Human Aminopeptidase PILS/ARTS1 Antibody | R&D Systems AF2334 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Aminopeptidase PILS/ARTS1 Antibody

catalog :

AF2334

quantity :

100 ug (also 25 ug)

price :

469 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 9

Reference
Temponeras I, Samiotaki M, Koumantou D, Nikopaschou M, Kuiper J, Panayotou G, et al. Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1. Eur J Immunol. 2023;:e2350449 pubmed publisher
Temponeras I, Stamatakis G, Samiotaki M, Georgiadis D, Pratsinis H, Panayotou G, et al. ERAP2 Inhibition Induces Cell-Surface Presentation by MOLT-4 Leukemia Cancer Cells of Many Novel and Potentially Antigenic Peptides. Int J Mol Sci. 2022;23: pubmed publisher
Arakawa A, Reeves E, Vollmer S, Arakawa Y, He M, Galinski A, et al. ERAP1 Controls the Autoimmune Response against Melanocytes in Psoriasis by Generating the Melanocyte Autoantigen and Regulating Its Amount for HLA-C*06:02 Presentation. J Immunol. 2021;207:2235-2244 pubmed publisher
Venema W, Hiddingh S, De Boer J, Claas F, Mulder A, den Hollander A, et al. ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29. Front Immunol. 2021;12:634441 pubmed publisher
Jiang P, Veenstra R, Seitz A, Nolte I, Hepkema B, Visser L, et al. Interaction between ERAP Alleles and HLA Class I Types Support a Role of Antigen Presentation in Hodgkin Lymphoma Development. Cancers (Basel). 2021;13: pubmed publisher
Saulle I, Vanetti C, Goglia S, Vicentini C, Tombetti E, Garziano M, et al. A New ERAP2/Iso3 Isoform Expression Is Triggered by Different Microbial Stimuli in Human Cells. Could It Play a Role in the Modulation of SARS-CoV-2 Infection?. Cells. 2020;9: pubmed publisher
Koumantou D, Barnea E, Martin Esteban A, Maben Z, Papakyriakou A, Mpakali A, et al. Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1). Cancer Immunol Immunother. 2019;: pubmed publisher
Papakyriakou A, Reeves E, Beton M, Mikolajek H, Douglas L, Cooper G, et al. The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1. J Biol Chem. 2018;293:7538-7548 pubmed publisher
Harrison S, Scambler T, Oubussad L, Wong C, Wittmann M, McDermott M, et al. Inositol-Requiring Enzyme 1-Mediated Downregulation of MicroRNA (miR)-146a and miR-155 in Primary Dermal Fibroblasts across Three TNFRSF1A Mutations Results in Hyperresponsiveness to Lipopolysaccharide. Front Immunol. 2018;9:173 pubmed publisher

product information

master code :

AF2334

SKU :

AF2334

product name :

Human Aminopeptidase PILS/ARTS1 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Aminopeptidase PILS/ARTS1 Antibody from R&D Systems is a goat polyclonal antibody to Aminopeptidase PILS/ARTS1. This antibody reacts with human. The Human Aminopeptidase PILS/ARTS1 Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunocytochemistry,Immunoprecipitation,Simple Western.

target :

Aminopeptidase PILS/ARTS1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Aminopeptidase PILS/ARTS1, Ala37-Met941, Accession # EAW96077

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human

specificity :

Detects human Aminopeptidase PILS/ARTS1 in direct ELISAs and Western blots. In direct ELISAs, approximately 45% cross-reactivity with recombinant mouse ARTS1 is observed.

gene symbol :

ERAP1

top caption :

Detection of Human Aminopeptidase PILS/ARTS1 antibody by Western Blot.

accessionNumbers :

EAW96077

applications :

Western Blot,Immunohistochemistry,Immunocytochemistry,Immunoprecipitation,Simple Western

USD :

469 USD

alt names :

Adipocyte-derived leucine aminopeptidase, A-LAP, A-LAPALAP, Aminopeptidase PILS, ARTS1, ARTS1aminopeptidase regulator of TNFR1 shedding, ARTS-1PILSAP, EC 3.4.11, EC 3.4.11.-, EC 3.4.11.1, endoplasmic reticulum aminopeptidase 1, endoplasmic reticulum aminopeptidase associated with antigen processing, ERAAP1, ERAP1, KIAA0525APPILS, PILS-AP, PILS-APERAAP, Puromycin-insensitive leucyl-specific aminopeptidase, Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage