product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Galectin-3BP/MAC-2BP Antibody
catalog :
AF2226
quantity :
100 ug (also 25 ug)
price :
509 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
R&D Systems product webpage
citations: 12
Reference
Yamanaka T, Araki K, Yokobori T, Muranushi R, Hoshino K, Hagiwara K, et al. Potential of Mac-2-binding protein glycan isomer as a new therapeutic target in pancreatic cancer. Cancer Sci. 2024;115:1241-1249 pubmed publisher
Kapustin A, Tsakali S, Whitehead M, Chennell G, Wu M, Molenaar C, et al. Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI. bioRxiv. 2023;: pubmed publisher
Dufrusine B, Capone E, Ponziani S, Lattanzio R, Lanuti P, Giansanti F, et al. Extracellular LGALS3BP: a potential disease marker and actionable target for antibody-drug conjugate therapy in glioblastoma. Mol Oncol. 2023;17:1460-1473 pubmed publisher
Jang G, Crabb J, Hu B, Willard B, Kalirai H, Singh A, et al. Proteomics of Primary Uveal Melanoma: Insights into Metastasis and Protein Biomarkers. Cancers (Basel). 2021;13: pubmed publisher
Capone E, Lamolinara A, Pastorino F, Gentile R, Ponziani S, Di Vittorio G, et al. Targeting Vesicular LGALS3BP by an Antibody-Drug Conjugate as Novel Therapeutic Strategy for Neuroblastoma. Cancers (Basel). 2020;12: pubmed publisher
Ferdoushi A, Li X, Griffin N, Faulkner S, Jamaluddin M, Gao F, et al. Schwann Cell Stimulation of Pancreatic Cancer Cells: A Proteomic Analysis. Front Oncol. 2020;10:1601 pubmed publisher
Dolgormaa G, Harimoto N, Ishii N, Yamanaka T, Hagiwara K, Tsukagoshi M, et al. Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling. Br J Cancer. 2020;123:1145-1153 pubmed publisher
Seki T, Kanagawa M, Kobayashi K, Kowa H, Yahata N, Maruyama K, et al. Galectin 3-binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein. J Biol Chem. 2020;295:3678-3691 pubmed publisher
Cherepanova N, Venev S, Leszyk J, Shaffer S, Gilmore R. Quantitative glycoproteomics reveals new classes of STT3A- and STT3B-dependent N-glycosylation sites. J Cell Biol. 2019;218:2782-2796 pubmed publisher
Woo J, Jang J, Kang J, Seong J, Yoon Y, Kim H, et al. Lectin, Galactoside-Binding Soluble 3 Binding Protein Promotes 17-N-Allylamino-17-demethoxygeldanamycin Resistance through PI3K/Akt Pathway in Lung Cancer Cell Line. Mol Cancer Ther. 2017;16:1355-1365 pubmed publisher
Langley S, Willeit K, Didangelos A, Matic L, Skroblin P, Barallobre Barreiro J, et al. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques. J Clin Invest. 2017;127:1546-1560 pubmed publisher
Wang Q, Zhang X, Han Y, Wang X, Gao G. M2BP inhibits HIV-1 virion production in a vimentin filaments-dependent manner. Sci Rep. 2016;6:32736 pubmed publisher
product information
brand :
R&D Systems
master code :
AF2226
SKU :
AF2226
product name :
Human Galectin-3BP/MAC-2BP Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human Galectin-3BP/MAC-2BP Antibody from R&D Systems is a goat polyclonal antibody to Galectin-3BP/MAC-2BP/LGALS3BP. This antibody reacts with human,primate - macaca mulatta (rhesus macaque). The Human Galectin-3BP/MAC-2BP Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunocytochemistry,Simple Western.
target :
Galectin-3BP/MAC-2BP
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.2 ug/mL, Simple Western 10 ug/mL, Immunocytochemistry 1-15 ug/mL
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant human Galectin-3BP/MAC-2BP, Val19-Asp585, Accession # Q08380
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Primate - Macaca mulatta (Rhesus Macaque)
specificity :
Detects human Galectin-3BP/MAC-2BP in direct ELISAs and Western blots. In direct ELISAs, less than 20% cross-reactivity with recombinant mouse Galectin-3BP/MAC-2BP is observed.
gene symbol :
LGALS3BP
top caption :
Detection of Human Galectin-3BP/MAC-2BP antibody by Western Blot.
accessionNumbers :
Q08380
applications :
Simple Western,Immunohistochemistry,Western Blot,Immunocytochemistry
USD :
509 USD
alt names :
90K, Basement membrane autoantigen p105, BTBD17B, galectin-3-binding protein, Galectin3BP, L3 antigen, Lectin galactoside-binding soluble 3-binding protein, lectin, galactoside-binding, soluble, 3 binding protein, LGALS3BP, M2BP, Mac-2 BP, Mac-2-binding protein, MAC2BP, MAC-2BP, MAC-2-BP, serum protein 90K, Tumor-associated antigen 90K
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.