product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human TNF RI/TNFRSF1A Antibody
catalog :
AF225
quantity :
100 ug (also 25 ug)
price :
519 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 7
Reference
Nam Y, Shin J, Kim S, Hwang C, Lee C, Hwang G, et al. EGFR inhibits TNF-α-mediated pathway by phosphorylating TNFR1 at tyrosine 360 and 401. Cell Death Differ. 2024;31:1318-1332 pubmed publisher
Carracedo M, Ericson E, xc5 gren R, Forsl xf6 w A, Madeyski Bengtson K, Svensson A, et al. APOL1 promotes endothelial cell activation beyond the glomerulus. iScience. 2023;26:106830 pubmed publisher
McMillan D, Martinez Fleites C, Porter J, Fox D, Davis R, Mori P, et al. Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF. Nat Commun. 2021;12:582 pubmed publisher
Rodriguez Garcia A, Sharma P, Poussin M, Boesteanu A, Minutolo N, Gitto S, et al. CAR T Cells Targeting MISIIR for the Treatment of Ovarian Cancer and Other Gynecologic Malignancies. Mol Ther. 2020;28:548-560 pubmed publisher
O Connell J, Porter J, Kroeplien B, Norman T, Rapecki S, Davis R, et al. Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer. Nat Commun. 2019;10:5795 pubmed publisher
Luci C, Bekri S, Bihl F, Pini J, Bourdely P, Nouhen K, et al. NKp46+ Innate Lymphoid Cells Dampen Vaginal CD8 T Cell Responses following Local Immunization with a Cholera Toxin-Based Vaccine. PLoS ONE. 2015;10:e0143224 pubmed publisher
Wang Y, Tan B, Mu R, Chang Y, Wu M, Tu H, et al. Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor κB (NF-κB) signaling. J Biol Chem. 2015;290:10395-405 pubmed publisher
product information
master code :
AF225
SKU :
AF225
product name :
Human TNF RI/TNFRSF1A Antibody
unit size :
100 ug (also 25 ug)
description :
The Human TNF RI/TNFRSF1A Antibody from R&D Systems is a goat polyclonal antibody to TNF RI/TNFRSF1A. This antibody reacts with human,mouse,porcine. The Human TNF RI/TNFRSF1A Antibody has been validated for the following applications: Immunohistochemistry,Immunocytochemistry,ELISA Development,Immunoprecipitation,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Flow Cytometry,Western Blot,Agonist Activity,CyTOF-ready.
target :
TNF RI/TNFRSF1A
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
E. coli -derived recombinant human sTNF RI/TNFRSF1A, Accession # NP_001056
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Porcine
specificity :
Detects human sTNF RI/TNFRSF1A in direct ELISAs and Western blots. In direct ELISAs, less than 20% cross-reactivity with recombinant mouse TNF sRI and recombinant rat TNF sRI is observed. This anti-human TNF RI antibody can interact with the cell surface 55 kDa human TNF RI and exhibits TNF agonist activities on the A549 human lung carcinoma cell line. This antibody also exhibits TNF agonist activities on the L-929 mouse fibroblast cell line, suggesting that it has cross-species activity with mouse cell surface TNF RI.
gene symbol :
TNFRSF1A
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
TNF RI/TNFRSF1A antibody in Human Peripheral Blood Lymphocytes by Immunocytochemistry (ICC).
accessionNumbers :
NP_001056
applications :
Immunocytochemistry,ELISA Development,Immunoprecipitation,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Flow Cytometry,Western Blot,Agonist Activity,CyTOF-ready
USD :
519 USD
alt names :
CD120a, CD120a antigen, FPF, p55, p55-R, p60, TNFARMGC19588, TNF-R, TNF-R1, TNFR1TBP1, TNFR55, TNF-R55, TNFR60, TNFRI, TNF-RI, TNF-R-I, TNFR-I, TNFRSF1A, tumor necrosis factor binding protein 1, Tumor necrosis factor receptor 1, tumor necrosis factor receptor 1A isoform beta, tumor necrosis factor receptor superfamily member 1A, tumor necrosis factor receptor superfamily, member 1A, tumor necrosis factor receptor type 1, Tumor necrosis factor receptor type I, tumor necrosis factor-alpha receptor
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.