product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse/Rat TrkC Antibody
catalog :
AF1404
quantity :
100 ug (also 25 ug)
price :
509 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 46
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:500; fig 2c
Alshawaf A, Viventi S, Qiu W, D Abaco G, Nayagam B, Erlichster M, et al. Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells. Sci Rep. 2018;8:603 pubmed publisher
  • western blot; human; fig 4i
Wang R, Cao X, Kulej K, Liu W, Ma T, MacDonald M, et al. Uncovering BRD4 hyperphosphorylation associated with cellular transformation in NUT midline carcinoma. Proc Natl Acad Sci U S A. 2017;114:E5352-E5361 pubmed publisher
  • western blot; human; 1:200; loading ...; fig s3
Pinet S, Bessette B, Vedrenne N, Lacroix A, Richard L, Jauberteau M, et al. TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells. Oncotarget. 2016;7:50349-50364 pubmed publisher
Koui Y, Song S, Dong X, Mukouyama Y. Local keratinocyte-nociceptor interactions enhance obesity-mediated small fiber neuropathy via NGF-TrkA-PI3K signaling axis. bioRxiv. 2024;: pubmed publisher
Cameron B, Torres Hernandez L, Montague V, Lewis K, Smith H, Fox J, et al. Titin is a nucleolar protein in neurons. Res Sq. 2024;: pubmed publisher
Kim H, Lee H, Jeon Y, Jang S, Shin Y, Yun J, et al. Targeting SARM1 improves autophagic stress-induced axonal neuropathy. Autophagy. 2024;20:29-44 pubmed publisher
Frezel N, Ranucci M, Foster E, Wende H, Pelczar P, Mendes R, et al. c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy. Cell Rep. 2023;42:112295 pubmed publisher
Liu S, Xiang K, Yuan F, Xiang M. Generation of self-organized autonomic ganglion organoids from fibroblasts. iScience. 2023;26:106241 pubmed publisher
Schmidbauer D, Fink S, Rousset F, L xf6 wenheim H, Senn P, Glueckert R. Closing the Gap between the Auditory Nerve and Cochlear Implant Electrodes: Which Neurotrophin Cocktail Performs Best for Axonal Outgrowth and Is Electrical Stimulation Beneficial?. Int J Mol Sci. 2023;24: pubmed publisher
Sultan N, Scheven B. Exploring the potential application of dental pulp stem cells in neuroregenerative medicine. Neural Regen Res. 2022;17:775-776 pubmed publisher
Lindquist K, Belugin S, Hovhannisyan A, Corey T, Salmon A, Akopian A. Identification of Trigeminal Sensory Neuronal Types Innervating Masseter Muscle. Eneuro. 2021;8: pubmed publisher
Muzyka V, Badea T. Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification. Neural Dev. 2021;16:5 pubmed publisher
Tang Q, Xie M, Zhang Y, Xue R, Zhu X, Yang H. Targeted deletion of Atoh8 results in severe hearing loss in mice. Genesis. 2021;59:e23442 pubmed publisher
Landy M, Goyal M, Lai H. Nociceptor subtypes are born continuously over DRG development. Dev Biol. 2021;479:91-98 pubmed publisher
Sultan N, Amin L, Zaher A, Grawish M, Scheven B. Dental pulp stem cells stimulate neuronal differentiation of PC12 cells. Neural Regen Res. 2021;16:1821-1828 pubmed publisher
Kampanis V, Tolou Dabbaghian B, Zhou L, Roth W, Puttagunta R. Cyclic Stretch of Either PNS or CNS Located Nerves Can Stimulate Neurite Outgrowth. Cells. 2020;10: pubmed publisher
Escalante A, Klein R. Spinal Inhibitory Ptf1a-Derived Neurons Prevent Self-Generated Itch. Cell Rep. 2020;33:108422 pubmed publisher
Gatto G, Bourane S, Ren X, Di Costanzo S, Fenton P, Halder P, et al. A Functional Topographic Map for Spinal Sensorimotor Reflexes. Neuron. 2021;109:91-104.e5 pubmed publisher
Faure L, Wang Y, Kastriti M, Fontanet P, Cheung K, Petitpré C, et al. Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates. Nat Commun. 2020;11:4175 pubmed publisher
Xiao D, Deng Q, Guo Y, Huang X, Zou M, Zhong J, et al. Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts. Sci Adv. 2020;6:eaaz5858 pubmed publisher
Targowska Duda K, Ozawa A, Bertels Z, Cippitelli A, Marcus J, Mielke Maday H, et al. NOP receptor agonist attenuates nitroglycerin-induced migraine-like symptoms in mice. Neuropharmacology. 2020;170:108029 pubmed publisher
Pagella P, Caton J, Meisel C, Mitsiadis T. Ameloblastomas Exhibit Stem Cell Potential, Possess Neurotrophic Properties, and Establish Connections with Trigeminal Neurons. Cells. 2020;9: pubmed publisher
Bohic M, Marics I, Santos C, Malapert P, Ben Arie N, Salio C, et al. Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner. Cell Rep. 2020;30:602-610.e6 pubmed publisher
Paixão S, Loschek L, Gaitanos L, Alcalà Morales P, Goulding M, Klein R. Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements. Neuron. 2019;104:749-764.e6 pubmed publisher
Wang Y, Wu H, Zelenin P, Fontanet P, Wanderoy S, Petitpré C, et al. Muscle-selective RUNX3 dependence of sensorimotor circuit development. Development. 2019;146: pubmed publisher
Dvorakova M, Macova I, Bohuslavova R, Anderova M, Fritzsch B, Pavlinkova G. Early ear neuronal development, but not olfactory or lens development, can proceed without SOX2. Dev Biol. 2020;457:43-56 pubmed publisher
Wang Y, Wu H, Fontanet P, Codeluppi S, Akkuratova N, Petitpré C, et al. A cell fitness selection model for neuronal survival during development. Nat Commun. 2019;10:4137 pubmed publisher
Weir G, Pettingill P, Wu Y, Duggal G, Ilie A, Akerman C, et al. The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing. Front Mol Neurosci. 2019;12:170 pubmed publisher
Acton D, Ren X, Di Costanzo S, Dalet A, Bourane S, Bertocchi I, et al. Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch. Cell Rep. 2019;28:625-639.e6 pubmed publisher
Patil M, Hovhannisyan A, Wangzhou A, Mecklenburg J, Koek W, Goffin V, et al. Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent. J Neuroendocrinol. 2019;31:e12759 pubmed publisher
Wiszniak S, Schwarz Q. Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration. BMC Neurosci. 2019;20:21 pubmed publisher
Takeoka A, Arber S. Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury. Cell Rep. 2019;27:71-85.e3 pubmed publisher
Desiderio S, Vermeiren S, Van Campenhout C, Kricha S, Malki E, Richts S, et al. Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA. Cell Rep. 2019;26:3522-3536.e5 pubmed publisher
Bartesaghi L, Wang Y, Fontanet P, Wanderoy S, Berger F, Wu H, et al. PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis. Cell Rep. 2019;26:3484-3492.e4 pubmed publisher
Zhang M, Wang Y, Geng J, Zhou S, Xiao B. Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice. Cell Rep. 2019;26:1419-1431.e4 pubmed publisher
Patil M, Hovhannisyan A, Akopian A. Characteristics of sensory neuronal groups in CGRP-cre-ER reporter mice: Comparison to Nav1.8-cre, TRPV1-cre and TRPV1-GFP mouse lines. PLoS ONE. 2018;13:e0198601 pubmed publisher
Tashima R, Koga K, Sekine M, Kanehisa K, Kohro Y, Tominaga K, et al. Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats. Eneuro. 2018;5: pubmed publisher
Bernal Sierra Y, Haseleu J, Kozlenkov A, Begay V, Lewin G. Genetic Tracing of Cav3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System. Front Mol Neurosci. 2017;10:70 pubmed publisher
Price E, Krasowska Zoladek A, Nanda K, Stachel S, Henze D. Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway. J Neurosci Methods. 2017;282:34-42 pubmed publisher
Urien L, Gaillard S, Lo Re L, Malapert P, Bohic M, Reynders A, et al. Genetic ablation of GINIP-expressing primary sensory neurons strongly impairs Formalin-evoked pain. Sci Rep. 2017;7:43493 pubmed publisher
Arbat Plana A, Cobianchi S, Herrando Grabulosa M, Navarro X, Udina E. Endogenous modulation of TrkB signaling by treadmill exercise after peripheral nerve injury. Neuroscience. 2017;340:188-200 pubmed publisher
Kue C, Kamkaew A, Voon S, Kiew L, Chung L, Burgess K, et al. Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy. Sci Rep. 2016;6:37209 pubmed publisher
Reed Geaghan E, Wright M, See L, Adelman P, Lee K, Koerber H, et al. Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes. J Neurosci. 2016;36:4362-76 pubmed publisher
Gay M, Valenta T, Herr P, Paratore Hari L, Basler K, Sommer L. Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biol. 2015;13:24 pubmed publisher
Oliveira Fernandes M, Tourtellotte W. Egr3-dependent muscle spindle stretch receptor intrafusal muscle fiber differentiation and fusimotor innervation homeostasis. J Neurosci. 2015;35:5566-78 pubmed publisher
Usoskin D, Furlan A, Islam S, Abdo H, Lönnerberg P, Lou D, et al. Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nat Neurosci. 2015;18:145-53 pubmed publisher
product information
master code :
AF1404
SKU :
AF1404
product name :
Mouse/Rat TrkC Antibody
unit size :
100 ug (also 25 ug)
description :
The Mouse/Rat TrkC Antibody from R&D Systems is a goat polyclonal antibody to TrkC. This antibody reacts with human,mouse,rat,transgenic mouse. The Mouse/Rat TrkC Antibody has been validated for the following applications: Immunohistochemistry,ELISA Development (Capture),IHC-F,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunofluorescence,Immunocytochemistry,Simple Western,Blockade of Receptor-ligand Interaction.
target :
TrkC
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse TrkC, Cys32-Thr429, Accession # Q6VNS1
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Rat,Transgenic Mouse
specificity :
Detects mouse TrkC in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant human (rh) TrkC is observed and less than 2% cross-reactivity with recombinant mouse TrkB, recombinant rat TrkA, and rhTrkA is observed.
gene symbol :
NTRK3
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Detection of Mouse and Rat TrkC antibody by Western Blot.
accessionNumbers :
Q6VNS1
applications :
Immunohistochemistry,ELISA Development (Capture),IHC-F,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunofluorescence,Immunocytochemistry,Simple Western,Blockade of Receptor-ligand Interaction
USD :
509 USD
alt names :
EC 2.7.10, EC 2.7.10.1, ETS related protein-neurotrophic receptor tyrosine kinase fusion protein, ETV6-NTRK3 fusion, gp145(trkC), GP145-TrkC, Neurotrophic tyrosine kinase receptor type 3, neurotrophic tyrosine kinase, receptor, type 3, NT 3 receptor, NT-3 growth factor receptor, NTRK3, Trk-C, TrkC tyrosine kinase, TRKCneurotrophin 3 receptor, tyrosine kinase receptor C
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.