Mouse Klotho Antibody | R&D Systems AF1819 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse Klotho Antibody

catalog :

AF1819

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 22

Reference
Brandt S, Bernhardt A, H xe4 berer S, Wolters K, Gehringer F, Reichardt C, et al. Comparative Analysis of Acute Kidney Injury Models and Related Fibrogenic Responses: Convergence on Methylation Patterns Regulated by Cold Shock Protein. Cells. 2024;13: pubmed publisher
Charrin E, Dabaghie D, Sen I, Unnersj xf6 Jess D, M xf6 ller Hackbarth K, Burmakin M, et al. Soluble Klotho protects against glomerular injury through regulation of ER stress response. Commun Biol. 2023;6:208 pubmed publisher
Tan Z, Li Y, Guan Y, Iqbal J, Wang C, Yan R, et al. Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience in Rats. Int J Mol Sci. 2023;24: pubmed publisher
Bartos K, Ramakrishnan S, Braga Lagache S, H xe4 nzi B, Durussel F, Prakash Sridharan A, et al. Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activity. J Cell Commun Signal. 2023;17:705-722 pubmed publisher
Zhu M, Ling X, Zhou S, Meng P, Chen Q, Chen S, et al. KYA1797K, a Novel Small Molecule Destabilizing β-Catenin, Is Superior to ICG-001 in Protecting against Kidney Aging. Kidney Dis (Basel). 2022;8:408-423 pubmed publisher
Ni J, Wang X, Xie H, Yang N, Li J, Sun X, et al. Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II. Acta Pharmacol Sin. 2022;: pubmed publisher
Zhu Y, Prata L, Gerdes E, Netto J, Pirtskhalava T, Giorgadze N, et al. Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans. EBioMedicine. 2022;77:103912 pubmed publisher
Yuan Q, Ren Q, Li L, Tan H, Lu M, Tian Y, et al. A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling. Nat Commun. 2022;13:438 pubmed publisher
Li M, Deng L, Xu G. METTL14 promotes glomerular endothelial cell injury and diabetic nephropathy via m6A modification of α-klotho. Mol Med. 2021;27:106 pubmed publisher
Zhou S, Ling X, Meng P, Liang Y, Shen K, Wu Q, et al. Cannabinoid receptor 2 plays a central role in renal tubular mitochondrial dysfunction and kidney ageing. J Cell Mol Med. 2021;25:8957-8972 pubmed publisher
Ursem S, Diepenbroek C, Bacic V, Unmehopa U, Eggels L, Maya Monteiro C, et al. Localization of fibroblast growth factor 23 protein in the rat hypothalamus. Eur J Neurosci. 2021;54:5261-5271 pubmed publisher
Clemens Z, Sivakumar S, Pius A, Sahu A, Shinde S, Mamiya H, et al. The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function. elife. 2021;10: pubmed publisher
Miao J, Huang J, Luo C, Ye H, Ling X, Wu Q, et al. Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells. Physiol Rep. 2021;9:e14696 pubmed publisher
Kawarazaki W, Mizuno R, Nishimoto M, Ayuzawa N, Hirohama D, Ueda K, et al. Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency. J Clin Invest. 2020;130:4152-4166 pubmed publisher
Chu Y, Lan R, Huang R, Feng H, Kumar R, Dayal S, et al. Glutathione peroxidase-1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice. Aging Cell. 2020;19:e13154 pubmed publisher
Mazucanti C, Liu Q, Lang D, Huang N, O Connell J, Camandola S, et al. Release of insulin produced by the choroid plexis is regulated by serotonergic signaling. JCI Insight. 2019;4: pubmed publisher
Miao J, Liu J, Niu J, Zhang Y, Shen W, Luo C, et al. Wnt/β-catenin/RAS signaling mediates age-related renal fibrosis and is associated with mitochondrial dysfunction. Aging Cell. 2019;18:e13004 pubmed publisher
Zhou L, Chen X, Lu M, Wu Q, Yuan Q, Hu C, et al. Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria. Kidney Int. 2019;95:830-845 pubmed publisher
Ahrens H, Huettemeister J, Schmidt M, Kaether C, von Maltzahn J. Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle. Skelet Muscle. 2018;8:20 pubmed publisher
Bär L, Feger M, Fajol A, Klotz L, Zeng S, Lang F, et al. Insulin suppresses the production of fibroblast growth factor 23 (FGF23). Proc Natl Acad Sci U S A. 2018;115:5804-5809 pubmed publisher
Chen J, Fan J, Wang S, Sun Z. Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1. Hypertension. 2018;71:877-885 pubmed publisher
Kawakami K, Takeshita A, Furushima K, Miyajima M, Hatamura I, Kuro O M, et al. Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease. Sci Rep. 2017;7:40534 pubmed publisher

product information

brand :

R&D Systems

master code :

AF1819

SKU :

AF1819

product name :

Mouse Klotho Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Mouse Klotho Antibody from R&D Systems is a goat polyclonal antibody to Klotho. This antibody reacts with human,mouse,rat,transgenic mouse. The Mouse Klotho Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,ELISA Development,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,ELISA.

target :

Klotho

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.2 ug/mL, ELISA, Immunohistochemistry 2-15 ug/mL

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse Klotho, Arg31-His550, Accession # BAA25307

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat,Transgenic Mouse

specificity :

Detects mouse Klotho in direct ELISAs and Western blots.

gene symbol :

top caption :

Detection of Mouse Klotho antibody by Western Blot.

accessionNumbers :

BAA25307

applications :

ELISA,ELISA Development,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

499 USD

alt names :

EC 3.2.1, EC 3.2.1.31, KL, klotho

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage