Human Progranulin/PGRN Antibody | R&D Systems AF2420 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Progranulin/PGRN Antibody

catalog :

AF2420

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 25

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:500; loading ...; fig 5c	Zin E, Han D, Tran J, Morisson Welch N, Visel M, Kuronen M, et al. Outcomes of progranulin gene therapy in the retina are dependent on time and route of delivery. Mol Ther Methods Clin Dev. 2021;22:40-51 pubmed publisher
immunohistochemistry; mouse; 1:1000; fig 5a	Frew J, Nygaard H. Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice. Acta Neuropathol Commun. 2021;9:57 pubmed publisher
	Takahashi H, Bhagwagar S, Nies S, Ye H, Han X, Chiasseu M, et al. Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase. Nat Commun. 2024;15:1434 pubmed publisher
	Ullgren A, xd6 ijerstedt L, Olofsson J, Bergstr xf6 m S, Remnest xe5 l J, van Swieten J, et al. Altered plasma protein profiles in genetic FTD - a GENFI study. Mol Neurodegener. 2023;18:85 pubmed publisher
	He Y, Kaya I, Shariatgorji R, Lundkvist J, Wahlberg L, Nilsson A, et al. Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents. Nat Commun. 2023;14:5804 pubmed publisher
	Feng T, Minevich G, Liu P, Qin H, Wozniak G, Pham J, et al. AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b-/-Grn-/- mice. iScience. 2023;26:107247 pubmed publisher
	Hasan S, Fernandopulle M, Humble S, Frankenfield A, Li H, Prestil R, et al. Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons. bioRxiv. 2023;: pubmed publisher
	Cimini S, Bellini S, Saraceno C, Benussi L, Ghidoni R, Giliani S, et al. Pathological 25 kDa C-Terminal Fragments of TDP-43 Are Present in Lymphoblastoid Cell Lines and Extracellular Vesicles from Patients Affected by Frontotemporal Lobar Degeneration and Neuronal Ceroidolipofuscinosis Carrying a GRN Mutation. Int J Mol Sci. 2022;23: pubmed publisher
	Boland S, Swarup S, Ambaw Y, Malia P, Richards R, Fischer A, et al. Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Nat Commun. 2022;13:5924 pubmed publisher
	Devireddy S, Ferguson S. Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo. J Cell Biol. 2022;221: pubmed publisher
	Logan T, Simon M, Rana A, Cherf G, Srivastava A, Davis S, et al. Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic. Cell. 2021;184:4651-4668.e25 pubmed publisher
	Monteys A, Hundley A, Ranum P, Tecedor L, Muehlmatt A, Lim E, et al. Regulated control of gene therapies by drug-induced splicing. Nature. 2021;596:291-295 pubmed publisher
	Davis S, Roth J, Aljabi Q, Hakim A, Savell K, Day J, et al. Delivering progranulin to neuronal lysosomes protects against excitotoxicity. J Biol Chem. 2021;:100993 pubmed publisher
	Berger K, Rhost S, Rafnsdóttir S, Hughes E, Magnusson Y, Ekholm M, et al. Tumor co-expression of progranulin and sortilin as a prognostic biomarker in breast cancer. BMC Cancer. 2021;21:185 pubmed publisher
	Holzer I, Machado Weber A, Marshall A, Freis A, Jauckus J, Strowitzki T, et al. GRN, NOTCH3, FN1, and PINK1 expression in eutopic endometrium - potential biomarkers in the detection of endometriosis - a pilot study. J Assist Reprod Genet. 2020;37:2723-2732 pubmed publisher
	Frew J, Baradaran Heravi A, Balgi A, Wu X, Yan T, Arns S, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020;15:21 pubmed publisher
	Sarkar S, Dammer E, Malovic E, Olsen A, Raza S, Gao T, et al. Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells. Front Immunol. 2020;11:33 pubmed publisher
	Walker D, Tang T, Mendsaikhan A, Tooyama I, Serrano G, Sue L, et al. Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains. Int J Mol Sci. 2020;21: pubmed publisher
	Kuang L, Hashimoto K, Huang E, Gentry M, Zhu H. Frontotemporal dementia non-sense mutation of progranulin rescued by aminoglycosides. Hum Mol Genet. 2020;29:624-634 pubmed publisher
	Mendsaikhan A, Tooyama I, Bellier J, Serrano G, Sue L, Lue L, et al. Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology. Acta Neuropathol Commun. 2019;7:215 pubmed publisher
	Tian R, Gachechiladze M, Ludwig C, Laurie M, Hong J, Nathaniel D, et al. CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons. Neuron. 2019;104:239-255.e12 pubmed publisher
	Mendsaikhan A, Tooyama I, Walker D. Microglial Progranulin: Involvement in Alzheimer's Disease and Neurodegenerative Diseases. Cells. 2019;8: pubmed publisher
	Nicholson A, Zhou X, Perkerson R, Parsons T, Chew J, Brooks M, et al. Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity. Acta Neuropathol Commun. 2018;6:42 pubmed publisher
	Zhou X, Paushter D, Feng T, Sun L, Reinheckel T, Hu F. Lysosomal processing of progranulin. Mol Neurodegener. 2017;12:62 pubmed publisher
	Lee C, Stankowski J, Chew J, Cook C, Lam Y, Almeida S, et al. The lysosomal protein cathepsin L is a progranulin protease. Mol Neurodegener. 2017;12:55 pubmed publisher

product information

brand :

R&D Systems

master code :

AF2420

SKU :

AF2420

product name :

Human Progranulin/PGRN Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human Progranulin/PGRN Antibody from R&D Systems is a goat polyclonal antibody to Progranulin/PGRN. This antibody reacts with human,mouse. The Human Progranulin/PGRN Antibody has been validated for the following applications: ELISA Capture,Bioassay,FRET,Immunoprecipitation,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Knockout Validated.

target :

Progranulin/PGRN

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Immunohistochemistry 5-15 ug/mL, Knockout Validated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Progranulin/PGRN, Thr18-Leu593, Accession # P28799

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse

specificity :

Detects human Progranulin/PGRN in direct ELISAs and Western blots.

gene symbol :

GRN

Antibody validation :

Knockout/Knockdown

top caption :

Detection of Human Progranulin/PGRN antibody by Western Blot.

accessionNumbers :

P28799

applications :

Knockout Validated,Bioassay,FRET,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,ELISA Capture

USD :

499 USD

alt names :

Acrogranin, CLN11, GEP, GP88, granulin precursor, GRN, PCDGF, PEPI, PGRN, Proepithelin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage