Mouse CHL-1/L1CAM-2 Antibody | R&D Systems AF2147 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse CHL-1/L1CAM-2 Antibody

catalog :

AF2147

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 11

Reference
Maejima I, Hara T, Tsukamoto S, Koizumi H, Kawauchi T, Akuzawa T, et al. RAB35 is required for murine hippocampal development and functions by regulating neuronal cell distribution. Commun Biol. 2023;6:440 pubmed publisher
Duregotti E, Reumiller C, Mayr U, Hasman M, Schmidt L, Burnap S, et al. Reduced secretion of neuronal growth regulator 1 contributes to impaired adipose-neuronal crosstalk in obesity. Nat Commun. 2022;13:7269 pubmed publisher
Zhou R, Han B, Nowak R, Lu Y, Heller E, Xia C, et al. Proteomic and functional analyses of the periodic membrane skeleton in neurons. Nat Commun. 2022;13:3196 pubmed publisher
Loers G, Theis T, Baixia Hao H, Kleene R, Arsha S, Samuel N, et al. Interplay in neural functions of cell adhesion molecule close homolog of L1 (CHL1) and Programmed Cell Death 6 (PDCD6). FASEB Bioadv. 2022;4:43-59 pubmed publisher
Kim W, Watanabe H, Lomoio S, Tesco G. Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo. J Biol Chem. 2021;296:100372 pubmed publisher
Simoes S, Neufeld J, Triana Baltzer G, Moughadam S, Chen E, Kothiya M, et al. Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans. Sci Transl Med. 2020;12: pubmed publisher
Lombardo S, Chiacchiaretta M, Tarr A, Kim W, Cao T, Sigal G, et al. BACE1 partial deletion induces synaptic plasticity deficit in adult mice. Sci Rep. 2019;9:19877 pubmed publisher
Bye C, Rytova V, Alsanie W, Parish C, Thompson L. Axonal Growth of Midbrain Dopamine Neurons is Modulated by the Cell Adhesion Molecule ALCAM Through Trans-Heterophilic Interactions with L1cam, Chl1, and Semaphorins. J Neurosci. 2019;39:6656-6667 pubmed publisher
Mohan V, Wade S, Sullivan C, Kasten M, Sweetman C, Stewart R, et al. Close Homolog of L1 Regulates Dendritic Spine Density in the Mouse Cerebral Cortex Through Semaphorin 3B. J Neurosci. 2019;39:6233-6250 pubmed publisher
Tai Y, Gallo N, Wang M, Yu J, Van Aelst L. Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM. Neuron. 2019;102:358-372.e9 pubmed publisher
Kim W, Ma L, Lomoio S, Willen R, Lombardo S, Dong J, et al. BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice. Mol Neurodegener. 2018;13:6 pubmed publisher

product information

brand :

R&D Systems

master code :

AF2147

SKU :

AF2147

product name :

Mouse CHL-1/L1CAM-2 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Mouse CHL-1/L1CAM-2 Antibody from R&D Systems is a goat polyclonal antibody to CHL-1/L1CAM-2. This antibody reacts with mouse,rat. The Mouse CHL-1/L1CAM-2 Antibody has been validated for the following applications: Flow Cytometry,Immunoprecipitation,Western Blot,Neutralization,Cell Culture,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry,Simple Western.

target :

CHL-1/L1CAM-2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.25 ug/mL, Simple Western 2.5 ug/mL, Immunohistochemistry 5-15 ug/mL

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse CHL-1/L1CAM-2, Ala25-Gln1043 (Leu227-Gln242 del, Ala243Ser), Accession # BAC30699

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Mouse,Rat

specificity :

Detects mouse CHL-1/L1CAM-2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 40% cross-reactivity with recombinant human CHL-1 is observed.

gene symbol :

CHL1

top caption :

Detection of Mouse CHL-1/L1CAM-2 antibody by Western Blot.

accessionNumbers :

BAC30699

applications :

Simple Western,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry,Cell Culture

USD :

489 USD

alt names :

CALL, CALLClose homolog of L1, cell adhesion molecule with homology to L1CAM (close homolog of L1), cell adhesion molecule with homology to L1CAM (close homologue of L1), CHL1, FLJ44930, L1CAM-2, L1CAM2L1 cell adhesion molecule 2, MGC132578, neural cell adhesion molecule L1-like protein

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage