product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse Phospho-HGFR/c-MET (Y1234/Y1235) Antibody
catalog :
AF2480
quantity :
50 ug (also 25 ug)
price :
389 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 7
Reference
Song K, Han Y, Roehrich H, Brown M, Torres Cabala C, Giubellino A. MET Receptor Tyrosine Kinase Inhibition Reduces Interferon-Gamma (IFN-γ)-Stimulated PD-L1 Expression through the STAT3 Pathway in Melanoma Cells. Cancers (Basel). 2023;15: pubmed publisher
Modica C, Cortese M, Bersani F, Lombardi A, Napoli F, Righi L, et al. Genetic Ablation of the MET Oncogene Defines a Crucial Role of the HGF/MET Axis in Cell-Autonomous Functions Driving Tumor Dissemination. Cancers (Basel). 2023;15: pubmed publisher
Modica C, Basilico C, Chiriaco C, Borrelli N, Comoglio P, Vigna E. A receptor-antibody hybrid hampering MET-driven metastatic spread. J Exp Clin Cancer Res. 2021;40:32 pubmed publisher
Virzì A, Gentile A, Benvenuti S, Comoglio P. Reviving oncogenic addiction to MET bypassed by BRAF (G469A) mutation. Proc Natl Acad Sci U S A. 2018;115:10058-10063 pubmed publisher
Kato K, Diéguez Hurtado R, Park D, Hong S, Kato Azuma S, Adams S, et al. Pulmonary pericytes regulate lung morphogenesis. Nat Commun. 2018;9:2448 pubmed publisher
Wang D, Sun Y, Li W, Ye F, Zhang Y, Guo Y, et al. Antiproliferative effects of the CDK6 inhibitor PD0332991 and its effect on signaling networks in gastric cancer cells. Int J Mol Med. 2018;41:2473-2484 pubmed publisher
Apicella M, Migliore C, Capelôa T, Menegon S, Cargnelutti M, Degiuli M, et al. Dual MET/EGFR therapy leads to complete response and resistance prevention in a MET-amplified gastroesophageal xenopatient cohort. Oncogene. 2017;36:1200-1210 pubmed publisher
product information
brand :
R&D Systems
master code :
AF2480
SKU :
AF2480
product name :
Human/Mouse Phospho-HGFR/c-MET (Y1234/Y1235) Antibody
unit size :
50 ug (also 25 ug)
seo description :
The Human/Mouse Phospho-HGFR/c-MET (Y1234/Y1235) Antibody from R&D Systems is a rabbit polyclonal antibody to HGFR/c-MET. This antibody reacts with human,mouse,xenograft. The Human/Mouse Phospho-HGFR/c-MET (Y1234/Y1235) Antibody has been validated for the following applications: Western Blot,Array Development,Flow Cytometry,Protein Array,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Simple Western,Intracellular Staining by Flow Cytometry,Immunocytochemistry,CyTOF-reported.
target :
HGFR/c-MET
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.5 ug/mL, Simple Western 5 ug/mL, Immunohistochemistry 5-15 ug/mL, Intracellular Staining by Flow Cytometry 2.5 ug/10^6 cells, Immunocytochemistry 5-15 ug/mL, CyTOF-reported
host :
Rabbit
immunogen :
Phosphopeptide containing human HGF R/c-MET Y1234/1235 sites
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Xenograft
specificity :
Detects human and mouse HGF R/c-MET when phosphorylated at Y1234/Y1235 in Western blots.
gene symbol :
MET
top caption :
Detection of Human Phospho-HGF R/c-MET (Y1234/Y1235) antibody by Western Blot.
applications :
Simple Western,Intracellular Staining by Flow Cytometry,Immunocytochemistry,CyTOF-reported,Array Development,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Protein Array
USD :
389 USD
alt names :
AUTS9, c-Met, cMET, EC 2.7.10, EC 2.7.10.1, hepatocyte growth factor receptor, HGF R, HGF receptor, HGF/SF receptor, HGFR, MET, Met (c-Met), met proto-oncogene (hepatocyte growth factor receptor), met proto-oncogene tyrosine kinase, oncogene MET, Proto-oncogene c-Met, RCCP2, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.