| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; loading ...; fig 1a
| Iwama H, Mehanna S, Imasaka M, Hashidume S, Nishiura H, Yamamura K, et al. Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis. Sci Rep. 2021;11:6596 pubmed publisher |
- western blot; mouse; loading ...; fig 6d
| Safaiyan S, Besson Girard S, Kaya T, Cantuti Castelvetri L, Liu L, Ji H, et al. White matter aging drives microglial diversity. Neuron. 2021;109:1100-1117.e10 pubmed publisher |
| Do x11f ru A, Rehders M, Brix K. Investigations on Primary Cilia of Nthy-ori 3-1 Cells upon Cysteine Cathepsin Inhibition or Thyrotropin Stimulation. Int J Mol Sci. 2023;24: pubmed publisher |
| Zhang H, Chen Y, Li F, Wu C, Cai W, Ye H, et al. Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization. J Neuroinflammation. 2023;20:6 pubmed publisher |
| Li C, Liu Z, Chen M, Zhang L, Shi R, Zhong H. Critical Role of Cathepsin L/V in Regulating Endothelial Cell Senescence. Biology (Basel). 2022;12: pubmed publisher |
| Polesel M, Kaminska M, Haenni D, Bugarski M, Schuh C, Jankovic N, et al. Spatiotemporal organisation of protein processing in the kidney. Nat Commun. 2022;13:5732 pubmed publisher |
| Ratto E, Chowdhury S, Siefert N, Schneider M, Wittmann M, Helm D, et al. Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly. Nat Commun. 2022;13:4848 pubmed publisher |
| Cui Z, Zeng C, Huang F, Yuan F, Yan J, Zhao Y, et al. Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection. Nat Chem Biol. 2022;18:1056-1064 pubmed publisher |
| Feng T, Luan L, Katz I, Ullah M, Van Deerlin V, Trojanowski J, et al. TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss. Acta Neuropathol Commun. 2022;10:33 pubmed publisher |
| Dang T, Back S. Translation Inhibitors Activate Autophagy Master Regulators TFEB and TFE3. Int J Mol Sci. 2021;22: pubmed publisher |
| Kamle S, Ma B, He C, Akosman B, Zhou Y, Lee C, et al. Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19. JCI Insight. 2021;6: pubmed publisher |
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| Liu L, Doray B. Elevated mRNA expression and defective processing of cathepsin D in HeLa cells lacking the mannose 6-phosphate pathway. FEBS Open Bio. 2021;11:1695-1703 pubmed publisher |
| Shibamura Fujiogi M, Yuki K, Hou L. Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis. Int Immunopharmacol. 2021;93:107425 pubmed publisher |
| Kamle S, Ma B, He C, Akosman B, Zhou Y, Lee C, et al. Chitinase 3-like-1 is a Therapeutic Target That Mediates the Effects of Aging in COVID-19. bioRxiv. 2021;: pubmed publisher |
| Ketterer S, Mitschke J, Ketscher A, Schlimpert M, Reichardt W, Baeuerle N, et al. Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling. Nat Commun. 2020;11:5133 pubmed publisher |
| Westermann L, Fleischhauer L, Vogel J, Jenei Lanzl Z, Ludwig N, Schau L, et al. Imbalanced cellular metabolism compromises cartilage homeostasis and joint function in a mouse model of mucolipidosis type III gamma. Dis Model Mech. 2020;13: pubmed publisher |
| Werner G, Damme M, Schludi M, Gn xf6 rich J, Wind K, Fellerer K, et al. Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice. EMBO Rep. 2020;21:e50241 pubmed publisher |
| Feng T, Mai S, Roscoe J, Sheng R, Ullah M, Zhang J, et al. Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice. EMBO Rep. 2020;21:e50219 pubmed publisher |
| Parigiani M, Ketscher A, Timme S, Bronsert P, Schlimpert M, Kammerer B, et al. Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression. Cancers (Basel). 2020;12: pubmed publisher |
| Ziros P, Renaud C, Chartoumpekis D, Bongiovanni M, Habeos I, Liao X, et al. Mice Hypomorphic for Keap1, a Negative Regulator of the Nrf2 Antioxidant Response, Show Age-Dependent Diffuse Goiter with Elevated Thyrotropin Levels. Thyroid. 2021;31:23-35 pubmed publisher |
| Goren L, Zhang G, Kaushik S, Breslin P, Du Y, Foster D. (-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells. PLoS ONE. 2019;14:e0216024 pubmed publisher |
| Bullard W, Kara M, Gay L, Sethuraman S, Wang Y, Nirmalan S, et al. Identification of murine gammaherpesvirus 68 miRNA-mRNA hybrids reveals miRNA target conservation among gammaherpesviruses including host translation and protein modification machinery. PLoS Pathog. 2019;15:e1007843 pubmed publisher |
| Li Y, Jones J, M C Choi H, Sarkar C, KANE M, Koh E, et al. cPLA2 activation contributes to lysosomal defects leading to impairment of autophagy after spinal cord injury. Cell Death Dis. 2019;10:531 pubmed publisher |
| Sarkar C, Jones J, Hegdekar N, Thayer J, Kumar A, Faden A, et al. PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma. Autophagy. 2019;:1-20 pubmed publisher |
| Weiss Sadan T, Itzhak G, Kaschani F, Yu Z, Mahameed M, Anaki A, et al. Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation. Mol Cell Proteomics. 2019;: pubmed publisher |
| Parks A, Nahata J, Edouard N, Temenoff J, Platt M. Sequential, but not Concurrent, Incubation of Cathepsin K and L with Type I Collagen Results in Extended Proteolysis. Sci Rep. 2019;9:5399 pubmed publisher |
| Götzl J, Colombo A, Fellerer K, Reifschneider A, Werner G, Tahirovic S, et al. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice. Mol Neurodegener. 2018;13:48 pubmed publisher |
| Lloyd Lewis B, Krueger C, Sargeant T, D Angelo M, Deery M, Feret R, et al. Stat3-mediated alterations in lysosomal membrane protein composition. J Biol Chem. 2018;293:4244-4261 pubmed publisher |
| Palm W, Araki J, King B, Dematteo R, Thompson C. Critical role for PI3-kinase in regulating the use of proteins as an amino acid source. Proc Natl Acad Sci U S A. 2017;114:E8628-E8636 pubmed publisher |
| Klein Z, Takahashi H, Ma M, Stagi M, Zhou M, Lam T, et al. Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice. Neuron. 2017;95:281-296.e6 pubmed publisher |
| Cvetkovic C, Ferrall Fairbanks M, Ko E, Grant L, Kong H, Platt M, et al. Investigating the Life Expectancy and Proteolytic Degradation of Engineered Skeletal Muscle Biological Machines. Sci Rep. 2017;7:3775 pubmed publisher |
| Khamaysi I, Singh P, Nasser S, Awad H, Chowers Y, Sabo E, et al. The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target. Sci Rep. 2017;7:715 pubmed publisher |
| Boels M, van Faassen E, Avramut M, van der Vlag J, van den Berg B, Rabelink T. Direct Observation of Enhanced Nitric Oxide in a Murine Model of Diabetic Nephropathy. PLoS ONE. 2017;12:e0170065 pubmed publisher |
