product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse NKp46/NCR1 Antibody
catalog :
AF2225
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 46
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 4d
Xu B, Tian L, Chen J, Wang J, Ma R, Dong W, et al. An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma. Nat Commun. 2021;12:5908 pubmed publisher
Biniaris Georgallis S, Aschman T, Stergioula K, Schreiber F, Jafari V, Taranko A, et al. Amplification of autoimmune organ damage by NKp46-activated ILC1s. Nature. 2024;634:952-960 pubmed publisher
Luckett T, Abudula M, Ireland L, Glenn M, Bellomo G, Stafferton R, et al. Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis. Cancer Res. 2024;84:527-544 pubmed publisher
Yoneda H, Mitsuhashi A, Yoshida A, Ogino H, Itakura S, Nguyen N, et al. Antipodoplanin antibody enhances the antitumor effects of CTLA-4 blockade against malignant mesothelioma by natural killer cells. Cancer Sci. 2024;115:357-368 pubmed publisher
Raufi A, Pellicciotta I, Palermo C, Sastra S, Chen A, Alouani E, et al. Cytotoxic chemotherapy potentiates the immune response and efficacy of combination CXCR4/PD-1 inhibition in models of pancreatic ductal adenocarcinoma. bioRxiv. 2023;: pubmed publisher
Bhin J, Yemelyanenko J, Chao X, Klarenbeek S, Opdam M, Malka Y, et al. MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer. J Exp Med. 2023;220: pubmed publisher
Farahmand P, Gyurászová K, Rooney C, Raffo Iraolagoitia X, Jayasekera G, Hedley A, et al. Asbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma. Front Toxicol. 2023;5:1200650 pubmed publisher
Chibaya L, Murphy K, DeMarco K, Gopalan S, Liu H, Parikh C, et al. EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance. Nat Cancer. 2023;4:872-892 pubmed publisher
Takasago T, Hayashi R, Ueno Y, Ariyoshi M, Onishi K, Yamashita K, et al. Anti-tumor necrosis factor-alpha monoclonal antibody suppresses colorectal cancer growth in an orthotopic transplant mouse model. PLoS ONE. 2023;18:e0283822 pubmed publisher
Hu J, S xe1 nchez Rivera F, Wang Z, Johnson G, Ho Y, Ganesh K, et al. STING inhibits the reactivation of dormant metastasis in lung adenocarcinoma. Nature. 2023;616:806-813 pubmed publisher
Lozano A, Souche F, Chavey C, Dardalhon V, Ramirez C, Vegna S, et al. Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma. elife. 2023;12: pubmed publisher
Zhang Z, Kong X, Ligtenberg M, van Hal van Veen S, Visser N, de Bruijn B, et al. RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells. Cell Rep Med. 2022;3:100655 pubmed publisher
Nixon B, Chou C, Krishna C, Dadi S, Michel A, Cornish A, et al. Cytotoxic granzyme C-expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity. Sci Immunol. 2022;7:eabi8642 pubmed publisher
Parida P, Marquez Palencia M, Nair V, Kaushik A, Kim K, Sudderth J, et al. Metabolic diversity within breast cancer brain-tropic cells determines metastatic fitness. Cell Metab. 2022;34:90-105.e7 pubmed publisher
Qadir A, Guegan J, Ginestier C, Chaibi A, Bessede A, Charafe Jauffret E, et al. CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells. iScience. 2021;24:103348 pubmed publisher
Fitzgerald A, Wang S, Agarwal V, Marcisak E, Zuo A, Jablonski S, et al. DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinoma. J Immunother Cancer. 2021;9: pubmed publisher
Zhao N, Bardine C, Louren xe7 o A, Wang Y, Huang Y, Cleary S, et al. In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET. ACS Cent Sci. 2021;7:1638-1649 pubmed publisher
Ciurkiewicz M, Floess S, Beckstette M, Kummerfeld M, Baumg xe4 rtner W, Huehn J, et al. Transcriptome analysis following neurotropic virus infection reveals faulty innate immunity and delayed antigen presentation in mice susceptible to virus-induced demyelination. Brain Pathol. 2021;31:e13000 pubmed publisher
Tello Lafoz M, Srpan K, Sanchez E, Hu J, Remšík J, Romin Y, et al. Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer. Immunity. 2021;54:1037-1054.e7 pubmed publisher
Bianchi A, Marchetti L, Hall Z, Lemos H, Vacca M, Paish H, et al. Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis. J Immunol. 2021;206:904-916 pubmed publisher
Wei D, Li D, Gu A, Ji W, Yang Y, Peng J. A novel Cytochrome P450 26A1 expressing NK cell subset at the mouse maternal-foetal interface. J Cell Mol Med. 2021;25:1771-1782 pubmed publisher
Calabrese D, Aminian E, Mallavia B, Liu F, Cleary S, Aguilar O, et al. Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury. J Clin Invest. 2021;131: pubmed publisher
Jin W, Shi K, He W, Sun J, Van Kaer L, Shi F, et al. Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition. Nat Neurosci. 2021;24:61-73 pubmed publisher
Kobia F, Preusse K, Dai Q, Weaver N, Hass M, Chaturvedi P, et al. Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. PLoS Biol. 2020;18:e3000850 pubmed publisher
Hargrave A, Courson J, Pham V, Landry P, Magadi S, Shankar P, et al. Corneal dysfunction precedes the onset of hyperglycemia in a mouse model of diet-induced obesity. PLoS ONE. 2020;15:e0238750 pubmed publisher
Koundouros N, Karali E, Tripp A, Valle A, Inglese P, Perry N, et al. Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids. Cell. 2020;181:1596-1611.e27 pubmed publisher
Yun J, Lee S, Kim S, Jeong S, Kim J, Pyo K, et al. Antitumor Activity of Amivantamab (JNJ-61186372), an EGFR-MET Bispecific Antibody, in Diverse Models of EGFR Exon 20 Insertion-Driven NSCLC. Cancer Discov. 2020;10:1194-1209 pubmed publisher
Ruscetti M, Morris J, Mezzadra R, Russell J, Leibold J, Romesser P, et al. Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. Cell. 2020;181:424-441.e21 pubmed publisher
Ireland L, Luckett T, Schmid M, Mielgo A. Blockade of Stromal Gas6 Alters Cancer Cell Plasticity, Activates NK Cells, and Inhibits Pancreatic Cancer Metastasis. Front Immunol. 2020;11:297 pubmed publisher
Del Prete A, Sozio F, Schioppa T, Ponzetta A, Vermi W, Calza S, et al. The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance. Cancer Immunol Res. 2019;7:1775-1788 pubmed publisher
Su W, Han H, Wang Y, Zhang B, Zhou B, Cheng Y, et al. The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression. Cancer Cell. 2019;36:139-155.e10 pubmed publisher
Davies A, Kim H, González Cano R, Choi J, Back S, Roh S, et al. Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. Cell. 2019;176:716-728.e18 pubmed publisher
Nishina S, Yamauchi A, Kawaguchi T, Kaku K, Goto M, Sasaki K, et al. Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice. Cell Mol Gastroenterol Hepatol. 2019;7:115-134 pubmed publisher
Kikuchi N, Ye J, Hirakawa J, Kawashima H. Forced Expression of CXCL10 Prevents Liver Metastasis of Colon Carcinoma Cells by the Recruitment of Natural Killer Cells. Biol Pharm Bull. 2019;42:57-65 pubmed publisher
Janker F, Weder W, Jang J, Jungraithmayr W. Preclinical, non-genetic models of lung adenocarcinoma: a comparative survey. Oncotarget. 2018;9:30527-30538 pubmed publisher
Er E, Valiente M, Ganesh K, Zou Y, Agrawal S, Hu J, et al. Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nat Cell Biol. 2018;20:966-978 pubmed publisher
Singh K, Ji X, Singh S. Therapeutic Potential of Leelamine, a Novel Inhibitor of Androgen Receptor and Castration-Resistant Prostate Cancer. Mol Cancer Ther. 2018;17:2079-2090 pubmed publisher
Martin A, Seignez C, Racoeur C, Isambert N, Mabrouk N, Scagliarini A, et al. Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment. Oncotarget. 2018;9:28364-28378 pubmed publisher
Turchinovich G, Ganter S, Bärenwaldt A, Finke D. NKp46 Calibrates Tumoricidal Potential of Type 1 Innate Lymphocytes by Regulating TRAIL Expression. J Immunol. 2018;200:3762-3768 pubmed publisher
Putz E, Mayfosh A, Kos K, Barkauskas D, Nakamura K, Town L, et al. NK cell heparanase controls tumor invasion and immune surveillance. J Clin Invest. 2017;127:2777-2788 pubmed publisher
Lagumersindez Denis N, Wrzos C, Mack M, Winkler A, van der Meer F, Reinert M, et al. Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis. Acta Neuropathol. 2017;134:15-34 pubmed publisher
Sung S, Ge Y, Dai C, Wang H, Fu S, Sharma R, et al. Dependence of Glomerulonephritis Induction on Novel Intraglomerular Alternatively Activated Bone Marrow-Derived Macrophages and Mac-1 and PD-L1 in Lupus-Prone NZM2328 Mice. J Immunol. 2017;198:2589-2601 pubmed publisher
Luu T, Ganesan S, Wagner A, Sarhan D, Meinke S, Garbi N, et al. Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells. Sci Rep. 2016;6:37996 pubmed publisher
Krueger P, Narayanan S, Surette F, Brown M, Sung S, Hahn Y. Murine liver-resident group 1 innate lymphoid cells regulate optimal priming of anti-viral CD8+ T cells. J Leukoc Biol. 2017;101:329-338 pubmed publisher
Kritikou J, Dahlberg C, Baptista M, Wagner A, Banerjee P, Gwalani L, et al. IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo. Sci Rep. 2016;6:30636 pubmed publisher
Rabacal W, Pabbisetty S, Hoek K, Cendron D, Guo Y, Maseda D, et al. Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival. Proc Natl Acad Sci U S A. 2016;113:5370-5 pubmed publisher
product information
brand :
R&D Systems
master code :
AF2225
SKU :
AF2225
product name :
Mouse NKp46/NCR1 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Mouse NKp46/NCR1 Antibody from R&D Systems is a goat polyclonal antibody to NKp46/NCR1. This antibody reacts with human,mouse,rat,transgenic mouse,xenograft. The Mouse NKp46/NCR1 Antibody has been validated for the following applications: Immunohistochemistry,Immunocytochemistry,Bioassay,Flow Cytometry,Western Blot,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Agonist Activity,CyTOF-ready.
target :
NKp46/NCR1
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.1 ug/mL, Flow Cytometry 2.5 ug/10^6 cells, Immunohistochemistry 3-15 ug/mL, Agonist Activity 0.4-2.4 ug/mL, CyTOF-ready
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse NKp46/NCR1, Glu22-Asn255, Accession # Q8C567
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Rat,Transgenic Mouse
specificity :
Detects mouse NKp46/NCR1 in direct ELISAs and Western blots. In direct ELISAs, less than 15% cross-reactivity with recombinant human (rh) NKp46 is observed.
gene symbol :
NCR1
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Mouse NKp46/NCR1 Antibody Induces IFN-? Secretion antibody in Activated Mouse NK Cells.
accessionNumbers :
Q8C567
applications :
Agonist Activity,CyTOF-ready,Bioassay,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry,Functional Assay
USD :
499 USD
alt names :
CD335, CD335 antigen, hNKp46, Ly94, LY94lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46), Lymphocyte antigen 94 homolog, MAR-1, natural cytotoxicity triggering receptor 1, Natural killer cell p46-related protein, NCR1, NK cell-activating receptor, NKp46, NKP46FLJ99094, NK-p46lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46)
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.