product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human IL-27 Antibody
catalog :
AF2526
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, neutralization
more info or order :
R&D Systems product webpage
citations: 12
Reference
Hildenbrand K, Bohnacker S, Menon P, Kerle A, Prodjinotho U, Hartung F, et al. Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions. Sci Adv. 2023;9:eadg6874 pubmed publisher
Gringhuis S, Kaptein T, Remmerswaal E, Drewniak A, Wevers B, Theelen B, et al. Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs. Nat Immunol. 2022;23:1735-1748 pubmed publisher
Zhang X, Shen H, Qin X, Wang C, Hu W, Liu S, et al. IL-27 promotes decidualization via the STAT3-ESR/PGR regulatory axis. J Reprod Immunol. 2022;151:103623 pubmed publisher
Zheng Y, Han L, Chen Z, Li Y, Zhou B, Hu R, et al. PD-L1+CD8+ T cells enrichment in lung cancer exerted regulatory function and tumor-promoting tolerance. iScience. 2022;25:103785 pubmed publisher
Lei V, Handfield C, Kwock J, Kirchner S, Lee M, Coates M, et al. Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response. J Invest Dermatol. 2022;142:2249-2259.e9 pubmed publisher
O Connor R, Chauhan V, Mathieson L, Titmarsh H, Koppensteiner L, Young I, et al. T cells drive negative feedback mechanisms in cancer associated fibroblasts, promoting expression of co-inhibitory ligands, CD73 and IL-27 in non-small cell lung cancer. Oncoimmunology. 2021;10:1940675 pubmed publisher
Khanam A, Ayithan N, Tang L, Poonia B, Kottilil S. IL-21-Deficient T Follicular Helper Cells Support B Cell Responses Through IL-27 in Patients With Chronic Hepatitis B. Front Immunol. 2020;11:599648 pubmed publisher
Sprokholt J, Kaptein T, van Hamme J, Overmars R, Gringhuis S, Geijtenbeek T. RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production. PLoS Pathog. 2017;13:e1006738 pubmed publisher
Gregersen I, Sandanger Ø, Askevold E, Sagen E, Yang K, Holm S, et al. Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation. PLoS ONE. 2017;12:e0188387 pubmed publisher
Gajanayaka N, O Hara S, Konarski Y, Fernandes J, Muthumani K, Kozlowski M, et al. HIV and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathways. J Leukoc Biol. 2017;102:925-939 pubmed publisher
Garg A, Trout R, Spector S. Human Immunodeficiency Virus Type-1 Myeloid Derived Suppressor Cells Inhibit Cytomegalovirus Inflammation through Interleukin-27 and B7-H4. Sci Rep. 2017;7:44485 pubmed publisher
Tan G, Xiao Q, Song H, Ma F, Xu F, Peng D, et al. Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication. Cell Mol Immunol. 2018;15:272-281 pubmed publisher
product information
brand :
R&D Systems
master code :
AF2526
SKU :
AF2526
product name :
Human IL-27 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human IL-27 Antibody from R&D Systems is a goat polyclonal antibody to IL-27. This antibody reacts with human. The Human IL-27 Antibody has been validated for the following applications: ELISA Development,ELISA Development (Capture),Western Blot,Neutralization,Immunohistochemistry,ELISA Capture (Matched Antibody Pair).
target :
IL-27
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Neutralization, ELISA Capture (Matched Antibody Pair) 0.2-0.8 ug/mL
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant human IL-27 (R D Systems, Catalog # 2526-IL), Arg21-Lys229 (IL-27 EBI-3 subunit), Phe29-Pro243 (IL-27 p28 subunit), Accession # Q14213 (EBI-3 subunit), AAM34498 (p28 subunit)
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human
specificity :
Detects human IL-27 in ELISAs and Western blots.
gene symbol :
IL27
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Detection of Human IL-27 antibody by Western Blot.
accessionNumbers :
Q14213 (EBI-3 subunit), AAM34498 (p28 subunit)
applications :
ELISA Capture (Matched Antibody Pair),ELISA Development,ELISA Development (Capture),Immunohistochemistry,Western Blot,Neutralization
USD :
499 USD
alt names :
IL27, IL-27, IL-27 p28 subunit, IL-27 subunit alpha, IL27A, IL-27-A, IL27-A, IL27p28, IL30, interleukin 27, interleukin 30, interleukin-27 subunit alpha, MGC71873, p28IL-27A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.