Human Nectin-2/CD112 Antibody | R&D Systems AF2229 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Nectin-2/CD112 Antibody

catalog :

AF2229

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 8

Reference
Choi H, Lee Y, Park S, Lee J, Park J, Park J, et al. Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligands. Oncoimmunology. 2022;11:2138152 pubmed publisher
Joung J, Kirchgatterer P, Singh A, Cho J, Nety S, Larson R, et al. CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Nat Commun. 2022;13:1606 pubmed publisher
Li Y, Zhang Y, Cao G, Zheng X, Sun C, Wei H, et al. Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors. J Hematol Oncol. 2021;14:100 pubmed publisher
Kim J, Cooper J. Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers. Arterioscler Thromb Vasc Biol. 2021;41:346-359 pubmed publisher
Fearnley G, Abdul Zani I, Latham A, Hollstein M, Ladbury J, Wheatcroft S, et al. Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function. Biol Open. 2019;8: pubmed publisher
Molfetta R, Milito N, Zitti B, Lecce M, Fionda C, Cippitelli M, et al. The Ubiquitin-proteasome pathway regulates Nectin2/CD112 expression and impairs NK cell recognition and killing. Eur J Immunol. 2019;49:873-883 pubmed publisher
Zhang Q, Bi J, Zheng X, Chen Y, Wang H, Wu W, et al. Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity. Nat Immunol. 2018;19:723-732 pubmed publisher
Niu C, Jin H, Li M, Zhu S, Zhou L, Jin F, et al. Low-dose bortezomib increases the expression of NKG2D and DNAM-1 ligands and enhances induced NK and γδ T cell-mediated lysis in multiple myeloma. Oncotarget. 2017;8:5954-5964 pubmed publisher

product information

master code :

AF2229

SKU :

AF2229

product name :

Human Nectin-2/CD112 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Nectin-2/CD112 Antibody from R&D Systems is a goat polyclonal antibody to Nectin-2/CD112. This antibody reacts with human. The Human Nectin-2/CD112 Antibody has been validated for the following applications: Immunoprecipitation,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,Simple Western.

target :

Nectin-2/CD112

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Nectin-2/CD112 isoform a, Gln32-Leu360, Accession # NP_002847

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human

specificity :

Detects human Nectin-2/CD112 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 2% cross-reactivity with recombinant human (rh) Nectin-1, rhNectin-3 and rhNectin-4 is observed.

gene symbol :

PVRL2

top caption :

Detection of Human Nectin-2/CD112 antibody by Western Blot.

accessionNumbers :

NP_002847

applications :

Immunoprecipitation,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,Simple Western

USD :

499 USD

alt names :

CD112, CD112 antigen, Herpes virus entry mediator B, Herpesvirus entry mediator B, herpesvirus entry protein B, HVEB, HVEBpoliovirus receptor-like 2, MPH, nectin 2, Nectin2, Nectin-2, poliovirus receptor-related 2 (herpesvirus entry mediator B), poliovirus receptor-related protein 2, PRR2, PRR2nectin-2, PVRL2, PVRR2poliovirus receptor related 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage