product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse YM1/Chitinase 3-like 3 Antibody
catalog :
AF2446
quantity :
100 ug (also 25 ug)
price :
489 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 20
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:500; loading ...; fig 2c
Fleming Martinez A, D xf6 ppler H, Bastea L, Edenfield B, Liou G, Storz P. Ym1+ macrophages orchestrate fibrosis, lesion growth, and progression during development of murine pancreatic cancer. iScience. 2022;25:104327 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 8a
Passman A, Strauss R, McSpadden S, Finch Edmondson M, Andrewartha N, Woo K, et al. Maraviroc Prevents HCC Development by Suppressing Macrophages and the Liver Progenitor Cell Response in a Murine Chronic Liver Disease Model. Cancers (Basel). 2021;13: pubmed publisher
Heyndrickx I, Deswarte K, Verstraete K, Verschueren K, Smole U, Aegerter H, et al. Ym1 protein crystals promote type 2 immunity. elife. 2024;12: pubmed publisher
Hamley M, Leyk S, Casar C, Liebold I, Jawazneh A, Lanzloth C, et al. Nmes1 is a novel regulator of mucosal response influencing intestinal healing potential. Eur J Immunol. 2024;54:e2350434 pubmed publisher
Yu F, Bai T. Sevoflurane activates the IL-6/HO-1 pathway to promote macrophage M2 polarization and prostate cancer lung metastasis. Int Immunopharmacol. 2022;113:109380 pubmed publisher
Theocharidis G, Rahmani S, Lee S, Li Z, Lobao A, Kounas K, et al. Murine macrophages or their secretome delivered in alginate dressings enhance impaired wound healing in diabetic mice. Biomaterials. 2022;288:121692 pubmed publisher
Song J, Frieler R, Vigil T, Ma J, Brombacher F, Goonewardena S, et al. Inactivation of Interleukin-4 Receptor α Signaling in Myeloid Cells Protects Mice From Angiotensin II/High Salt-Induced Cardiovascular Dysfunction Through Suppression of Fibrotic Remodeling. J Am Heart Assoc. 2021;10:e017329 pubmed publisher
Yuan Y, Ren Y, Dijk M, Geertsema Doornbusch G, Atema Smit J, Busscher H, et al. Phagocytosis and macrophage polarization on bacterially contaminated dental implant materials and effects on tissue integration. Eur Cell Mater. 2021;41:421-430 pubmed publisher
Snyder J, Zhong G, Hogarth C, Huang W, Topping T, Lafrance J, et al. Knockout of Cyp26a1 and Cyp26b1 during postnatal life causes reduced lifespan, dermatitis, splenomegaly, and systemic inflammation in mice. FASEB J. 2020;34:15788-15804 pubmed publisher
Cerezo Wallis D, Contreras Alcalde M, Troulé K, Catena X, Mucientes C, Calvo T, et al. Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state. Nat Med. 2020;26:1865-1877 pubmed publisher
Chenery A, Alhallaf R, Agha Z, Ajendra J, Parkinson J, Cooper M, et al. Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung. J Immunol. 2019;203:2724-2734 pubmed publisher
Ryzhikov M, Ehlers A, Steinberg D, Xie W, Oberlander E, Brown S, et al. Diurnal Rhythms Spatially and Temporally Organize Autophagy. Cell Rep. 2019;26:1880-1892.e6 pubmed publisher
Hung L, Sen D, Oniskey T, Katzen J, Cohen N, Vaughan A, et al. Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism. Mucosal Immunol. 2019;12:64-76 pubmed publisher
Lu H, Chelvanambi S, Poirier C, Saliba J, March K, Clauss M, et al. EMAPII Monoclonal Antibody Ameliorates Influenza A Virus-Induced Lung Injury. Mol Ther. 2018;26:2060-2069 pubmed publisher
Draijer C, Robbe P, Boorsma C, Hylkema M, Melgert B. Dual role of YM1+ M2 macrophages in allergic lung inflammation. Sci Rep. 2018;8:5105 pubmed publisher
Dong J, Ma Q. Macrophage polarization and activation at the interface of multi-walled carbon nanotube-induced pulmonary inflammation and fibrosis. Nanotoxicology. 2018;12:153-168 pubmed publisher
Mittal M, Tiruppathi C, Nepal S, Zhao Y, Grzych D, Soni D, et al. TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury. Proc Natl Acad Sci U S A. 2016;113:E8151-E8158 pubmed
Finley P, DeClue C, Sell S, DeBartolo J, Shornick L. Diabetic Wounds Exhibit Decreased Ym1 and Arginase Expression with Increased Expression of IL-17 and IL-20. Adv Wound Care (New Rochelle). 2016;5:486-494 pubmed
De Cunto G, Lunghi B, Bartalesi B, Cavarra E, Fineschi S, Ulivieri C, et al. Severe Reduction in Number and Function of Peripheral T Cells Does Not Afford Protection toward Emphysema and Bronchial Remodeling Induced in Mice by Cigarette Smoke. Am J Pathol. 2016;186:1814-1824 pubmed publisher
Lunghi B, De Cunto G, Cavarra E, Fineschi S, Bartalesi B, Lungarella G, et al. Smoking p66Shc knocked out mice develop respiratory bronchiolitis with fibrosis but not emphysema. PLoS ONE. 2015;10:e0119797 pubmed publisher
product information
master code :
AF2446
SKU :
AF2446
product name :
Mouse YM1/Chitinase 3-like 3 Antibody
unit size :
100 ug (also 25 ug)
description :
The Mouse YM1/Chitinase 3-like 3 Antibody from R&D Systems is a goat polyclonal antibody to YM1/Chitinase 3-like 3. This antibody reacts with human,mouse,transgenic mouse. The Mouse YM1/Chitinase 3-like 3 Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Simple Western.
target :
YM1/Chitinase 3-like 3
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse YM1/Chitinase 3-like 3, Tyr22-Tyr398, Accession # O35744
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Transgenic Mouse
specificity :
Detects mouse YM1/Chitinase 3-like 3 in direct ELISAs and Western blots.
gene symbol :
CHI3L2
top caption :
Detection of Mouse YM1/Chitinase 3-like 3 antibody by Western Blot.
accessionNumbers :
O35744
applications :
Flow Cytometry,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Simple Western
USD :
489 USD
alt names :
AI505981, Chi3l3, Chitinase 3 like 3, Chitinase 3-like 3, ECF-L, Ym1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.