product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Human HNF-3▀/FoxA2 Antibody
catalog :
AF2400
quantity :
100 ug (also 25 ug)
price :
519 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 70
Reference
Dattani A, Corujo Simon E, Radley A, Heydari T, Taheriabkenar Y, Carlisle F, et al. Naive pluripotent stem cell-based models capture FGF-dependent human hypoblast lineage specification. Cell Stem Cell. 2024;31:1058-1071.e5 pubmed publisher
Daya N, D xf6 ring K, Zhuge H, Volke L, Stab V, Dietz J, et al. Generation of two hiPSCs lines of two patients carrying truncating mutations in the dimerization domain of filamin C. Stem Cell Res. 2024;76:103320 pubmed publisher
Feng L, Li D, Tian Y, Zhao C, Sun Y, Kou X, et al. One-step cell biomanufacturing platform: porous gelatin microcarrier beads promote human embryonic stem cell-derived midbrain dopaminergic progenitor cell differentiation in vitro and survival after transplantation in vivo. Neural Regen Res. 2024;19:458-464 pubmed publisher
Maimaitili M, Chen M, Febbraro F, Ucuncu E, Kelly R, Niclis J, et al. Enhanced production of mesencephalic dopaminergic neurons from lineage-restricted human undifferentiated stem cells. Nat Commun. 2023;14:7871 pubmed publisher
Pavlinov I, Tambe M, Abbott J, Nguyen H, Xu M, Pradhan M, et al. In depth characterization of midbrain organoids derived from wild type iPSC lines. PLoS ONE. 2023;18:e0292926 pubmed publisher
Boeing A, Mavrommatis L, Daya N, Zhuge H, Volke L, Kocabas A, et al. Generation of two human iPSC lines (HIMRi002-A and HIMRi003-A) derived from Caveolinopathy patients with rippling muscle disease. Stem Cell Res. 2023;72:103220 pubmed publisher
Balducci V, Scardigli F, Harakalová M, Peter van Tintelen J, Doevendans P, Costa K, et al. Generation and characterization of novel human induced pluripotent stem cell (iPSC) lines originating from five asymptomatic individuals carrying the PLN-R14del pathogenic variant and a non-carrier relative. Stem Cell Res. 2023;72:103208 pubmed publisher
Souralova T, Hulinova D, Jeseta M, Ventruba P, Hampl A, Koutna I. Truncated vitronectin with E-cadherin enables the xeno-free derivation of human embryonic stem cells. Sci Rep. 2023;13:15062 pubmed publisher
Montero Calle P, Flandes Iparraguirre M, Kuebler B, Ar xe1 n B, Larequi E, Anaut I, et al. Generation of an induced pluripotent stem cell line (ESi107-A) from a transthyretin amyloid cardiomyopathy (ATTR-CM) patient carrying a p.Ser43Asn mutation in the TTR gene. Stem Cell Res. 2023;71:103189 pubmed publisher
Chen M, Niclis J, Denham M. Protocol for generating reproducible miniaturized controlled midbrain organoids. STAR Protoc. 2023;4:102451 pubmed publisher
Kato T, Nishimura K, Hirao M, Shimohama S, Takata K. Expression and role of nicotinic acetylcholine receptors during midbrain dopaminergic neuron differentiation from human induced pluripotent stem cells. Neuropsychopharmacol Rep. 2023;43:440-445 pubmed publisher
Nishimura K, xc1 sgr xed msd xf3 ttir E, Yang S, Arenas E. A protocol for the differentiation of human embryonic stem cells into midbrain dopaminergic neurons. STAR Protoc. 2023;4:102355 pubmed publisher
Bogetofte H, Ryan B, Jensen P, Schmidt S, Vergoossen D, Barnkob M, et al. Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons. Cell Rep. 2023;42:112180 pubmed publisher
Inoue S, Nishimura K, Gima S, Nakano M, Takata K. CRISPR-Cas9-Edited SNCA Knockout Human Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons and Their Vulnerability to Neurotoxicity. Biol Pharm Bull. 2023;46:517-522 pubmed publisher
Yang L, Lu S, Yang Z, Yao J, Zhou P, Zhao M. Generation of an induced pluripotent stem cell line (IPCASi001-A) from an autism spectrum disorder individual without intellectual disability. Stem Cell Res. 2023;66:102994 pubmed publisher
Akda x15f E, Turan S, Guhathakurta D, Ekici A, Salar S, Chichung Lie D, et al. CRISPR/Cas9-mediated generation of hESC lines with homozygote and heterozygote p.R331W mutation in CTBP1 to model HADDTS syndrome. Stem Cell Res. 2022;67:103012 pubmed publisher
Olmsted Z, Paredes Espinosa M, Paluh J. Generation of human elongating multi-lineage organized cardiac gastruloids. STAR Protoc. 2022;3:101898 pubmed publisher
Pantazis C, Yang A, Lara E, McDonough J, Blauwendraat C, Peng L, et al. A reference human induced pluripotent stem cell line for large-scale collaborative studies. Cell Stem Cell. 2022;29:1685-1702.e22 pubmed publisher
Ruangrung K, Chakritbudsabong W, Thongon S, Rungarunlert S, Wattanapanitch M, Boonarkart C, et al. Analysis of Influenza A virus infection in human induced pluripotent stem cells (hiPSCs) and their derivatives. Virus Res. 2022;323:199009 pubmed publisher
Cattelani C, Battistella I, Di Leva F, Fioravanti G, Benedicenti F, Stanzial F, et al. Induced Pluripotent Stem Cell (iPSC) Lines from a Family with Resistant Epileptic Encephalopathy Caused by Compound Heterozygous Mutations in SZT2 Gene. Int J Mol Sci. 2022;23: pubmed publisher
Souralova T, Rehakova D, Jeseta M, Tesarova L, Beranek J, Ventruba P, et al. The Manufacture of Xeno- and Feeder-Free Clinical-Grade Human Embryonic Stem Cell Lines: First Step for Cell Therapy. Int J Mol Sci. 2022;23: pubmed publisher
Nakashima Y, Miyagi Shiohira C, Saitoh I, Watanabe M, Matsushita M, Tsukahara M, et al. Induced hepatic stem cells are suitable for human hepatocyte production. iScience. 2022;25:105052 pubmed publisher
Johnson H, Chakraborty S, Muckom R, Balsara N, Schaffer D. A scalable and tunable thermoreversible polymer for 3D human pluripotent stem cell biomanufacturing. iScience. 2022;25:104971 pubmed publisher
Trinh L, Osipovich A, Sampson L, Wong J, Wright C, Magnuson M. Differential regulation of alternate promoter regions in Sox17 during endodermal and vascular endothelial development. iScience. 2022;25:104905 pubmed publisher
Olmsted Z, Paluh J. A combined human gastruloid model of cardiogenesis and neurogenesis. iScience. 2022;25:104486 pubmed publisher
Tada T, Ohnishi H, Yamamoto N, Kuwata F, Hayashi Y, Okuyama H, et al. Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats. Regen Ther. 2022;19:77-87 pubmed publisher
Aldrin Kirk P, Akerblom M, Cardoso T, Nolbrant S, Adler A, Liu X, et al. A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants. Stem Cell Reports. 2021;: pubmed publisher
Masibag A, Bergin C, Haebe J, Zouggar A, Shah M, Sandouka T, et al. Pharmacological targeting of Sam68 functions in colorectal cancer stem cells. iScience. 2021;24:103442 pubmed publisher
Geusz R, Wang A, Lam D, Vinckier N, Alysandratos K, Roberts D, et al. Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors. Nat Commun. 2021;12:6636 pubmed publisher
Robbins M, Pisupati V, Azzarelli R, Nehme S, Barker R, Fruk L, et al. Biofunctionalised bacterial cellulose scaffold supports the patterning and expansion of human embryonic stem cell-derived dopaminergic progenitor cells. Stem Cell Res Ther. 2021;12:574 pubmed publisher
Bluhmki T, Traub S, Müller A, Bitzer S, Schruf E, Bammert M, et al. Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96‑Transwell air-liquid interface model. Sci Rep. 2021;11:17028 pubmed publisher
Fütterer A, Talavera Gutiérrez A, Pons T, de Celis J, Gutierrez J, Domínguez Plaza V, et al. Impaired stem cell differentiation and somatic cell reprogramming in DIDO3 mutants with altered RNA processing and increased R-loop levels. Cell Death Dis. 2021;12:637 pubmed publisher
Chen S, Han Y, Yang L, Kim T, Nair M, Harschnitz O, et al. SARS-CoV-2 Infection Causes Dopaminergic Neuron Senescence. Res Sq. 2021;: pubmed publisher
Mou H, Yang Y, Riehs M, Barrios J, Shivaraju M, Haber A, et al. Airway basal stem cells generate distinct subpopulations of PNECs. Cell Rep. 2021;35:109011 pubmed publisher
Guo G, Stirparo G, Strawbridge S, Spindlow D, Yang J, Clarke J, et al. Human naive epiblast cells possess unrestricted lineage potential. Cell Stem Cell. 2021;28:1040-1056.e6 pubmed publisher
Tao Y, Vermilyea S, Zammit M, Lu J, Olsen M, Metzger J, et al. Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys. Nat Med. 2021;27:632-639 pubmed publisher
Kim T, Piao J, Koo S, Kriks S, Chung S, Betel D, et al. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use. Cell Stem Cell. 2021;28:343-355.e5 pubmed publisher
Piao J, Zabierowski S, Dubose B, Hill E, Navare M, Claros N, et al. Preclinical Efficacy and Safety of a Human Embryonic Stem Cell-Derived Midbrain Dopamine Progenitor Product, MSK-DA01. Cell Stem Cell. 2021;28:217-229.e7 pubmed publisher
Kuebler B, Aran B, Flores R, Perez Jurado L, Veiga A, Corominas R, et al. Generation of induced pluripotent stem cells (iPSCs) by retroviral transduction of skin fibroblasts from four patients suffering Williams-Beuren syndrome (7q11.23 deletion). Stem Cell Res. 2020;49:102087 pubmed publisher
Kuebler B, Aran B, Flores R, Perez Jurado L, Veiga A, Cuscó I, et al. Derivation of induced pluripotent stem cells (iPSCs) by retroviral transduction of skin fibroblasts from four patients suffering 7q11.23 microduplication syndrome. Stem Cell Res. 2020;49:102092 pubmed publisher
Inglés Ferrándiz M, Martin Inaraja M, Herrera L, Villaverde M, Santos S, Vesga M, et al. Generation, establishment and characterization of a pluripotent stem cell line (CVTTHi001-A) from primary fibroblasts isolated from a patient with activated PI3 kinase delta syndrome (APDS2). Stem Cell Res. 2020;49:102082 pubmed publisher
Walsh P, Truong V, Nayak S, Sald xed as Montivero M, Low W, Parr A, et al. Accelerated differentiation of human pluripotent stem cells into neural lineages via an early intermediate ectoderm population. Stem Cells. 2020;38:1400-1408 pubmed publisher
Naumovska E, Aalderink G, Wong Valencia C, Kosim K, Nicolas A, Brown S, et al. Direct On-Chip Differentiation of Intestinal Tubules from Induced Pluripotent Stem Cells. Int J Mol Sci. 2020;21: pubmed publisher
Yang Z, Jiang X, Zhang Z, Zhao Z, Xing W, Liu Y, et al. HDAC3-dependent transcriptional repression of FOXA2 regulates FTO/m6A/MYC signaling to contribute to the development of gastric cancer. Cancer Gene Ther. 2021;28:141-155 pubmed publisher
Yang L, Han Y, Nilsson Payant B, Gupta V, Wang P, Duan X, et al. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell. 2020;27:125-136.e7 pubmed publisher
Yoshida S, Miwa H, Kawachi T, Kume S, Takahashi K. Generation of intestinal organoids derived from human pluripotent stem cells for drug testing. Sci Rep. 2020;10:5989 pubmed publisher
Fuchs N, Schieck M, Neuenkirch M, Tondera C, Schmitz H, Wendeburg L, et al. Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi-Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1). Stem Cell Res. 2020;43:101697 pubmed publisher
Kim Y, Kim H, Suh C, Liu H, Rosenwaks Z, Ku S. Effects of Natural Progesterone and Synthetic Progestin on Germ Layer Gene Expression in a Human Embryoid Body Model. Int J Mol Sci. 2020;21: pubmed publisher
Da Li -, Cao T, Sun X, Jin S, Di Xie -, Huang X, et al. Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform. Nat Commun. 2020;11:342 pubmed publisher
Hu Y, Domínguez C, Bauer J, Weigel S, Schipperges A, Oelschlaeger C, et al. Carbon-nanotube reinforcement of DNA-silica nanocomposites yields programmable and cell-instructive biocoatings. Nat Commun. 2019;10:5522 pubmed publisher
Bredenkamp N, Yang J, Clarke J, Stirparo G, von Meyenn F, Dietmann S, et al. Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency. Stem Cell Reports. 2019;13:1083-1098 pubmed publisher
Riessland M, Kolisnyk B, Kim T, Cheng J, Ni J, Pearson J, et al. Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. Cell Stem Cell. 2019;25:514-530.e8 pubmed publisher
Stuart H, Stirparo G, Lohoff T, Bates L, Kinoshita M, Lim C, et al. Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell Stem Cell. 2019;25:388-406.e8 pubmed publisher
Lee K, Cho H, Rickert R, Li Q, Pulecio J, Leslie C, et al. FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation. Cell Rep. 2019;28:382-393.e7 pubmed publisher
Yokoi R, Okabe M, Matsuda N, Odawara A, Karashima A, Suzuki I. Impact of Sleep-Wake-Associated Neuromodulators and Repetitive Low-Frequency Stimulation on Human iPSC-Derived Neurons. Front Neurosci. 2019;13:554 pubmed publisher
Calatayud C, Carola G, Fernandez Carasa I, Valtorta M, Jimenez Delgado S, Diaz M, et al. CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons. Sci Rep. 2019;9:6811 pubmed publisher
Connor Robson N, Booth H, Martin J, Gao B, Li K, Doig N, et al. An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Neurobiol Dis. 2019;127:512-526 pubmed publisher
Zhou T, Kim T, Chong C, Tan L, Amin S, Sadat Badieyan Z, et al. A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival. Nat Commun. 2018;9:4815 pubmed publisher
Ida H, Akiyama T, Ishiguro K, Goparaju S, Nakatake Y, Chikazawa Nohtomi N, et al. Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors. Stem Cell Res Ther. 2018;9:277 pubmed publisher
Senís E, Mosteiro L, Wilkening S, Wiedtke E, Nowrouzi A, Afzal S, et al. AAVvector-mediated in vivo reprogramming into pluripotency. Nat Commun. 2018;9:2651 pubmed publisher
Kuebler B, Aran B, Miquel Serra L, Muñoz Y, Ars E, Bullich G, et al. Generation of integration-free induced pluripotent stem cell lines derived from two patients with X-linked Alport syndrome (XLAS). Stem Cell Res. 2017;25:291-295 pubmed publisher
Miquel Serra L, Duarri A, Munoz Y, Kuebler B, Aran B, Costa C, et al. Generation of six multiple sclerosis patient-derived induced pluripotent stem cell lines. Stem Cell Res. 2017;24:155-159 pubmed publisher
Wong K, Ryan S, Ramnarine K, Rosen S, Mann S, Kulick A, et al. CryoPause: A New Method to Immediately Initiate Experiments after Cryopreservation of Pluripotent Stem Cells. Stem Cell Reports. 2017;9:355-365 pubmed publisher
Kondo Y, Toyoda T, Ito R, Funato M, Hosokawa Y, Matsui S, et al. Identification of a small molecule that facilitates the differentiation of human iPSCs/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells. Diabetologia. 2017;60:1454-1466 pubmed publisher
Lee J, Laronde S, Collins T, Shapovalova Z, Tanasijevic B, McNicol J, et al. Lineage-Specific Differentiation Is Influenced by State of Human Pluripotency. Cell Rep. 2017;19:20-35 pubmed publisher
Sampaziotis F, de Brito M, Geti I, Bertero A, Hannan N, Vallier L. Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells. Nat Protoc. 2017;12:814-827 pubmed publisher
Shiraishi A, Muguruma K, Sasai Y. Generation of thalamic neurons from mouse embryonic stem cells. Development. 2017;144:1211-1220 pubmed publisher
Rogler C, Bebawee R, Matarlo J, Locker J, Pattamanuch N, Gupta S, et al. Triple Staining Including FOXA2 Identifies Stem Cell Lineages Undergoing Hepatic and Biliary Differentiation in Cirrhotic Human Liver. J Histochem Cytochem. 2017;65:33-46 pubmed publisher
Raju R, Chau D, Cho D, Park Y, Verfaillie C, Hu W. Cell Expansion During Directed Differentiation of Stem Cells Toward the Hepatic Lineage. Stem Cells Dev. 2017;26:274-284 pubmed publisher
Sato H, Idiris A, Miwa T, Kumagai H. Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells. Sci Rep. 2016;6:31063 pubmed publisher
product information
brand :
R&D Systems
master code :
AF2400
SKU :
AF2400
product name :
Human HNF-3▀/FoxA2 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human HNF-3ß/FoxA2 Antibody from R&D Systems is a goat polyclonal antibody to HNF-3 beta/FoxA2. This antibody reacts with human,mouse,primate - macaca mulatta (rhesus macaque),rat,transgenic rat,xenograft. The Human HNF-3ß/FoxA2 Antibody has been validated for the following applications: Immunohistochemistry,Immunocytochemistry,Chromatin Immunoprecipitation,Flow Cytometry,CyTof,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Chromatin Immunoprecipitation (ChIP).
target :
HNF-3 beta/FoxA2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Immunohistochemistry 3-15 ug/mL, Chromatin Immunoprecipitation (ChIP) 5 ug/5 x 10^6 cells, Immunocytochemistry 5-15 ug/mL
host :
Goat
immunogen :
E. coli -derived recombinant human HNF-3▀/FoxA2, Met242-Ser457, Accession # Q9Y261
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Primate - Macaca mulatta (Rhesus Macaque),Rat,Transgenic Rat,Xenograft
specificity :
Detects human HNF-3▀/FoxA2 in direct ELISAs and Western blots.
gene symbol :
FOXA2
top caption :
Detection of HNF-3ss/FoxA2-regulated Genes antibody by Chromatin Immunoprecipitation.
accessionNumbers :
Q9Y261
applications :
CyTof,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry
USD :
519 USD
alt names :
forkhead box A2, Forkhead box protein A2, FoxA2, hepatic nuclear factor-3-beta, hepatocyte nuclear factor 3, beta, hepatocyte nuclear factor 3-beta, HNF3 beta, HNF-3B, HNF-3-beta, HNF3BTCF-3B, MGC19807, TCF3B, Transcription factor 3B
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.