sci Rep. 2020;10:11842 pubmed publisher |
| Kuang L, Hashimoto K, Huang E, Gentry M, Zhu H. Frontotemporal dementia non-sense mutation of progranulin rescued by aminoglycosides. Hum Mol Genet. 2020;29:624-634 pubmed publisher |
| Tang F, Zhao L, Zhao Y, Sun D, Zhu X, Mei L, et al. Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons. Cell Death Differ. 2020;: pubmed publisher |
| Wang C, Zhang L, Ndong J, Hettinghouse A, Sun G, Chen C, et al. Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice. J Neuroinflammation. 2019;16:238 pubmed publisher |
| Wei F, Jiang Z, Sun H, Pu J, Sun Y, Wang M, et al. Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling. PLoS Pathog. 2019;15:e1008062 pubmed publisher |
| Zhou X, Paushter D, Pagan M, Kim D, Nunez Santos M, Lieberman R, et al. Progranulin deficiency leads to reduced glucocerebrosidase activity. PLoS ONE. 2019;14:e0212382 pubmed publisher |
| Elia L, Mason A, Alijagic A, Finkbeiner S. Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway. J Neurosci. 2019;39:3332-3344 pubmed publisher |
| Lan Y, Sullivan P, Hu F. SMCR8 negatively regulates AKT and MTORC1 signaling to modulate lysosome biogenesis and tissue homeostasis. Autophagy. 2019;15:871-885 pubmed publisher |
| Arrant A, Filiano A, Patel A, Hoffmann M, Boyle N, Kashyap S, et al. Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice. Neurobiol Dis. 2019;124:152-162 pubmed publisher |
| Kuse Y, Ohuchi K, Nakamura S, Hara H, Shimazawa M. Microglia increases the proliferation of retinal precursor cells during postnatal development. Mol Vis. 2018;24:536-545 pubmed |
| Nicholson A, Zhou X, Perkerson R, Parsons T, Chew J, Brooks M, et al. Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity. Acta Neuropathol Commun. 2018;6:42 pubmed publisher |
| Uesaka N, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, et al. Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum. Neuron. 2018;97:796-805.e5 pubmed publisher |
| Fujita K, Chen X, Homma H, Tagawa K, Amano M, Saito A, et al. Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. Nat Commun. 2018;9:433 pubmed publisher |
| Arrant A, Onyilo V, Unger D, Roberson E. Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis. J Neurosci. 2018;38:2341-2358 pubmed publisher |
| Sugihara H, Miyaji K, Yamanouchi K, Matsuwaki T, Nishihara M. Progranulin deficiency leads to prolonged persistence of macrophages, accompanied with myofiber hypertrophy in regenerating muscle. J Vet Med Sci. 2018;80:346-353 pubmed publisher |
| Van Kampen J, Kay D. Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease. PLoS ONE. 2017;12:e0182896 pubmed publisher |
| Zhou X, Paushter D, Feng T, Sun L, Reinheckel T, Hu F. Lysosomal processing of progranulin. Mol Neurodegener. 2017;12:62 pubmed publisher |
| Petkau T, Blanco J, Leavitt B. Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice. Neurobiol Dis. 2017;106:14-22 pubmed publisher |
| Beel S, Moisse M, Damme M, De Muynck L, Robberecht W, Van Den Bosch L, et al. Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo. Hum Mol Genet. 2017;26:2850-2863 pubmed publisher |
| Kuse Y, Tsuruma K, Sugitani S, Izawa H, Ohno Y, Shimazawa M, et al. Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina. Sci Rep. 2016;6:23811 pubmed publisher |
