product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse Granzyme B Antibody
catalog :
AF1865
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 21
Reference
Malyshkina A, Bayer W, Podschwadt P, Otto L, Karakoese Z, Sutter K, et al. Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles. PLoS Pathog. 2023;19:e1011725 pubmed publisher
Xue J, Xu L, Zhong H, Bai M, Li X, Yao R, et al. Impaired regulatory function of granzyme B-producing B cells against T cell inflammatory responses in lupus mice. Lupus Sci Med. 2023;10: pubmed publisher
Umemoto S, Nakahashi Ouchida R, Yuki Y, Kurokawa S, Machita T, Uchida Y, et al. Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents. NPJ Vaccines. 2023;8:106 pubmed publisher
Napier T, Hunter C, Song P, Larimer B, Sorace A. Preclinical PET Imaging of Granzyme B Shows Promotion of Immunological Response Following Combination Paclitaxel and Immune Checkpoint Inhibition in Triple Negative Breast Cancer. Pharmaceutics. 2022;14: pubmed publisher
Deschuyter M, Leger D, Verboom A, Chaunavel A, Maftah A, Petit J. ST3GAL2 knock-down decreases tumoral character of colorectal cancer cells in vitro and in vivo. Am J Cancer Res. 2022;12:280-302 pubmed
Chen H, Yu H, Rudy R, Lim S, Chen Y, Wu S, et al. DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation. iScience. 2021;24:103086 pubmed publisher
Ho S, Lee Y, Ittmann M, Lin F, Chan K, Lin W. RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis. Cancer Lett. 2021;520:344-360 pubmed publisher
Koda Y, Teratani T, Chu P, Hagihara Y, Mikami Y, Harada Y, et al. CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells. Nat Commun. 2021;12:4474 pubmed publisher
Jia L, Wang Y, Wang C. circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation. Adv Sci (Weinh). 2021;8:2003376 pubmed publisher
Muhuri M, Zhan W, Maeda Y, Li J, Lotun A, Chen J, et al. Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction. Front Immunol. 2021;12:674242 pubmed publisher
Zhang W, Liu W, Jia L, Chen D, Chang I, Lake M, et al. Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress. Mol Cell. 2021;81:2148-2165.e9 pubmed publisher
Pires A, Greenshields Watson A, Jones E, Smart K, Lauder S, Somerville M, et al. Immune Remodeling of the Extracellular Matrix Drives Loss of Cancer Stem Cells and Tumor Rejection. Cancer Immunol Res. 2020;8:1520-1531 pubmed publisher
Shim Y, Khedraki R, Dhar J, Fan R, Dvorina N, Valujskikh A, et al. Early T cell infiltration is modulated by programed cell death-1 protein and its ligand (PD-1/PD-L1) interactions in murine kidney transplants. Kidney Int. 2020;98:897-905 pubmed publisher
Jia L, Zhang W, Wang C. BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse. Cell Stem Cell. 2020;: pubmed publisher
Abadie V, Kim S, Lejeune T, Palanski B, Ernest J, Tastet O, et al. IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease. Nature. 2020;578:600-604 pubmed publisher
Yu D, Liu X, Han G, Liu Y, Zhao X, Wang D, et al. The let-7 family of microRNAs suppresses immune evasion in head and neck squamous cell carcinoma by promoting PD-L1 degradation. Cell Commun Signal. 2019;17:173 pubmed publisher
Chan L, Li C, Xia W, Hsu J, Lee H, Cha J, et al. IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. J Clin Invest. 2019;129:3324-3338 pubmed publisher
Pantelidou C, Sonzogni O, De Oliveria Taveira M, Mehta A, Kothari A, Wang D, et al. PARP Inhibitor Efficacy Depends on CD8+ T-cell Recruitment via Intratumoral STING Pathway Activation in BRCA-Deficient Models of Triple-Negative Breast Cancer. Cancer Discov. 2019;9:722-737 pubmed publisher
Cha J, Yang W, Xia W, Wei Y, Chan L, Lim S, et al. Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. Mol Cell. 2018;71:606-620.e7 pubmed publisher
Yang W, Cha J, Xia W, Lee H, Chan L, Wang Y, et al. Juxtacrine Signaling Inhibits Antitumor Immunity by Upregulating PD-L1 Expression. Cancer Res. 2018;78:3761-3768 pubmed publisher
Farrag M, Amer H, Öhlschläger P, Hamad M, Almajhdi F. Novel recombinant DNA vaccine candidates for human respiratory syncytial virus: Preclinical evaluation of immunogenicity and protection efficiency. Hum Vaccin Immunother. 2017;13:1586-1597 pubmed publisher
product information
master code :
AF1865
SKU :
AF1865
product name :
Mouse Granzyme B Antibody
unit size :
100 ug (also 25 ug)
description :
The Mouse Granzyme B Antibody from R&D Systems is a goat polyclonal antibody to Granzyme B. This antibody reacts with human,mouse. The Mouse Granzyme B Antibody has been validated for the following applications: Immunohistochemistry,ELISA Development (Capture),Western Blot,Functional Assay,Immunohistochemistry-Frozen,Immunocytochemistry,Immunoprecipitation,Neutralization,ELISA Capture (Matched Antibody Pair).
target :
Granzyme B
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse Granzyme B, Lys17-Ser247, Accession # P04187
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse
specificity :
Detects mouse Granzyme B in ELISAs and Western blots.
gene symbol :
GZMB
top caption :
Granzyme B antibody in Mouse Splenocytes by Immunocytochemistry (ICC).
accessionNumbers :
P04187
applications :
Immunohistochemistry,ELISA Development (Capture),Western Blot,Functional Assay,Immunohistochemistry-Frozen,Immunocytochemistry,Immunoprecipitation,Neutralization,ELISA Capture (Matched Antibody Pair)
USD :
499 USD
alt names :
C11, CCPI, CGL1, CGL-1, CSPB, CSP-B, CTLA1, CTLA-1, CTSGL1, Fragmentin-2, granzyme B, Granzyme-2, GranzymeB, GRB, GrzB, GZMB, HLP, SECT
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.