Human Galectin-8 Antibody | R&D Systems AF1305 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Galectin-8 Antibody

catalog :

AF1305

quantity :

100 ug (also 25 ug)

price :

509 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 22

Reference
Bass A, Egan M, Alexander Floyd J, Lopes Fischer N, Doerner J, Shin S. Human GBP1 facilitates the rupture of the Legionella-containing vacuole and inflammasome activation. MBio. 2023;14:e0170723 pubmed publisher
Boyle K, Ellison C, Elliott P, Schuschnig M, Grimes K, Dionne M, et al. TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure. EMBO J. 2023;42:e113012 pubmed publisher
Pag xe1 n A, Lee L, Edwards Hicks J, Moens C, Tobin D, Busch Nentwich E, et al. mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity. Cell. 2022;185:3720-3738.e13 pubmed publisher
Pied N, Daussy C, Denis Z, Ragues J, Faure M, Iggo R, et al. TBK1 is part of a galectin 8 dependent membrane damage recognition complex and drives autophagy upon Adenovirus endosomal escape. PLoS Pathog. 2022;18:e1010736 pubmed publisher
Osman M, Shanahan J, Chu F, Takaki K, Pinckert M, Pagán A, et al. The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence. Proc Natl Acad Sci U S A. 2022;119:e2122161119 pubmed publisher
Pablos I, Machado Y, de Jesus H, Mohamud Y, Kappelhoff R, Lindskog C, et al. Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome. Cell Rep. 2021;37:109892 pubmed publisher
Eapen V, Swarup S, Hoyer M, Paulo J, Harper J. Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy. elife. 2021;10: pubmed publisher
Otten E, Werner E, Crespillo Casado A, Boyle K, Dharamdasani V, Pathe C, et al. Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection. Nature. 2021;594:111-116 pubmed publisher
Badgujar D, Anil A, Green A, Surve M, Madhavan S, Beckett A, et al. Structural insights into loss of function of a pore forming toxin and its role in pneumococcal adaptation to an intracellular lifestyle. PLoS Pathog. 2020;16:e1009016 pubmed publisher
Fisch D, Clough B, Domart M, Encheva V, Bando H, Snijders A, et al. Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death. Cell Rep. 2020;32:108008 pubmed publisher
Osman M, Pagán A, Shanahan J, Ramakrishnan L. Mycobacterium marinum phthiocerol dimycocerosates enhance macrophage phagosomal permeabilization and membrane damage. PLoS ONE. 2020;15:e0233252 pubmed publisher
Ellison C, Kukulski W, Boyle K, Munro S, Randow F. Transbilayer Movement of Sphingomyelin Precedes Catastrophic Breakage of Enterobacteria-Containing Vacuoles. Curr Biol. 2020;30:2974-2983.e6 pubmed publisher
Herbst S, Campbell P, Harvey J, Bernard E, Papayannopoulos V, Wood N, et al. LRRK2 activation controls the repair of damaged endomembranes in macrophages. EMBO J. 2020;:e104494 pubmed publisher
Wandel M, Kim B, Park E, Boyle K, Nayak K, Lagrange B, et al. Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms. Nat Immunol. 2020;21:880-891 pubmed publisher
Koerver L, Papadopoulos C, Liu B, Kravic B, Rota G, Brecht L, et al. The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage. EMBO Rep. 2019;20:e48014 pubmed publisher
Ravenhill B, Boyle K, von Muhlinen N, Ellison C, Masson G, Otten E, et al. The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria. Mol Cell. 2019;74:320-329.e6 pubmed publisher
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Bojic Trbojevic Z, Jovanović Krivokuća M, Vilotic A, Kolundžić N, Stefanoska I, Zetterberg F, et al. Human trophoblast requires galectin-3 for cell migration and invasion. Sci Rep. 2019;9:2136 pubmed publisher
Lerner T, Queval C, Fearns A, Repnik U, Griffiths G, Gutierrez M. Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells. BMC Biol. 2018;16:1 pubmed publisher
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product information

master code :

AF1305

SKU :

AF1305

product name :

Human Galectin-8 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Galectin-8 Antibody from R&D Systems is a goat polyclonal antibody to Galectin-8. This antibody reacts with complex species category,human,mouse,n/a. The Human Galectin-8 Antibody has been validated for the following applications: Immunocytochemistry,ELISA Detection,ELISA Development (Detection),Flow Cytometry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry,Simple Western.

target :

Galectin-8

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

E. coli -derived recombinant human Galectin-8, Met1-Trp317, Accession # O00214

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Complex Species Category,Human,Mouse,N/A

specificity :

Detects human Galectin-8 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant human (rh) rhGalectin-1 and rhGalectin-3 is observed, and less than 1% cross-reactivity with rhGalectin-2, rhGalectin-4 and rhGalectin-7 is observed.

gene symbol :

LGALS8

top caption :

Detection of Human Galectin-8 antibody by Western Blot.

accessionNumbers :

O00214

applications :

Immunocytochemistry,ELISA Detection,ELISA Development (Detection),Flow Cytometry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry,Simple Western

USD :

509 USD

alt names :

Gal-8, GAL8, galectin 8, galectin-8, Galectin8, galectin-8g, lectin, galactoside-binding, soluble, 8, LGALS8, PCTA1, PCTA-1Po66 carbohydrate-binding protein, Po66 carbohydrate binding protein, Po66-CBP, Prostate carcinoma tumor antigen 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage