Human PD-L1/B7-H1 Antibody | R&D Systems AF156 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human PD-L1/B7-H1 Antibody

catalog :

AF156

quantity :

100 ug (also 25 ug)

price :

509 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, neutralization, immunoprecipitation, flow cytometry

more info or order :

R&D Systems product webpage

citations: 16

Reference
Recoquillon S, Ali S, Justeau G, Riou J, Martinez M, Andriantsitohaina R, et al. Small Extracellular Vesicles Harboring PD-L1 in Obstructive Sleep Apnea. Int J Mol Sci. 2024;25: pubmed publisher
Hassan M, Trung V, Bedi D, Shaddox S, Gunturu D, Yates C, et al. Interference with pathways activated by topoisomerase inhibition alters the surface expression of PD-L1 and MHC I in colon cancer cells. Oncol Lett. 2023;25:41 pubmed publisher
Nguyen L, Zhang J, Rima X, Wang X, Kwak K, Okimoto T, et al. An immunogold single extracellular vesicular RNA and protein (Au SERP) biochip to predict responses to immunotherapy in non-small cell lung cancer patients. J Extracell Vesicles. 2022;11:e12258 pubmed publisher
Chu Z, Gu L, Hu Y, Zhang X, Li M, Chen J, et al. STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming. Nat Commun. 2022;13:1859 pubmed publisher
Lema D, Jankowska Gan E, Nair A, Kanaan S, Little C, Foley D, et al. Cross-decoration of dendritic cells by non-inherited maternal antigen-containing extracellular vesicles: Potential mechanism for PD-L1-based tolerance in cord blood and organ transplantation. Am J Transplant. 2022;22:1329-1338 pubmed publisher
Eljaafari A, Pestel J, le Magueresse Battistoni B, Chanon S, Watson J, Robert M, et al. Adipose-Tissue-Derived Mesenchymal Stem Cells Mediate PD-L1 Overexpression in the White Adipose Tissue of Obese Individuals, Resulting in T Cell Dysfunction. Cells. 2021;10: pubmed publisher
Cherif B, Triki H, Charfi S, Bouzidi L, Kridis W, Khanfir A, et al. Immune checkpoint molecules B7-H6 and PD-L1 co-pattern the tumor inflammatory microenvironment in human breast cancer. Sci Rep. 2021;11:7550 pubmed publisher
Park J, Thi E, Carpio V, Bi Y, Cole A, Dorsey B, et al. Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1. Nat Commun. 2021;12:1222 pubmed publisher
Tago Y, Kobayashi C, Ogura M, Wada J, Yamaguchi S, Yamaguchi T, et al. Human amnion-derived mesenchymal stem cells attenuate xenogeneic graft-versus-host disease by preventing T cell activation and proliferation. Sci Rep. 2021;11:2406 pubmed publisher
Deng R, Zuo C, Li Y, Xue B, Xun Z, Guo Y, et al. The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway. Cell Mol Immunol. 2020;17:1163-1179 pubmed publisher
Taechangam N, Iyer S, Walker N, Arzi B, Borjesson D. Mechanisms utilized by feline adipose-derived mesenchymal stem cells to inhibit T lymphocyte proliferation. Stem Cell Res Ther. 2019;10:188 pubmed publisher
Idelson M, Alper R, Obolensky A, Yachimovich Cohen N, Rachmilewitz J, Ejzenberg A, et al. Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Stem Cell Reports. 2018;11:681-695 pubmed publisher
Thampy L, Remy K, Walton A, Hong Z, Liu K, Liu R, et al. Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration. PLoS ONE. 2018;13:e0199497 pubmed publisher
Xue S, Hu M, Iyer V, Yu J. Blocking the PD-1/PD-L1 pathway in glioma: a potential new treatment strategy. J Hematol Oncol. 2017;10:81 pubmed publisher
Zhai N, Li H, Song H, Yang Y, Cui A, Li T, et al. Hepatitis C Virus Induces MDSCs-Like Monocytes through TLR2/PI3K/AKT/STAT3 Signaling. PLoS ONE. 2017;12:e0170516 pubmed publisher
Davies L, Heldring N, Kadri N, Le Blanc K. Mesenchymal Stromal Cell Secretion of Programmed Death-1 Ligands Regulates T Cell Mediated Immunosuppression. Stem Cells. 2017;35:766-776 pubmed publisher

product information

master code :

AF156

SKU :

AF156

product name :

Human PD-L1/B7-H1 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human PD-L1/B7-H1 Antibody from R&D Systems is a goat polyclonal antibody to PD-L1. This antibody reacts with feline,human,mouse. The Human PD-L1/B7-H1 Antibody has been validated for the following applications: Immunocytochemistry,ELISA Capture,Immunohistochemistry,Western Blot,Bioassay,ELISA Development,Inhibition,Flow Cytometry,Immunoprecipitation,Neutralization,ELISA,Simple Western.

target :

PD-L1/B7-H1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human PD-L1/B7-H1, Phe19-Thr239, Accession # Q9NZQ7

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Feline,Human,Mouse

specificity :

Detects human PD-L1/B7-H1 in direct ELISAs and Western blots. In direct ELISAs, less than 15% cross-reactivity with recombinant mouse PD-L1/B7-H1 is observed and less than 1% cross-reactivity with recombinant human PD-L2 is observed.

gene symbol :

CD274

top caption :

Detection of Human PD-L1/B7-H1 antibody by Western Blot.

accessionNumbers :

Q9NZQ7

applications :

Immunohistochemistry,Western Blot,Bioassay,ELISA Development,Inhibition,Flow Cytometry,Immunoprecipitation,Neutralization,ELISA,Simple Western

USD :

509 USD

alt names :

Avelumab, B7-H, B7H1, B7-H1, B7H1PDCD1L1, CD274, CD274 antigenMGC142294, CD274 molecule, PDCD1L1, PDCD1LG1, PDCD1LG1MGC142296, PDL1, PD-L1, PD-L1B7 homolog 1, PDL1PDCD1 ligand 1, programmed cell death 1 ligand 1, Programmed death ligand 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage