product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human LDLR Antibody
catalog :
AF2148
quantity :
100 ug (also 25 ug)
price :
519 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry
more info or order :
R&D Systems product webpage
citations: 29
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; fig 2b
Susan Resiga D, Girard E, Essalmani R, Roubtsova A, Marcinkiewicz J, Derbali R, et al. Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin. J Biol Chem. 2021;297:101177 pubmed publisher
Ritter M, Canus L, Gautam A, Vallet T, Zhong L, Lalande A, et al. The low-density lipoprotein receptor and apolipoprotein E associated with CCHFV particles mediate CCHFV entry into cells. Nat Commun. 2024;15:4542 pubmed publisher
Mikaeeli S, Ben Djoudi Ouadda A, Evagelidis A, Essalmani R, Ramos O, Fruchart Gaillard C, et al. Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C. Cells. 2024;13: pubmed publisher
Magalh xe3 es A, Ces xe1 rio V, Coutinho D, Matias I, Domingues G, Pinheiro C, et al. A high-cholesterol diet promotes the intravasation of breast tumor cells through an LDL-LDLR axis. Sci Rep. 2024;14:9471 pubmed publisher
Zakharova I, Shevchenko A, Arssan M, Sleptcov A, Nazarenko M, Zarubin A, et al. iPSC-Derived Endothelial Cells Reveal LDLR Dysfunction and Dysregulated Gene Expression Profiles in Familial Hypercholesterolemia. Int J Mol Sci. 2024;25: pubmed publisher
Vadon Le Goff S, Tessier A, Napoli M, Dieryckx C, Bauer J, Dussoyer M, et al. Identification of PCPE-2 as the endogenous specific inhibitor of human BMP-1/tolloid-like proteinases. Nat Commun. 2023;14:8020 pubmed publisher
Cui Q, Jeyachandran A, Garcia G, Qin C, Zhou Y, Zhang M, et al. The Apolipoprotein E neutralizing antibody inhibits SARS-CoV-2 infection by blocking cellular entry of lipoviral particles. MedComm (2020). 2023;4:e400 pubmed publisher
Fowler A, Van Rompay K, Sampson M, Leo J, Watanabe J, Usachenko J, et al. A virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in non-human primates. NPJ Vaccines. 2023;8:142 pubmed publisher
Fowler A, Van Rompay K, Sampson M, Leo J, Watanabe J, Usachenko J, et al. A Virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in Non-Human Primates. bioRxiv. 2023;: pubmed publisher
Engelen S, Ververs F, Markovska A, Lagerholm B, Kraaijenhof J, Yousif L, et al. Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T cells. JCI Insight. 2023;8: pubmed publisher
Essaidi Laziosi M, Royston L, Boda B, P xe9 rez Rodriguez F, Piuz I, Hulo N, et al. Altered cell function and increased replication of rhinoviruses and EV-D68 in airway epithelia of asthma patients. Front Microbiol. 2023;14:1106945 pubmed publisher
Jain V, Harper S, Versace A, Fingerman D, Brown G, Bhardwaj M, et al. Targeting UGCG overcomes resistance to lysosomal autophagy inhibition. Cancer Discov. 2022;: pubmed publisher
Vachon L, Smaani A, Tessier N, Jean G, Demers A, Milasan A, et al. Downregulation of low-density lipoprotein receptor mRNA in lymphatic endothelial cells impairs lymphatic function through changes in intracellular lipids. Theranostics. 2022;12:1440-1458 pubmed publisher
Acier A, Godard M, Gassiot F, Finetti P, Rubis M, Nowak J, et al. LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma. Commun Biol. 2021;4:987 pubmed publisher
Levine J, Oleaga C, Eren M, Amaral A, Shang M, Lux E, et al. Role of PAI-1 in hepatic steatosis and dyslipidemia. Sci Rep. 2021;11:430 pubmed publisher
Zhang C, Hao C, Shui G, Li W. BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor. elife. 2020;9: pubmed publisher
Banerjee S, Andrew R, Duff C, Fisher K, Jackson C, Lawrence C, et al. Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake. Sci Rep. 2019;9:11416 pubmed publisher
Huang L, Chambliss K, Gao X, Yuhanna I, Behling Kelly E, Bergaya S, et al. SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis. Nature. 2019;569:565-569 pubmed publisher
Sachan V, Lodge R, Mihara K, Hamelin J, Power C, Gelman B, et al. HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin. Cell Death Differ. 2019;: pubmed publisher
Volkmar N, Thezenas M, Louie S, Juszkiewicz S, Nomura D, Hegde R, et al. The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. J Cell Sci. 2019;132: pubmed publisher
Grin P, Dwivedi D, Chathely K, Trigatti B, Prat A, Seidah N, et al. Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor. Sci Rep. 2018;8:10496 pubmed publisher
Li X, Guo J, Liang N, Jiang X, Song Y, Ou S, et al. 6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol Efflux-Related Genes in HepG2 Cells. Front Pharmacol. 2018;9:159 pubmed publisher
Liang X, Sun H, Shen W, Wang S, Yao J, Migawa M, et al. Antisense oligonucleotides targeting translation inhibitory elements in 5' UTRs can selectively increase protein levels. Nucleic Acids Res. 2017;45:9528-9546 pubmed publisher
Felt S, Droby G, Grdzelishvili V. Ruxolitinib and Polycation Combination Treatment Overcomes Multiple Mechanisms of Resistance of Pancreatic Cancer Cells to Oncolytic Vesicular Stomatitis Virus. J Virol. 2017;91: pubmed publisher
Velázquez Moctezuma R, Law M, Bukh J, Prentoe J. Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A. PLoS Pathog. 2017;13:e1006214 pubmed publisher
Susan Resiga D, Girard E, Kiss R, Essalmani R, Hamelin J, Asselin M, et al. The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA. J Biol Chem. 2017;292:1573-1590 pubmed publisher
Fan J, Zareyan S, Zhao W, Shimizu Y, Pfeifer T, Tak J, et al. Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes. PLoS ONE. 2016;11:e0162384 pubmed publisher
Weider E, Susan Resiga D, Essalmani R, Hamelin J, Asselin M, Nimesh S, et al. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation. J Biol Chem. 2016;291:16659-71 pubmed publisher
Ramanathan A, Gusarova V, Stahl N, Gurnett Bander A, Kyratsous C. Alirocumab, a Therapeutic Human Antibody to PCSK9, Does Not Affect CD81 Levels or Hepatitis C Virus Entry and Replication into Hepatocytes. PLoS ONE. 2016;11:e0154498 pubmed publisher
product information
brand :
R&D Systems
master code :
AF2148
SKU :
AF2148
product name :
Human LDLR Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human LDLR Antibody from R&D Systems is a goat polyclonal antibody to LDLR. This antibody reacts with hamster,human,mouse,primate - cercopithecus aethiops (african green monkey),primate - macaca fascicularis (crab-eating monkey or cynomolgus macaque),rat. The Human LDLR Antibody has been validated for the following applications: Blockade of Receptor-ligand Interaction,Flow Cytometry,Western Blot,Neutralization,Immunocytochemistry,Functional Assay,Blocking,Immunoprecipitation,Immunohistochemistry.
target :
LDLR
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.1 ug/mL, Immunohistochemistry 5-15 ug/mL, Blockade of Receptor-ligand Interaction, Immunocytochemistry 1-15 ug/mL
host :
Goat
immunogen :
Chinese hamster ovary cell line CHO-derived recombinant human LDL R, Asp193-Arg788, Accession # P01130
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Hamster,Human,Mouse,Primate - Cercopithecus aethiops (African Green Monkey),Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque),Rat
specificity :
Detects human LDL R in direct ELISAs and Western blots. In direct ELISAs, approximately 15% cross-reactivity with recombinant mouse LDL R is observed.
gene symbol :
LDLR
Antibody validation :
Knockout/Knockdown
top caption :
LDL R antibody in HepG2 Human Cell Line by Immunocytochemistry (ICC).
accessionNumbers :
P01130
applications :
Blockade of Receptor-ligand Interaction,Blocking,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Neutralization,Immunocytochemistry,Functional Assay
USD :
519 USD
alt names :
FH, FHC, LDL R, LDL receptor, LDLCQ2, low density lipoprotein receptor, low-density lipoprotein receptor, low-density lipoprotein receptor class A domain-containing protein 3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.