Mouse Osteoactivin/GPNMB Antibody | R&D Systems AF2330 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse Osteoactivin/GPNMB Antibody

catalog :

AF2330

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section, western blot knockout validation

more info or order :

R&D Systems product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; fig s1b	Nickl B, Qadri F, Bader M. Anti-inflammatory role of Gpnmb in adipose tissue of mice. Sci Rep. 2021;11:19614 pubmed publisher
	Yalcin F, Haneke H, Efe I, Kuhrt L, Motta E, Nickl B, et al. Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma. Acta Neuropathol Commun. 2024;12:50 pubmed publisher
	Chuaychob S, Lyu R, Tanaka M, Haginiwa A, Kitada A, Nakamura T, et al. Mimicking angiogenic microenvironment of alveolar soft-part sarcoma in a microfluidic coculture vasculature chip. Proc Natl Acad Sci U S A. 2024;121:e2312472121 pubmed publisher
	Schonhoff A, Figge D, Williams G, Jurkuvenaite A, Gallups N, Childers G, et al. Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease. Nat Commun. 2023;14:3754 pubmed publisher
	Zhang T, Feng T, Wu K, Guo J, Nana A, Yang G, et al. Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination. Acta Neuropathol. 2023;146:97-119 pubmed publisher
	Xiong A, Zhang J, Chen Y, Zhang Y, Yang F. Integrated single-cell transcriptomic analyses reveal that GPNMB-high macrophages promote PN-MES transition and impede T cell activation in GBM. EBioMedicine. 2022;83:104239 pubmed publisher
	Burl R, Rondini E, Wei H, Pique Regi R, Granneman J. Deconstructing cold-induced brown adipocyte neogenesis in mice. elife. 2022;11: pubmed publisher
	Suda M, Shimizu I, Katsuumi G, Hsiao C, Yoshida Y, Matsumoto N, et al. Glycoprotein nonmetastatic melanoma protein B regulates lysosomal integrity and lifespan of senescent cells. Sci Rep. 2022;12:6522 pubmed publisher
	Kingston R, Amin D, Misra S, Gross J, Kuwajima T. Serotonin transporter-mediated molecular axis regulates regional retinal ganglion cell vulnerability and axon regeneration after nerve injury. PLoS Genet. 2021;17:e1009885 pubmed publisher
	Prabata A, Ikeda K, Rahardini E, Hirata K, Emoto N. GPNMB plays a protective role against obesity-related metabolic disorders by reducing macrophage inflammatory capacity. J Biol Chem. 2021;297:101232 pubmed publisher
	DU H, Wong M, Zhang T, Santos M, Hsu C, Zhang J, et al. A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses. Life Sci Alliance. 2021;4: pubmed publisher
	Robinet P, Ritchey B, Lorkowski S, Alzayed A, DeGeorgia S, Schodowski E, et al. Quantitative trait locus mapping identifies the Gpnmb gene as a modifier of mouse macrophage lysosome function. Sci Rep. 2021;11:10249 pubmed publisher
	van der Lienden M, Aten J, Marques A, Waas I, Larsen P, Claessen N, et al. GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice. Int J Mol Sci. 2021;22: pubmed publisher
	Huang M, Modeste E, Dammer E, Merino P, Taylor G, Duong D, et al. Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations. Acta Neuropathol Commun. 2020;8:163 pubmed publisher
	Feng T, Mai S, Roscoe J, Sheng R, Ullah M, Zhang J, et al. Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice. EMBO Rep. 2020;21:e50219 pubmed publisher
	Marshall J, Nietupski J, Park H, Cao J, Bangari D, Silvescu C, et al. Substrate Reduction Therapy for Sandhoff Disease through Inhibition of Glucosylceramide Synthase Activity. Mol Ther. 2019;: pubmed publisher
	Hüttenrauch M, Ogorek I, Klafki H, Otto M, Stadelmann C, Weggen S, et al. Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia. Acta Neuropathol Commun. 2018;6:108 pubmed publisher
	Tol M, van der Lienden M, Gabriel T, Hagen J, Scheij S, Veenendaal T, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 2018;14:437-449 pubmed publisher
	Ono Y, Tsuruma K, Takata M, Shimazawa M, Hara H. Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase. Sci Rep. 2016;6:23241 pubmed publisher
	Marques A, Gabriel T, Aten J, van Roomen C, Ottenhoff R, Claessen N, et al. Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease. PLoS ONE. 2016;11:e0147208 pubmed publisher

product information

brand :

R&D Systems

master code :

AF2330

SKU :

AF2330

product name :

Mouse Osteoactivin/GPNMB Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Mouse Osteoactivin/GPNMB Antibody from R&D Systems is a goat polyclonal antibody to Osteoactivin/GPNMB. This antibody reacts with human,mouse,transgenic mouse. The Mouse Osteoactivin/GPNMB Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA Capture (Matched Antibody Pair).

target :

Osteoactivin/GPNMB

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.1 ug/mL, Neutralization 0.2-0.8 ug/mL, ELISA Capture (Matched Antibody Pair) 0.2-0.8 ug/mL

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse Osteoactivin/GPNMB, Lys23-Asn502, Accession # Q8BVA0

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Transgenic Mouse

specificity :

Detects mouse Osteoactivin/GPNMB in ELISAs and Western blots. In sandwich immunoassays, less than 0.2% cross-reactivity with recombinant human (rh) Osteoactivin, rhSyndecan-4, and recombinant mouse Syndecan-4 is observed.

gene symbol :

GPNMB

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Cell Adhesion Mediated by Osteoactivin/GPNMB and Neutralization by Mouse Osteoactivin/GPNMB Antibody.

accessionNumbers :

Q8BVA0

applications :

ELISA Capture (Matched Antibody Pair),Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry

USD :

499 USD

alt names :

DC-HIL, glycoprotein (transmembrane) nmb, glycoprotein NMB, GPNMB, HGFIN, HGFINglycoprotein nmb-like protein, NMBosteoactivin, Transmembrane glycoprotein HGFIN, transmembrane glycoprotein NMB

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage