Human Jagged 1 Antibody | R&D Systems AF1277 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Jagged 1 Antibody

catalog :

AF1277

quantity :

100 ug (also 25 ug)

price :

509 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section, In-Cell Western

more info or order :

R&D Systems product webpage

citations: 14

Reference
Mikuli x107 P, Ogorevc M, Petri x10d evi x107 M, Kali x10d anin D, Tafra R, Saraga Babi x107 M, et al. SOX2, JAGGED1, β-Catenin, and Vitamin D Receptor Expression Patterns during Early Development and Innervation of the Human Inner Ear. Int J Mol Sci. 2024;25: pubmed publisher
Herrera J, Komatsu M. Akt3 activation by R-Ras in an endothelial cell enforces quiescence and barrier stability of neighboring endothelial cells via Jagged1. Cell Rep. 2024;43:113837 pubmed publisher
Wang G, Heijs B, Kostidis S, Rietjens R, Koning M, Yuan L, et al. Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation. Cell Stem Cell. 2022;29:1580-1593.e7 pubmed publisher
Zhao L, Lei J, Gu S, Zhang Y, Jing X, Wang L, et al. A yes-associated protein 1- Notch1 receptor positive feedback loop promotes breast cancer lung metastasis by attenuating the bone morphogenetic protein 4-SMAD family member 1/5 signaling. Carcinogenesis. 2022;43:1162-1175 pubmed publisher
Parkin E, Hammond J, Owens L, Hodges M. The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein. PLoS ONE. 2022;17:e0255715 pubmed publisher
Iosifidis T, Sutanto E, Montgomery S, Agudelo Romero P, Looi K, Ling K, et al. Dysregulated Notch Signaling in the Airway Epithelium of Children with Wheeze. J Pers Med. 2021;11: pubmed publisher
Pagella P, De Vargas Roditi L, Stadlinger B, Moor A, Mitsiadis T. Notch signaling in the dynamics of perivascular stem cells and their niches. Stem Cells Transl Med. 2021;10:1433-1445 pubmed publisher
Yu J, Zhu C, Wang X, Kim K, Bartolomé A, Dongiovanni P, et al. Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis. Sci Transl Med. 2021;13: pubmed publisher
Palano M, Giannandrea D, Platonova N, Gaudenzi G, Falleni M, Tosi D, et al. Jagged Ligands Enhance the Pro-Angiogenic Activity of Multiple Myeloma Cells. Cancers (Basel). 2020;12: pubmed publisher
Bersini S, Schulte R, Huang L, Tsai H, Hetzer M. Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. elife. 2020;9: pubmed publisher
Low J, Li P, Chew E, Zhou B, Suzuki K, Zhang T, et al. Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network. Cell Stem Cell. 2019;25:373-387.e9 pubmed publisher
De Falco F, Del Papa B, Baldoni S, Sabatini R, Falzetti F, Di Ianni M, et al. IL-4-dependent Jagged1 expression/processing is associated with survival of chronic lymphocytic leukemia cells but not with Notch activation. Cell Death Dis. 2018;9:1160 pubmed publisher
Bellon M, Moles R, Chaib Mezrag H, Pancewicz J, Nicot C. JAG1 overexpression contributes to Notch1 signaling and the migration of HTLV-1-transformed ATL cells. J Hematol Oncol. 2018;11:119 pubmed publisher
Sansone P, Berishaj M, Rajasekhar V, Ceccarelli C, Chang Q, Strillacci A, et al. Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles. Cancer Res. 2017;77:1927-1941 pubmed publisher

product information

master code :

AF1277

SKU :

AF1277

product name :

Human Jagged 1 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Jagged 1 Antibody from R&D Systems is a goat polyclonal antibody to Jagged 1. This antibody reacts with human. The Human Jagged 1 Antibody has been validated for the following applications: Bioassay,Immunohistochemistry,Immunocytochemistry,In-Cell Western (ICW),Western Blot,Neutralization,Immunohistochemistry-Paraffin.

target :

Jagged 1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Jagged 1, Ser32-Asp296, Accession # P78504

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human

specificity :

Detects human Jagged 1 in direct ELISAs and Western blots.

gene symbol :

JAG1

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Human Jagged 1 antibody by Western Blot.

accessionNumbers :

P78504

applications :

Immunohistochemistry,Immunocytochemistry,Bioassay,In-Cell Western (ICW),Western Blot,Neutralization,Immunohistochemistry-Paraffin

USD :

509 USD

alt names :

AGS, AHDMGC104644, Alagille syndrome, AWS, CD339, CD339 antigen, HJ1, JAG1, jagged 1, Jagged1, JAGL1, protein jagged-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage