| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry; mouse; loading ...; fig 1d
- western blot; mouse; 1:500; loading ...; fig 2d
| Hu Y, Li C, Wang X, Chen W, Qian Y, Dai X. TREM2, Driving the Microglial Polarization, Has a TLR4 Sensitivity Profile After Subarachnoid Hemorrhage. Front Cell Dev Biol. 2021;9:693342 pubmed publisher |
- blocking or activating experiments; human; 1:30; fig 1g
| Hall Roberts H, Agarwal D, Obst J, Smith T, Monzón Sandoval J, Di Daniel E, et al. TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages. Alzheimers Res Ther. 2020;12:151 pubmed publisher |
- immunohistochemistry - frozen section; human; 1:200; loading ...; fig 1b
| Cignarella F, Filipello F, Bollman B, Cantoni C, Locca A, Mikesell R, et al. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta Neuropathol. 2020;140:513-534 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 5f
| Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, et al. The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk. Sci Transl Med. 2019;11: pubmed publisher |
- immunohistochemistry - frozen section; human; 1:50; loading ...; fig s1b
- western blot; human; 1:500; loading ...; fig s6d
| Zhong L, Xu Y, Zhuo R, Wang T, Wang K, Huang R, et al. Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model. Nat Commun. 2019;10:1365 pubmed publisher |
- western blot; human; loading ...; fig s3f
| Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher |
- western blot; human; loading ...; fig 5a
| Zhong L, Chen X, Wang T, Wang Z, Liao C, Wang Z, et al. Soluble TREM2 induces inflammatory responses and enhances microglial survival. J Exp Med. 2017;214:597-607 pubmed publisher |
| Wißfeld J, Mathews M, Mossad O, Picardi P, Cinti A, Redaelli L, et al. Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia. Sci Rep. 2021;11:13462 pubmed publisher |
| Diaz Lucena D, Kruse N, Thune K, Schmitz M, Villar Piqué A, da Cunha J, et al. TREM2 expression in the brain and biological fluids in prion diseases. Acta Neuropathol. 2021;141:841-859 pubmed publisher |
| Schapansky J, Grinberg Y, Osiecki D, Freeman E, Walker S, Karran E, et al. MEK1/2 activity modulates TREM2 cell surface recruitment. J Biol Chem. 2021;296:100218 pubmed publisher |
| McQuade A, Kang Y, Hasselmann J, Jairaman A, Sotelo A, Coburn M, et al. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nat Commun. 2020;11:5370 pubmed publisher |
| Knapskog A, Henjum K, Idland A, Eldholm R, Persson K, Saltvedt I, et al. Cerebrospinal fluid sTREM2 in Alzheimer's disease: comparisons between clinical presentation and AT classification. Sci Rep. 2020;10:15886 pubmed publisher |
| Grubman A, Vandekolk T, Schröder J, Sun G, Hatwell Humble J, Chan J, et al. A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture. Stem Cell Reports. 2020;14:1018-1032 pubmed publisher |
| Schlepckow K, Monroe K, Kleinberger G, Cantuti Castelvetri L, Parhizkar S, Xia D, et al. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO Mol Med. 2020;12:e11227 pubmed publisher |
| Nordengen K, Kirsebom B, Henjum K, Selnes P, Gisladottir B, Wettergreen M, et al. Glial activation and inflammation along the Alzheimer's disease continuum. J Neuroinflammation. 2019;16:46 pubmed publisher |
| Henjum K, Quist Paulsen E, Zetterberg H, Blennow K, Nilsson L, Watne L. CSF sTREM2 in delirium-relation to Alzheimer's disease CSF biomarkers Aβ42, t-tau and p-tau. J Neuroinflammation. 2018;15:304 pubmed publisher |
| Garcia Reitboeck P, Phillips A, Piers T, Villegas Llerena C, Butler M, Mallach A, et al. Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis. Cell Rep. 2018;24:2300-2311 pubmed publisher |
| Yanaizu M, Sakai K, Tosaki Y, Kino Y, Satoh J. Small nuclear RNA-mediated modulation of splicing reveals a therapeutic strategy for a TREM2 mutation and its post-transcriptional regulation. Sci Rep. 2018;8:6937 pubmed publisher |
| Zhao Y, Li X, Huang T, Jiang L, Tan Z, Zhang M, et al. Intracellular trafficking of TREM2 is regulated by presenilin 1. Exp Mol Med. 2017;49:e405 pubmed publisher |
| Lee C, Daggett A, Gu X, Jiang L, Langfelder P, Li X, et al. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. 2018;97:1032-1048.e5 pubmed publisher |
| Thornton P, Sevalle J, Deery M, Fraser G, Zhou Y, Ståhl S, et al. TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant. EMBO Mol Med. 2017;9:1366-1378 pubmed publisher |
| Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler S, Steiner H, et al. An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. EMBO Mol Med. 2017;9:1356-1365 pubmed publisher |
| Varnum M, Clayton K, Yoshii Kitahara A, Yonemoto G, Koro L, Ikezu S, et al. A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. J Biol Chem. 2017;292:10651-10663 pubmed publisher |
| Jiang H, Si Y, Li Z, Huang X, Chen S, Zheng Y, et al. TREM-2 promotes acquired cholesteatoma-induced bone destruction by modulating TLR4 signaling pathway and osteoclasts activation. Sci Rep. 2016;6:38761 pubmed publisher |
