Mouse IL-6R alpha Antibody | R&D Systems AF1830 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse IL-6R alpha Antibody

catalog :

AF1830

quantity :

100 ug (also 25 ug)

price :

509 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 13

Reference
Singh Kakan S, Li X, Edman M, Okamoto C, Hjelm B, Hamm Alvarez S. The miRNA Landscape of Lacrimal Glands in a Murine Model of Autoimmune Dacryoadenitis. Invest Ophthalmol Vis Sci. 2023;64:1 pubmed publisher
Sharma A, Sari E, Lee Y, Patel S, Brenner M, Marambaud P, et al. Extracellular CIRP Induces Calpain Activation in Neurons via PLC-IP3-Dependent Calcium Pathway. Mol Neurobiol. 2023;60:3311-3328 pubmed publisher
Gutierrez A, Gao Z, Hamidi V, Zhu L, Saint Andre K, Riggs K, et al. Anti-diabetic effects of GLP1 analogs are mediated by thermogenic interleukin-6 signaling in adipocytes. Cell Rep Med. 2022;3:100813 pubmed publisher
Matsumura F, Polz R, Singh S, Matsumura A, Scheller J, Yamashiro S. Investigation of Fascin1, a Marker of Mature Dendritic Cells, Reveals a New Role for IL-6 Signaling in CCR7-Mediated Chemotaxis. J Immunol. 2021;207:938-949 pubmed publisher
Shimada A, Hasegawa Ishii S. Increased cytokine expression in the choroid plexus stroma and epithelium in response to endotoxin-induced systemic inflammation in mice. Toxicol Rep. 2021;8:520-528 pubmed publisher
Zhao D, Cai L, Lu X, Liang X, Li J, Chen P, et al. Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer. Cancer Discov. 2020;10:1374-1387 pubmed publisher
Zhou M, Aziz M, Denning N, Yen H, Ma G, Wang P. Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R-mediated STAT3 activation. JCI Insight. 2020;5: pubmed publisher
Huang H, Zhang Y, Gallegos V, Sorrelle N, Zaid M, Toombs J, et al. Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer. EMBO Mol Med. 2019;11:e10515 pubmed publisher
Kim S, Neuendorff N, Earnest D. Role of Proinflammatory Cytokines in Feedback Modulation of Circadian Clock Gene Rhythms by Saturated Fatty Acids. Sci Rep. 2019;9:8909 pubmed publisher
St Leger A, Hansen A, Karauzum H, Horai R, Yu C, Laurence A, et al. STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection. J Exp Med. 2018;215:1079-1090 pubmed publisher
Wang X, Miller E, Goswami M, Zhang P, Ronning K, Karlen S, et al. Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130. J Neuroinflammation. 2017;14:121 pubmed publisher
Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, et al. Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling. Sci Rep. 2017;7:44053 pubmed publisher
Owusu Boaitey N, Bauckman K, Zhang T, Mysorekar I. Macrophagic control of the response to uropathogenic E. coli infection by regulation of iron retention in an IL-6-dependent manner. Immun Inflamm Dis. 2016;4:413-426 pubmed

product information

master code :

AF1830

SKU :

AF1830

product name :

Mouse IL-6R alpha Antibody

unit size :

100 ug (also 25 ug)

description :

The Mouse IL-6R alpha Antibody from R&D Systems is a goat polyclonal antibody to IL-6R alpha. This antibody reacts with human,mouse,rat. The Mouse IL-6R alpha Antibody has been validated for the following applications: Immunocytochemistry,In vivo assay,Western Blot,Bioassay,ELISA Development,Flow Cytometry,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,ELISA Capture (Matched Antibody Pair),CyTOF-ready.

target :

IL-6R alpha

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse IL-6R alpha, Leu20-Glu357, Accession # P22272

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse

specificity :

Detects mouse IL-6R alpha in ELISAs and Western blots. In sandwich ELISAs, less than 0.3% cross-reactivity with recombinant mouse (rm) IL-6, recombinant human IL-6 R and rmgp130 is observed.

gene symbol :

Il6ra

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

IL-6R alpha antibody in Mouse Thymus by Immunohistochemistry (IHC-Fr).

accessionNumbers :

P22272

applications :

Western Blot,Bioassay,ELISA Development,Flow Cytometry,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA Capture (Matched Antibody Pair),CyTOF-ready

USD :

509 USD

alt names :

CD126, gp80, IL-6 R alpha, IL6Q, IL6R, IL6R alpha, IL-6R-1, IL6RA, IL-6RA, IL6RQ, interleukin 6 receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage