product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human NKp46/NCR1 Antibody
catalog :
AF1850
quantity :
100 ug (also 25 ug)
price :
489 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 7
Reference
Chibaya L, Murphy K, DeMarco K, Gopalan S, Liu H, Parikh C, et al. EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance. Nat Cancer. 2023;4:872-892 pubmed publisher
Francescone R, Barbosa Vendramini Costa D, Franco Barraza J, Wagner J, Muir A, Lau A, et al. Netrin G1 Promotes Pancreatic Tumorigenesis through Cancer-Associated Fibroblast-Driven Nutritional Support and Immunosuppression. Cancer Discov. 2021;11:446-479 pubmed publisher
Mikulak J, Oriolo F, Bruni E, Roberto A, Colombo F, Villa A, et al. NKp46-expressing human gut-resident intraepithelial Vδ1 T cell subpopulation exhibits high antitumor activity against colorectal cancer. JCI Insight. 2019;4: pubmed publisher
Belkaya S, Michailidis E, Korol C, Kabbani M, Cobat A, Bastard P, et al. Inherited IL-18BP deficiency in human fulminant viral hepatitis. J Exp Med. 2019;: pubmed publisher
Nishina S, Yamauchi A, Kawaguchi T, Kaku K, Goto M, Sasaki K, et al. Dipeptidyl Peptidase 4 Inhibitors Reduce Hepatocellular Carcinoma by Activating Lymphocyte Chemotaxis in Mice. Cell Mol Gastroenterol Hepatol. 2019;7:115-134 pubmed publisher
V ly F, Barlogis V, Vallentin B, Neven B, Piperoglou C, Ebbo M, et al. Evidence of innate lymphoid cell redundancy in humans. Nat Immunol. 2016;17:1291-1299 pubmed publisher
Sips M, Krykbaeva M, Diefenbach T, Ghebremichael M, Bowman B, Dugast A, et al. Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies. Mucosal Immunol. 2016;9:1584-1595 pubmed publisher
product information
master code :
AF1850
SKU :
AF1850
product name :
Human NKp46/NCR1 Antibody
unit size :
100 ug (also 25 ug)
description :
The Human NKp46/NCR1 Antibody from R&D Systems is a goat polyclonal antibody to NKp46/NCR1. This antibody reacts with human. The Human NKp46/NCR1 Antibody has been validated for the following applications: Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Western Blot.
target :
NKp46/NCR1
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant human NKp46/NCR1, Gln22-Asn254, Accession # AAH64806
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human
specificity :
Detects human NKp46 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant mouse NKp46 (MAR-1) is observed and less than 1% cross-reactivity with recombinant human (rh) NKp30, rhNKp44, and rhNKp80 is observed.
gene symbol :
NCR1
top caption :
NKp46/NCR1 antibody in NK-92 human cell line
accessionNumbers :
AAH64806
applications :
Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Western Blot
USD :
489 USD
alt names :
CD335, CD335 antigen, hNKp46, Ly94, LY94lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46), Lymphocyte antigen 94 homolog, MAR-1, natural cytotoxicity triggering receptor 1, Natural killer cell p46-related protein, NCR1, NK cell-activating receptor, NKp46, NKP46FLJ99094, NK-p46lymphocyte antigen 94 (mouse) homolog (activating NK-receptor; NK-p46)
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.