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company name :
R&D Systems
product type :
antibody
product name :
Human IL-13 R alpha 2 Antibody
catalog :
AF146
quantity :
100 ug (also 25 ug)
price :
519 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 17
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 5a
Lu Z, Xiao S, Chen W, Zhu R, Yang H, Steinhoff M, et al. IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis. FASEB J. 2022;36:e22334 pubmed publisher
Bagley S, Logun M, Fraietta J, Wang X, Desai A, Bagley L, et al. Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results. Nat Med. 2024;30:1320-1329 pubmed publisher
Starr R, Aguilar B, Gumber D, Maker M, Huard S, Wang D, et al. Inclusion of 4-1BB Costimulation Enhances Selectivity and Functionality of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells. Cancer Res Commun. 2023;3:66-79 pubmed publisher
D Arcy Q, Gharaee Kermani M, Zhilin Roth A, Macoska J. The IL-4/IL-13 signaling axis promotes prostatic fibrosis. PLoS ONE. 2022;17:e0275064 pubmed publisher
Qi H, Dong L, Fang D, Chen L, Wang Y, Fan N, et al. A Novel Role of IL13Rα2 in the Pathogenesis of Proliferative Vitreoretinopathy. Front Med (Lausanne). 2022;9:831436 pubmed publisher
Barish M, Weng L, Awabdeh D, Zhai Y, Starr R, D Apuzzo M, et al. Spatial organization of heterogeneous immunotherapy target antigen expression in high-grade glioma. Neoplasia. 2022;30:100801 pubmed publisher
Arain F, Abraityte A, Bogdanova M, Solberg O, Michelsen A, Lekva T, et al. YKL-40 (Chitinase-3-Like Protein 1) Serum Levels in Aortic Stenosis. Circ Heart Fail. 2020;13:e006643 pubmed publisher
Donovan L, Delaidelli A, Joseph S, Bielamowicz K, Fousek K, Holgado B, et al. Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma. Nat Med. 2020;26:720-731 pubmed publisher
Wang M, Yao R, Wang Y. Silencing of IL13RA2 promotes partial epithelial-mesenchymal transition in hepatocellular carcinoma via ERK signaling pathway activation. FEBS Open Bio. 2019;: pubmed publisher
Bhardwaj R, Suzuki A, Leland P, Joshi B, Puri R. Identification of a novel role of IL-13Rα2 in human Glioblastoma multiforme: interleukin-13 mediates signal transduction through AP-1 pathway. J Transl Med. 2018;16:369 pubmed publisher
Berlow N, Svalina M, Quist M, Settelmeyer T, Zherebitskiy V, Kogiso M, et al. IL-13 receptors as possible therapeutic targets in diffuse intrinsic pontine glioma. PLoS ONE. 2018;13:e0193565 pubmed publisher
Brown C, Aguilar B, Starr R, Yang X, Chang W, Weng L, et al. Optimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma. Mol Ther. 2018;26:31-44 pubmed publisher
Bielamowicz K, Fousek K, Byrd T, Samaha H, Mukherjee M, Aware N, et al. Trivalent CAR T-cells Overcome Interpatient Antigenic Variability in Glioblastoma. Neuro Oncol. 2017;: pubmed publisher
Gaggianesi M, Turdo A, Chinnici A, Lipari E, Apuzzo T, Benfante A, et al. IL4 Primes the Dynamics of Breast Cancer Progression via DUSP4 Inhibition. Cancer Res. 2017;77:3268-3279 pubmed publisher
Meng M, Liao H, Zhang B, Pan Y, Kong Y, Liu W, et al. Cigarette smoke extracts induce overexpression of the proto-oncogenic gene interleukin-13 receptor ?2 through activation of the PKA-CREB signaling pathway to trigger malignant transformation of lung vascular endothelial cells and angiogenesis. Cell Signal. 2017;31:15-25 pubmed publisher
Lee C, He C, Nour A, Zhou Y, Ma B, Park J, et al. IL-13R?2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses. Nat Commun. 2016;7:12752 pubmed publisher
Hegde M, Mukherjee M, Grada Z, Pignata A, Landi D, Navai S, et al. Tandem CAR T cells targeting HER2 and IL13R?2 mitigate tumor antigen escape. J Clin Invest. 2016;126:3036-52 pubmed publisher
product information
brand :
R&D Systems
master code :
AF146
SKU :
AF146
product name :
Human IL-13 R alpha 2 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human IL-13 R alpha 2 Antibody from R&D Systems is a goat polyclonal antibody to IL-13R alpha 2. This antibody reacts with human,mouse,xenograft. The Human IL-13 R alpha 2 Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,CAR-T (Flow Cytometry),CAR-T (IHC-P),Flow Cytometry,Immunoprecipitation,Neutralization,Immunohistochemistry-Paraffin,Immunocytochemistry,Simple Western,Blockade of Receptor-ligand Interaction,CyTOF-ready.
target :
IL-13 R alpha 2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.2 ug/mL, Simple Western 10 ug/mL, Flow Cytometry 2.5 ug/10^6 cells, Immunohistochemistry 5-15 ug/mL, Blockade of Receptor-ligand Interaction, CyTOF-ready
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant human IL-13 R alpha 2, Cys22-Leu342, Accession # Q14627
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Xenograft
specificity :
Detects human IL-13 R alpha 2 in direct ELISAs and Western blots. In direct ELISAs, approximately 5% cross-reactivity with recombinant mouse IL-13 R alpha 2 is observed and less than 1% cross-reactivity with recombinant human IL-13 R alpha 1 is observed.
gene symbol :
IL13RA2
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Detection of Human IL-13 Ra2 antibody by Western Blot.
accessionNumbers :
Q14627
applications :
Simple Western,Blockade of Receptor-ligand Interaction,CyTOF-ready,CAR-T (Flow Cytometry),CAR-T (IHC-P),Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry
USD :
519 USD
alt names :
cancer/testis antigen 19, CD213a2, CD213a2 antigen, CT19, IL-13 receptor subunit alpha-2, IL13BP, IL13R, IL-13R, IL13R alpha 2, IL-13R subunit alpha-2, IL13RA2, IL-13RA2, IL-13R-alpha-2, interleukin 13 binding protein, interleukin 13 receptor alpha 2 chain, interleukin 13 receptor, alpha 2, interleukin-13 receptor subunit alpha-2, Interleukin-13-binding protein
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.