| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry; mouse; 1:150; fig 8c
| Pankiewicz J, Lizińczyk A, Franco L, Díaz J, Martá Ariza M, Sadowski M. Absence of Apolipoprotein E is associated with exacerbation of prion pathology and promotes microglial neurodegenerative phenotype. Acta Neuropathol Commun. 2021;9:157 pubmed publisher |
- immunohistochemistry; mouse; loading ...; fig 4j
| Cheng J, Dong Y, Ma J, Pan R, Liao Y, Kong X, et al. Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer's disease pathology. Sci Adv. 2021;7: pubmed publisher |
- western blot; mouse; 1:400; loading ...; fig 6b
| Emre C, Do K, Jun B, Hjorth E, Alcalde S, Kautzmann M, et al. Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2021;9:116 pubmed publisher |
- immunohistochemistry; human; 1:200; loading ...; fig 1d
| Huang Y, Happonen K, Burrola P, O Connor C, Hah N, Huang L, et al. Microglia use TAM receptors to detect and engulf amyloid β plaques. Nat Immunol. 2021;22:586-594 pubmed publisher |
- western blot; mouse; fig 4a
| Pons V, Lévesque P, Plante M, Rivest S. Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer's disease. Alzheimers Res Ther. 2021;13:8 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 2d
| Wang Y, Lin Y, Wang L, Zhan H, Luo X, Zeng Y, et al. TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice. Aging (Albany NY). 2020;12:20862-20879 pubmed publisher |
- immunocytochemistry; mouse; loading ...; fig 3d
| Zhao Y, Wu X, Li X, Jiang L, Gui X, Liu Y, et al. TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function. Neuron. 2018;97:1023-1031.e7 pubmed publisher |
| Vecchiarelli H, Bisht K, Sharma K, Weiser Novak S, Traetta M, Garcia Segura M, et al. Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2. bioRxiv. 2024;: pubmed publisher |
| Ni W, Niu Y, Cao S, Fan C, Fan J, Zhu L, et al. Intermittent hypoxia exacerbates anxiety in high-fat diet-induced diabetic mice by inhibiting TREM2-regulated IFNAR1 signaling. J Neuroinflammation. 2024;21:166 pubmed publisher |
| Zhang Y, Park Y, Kim I. A Distinct Microglial Cell Population Expressing Both CD86 and CD206 Constitutes a Dominant Type and Executes Phagocytosis in Two Mouse Models of Retinal Degeneration. Int J Mol Sci. 2023;24: pubmed publisher |
| Fruhw xfc rth S, Reinert L, xd6 berg C, Sakr M, Henricsson M, Zetterberg H, et al. TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain. Sci Adv. 2023;9:eadf5808 pubmed publisher |
| Seidel F, Fluiter K, Kleemann R, Worms N, van Nieuwkoop A, Caspers M, et al. Ldlr-/-.Leiden mice develop neurodegeneration, age-dependent astrogliosis and obesity-induced changes in microglia immunophenotype which are partly reversed by complement component 5 neutralizing antibody. Front Cell Neurosci. 2023;17:1205261 pubmed publisher |
| Yin T, D ADAMIO L. BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer's disease and related dementias. bioRxiv. 2023;: pubmed publisher |
| Sideris Lampretsas G, Oggero S, Zeboudj L, Silva R, Bajpai A, Dharmalingam G, et al. Galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling Alzheimer's disease. Nat Commun. 2023;14:3579 pubmed publisher |
| Gedam M, Comerota M, Propson N, Chen T, Jin F, Wang M, et al. Complement C3aR depletion reverses HIF-1α-induced metabolic impairment and enhances microglial response to Aβ pathology. J Clin Invest. 2023;133: pubmed publisher |
| Wu K, Liu Y, Shao S, Song W, Chen X, Dong Y, et al. The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis. Brain Behav Immun. 2023;112:96-117 pubmed publisher |
| Wang R, Li H, Ling C, Zhang X, Lu J, Luan W, et al. A novel phenotype of B cells associated with enhanced phagocytic capability and chemotactic function after ischemic stroke. Neural Regen Res. 2023;18:2413-2423 pubmed publisher |
| Zhang T, Pang W, Feng T, Guo J, Wu K, Nunez Santos M, et al. TMEM106B regulates microglial proliferation and survival in response to demyelination. Sci Adv. 2023;9:eadd2676 pubmed publisher |
| Gong J, Liu S, Wang S, Ruan H, Mou Q, Fan P, et al. Identification of fecal microbiome signatures associated with familial longevity and candidate metabolites for healthy aging. Aging Cell. 2023;22:e13848 pubmed publisher |
| Zhang T, Feng T, Wu K, Guo J, Nana A, Yang G, et al. Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination. Acta Neuropathol. 2023;146:97-119 pubmed publisher |
| Shu X, Wei C, Tu W, Zhong K, Qi S, Wang A, et al. Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome. Cell Rep. 2023;42:112133 pubmed publisher |
| Beckmann N, Neuhaus A, Zurbruegg S, Volkmer P, Patiño C, Joller S, et al. Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model. J Neuroinflammation. 2023;20:29 pubmed publisher |
| Huang Y, Lemke G. Adaptable toolbox to characterize Alzheimer's disease pathology in mouse models. STAR Protoc. 2022;3:101891 pubmed publisher |
| Rother C, Uhlmann R, M xfc ller S, Schelle J, Skodras A, Oberm xfc ller U, et al. Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae. Nat Commun. 2022;13:7333 pubmed publisher |
| Wood J, Wong E, Joghee R, Balbaa A, Vitanova K, Stringer K, et al. Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology. Cell Rep. 2022;41:111686 pubmed publisher |
| Roshanbin S, Julku U, Xiong M, Eriksson J, Masliah E, Hultqvist G, et al. Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody. Pharmaceutics. 2022;14: pubmed publisher |
| Emre C, Arroyo Garc xed a L, Do K, Jun B, Ohshima M, Alcalde S, et al. Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice. Commun Biol. 2022;5:245 pubmed publisher |
| Omoluabi T, Torraville S, Maziar A, Ghosh A, Power K, Reinhardt C, et al. Novelty-like activation of locus coeruleus protects against deleterious human pretangle tau effects while stress-inducing activation worsens its effects. Alzheimers Dement (N Y). 2021;7:e12231 pubmed publisher |
| Doust Y, Rowe R, Adelson P, Lifshitz J, Ziebell J. Age-at-Injury Determines the Extent of Long-Term Neuropathology and Microgliosis After a Diffuse Brain Injury in Male Rats. Front Neurol. 2021;12:722526 pubmed publisher |
| Logan T, Simon M, Rana A, Cherf G, Srivastava A, Davis S, et al. Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic. Cell. 2021;184:4651-4668.e25 pubmed publisher |
| Zhang L, Qian Y, Li J, Zhou X, Xu H, Yan J, et al. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology. iScience. 2021;24:102942 pubmed publisher |
| Gouna G, Klose C, Bosch Queralt M, Liu L, Gokce O, Schifferer M, et al. TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination. J Exp Med. 2021;218: pubmed publisher |
| DU H, Wong M, Zhang T, Santos M, Hsu C, Zhang J, et al. A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses. Life Sci Alliance. 2021;4: pubmed publisher |
| Vilalta A, Zhou Y, Sevalle J, Griffin J, Satoh K, Allendorf D, et al. Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation. J Biol Chem. 2021;296:100631 pubmed publisher |
| Bosch Queralt M, Cantuti Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, et al. Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nat Metab. 2021;3:211-227 pubmed publisher |
| Biechele G, Wind K, Blume T, Sacher C, Beyer L, Eckenweber F, et al. Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in AppNL-G-F mice. Neuroimage. 2021;230:117707 pubmed publisher |
| Manich G, Gómez López A, Almolda B, Villacampa N, Recasens M, Shrivastava K, et al. Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models. Front Cell Neurosci. 2020;14:567404 pubmed publisher |
| Guo X, Liu Y, Morgan D, Zhao L. Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice. Aging Dis. 2020;11:1423-1443 pubmed publisher |
| Jadhav V, Lin P, Pennington T, Di Prisco G, Jannu A, Xu G, et al. Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice. Mol Neurodegener. 2020;15:62 pubmed publisher |
| Werner G, Damme M, Schludi M, Gn xf6 rich J, Wind K, Fellerer K, et al. Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice. EMBO Rep. 2020;21:e50241 pubmed publisher |
| Pankiewicz J, Díaz J, Martá Ariza M, Lizińczyk A, Franco L, Sadowski M. Peroxiredoxin 6 mediates protective function of astrocytes in Aβ proteostasis. Mol Neurodegener. 2020;15:50 pubmed publisher |
| Holloway O, King A, Ziebell J. Microglia Demonstrate Local Mixed Inflammation and a Defined Morphological Shift in an APP/PS1 Mouse Model. J Alzheimers Dis. 2020;77:1765-1781 pubmed publisher |
| Fani Maleki A, Cisbani G, Plante M, Prefontaine P, Laflamme N, Gosselin J, et al. Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer's disease. J Neuroinflammation. 2020;17:218 pubmed publisher |
| Sebastian Monasor L, Müller S, Colombo A, Tanrioever G, König J, Roth S, et al. Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models. elife. 2020;9: pubmed publisher |
| Schlepckow K, Monroe K, Kleinberger G, Cantuti Castelvetri L, Parhizkar S, Xia D, et al. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO Mol Med. 2020;12:e11227 pubmed publisher |
| Sacher C, Blume T, Beyer L, Peters F, Eckenweber F, Sgobio C, et al. Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second-Generation Amyloid-β Mouse Model. J Nucl Med. 2019;60:1787-1793 pubmed publisher |
| Stephen T, Cacciottolo M, Balu D, Morgan T, LaDu M, Finch C, et al. APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice. Acta Neuropathol Commun. 2019;7:82 pubmed publisher |
| Pan R, Ma J, Kong X, Wang X, Li S, Qi X, et al. Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-β clearance. Sci Adv. 2019;5:eaau6328 pubmed publisher |
| Cheng Hathaway P, Reed Geaghan E, Jay T, Casali B, Bemiller S, Puntambekar S, et al. The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease. Mol Neurodegener. 2018;13:29 pubmed publisher |
| Zhao Y, Li X, Huang T, Jiang L, Tan Z, Zhang M, et al. Intracellular trafficking of TREM2 is regulated by presenilin 1. Exp Mol Med. 2017;49:e405 pubmed publisher |
| Lee C, Daggett A, Gu X, Jiang L, Langfelder P, Li X, et al. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. 2018;97:1032-1048.e5 pubmed publisher |
| Nam K, Mounier A, Wolfe C, Fitz N, Carter A, Castranio E, et al. Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice. Sci Rep. 2017;7:4307 pubmed publisher |
| Saika R, Sakuma H, Noto D, Yamaguchi S, Yamamura T, Miyake S. MicroRNA-101a regulates microglial morphology and inflammation. J Neuroinflammation. 2017;14:109 pubmed publisher |
| Castranio E, Mounier A, Wolfe C, Nam K, Fitz N, Letronne F, et al. Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury. Neurobiol Dis. 2017;105:1-14 pubmed publisher |
| ZHANG Z, Takeda Uchimura Y, Foyez T, Ohtake Niimi S, Narentuya -, Akatsu H, et al. Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology. Proc Natl Acad Sci U S A. 2017;114:E2947-E2954 pubmed publisher |
