Mouse/Rat CD47 N-terminal IgV-like Extracellular Domain Antibody

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse/Rat CD47 N-terminal IgV-like Extracellular Domain Antibody

catalog :

AF1866

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

R&D Systems product webpage

citations: 10

Reference
Moon S, Han S, Jang I, Ryu J, Rha M, Cho H, et al. Airway epithelial CD47 plays a critical role in inducing influenza virus-mediated bacterial super-infection. Nat Commun. 2024;15:3666 pubmed publisher
Tang Z, Zhong M, Qian J, Galindo C, Davidson D, Li J, et al. CD47 masks pro-phagocytic ligands in cis on tumor cells to suppress antitumor immunity. Nat Immunol. 2023;24:2032-2041 pubmed publisher
Du L, Su Z, Wang S, Meng Y, Xiao F, Xu D, et al. EGFR-Induced and c-Src-Mediated CD47 Phosphorylation Inhibits TRIM21-Dependent Polyubiquitylation and Degradation of CD47 to Promote Tumor Immune Evasion. Adv Sci (Weinh). 2023;:e2206380 pubmed publisher
Pizzato H, Alonso Guallart P, Woods J, Johannesson B, Connelly J, Fehniger T, et al. Engineering Human Pluripotent Stem Cell Lines to Evade Xenogeneic Transplantation Barriers. bioRxiv. 2023;: pubmed publisher
Singla B, Aithbathula R, Pervaiz N, Kathuria I, Swanson M, Ekuban F, et al. CD47 Activation by Thrombospondin-1 in Lymphatic Endothelial Cells Suppresses Lymphangiogenesis and Promotes Atherosclerosis. Arterioscler Thromb Vasc Biol. 2023;43:1234-1250 pubmed publisher
Mueller P, Kojima Y, Huynh K, Maldonado R, Ye J, Tavori H, et al. Macrophage LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Is Required for the Effect of CD47 Blockade on Efferocytosis and Atherogenesis-Brief Report. Arterioscler Thromb Vasc Biol. 2022;42:e1-e9 pubmed publisher
Ding X, Wang J, Huang M, Chen Z, Liu J, Zhang Q, et al. Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration. Nat Commun. 2021;12:2030 pubmed publisher
Lerbs T, Cui L, King M, Chai T, Muscat C, Chung L, et al. CD47 prevents the elimination of diseased fibroblasts in scleroderma. JCI Insight. 2020;5: pubmed publisher
Azcutia V, Kelm M, Luissint A, Boerner K, Flemming S, Quirós M, et al. Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo. Mucosal Immunol. 2020;: pubmed publisher
Reed M, Luissint A, Azcutia V, Fan S, O Leary M, Quirós M, et al. Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo. Nat Commun. 2019;10:5004 pubmed publisher

product information

master code :

AF1866

SKU :

AF1866

product name :

Mouse/Rat CD47 N-terminal IgV-like Extracellular Domain Antibody

unit size :

100 ug (also 25 ug)

description :

The Mouse/Rat CD47 N-terminal IgV-like Extracellular Domain Antibody from R&D Systems is a goat polyclonal antibody to CD47. This antibody reacts with human,mouse,rat. The Mouse/Rat CD47 N-terminal IgV-like Extracellular Domain Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Flow Cytometry,Immunoprecipitation,Immunofluorescence,Immunocytochemistry.

target :

CD47

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse CD47 N-terminal IgV-like, Gln19-Pro158, Accession # NP_034711

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat

specificity :

Detects mouse CD47 N-terminal IgV-like in direct ELISAs and Western blots. In direct ELISAs, less than 15% cross-reactivity with recombinant human CD47 is observed.

gene symbol :

CD47

top caption :

Detection of Mouse CD47 antibody by Western Blot.

accessionNumbers :

NP_034711

applications :

Immunohistochemistry,Western Blot,Flow Cytometry,Immunoprecipitation,Immunofluorescence,Immunocytochemistry

USD :

499 USD

alt names :

antigen identified by monoclonal 1D8, Antigenic surface determinant protein OA3, CD47, CD47 antigen, CD47 antigen (Rh-related antigen, integrin-associated signal transducer), CD47 glycoprotein, CD47 molecule, IAP, IAPintegrin associated protein, Integrin-associated protein, leukocyte surface antigen CD47, MER6, MER6integrin-associated signal transducer, OA3, Protein MER6, Rh-related antigen

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage