product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse Aminopeptidase N/CD13 Antibody
catalog :
AF2335
quantity :
100 ug (also 25 ug)
price :
489 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
citations: 51
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - free floating section; mouse; 1:200; loading ...; fig 4b, 5b
O Shea T, Ao Y, Wang S, Wollenberg A, Kim J, Ramos Espinoza R, et al. Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice. Nat Commun. 2022;13:5702 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 4a
Zhao Q, Dai W, Chen H, Jacobs R, Zlokovic B, Lund B, et al. Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation. Proc Natl Acad Sci U S A. 2022;119:e2113310119 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 1g, s2a
Nikolakopoulou A, Wang Y, Ma Q, Sagare A, Montagne A, Huuskonen M, et al. Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A. J Exp Med. 2021;218: pubmed publisher
Weber R, Buil B, Rentsch N, Bosworth A, Zhang M, Kisler K, et al. A molecular brain atlas reveals cellular shifts during the repair phase of stroke. bioRxiv. 2024;: pubmed publisher
Bennett H, Zhang Q, Wu Y, Manjila S, Chon U, Shin D, et al. Aging drives cerebrovascular network remodeling and functional changes in the mouse brain. Nat Commun. 2024;15:6398 pubmed publisher
Dong J, Wang L, Sullivan B, Sun L, Chang L, Martinez Smith V, et al. Patch and matrix striatonigral neurons differentially regulate locomotion. bioRxiv. 2024;: pubmed publisher
Wei C, Jiang W, Wang R, Zhong H, He H, Gao X, et al. Brain endothelial GSDMD activation mediates inflammatory BBB breakdown. Nature. 2024;629:893-900 pubmed publisher
Zhang D, Ruan J, Peng S, Li J, Hu X, Zhang Y, et al. Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling. Nat Neurosci. 2024;27:232-248 pubmed publisher
Wilk C, Cathomas F, T xf6 r xf6 k O, Le Bérichel J, Park M, Heaton G, et al. Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration. bioRxiv. 2023;: pubmed publisher
Jovanovic Macura I, Zivanovic A, Perovic M, Ciric J, Major T, Kanazir S, et al. The Expression of Major Facilitator Superfamily Domain-Containing Protein2a (Mfsd2a) and Aquaporin 4 Is Altered in the Retinas of a 5xFAD Mouse Model of Alzheimer's Disease. Int J Mol Sci. 2023;24: pubmed publisher
Bennett H, Zhang Q, Wu Y, Chon U, Pi H, Drew P, et al. Aging drives cerebrovascular network remodeling and functional changes in the mouse brain. bioRxiv. 2023;: pubmed publisher
Kurki S, Uvarov P, Pospelov A, Trontti K, H xfc bner A, Srinivasan R, et al. Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development. Cereb Cortex. 2023;33:5906-5923 pubmed publisher
Weber R, Mulders G, Perron P, Tackenberg C, Rust R. Molecular and anatomical roadmap of stroke pathology in immunodeficient mice. Front Immunol. 2022;13:1080482 pubmed publisher
Drieu A, Du S, Storck S, Rustenhoven J, Papadopoulos Z, Dykstra T, et al. Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid. Nature. 2022;611:585-593 pubmed publisher
Lauver M, Jin G, Ayers K, Carey S, Specht C, Abendroth C, et al. T cell deficiency precipitates antibody evasion and emergence of neurovirulent polyomavirus. elife. 2022;11: pubmed publisher
Barisano G, Kisler K, Wilkinson B, Nikolakopoulou A, Sagare A, Wang Y, et al. A "multi-omics" analysis of blood-brain barrier and synaptic dysfunction in APOE4 mice. J Exp Med. 2022;219: pubmed publisher
Britton R, Liu A, Rege S, Adams J, Akrapongpisak L, Le D, et al. Molecular and histological correlates of cognitive decline across age in male C57BL/6J mice. Brain Behav. 2022;12:e2736 pubmed publisher
Takashima M, Nakamura K, Kiyohara T, Wakisaka Y, Hidaka M, Takaki H, et al. Low-dose sodium-glucose cotransporter 2 inhibitor ameliorates ischemic brain injury in mice through pericyte protection without glucose-lowering effects. Commun Biol. 2022;5:653 pubmed publisher
Kiani Shabestari S, Morabito S, Danhash E, McQuade A, Sanchez J, Miyoshi E, et al. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice. Cell Rep. 2022;39:110961 pubmed publisher
Burda J, O Shea T, Ao Y, Suresh K, Wang S, Bernstein A, et al. Divergent transcriptional regulation of astrocyte reactivity across disorders. Nature. 2022;606:557-564 pubmed publisher
Wang Y, Kisler K, Nikolakopoulou A, Fernandez J, Griffin J, Zlokovic B. 3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice. Front Neurosci. 2022;16:841916 pubmed publisher
Choe Y, Yoon J, Joo J, Kim B, Hong S, Koh G, et al. Pericyte Loss Leads to Capillary Stalling Through Increased Leukocyte-Endothelial Cell Interaction in the Brain. Front Cell Neurosci. 2022;16:848764 pubmed publisher
Higa T, Okita Y, Matsumoto A, Nakayama S, Oka T, Sugahara O, et al. Spatiotemporal reprogramming of differentiated cells underlies regeneration and neoplasia in the intestinal epithelium. Nat Commun. 2022;13:1500 pubmed publisher
Sakaue T, Fujishima Y, Fukushima Y, Tsugawa Shimizu Y, Fukuda S, Kita S, et al. Adiponectin accumulation in the retinal vascular endothelium and its possible role in preventing early diabetic microvascular damage. Sci Rep. 2022;12:4159 pubmed publisher
Womack T, Vollert C, Ohia Nwoko O, Schmitt M, Montazari S, Beckett T, et al. Prostacyclin Promotes Degenerative Pathology in a Model of Alzheimer's Disease. Front Cell Neurosci. 2022;16:769347 pubmed publisher
Montagne A, Nikolakopoulou A, Huuskonen M, Sagare A, Lawson E, Lazic D, et al. APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β. Nat Aging. 2021;1:506-520 pubmed publisher
Hicks A, Kobrinsky S, Zhou S, Yang J, Prager Khoutorsky M. Anatomical Organization of the Rat Subfornical Organ. Front Cell Neurosci. 2021;15:691711 pubmed publisher
Bisht K, Okojie K, Sharma K, Lentferink D, Sun Y, Chen H, et al. Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice. Nat Commun. 2021;12:5289 pubmed publisher
Schaffenrath J, Huang S, Wyss T, Delorenzi M, Keller A. Characterization of the blood-brain barrier in genetically diverse laboratory mouse strains. Fluids Barriers CNS. 2021;18:34 pubmed publisher
Williamson M, Fuertes C, Dunn A, Drew M, Jones T. Reactive astrocytes facilitate vascular repair and remodeling after stroke. Cell Rep. 2021;35:109048 pubmed publisher
Wu Y, Wu H, Zeng J, Pluimer B, Dong S, Xie X, et al. Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice. Acta Neuropathol Commun. 2021;9:74 pubmed publisher
Gu xe9 rit S, Fidan E, Macas J, Czupalla C, Figueiredo R, Vijikumar A, et al. Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance. Prog Neurobiol. 2021;199:101937 pubmed publisher
OʼShea T, Wollenberg A, Kim J, Ao Y, Deming T, Sofroniew M. Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions. Nat Commun. 2020;11:6203 pubmed publisher
Kisler K, Nikolakopoulou A, Sweeney M, Lazic D, Zhao Z, Zlokovic B. Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling. Front Cell Neurosci. 2020;14:27 pubmed publisher
Shibahara T, Ago T, Nakamura K, Tachibana M, Yoshikawa Y, Komori M, et al. Pericyte-Mediated Tissue Repair through PDGFRβ Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke. Eneuro. 2020;7: pubmed publisher
Pous L, Deshpande S, Nath S, Mezey S, Malik S, Schildge S, et al. Fibrinogen induces neural stem cell differentiation into astrocytes in the subventricular zone via BMP signaling. Nat Commun. 2020;11:630 pubmed publisher
Grubb S, Cai C, Hald B, Khennouf L, Murmu R, Jensen A, et al. Precapillary sphincters maintain perfusion in the cerebral cortex. Nat Commun. 2020;11:395 pubmed publisher
Rajani R, Ratelade J, Domenga Denier V, Hase Y, Kalimo H, Kalaria R, et al. Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL. Acta Neuropathol Commun. 2019;7:187 pubmed publisher
Faraco G, Hochrainer K, Segarra S, Schaeffer S, Santisteban M, Menon A, et al. Dietary salt promotes cognitive impairment through tau phosphorylation. Nature. 2019;: pubmed publisher
Nakamura K, Ikeuchi T, Nara K, Rhodes C, Zhang P, Chiba Y, et al. Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier. J Cell Biol. 2019;218:3506-3525 pubmed publisher
Chen D, Sun N, Lu Y, Hong L, Cui T, Wang C, et al. GPR124 facilitates pericyte polarization and migration by regulating the formation of filopodia during ischemic injury. Theranostics. 2019;9:5937-5955 pubmed publisher
Wu Q, Yuan X, Bai J, Han R, Li Z, Zhang H, et al. MicroRNA-181a protects against pericyte apoptosis via directly targeting FOXO1: implication for ameliorated cognitive deficits in APP/PS1 mice. Aging (Albany NY). 2019;11:6120-6133 pubmed publisher
Ayyaz A, Kumar S, Sangiorgi B, Ghoshal B, Gosio J, Ouladan S, et al. Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell. Nature. 2019;569:121-125 pubmed publisher
Bellver Landete V, Bretheau F, Mailhot B, Vallières N, Lessard M, Janelle M, et al. Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury. Nat Commun. 2019;10:518 pubmed publisher
Hendrikx S, Coso S, Prat Luri B, Wetterwald L, Sabine A, Franco C, et al. Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2. Cell Rep. 2019;26:1227-1241.e6 pubmed publisher
Jia C, Keasey M, Malone H, Lovins C, Sante R, Razskazovskiy V, et al. Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF. Exp Neurol. 2019;312:20-32 pubmed publisher
Ma Q, Zhao Z, Sagare A, Wu Y, Wang M, Owens N, et al. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Mol Neurodegener. 2018;13:57 pubmed publisher
Koizumi K, Hattori Y, Ahn S, Buendia I, Ciacciarelli A, Uekawa K, et al. Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function. Nat Commun. 2018;9:3816 pubmed publisher
Anderson M, O Shea T, Burda J, Ao Y, Barlatey S, Bernstein A, et al. Required growth facilitators propel axon regeneration across complete spinal cord injury. Nature. 2018;561:396-400 pubmed publisher
Zhu W, Chen W, Zou D, Wang L, Bao C, Zhan L, et al. Thalidomide Reduces Hemorrhage of Brain Arteriovenous Malformations in a Mouse Model. Stroke. 2018;49:1232-1240 pubmed publisher
Nikolakopoulou A, Zhao Z, Montagne A, Zlokovic B. Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling. PLoS ONE. 2017;12:e0176225 pubmed publisher
product information
master code :
AF2335
SKU :
AF2335
product name :
Mouse Aminopeptidase N/CD13 Antibody
unit size :
100 ug (also 25 ug)
description :
The Mouse Aminopeptidase N/CD13 Antibody from R&D Systems is a goat polyclonal antibody to Aminopeptidase N/CD13. This antibody reacts with human,mouse,rat,transgenic mouse. The Mouse Aminopeptidase N/CD13 Antibody has been validated for the following applications: Immunohistochemistry,IHC-F,Flow Cytometry,Western Blot,Immunohistochemistry-Frozen,Immunocytochemistry,Immunoprecipitation,CyTOF-ready.
target :
Aminopeptidase N/CD13
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse Aminopeptidase N/CD13, Lys69-Ser966, Accession # P97449
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Rat,Transgenic Mouse
specificity :
Detects mouse Aminopeptidase N/CD13 in direct ELISAs and Western blots.
gene symbol :
ANPEP
top caption :
Aminopeptidase N/CD13 antibody in Mouse Splenocytes by Immunocytochemistry (ICC).
accessionNumbers :
P97449
applications :
Immunohistochemistry,IHC-F,Flow Cytometry,Western Blot,Immunohistochemistry-Frozen,Immunocytochemistry,Immunoprecipitation,CyTOF-ready
USD :
489 USD
alt names :
alanyl (membrane) aminopeptidase, Alanyl aminopeptidase, Aminopeptidase M, aminopeptidase N, ANPEP, AP-M, APN, AP-N, CD13, CD13 antigen, CD13APN, EC 3.4.11, EC 3.4.11.2, gp150, LAP1, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, P150, PEPN, PEPNhAPN
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.