product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human ROR1 Antibody
catalog :
AF2000
quantity :
100 ug (also 25 ug)
price :
509 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
more info or order :
R&D Systems product webpage
citations: 13
Reference
Nishita M, Kamizaki K, Hoshi K, Aruga K, Nishikaku I, Shibuya H, et al. Rho family small GTPase Rif regulates Wnt5a-Ror1-Dvl2 signaling and promotes lung adenocarcinoma progression. J Biol Chem. 2023;299:105248 pubmed publisher
Liu D, Kaufmann G, Breitmeyer J, Dickson K, Marsh D, Ford C. The Anti-ROR1 Monoclonal Antibody Zilovertamab Inhibits the Proliferation of Ovarian and Endometrial Cancer Cells. Pharmaceutics. 2022;14: pubmed publisher
Liu Y, Deng H, Liang L, Zhang G, Xia J, Ding K, et al. Depletion of VPS35 attenuates metastasis of hepatocellular carcinoma by restraining the Wnt/PCP signaling pathway. Genes Dis. 2021;8:232-240 pubmed publisher
Liu D, Gunther K, Enriquez L, Daniels B, O Mara T, Tang K, et al. ROR1 is upregulated in endometrial cancer and represents a novel therapeutic target. Sci Rep. 2020;10:13906 pubmed publisher
Ljungars A, Svensson C, Carlsson A, Birgersson E, Tornberg U, Frendéus B, et al. Deep Mining of Complex Antibody Phage Pools Generated by Cell Panning Enables Discovery of Rare Antibodies Binding New Targets and Epitopes. Front Pharmacol. 2019;10:847 pubmed publisher
Islam S, Uddin M, Noman A, Akter H, Dity N, Basiruzzman M, et al. Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1. EBioMedicine. 2019;43:211-224 pubmed publisher
Yamaguchi T, Hayashi M, Ida L, Yamamoto M, Lu C, Kajino T, et al. ROR1-CAVIN3 interaction required for caveolae-dependent endocytosis and pro-survival signaling in lung adenocarcinoma. Oncogene. 2019;: pubmed publisher
Daneshmanesh A, Hojjat Farsangi M, Ghaderi A, Moshfegh A, Hansson L, Schultz J, et al. A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib. PLoS ONE. 2018;13:e0198038 pubmed publisher
Chow M, Gao L, Macmaniman J, Bicocca V, Chang B, Alumkal J, et al. Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALL. Oncogene. 2018;37:5221-5232 pubmed publisher
Henry C, Llamosas E, Daniels B, Coopes A, Tang K, Ford C. ROR1 and ROR2 play distinct and opposing roles in endometrial cancer. Gynecol Oncol. 2018;148:576-584 pubmed publisher
Henry C, Hacker N, Ford C. Silencing ROR1 and ROR2 inhibits invasion and adhesion in an organotypic model of ovarian cancer metastasis. Oncotarget. 2017;8:112727-112738 pubmed publisher
Karvonen H, Summala K, Niininen W, Barker H, Ungureanu D. Interaction between ROR1 and MuSK activation complex in myogenic cells. FEBS Lett. 2018;592:434-445 pubmed publisher
Yamaguchi T, Lu C, Ida L, Yanagisawa K, Usukura J, Cheng J, et al. ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. Nat Commun. 2016;7:10060 pubmed publisher
product information
master code :
AF2000
SKU :
AF2000
product name :
Human ROR1 Antibody
unit size :
100 ug (also 25 ug)
description :
The Human ROR1 Antibody from R&D Systems is a goat polyclonal antibody to ROR1. This antibody reacts with human. The Human ROR1 Antibody has been validated for the following applications: Flow Cytometry,Neutralization,Immunoprecipitation,Western Blot,Immunohistochemistry,Immunocytochemistry,Simple Western,CyTOF-ready.
target :
ROR1
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant human ROR1, Ala24-Glu403, Accession # Q01973
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human
specificity :
Detects human ROR1 in direct ELISAs and Western blots.
gene symbol :
ROR1
Antibody validation :
Knockout/Knockdown
top caption :
Detection of ROR1 antibody by Western Blot.
accessionNumbers :
Q01973
applications :
Flow Cytometry,Immunoprecipitation,Western Blot,Immunohistochemistry,Immunocytochemistry,Simple Western,CyTOF-ready
USD :
509 USD
alt names :
EC 2.7.10.1, MGC99659, neurotrophic tyrosine kinase receptor-related 1, Neurotrophic tyrosine kinase, receptor-related 1, NTRKR1, NTRKR1dJ537F10.1, receptor tyrosine kinase-like orphan receptor 1, tyrosine-protein kinase transmembrane receptor ROR1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.