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company name :
R&D Systems
product type :
antibody
product name :
Mouse DLL4 Antibody
catalog :
AF1389
quantity :
100 ug (also 25 ug)
price :
509 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 32
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse; 1:100; loading ...; fig s4c
  • immunohistochemistry; mouse; 1:100; loading ...; fig 3a
  • western blot; mouse; 1:1000; loading ...; fig s4d
D Amico G, Fernandez I, Gómez Escudero J, Kim H, Maniati E, Azman M, et al. ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning. Development. 2022;149: pubmed publisher
Ren J, Bai W, Ding J, Ge H, Wang S, Chen X, et al. Hypoxia-induced AFAP1L1 regulates pathological neovascularization via the YAP-DLL4-NOTCH axis. J Transl Med. 2023;21:651 pubmed publisher
Bai W, Ren J, Xia M, Zhao Y, Ding J, Chen X, et al. Targeting FSCN1 with an oral small-molecule inhibitor for treating ocular neovascularization. J Transl Med. 2023;21:555 pubmed publisher
Biswas S, Shahriar S, Bachay G, Arvanitis P, Brunken W, Agalliu D. Glutamatergic neuronal activity regulates angiogenesis and blood-retinal barrier maturation via Norrin/β-catenin signaling. bioRxiv. 2023;: pubmed publisher
Davies E, Gurung R, Le K, Roan K, Harvey R, Mitchell G, et al. PI(4,5)P2-dependent regulation of endothelial tip cell specification contributes to angiogenesis. Sci Adv. 2023;9:eadd6911 pubmed publisher
Hou Q, Jia J, Lin J, Zhu L, Xie S, Yu Q, et al. Bacillus subtilis programs the differentiation of intestinal secretory lineages to inhibit Salmonella infection. Cell Rep. 2022;40:111416 pubmed publisher
Katreddi R, Taroc E, Hicks S, Lin J, Liu S, Xiang M, et al. Notch signaling determines cell-fate specification of the two main types of vomeronasal neurons of rodents. Development. 2022;149: pubmed publisher
Bae J, Yang M, Jeong S, Kim J, Hong S, Kim J, et al. Gatekeeping role of Nf2/Merlin in vascular tip EC induction through suppression of VEGFR2 internalization. Sci Adv. 2022;8:eabn2611 pubmed publisher
Lee C, Park B, Jo T, Park C, Kim J, Chung K, et al. Dll4 Inhibition Promotes Graft Retention in Fat Grafting Enriched with Adipose-Derived Stem Cells. Stem Cells Transl Med. 2022;11:742-752 pubmed publisher
Xu C, Dinh V, Kruse K, Jeong H, Watson E, Adams S, et al. Induction of osteogenesis by bone-targeted Notch activation. elife. 2022;11: pubmed publisher
Zhu G, Lin Y, Ge T, Singh S, Liu H, Fan L, et al. A novel peptide inhibitor of Dll4-Notch1 signalling and its pro-angiogenic functions. Br J Pharmacol. 2022;179:1716-1731 pubmed publisher
Yu R, Kim N, Li Y, Jeong J, Park S, Zhou B, et al. Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice. Transl Stroke Res. 2022;13:142-159 pubmed publisher
Azzoni E, Frontera V, Anselmi G, Rode C, James C, Deltcheva E, et al. The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition. Cell Rep. 2021;37:110103 pubmed publisher
Su W, Sun S, Tian B, Tai P, Luo Y, Ko J, et al. Efficacious, safe, and stable inhibition of corneal neovascularization by AAV-vectored anti-VEGF therapeutics. Mol Ther Methods Clin Dev. 2021;22:107-121 pubmed publisher
Zarkada G, Howard J, Xiao X, Park H, Bizou M, Leclerc S, et al. Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation. Dev Cell. 2021;56:2237-2251.e6 pubmed publisher
Yeom D, Lee Y, Ryu I, Lee S, Sung B, Lee H, et al. ABL001, a Bispecific Antibody Targeting VEGF and DLL4, with Chemotherapy, Synergistically Inhibits Tumor Progression in Xenograft Models. Int J Mol Sci. 2020;22: pubmed publisher
Sharma G, Jagtap J, Parchur A, Gogineni V, Ran S, Bergom C, et al. Heritable modifiers of the tumor microenvironment influence nanoparticle uptake, distribution and response to photothermal therapy. Theranostics. 2020;10:5368-5383 pubmed publisher
Viallard C, Audiger C, Popovic N, Akla N, Lanthier K, Legault Navarrete I, et al. BMP9 signaling promotes the normalization of tumor blood vessels. Oncogene. 2020;39:2996-3014 pubmed publisher
Fu R, Lv W, Xu Y, Gong M, Chen X, Jiang N, et al. Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis. Nat Commun. 2020;11:460 pubmed publisher
Yasuda D, Kobayashi D, Akahoshi N, Ohto Nakanishi T, Yoshioka K, Takuwa Y, et al. Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4. J Clin Invest. 2019;130:4332-4349 pubmed publisher
Payne S, Gunadasa Rohling M, Neal A, Redpath A, Patel J, Chouliaras K, et al. Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart. Nat Commun. 2019;10:3276 pubmed publisher
Gong Z, Shang B, Chu Y, Chen X, Li Q, Liu K, et al. Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development. Cell Death Dis. 2019;10:440 pubmed publisher
Fernández Chacón M, Casquero García V, Luo W, Francesca Lunella F, Ferreira Rocha S, Del Olmo Cabrera S, et al. iSuRe-Cre is a genetic tool to reliably induce and report Cre-dependent genetic modifications. Nat Commun. 2019;10:2262 pubmed publisher
Neal A, Nornes S, Payne S, Wallace M, Fritzsche M, Louphrasitthiphol P, et al. Venous identity requires BMP signalling through ALK3. Nat Commun. 2019;10:453 pubmed publisher
Tetzlaff F, Adam M, Feldner A, Moll I, Menuchin A, Rodriguez Vita J, et al. MPDZ promotes DLL4-induced Notch signaling during angiogenesis. elife. 2018;7: pubmed publisher
Chaqour J, Lee S, Ravichandra A, Chaqour B. Abscisic acid - an anti-angiogenic phytohormone that modulates the phenotypical plasticity of endothelial cells and macrophages. J Cell Sci. 2018;131: pubmed publisher
Shah A, Birdsey G, Peghaire C, Pitulescu M, Dufton N, Yang Y, et al. The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability. Nat Commun. 2017;8:16002 pubmed publisher
Davis R, Kechele D, Blakeney E, Pawlak J, Caron K. Lymphatic deletion of calcitonin receptor-like receptor exacerbates intestinal inflammation. JCI Insight. 2017;2:e92465 pubmed publisher
Chung J, Ebens C, Perkey E, Radojcic V, Koch U, Scarpellino L, et al. Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands. J Clin Invest. 2017;127:1574-1588 pubmed publisher
Nakata T, Shimizu H, Nagata S, Ito G, Fujii S, Suzuki K, et al. Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine. Data Brief. 2017;10:551-556 pubmed publisher
Ramasamy S, Kusumbe A, Schiller M, Zeuschner D, Bixel M, Milia C, et al. Blood flow controls bone vascular function and osteogenesis. Nat Commun. 2016;7:13601 pubmed publisher
Chennupati V, Koch U, Coutaz M, Scarpellino L, Tacchini Cottier F, Luther S, et al. Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells. J Immunol. 2016;197:771-82 pubmed publisher
product information
brand :
R&D Systems
master code :
AF1389
SKU :
AF1389
product name :
Mouse DLL4 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Mouse DLL4 Antibody from R&D Systems is a goat polyclonal antibody to DLL4. This antibody reacts with human,mouse,rat,transgenic mouse. The Mouse DLL4 Antibody has been validated for the following applications: Immunohistochemistry,IHC-F,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry.
target :
DLL4
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 2 ug/mL, Immunohistochemistry 5-15 ug/mL, Immunocytochemistry 5-15 ug/mL
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse DLL4, Ser28-Pro525, Accession # BAB18580
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Rat,Transgenic Mouse
specificity :
Detects mouse DLL4 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant human DLL4 is observed.
gene symbol :
DLL4
top caption :
Detection of Mouse DLL4 antibody by Western Blot.
accessionNumbers :
BAB18580
applications :
IHC-F,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry
USD :
509 USD
alt names :
delta 4, Delta 4 precursor, delta ligand 4, delta4, delta-like 4 (Drosophila), delta-like 4 homolog, delta-like 4 homolog (Drosophila), delta-like 4 protein, delta-like protein 4, Drosophila Delta homolog 4, hdelta2, MGC126344, notch ligand delta-2, notch ligand DLL4
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.