Human/Mouse/Rat MDM2/HDM2 Antibody | R&D Systems AF1244 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse/Rat MDM2/HDM2 Antibody

catalog :

AF1244

quantity :

100 ug (also 25 ug)

price :

409 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 12

Reference
Nakagawa Saito Y, Mitobe Y, Togashi K, Suzuki S, Sugai A, Takenouchi S, et al. The MDM2-p53 Axis Represents a Therapeutic Vulnerability Unique to Glioma Stem Cells. Int J Mol Sci. 2024;25: pubmed publisher
Meah A, Vedarethinam V, Bronstein R, Gujarati N, Jain T, Mallipattu S, et al. Single-Cell Spatial MIST for Versatile, Scalable Detection of Protein Markers. Biosensors (Basel). 2023;13: pubmed publisher
Mitobe Y, Suzuki S, Nakagawa Saito Y, Togashi K, Sugai A, Sonoda Y, et al. Antagonizing MDM2 Overexpression Induced by MDM4 Inhibitor CEP-1347 Effectively Reactivates Wild-Type p53 in Malignant Brain Tumor Cells. Cancers (Basel). 2023;15: pubmed publisher
Mitobe Y, Suzuki S, Nakagawa Saito Y, Togashi K, Sugai A, Sonoda Y, et al. The Novel MDM4 Inhibitor CEP-1347 Activates the p53 Pathway and Blocks Malignant Meningioma Growth In Vitro and In Vivo. Biomedicines. 2023;11: pubmed publisher
Arcones A, Martínez Cignoni M, Vila Bedmar R, Yañez C, Lladó I, Proenza A, et al. Cardiac GRK2 Protein Levels Show Sexual Dimorphism during Aging and Are Regulated by Ovarian Hormones. Cells. 2021;10: pubmed publisher
Thadi A, Morano W, Khalili M, Babcock B, Shaikh M, Foster D, et al. Molecular Targeting of H/MDM-2 Oncoprotein in Human Colon Cancer Cells and Stem-like Colonic Epithelial-derived Progenitor Cells. Anticancer Res. 2021;41:27-42 pubmed publisher
Xiao G, Annor G, Fung K, Keinänen O, Zeglis B, Bargonetti J. Targeting Triple Negative Breast Cancer with a Nucleus-Directed p53 Tetramerization Domain Peptide. Mol Pharm. 2021;18:338-346 pubmed publisher
Colmenero Repiso A, G xf3 mez Mu xf1 oz M, Rodr xed guez Prieto I, Amador xc1 lvarez A, Henrich K, Pascual Vaca D, et al. Identification of VRK1 as a New Neuroblastoma Tumor Progression Marker Regulating Cell Proliferation. Cancers (Basel). 2020;12: pubmed publisher
Thadi A, Lewis L, Goldstein E, Aggarwal A, Khalili M, Steele L, et al. Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic Cells. Anticancer Res. 2020;40:4857-4867 pubmed publisher
Xiao R, An Y, Ye W, Derakhshan A, Cheng H, Yang X, et al. Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV- and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy. Clin Cancer Res. 2019;25:6463-6474 pubmed publisher
Coutu D, Kokkaliaris K, Kunz L, Schroeder T. Multicolor quantitative confocal imaging cytometry. Nat Methods. 2018;15:39-46 pubmed publisher
Schreckenberg R, Bencsik P, Weber M, Abdallah Y, Csonka C, Gömöri K, et al. Adverse Effects on β-Adrenergic Receptor Coupling: Ischemic Postconditioning Failed to Preserve Long-Term Cardiac Function. J Am Heart Assoc. 2017;6: pubmed publisher

product information

master code :

AF1244

SKU :

AF1244

product name :

Human/Mouse/Rat MDM2/HDM2 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human/Mouse/Rat MDM2/HDM2 Antibody from R&D Systems is a rabbit polyclonal antibody to MDM2/HDM2. This antibody reacts with human,mouse,rat. The Human/Mouse/Rat MDM2/HDM2 Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin.

target :

MDM2/HDM2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Rabbit

immunogen :

E. coli -derived recombinant human MDM2, Asn3-Pro491, Accession # Q00987

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat

specificity :

Detects human, mouse, and rat MDM2.

gene symbol :

MDM2

accessionNumbers :

Q00987

applications :

Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin

USD :

409 USD

alt names :

ACTFS, HDM2, HDMX, MDM2 oncogene, E3 ubiquitin protein ligase

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage