Human Phospho-Axl (Y779) Antibody | R&D Systems AF2228 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Phospho-Axl (Y779) Antibody

catalog :

AF2228

quantity :

100 ug (also 25 ug)

price :

429 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 28

Reference
Kim J, Nam G, Shin Y, Vilaplana Lopera N, Jeung H, Moon E, et al. Targeting AXL Using the AVB-500 Soluble Receptor and through Genetic Knockdown Inhibits Bile Duct Cancer Growth and Metastasis. Cancers (Basel). 2023;15: pubmed publisher
Shen Y, Zhu Q, Xiao M, Yin L, Feng W, Feng J, et al. Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop. Cell Death Dis. 2022;13:749 pubmed publisher
Hong J, Maacha S, Pidkovka N, Bates A, Salaria S, Washington M, et al. AXL Promotes Metformin-Induced Apoptosis Through Mediation of Autophagy by Activating ROS-AMPK-ULK1 Signaling in Human Esophageal Adenocarcinoma. Front Oncol. 2022;12:903874 pubmed publisher
Ye G, Huang M, Li Y, Ouyang J, Chen M, Wen Q, et al. The FAP α -activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway. Acta Pharm Sin B. 2022;12:1288-1304 pubmed publisher
Al Kafri N, Ahnstr xf6 m J, Teráz Orosz A, Chaput L, Singh N, Villoutreix B, et al. The first laminin G-like domain of protein S is essential for binding and activation of Tyro3 receptor and intracellular signalling. Biochem Biophys Rep. 2022;30:101263 pubmed publisher
George B, Haque A, Sahu V, Joldoshova A, Singh Y, Quinones J, et al. Enhancing Antigen Retrieval to Unmask Signaling Phosphoproteins in Formalin-fixed Archival Tissues. Appl Immunohistochem Mol Morphol. 2022;30:333-339 pubmed publisher
Synn C, Kim S, Lee H, Kim M, Kim J, Lee J, et al. SKI-G-801, an AXL kinase inhibitor, blocks metastasis through inducing anti-tumor immune responses and potentiates anti-PD-1 therapy in mouse cancer models. Clin Transl Immunology. 2022;11:e1364 pubmed publisher
Tirado Gonzalez I, Descot A, Soetopo D, Nevmerzhitskaya A, Schaffer A, Kur I, et al. AXL Inhibition in Macrophages Stimulates Host-versus-Leukemia Immunity and Eradicates Naïve and Treatment-Resistant Leukemia. Cancer Discov. 2021;11:2924-2943 pubmed publisher
Huang M, Chen M, Qi M, Ye G, Pan J, Shi C, et al. Perivascular cell-derived extracellular vesicles stimulate colorectal cancer revascularization after withdrawal of antiangiogenic drugs. J Extracell Vesicles. 2021;10:e12096 pubmed publisher
Jerkic M, Litvack M, Gagnon S, Otulakowski G, Zhang H, Rotstein O, et al. Embryonic-Derived Myb- Macrophages Enhance Bacterial Clearance and Improve Survival in Rat Sepsis. Int J Mol Sci. 2021;22: pubmed publisher
Han S, Wang Y, Ge C, Gao M, Wang X, Wang F, et al. Pharmaceutical inhibition of AXL suppresses tumor growth and invasion of esophageal squamous cell carcinoma. Exp Ther Med. 2020;20:41 pubmed publisher
Du W, Sun L, Liu T, Zhu J, Zeng Y, Zhang Y, et al. The miR‑625‑3p/AXL axis induces non‑T790M acquired resistance to EGFR‑TKI via activation of the TGF‑β/Smad pathway and EMT in EGFR‑mutant non‑small cell lung cancer. Oncol Rep. 2020;44:185-195 pubmed publisher
Ireland L, Luckett T, Schmid M, Mielgo A. Blockade of Stromal Gas6 Alters Cancer Cell Plasticity, Activates NK Cells, and Inhibits Pancreatic Cancer Metastasis. Front Immunol. 2020;11:297 pubmed publisher
Kuo M, Long Y, Tsai W, Li Y, Chen H, Feun L, et al. Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors. Transl Oncol. 2020;13:355-364 pubmed publisher
Hoj J, Mayro B, Pendergast A. A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis. Cell Rep. 2019;29:3421-3434.e8 pubmed publisher
Al Kafri N, Hafizi S. Tumour-Secreted Protein S (ProS1) Activates a Tyro3-Erk Signalling Axis and Protects Cancer Cells from Apoptosis. Cancers (Basel). 2019;11: pubmed publisher
Bracht J, Karachaliou N, Berenguer J, Pedraz Valdunciel C, Filipska M, Codony Servat C, et al. Osimertinib and pterostilbene in EGFR-mutation-positive non-small cell lung cancer (NSCLC). Int J Biol Sci. 2019;15:2607-2614 pubmed publisher
Dolan M, Mastri M, Tracz A, Christensen J, Chatta G, Ebos J. Enhanced efficacy of sitravatinib in metastatic models of antiangiogenic therapy resistance. PLoS ONE. 2019;14:e0220101 pubmed publisher
Paccez J, Duncan K, Sekar D, Correa R, Wang Y, Gu X, et al. Dihydroartemisinin inhibits prostate cancer via JARID2/miR-7/miR-34a-dependent downregulation of Axl. Oncogenesis. 2019;8:14 pubmed publisher
Li W, Dick A, Lu F, Zhang H, Sun H. Induction of MET Receptor Tyrosine Kinase Down-regulation through Antibody-mediated Receptor Clustering. Sci Rep. 2019;9:1988 pubmed publisher
Cheng L, Chen Y, Cheng A, Lee A, Cho C, Huang J, et al. AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells. J Biomed Sci. 2018;25:80 pubmed publisher
Maacha S, Hong J, von Lersner A, Zijlstra A, Belkhiri A. AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking. Neoplasia. 2018;20:1008-1022 pubmed publisher
Leonard B, Brand T, O Keefe R, Lee E, Zeng Y, Kemmer J, et al. BET Inhibition Overcomes Receptor Tyrosine Kinase-Mediated Cetuximab Resistance in HNSCC. Cancer Res. 2018;78:4331-4343 pubmed publisher
Chen Y, Tsai Y, Chao T, Wu Y, Chen M, Lin Y, et al. DAPK and CIP2A are involved in GAS6/AXL-mediated Schwann cell proliferation in a rat model of bilateral cavernous nerve injury. Oncotarget. 2018;9:6402-6415 pubmed publisher
Iida K, Sakai R, Yokoyama S, Kobayashi N, Togo S, Yoshikawa H, et al. Cell softening in malignant progression of human lung cancer cells by activation of receptor tyrosine kinase AXL. Sci Rep. 2017;7:17770 pubmed publisher
Shin H, Kim D, Helfman D. Tropomyosin isoform Tpm2.1 regulates collective and amoeboid cell migration and cell aggregation in breast epithelial cells. Oncotarget. 2017;8:95192-95205 pubmed publisher
Dantas Barbosa C, Lesluyes T, Loarer F, Chibon F, Treilleux I, Coindre J, et al. Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma. Br J Cancer. 2017;117:1787-1797 pubmed publisher
Kanzaki R, Naito H, Kise K, Takara K, Eino D, Minami M, et al. Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy. Sci Rep. 2017;7:10613 pubmed publisher

product information

brand :

R&D Systems

master code :

AF2228

SKU :

AF2228

product name :

Human Phospho-Axl (Y779) Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human Phospho-Axl (Y779) Antibody from R&D Systems is a rabbit polyclonal antibody to Axl. This antibody reacts with human,mouse,rat. The Human Phospho-Axl (Y779) Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Flow Cytometry,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry.

target :

Axl

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Immunohistochemistry 5-15 ug/mL, Immunocytochemistry 5-15 ug/mL

host :

Rabbit

immunogen :

Phosphopeptide containing human Axl Y779 site

isotype :

IgG

purity :

Antigen and protein A Affinity-purified

species :

Human,Mouse,Rat

specificity :

Detects human and mouse Axl when phosphorylated at Y779.

gene symbol :

AXL

top caption :

Phospho-Axl (Y779) antibody in Human Stomach Cancer Tissue by Immunohistochemistry (IHC-P).

applications :

Immunocytochemistry,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen

USD :

429 USD

alt names :

AI323647, ARK, AXL oncogene, AXL receptor tyrosine kinase, AXL transforming sequence/gene, EC 2.7.10, EC 2.7.10.1, JTK11, Tyro7, tyrosine-protein kinase receptor UFO, UFO, UFOoncogene AXL

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage