product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse/Rat Galectin-3 Antibody
catalog :
AF1197
quantity :
100 ug (also 25 ug)
price :
509 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 35
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:200; loading ...; fig 6b
Emre C, Do K, Jun B, Hjorth E, Alcalde S, Kautzmann M, et al. Age-related changes in brain phospholipids and bioactive lipids in the APP knock-in mouse model of Alzheimer's disease. Acta Neuropathol Commun. 2021;9:116 pubmed publisher
  • immunohistochemistry; mouse; loading ...
Li B, Yin J, Chang J, Zhang J, Wang Y, Huang H, et al. Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction. J Endocrinol. 2021;249:1-18 pubmed publisher
Makar A, Boraman A, Mosen P, Simpson J, Marques J, Michelberger T, et al. The V-ATPase complex component RNAseK is required for lysosomal hydrolase delivery and autophagosome degradation. Nat Commun. 2024;15:7743 pubmed publisher
Sideris Lampretsas G, Oggero S, Zeboudj L, Silva R, Bajpai A, Dharmalingam G, et al. Galectin-3 activates spinal microglia to induce inflammatory nociception in wild type but not in mice modelling Alzheimer's disease. Nat Commun. 2023;14:3579 pubmed publisher
Mouton A, Aitken N, Moak S, do Carmo J, da Silva A, Omoto A, et al. Temporal changes in glucose metabolism reflect polarization in resident and monocyte-derived macrophages after myocardial infarction. Front Cardiovasc Med. 2023;10:1136252 pubmed publisher
Bhattarai U, He X, Xu R, Liu X, Pan L, Sun Y, et al. IL-12α deficiency attenuates pressure overload-induced cardiac inflammation, hypertrophy, dysfunction, and heart failure progression. Front Immunol. 2023;14:1105664 pubmed publisher
Arroyo Garc xed a L, Bachiller S, Ruiz R, Boza Serrano A, Rodr xed guez Moreno A, Deierborg T, et al. Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer's disease. Transl Neurodegener. 2023;12:6 pubmed publisher
Chadarevian J, Lombroso S, Peet G, Hasselmann J, Tu C, Marzan D, et al. Engineering an inhibitor-resistant human CSF1R variant for microglia replacement. J Exp Med. 2023;220: pubmed publisher
Shi H, Yin Z, Koronyo Y, Fuchs D, Sheyn J, Davis M, et al. Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia. Acta Neuropathol Commun. 2022;10:136 pubmed publisher
Maupin K, Diegel C, Stevens P, Dick D, Williams B. Mutation of the galectin-3 glycan-binding domain (Lgals3-R200S) enhances cortical bone expansion in male mice and trabecular bone mass in female mice. FEBS Open Bio. 2022;12:1717-1728 pubmed publisher
Margeta M, Yin Z, Madore C, Pitts K, Letcher S, Tang J, et al. Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma. Immunity. 2022;55:1627-1644.e7 pubmed publisher
Novo E, Cappon A, Villano G, Quarta S, Cannito S, Bocca C, et al. SerpinB3 as a Pro-Inflammatory Mediator in the Progression of Experimental Non-Alcoholic Fatty Liver Disease. Front Immunol. 2022;13:910526 pubmed publisher
Uff C, Patel K, Yeung C, Yip P. Advances in Visualizing Microglial Cells in Human Central Nervous System Tissue. Biomolecules. 2022;12: pubmed publisher
Duarte C, Yamada C, Garcia C, Akkaoui J, Ho A, Nichols F, et al. Crosstalk between dihydroceramides produced by Porphyromonas gingivalis and host lysosomal cathepsin B in the promotion of osteoclastogenesis. J Cell Mol Med. 2022;26:2841-2851 pubmed publisher
Wan T, Zhu W, Zhao Y, Zhang X, Ye R, Zuo M, et al. Astrocytic phagocytosis contributes to demyelination after focal cortical ischemia in mice. Nat Commun. 2022;13:1134 pubmed publisher
Fern xe1 ndez Mart xed n J, Espinosa Oliva A, Garc xed a Dom xed nguez I, Rosado S xe1 nchez I, Pacheco Y, Moyano R, et al. Gal3 Plays a Deleterious Role in a Mouse Model of Endotoxemia. Int J Mol Sci. 2022;23: pubmed publisher
Xu X, Zhang J, Li S, Al Nusaif M, Zhou Q, Chen S, et al. Bone Marrow Stromal Cell Antigen 2: Is a Potential Neuroinflammation Biomarker of SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis in Pre-symptomatic Stage. Front Neurosci. 2021;15:788730 pubmed publisher
Lu Q, Zhang R, Chen S, Li T, Wang Y, Xue Y, et al. The Diagnostic and Prognostic Value of Plasma Galectin 3 in HFrEF Related to the Etiology of Heart Failure. Front Cardiovasc Med. 2021;8:748875 pubmed publisher
Edgar L, Akbar N, Braithwaite A, Krausgruber T, Gallart Ayala H, Bailey J, et al. Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis. Circulation. 2021;144:961-982 pubmed publisher
Mendes M, Le L, Atlas J, Brehm Z, Ladrón de Guevara A, Matei E, et al. The role of P2Y12 in the kinetics of microglial self-renewal and maturation in the adult visual cortex in vivo. elife. 2021;10: pubmed publisher
Argyrofthalmidou M, Spathis A, Maniati M, Poula A, Katsianou M, Sotiriou E, et al. Nurr1 repression mediates cardinal features of Parkinson's disease in α-synuclein transgenic mice. Hum Mol Genet. 2021;30:1469-1483 pubmed publisher
Esposito N, Mazzoni F, Vargas J, Finnemann S. Diurnal Photoreceptor Outer Segment Renewal in Mice Is Independent of Galectin-3. Invest Ophthalmol Vis Sci. 2021;62:7 pubmed publisher
Huang M, Modeste E, Dammer E, Merino P, Taylor G, Duong D, et al. Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations. Acta Neuropathol Commun. 2020;8:163 pubmed publisher
Han C, Kang I, Omer M, Wang S, Wietecha T, Wight T, et al. Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties. JCI Insight. 2020;5: pubmed publisher
Lee Y, Joo H, Lee E, Park M, Cho H, Kim S, et al. Plasma APE1/Ref-1 Correlates with Atherosclerotic Inflammation in ApoE-/- Mice. Biomedicines. 2020;8: pubmed publisher
Han C, Kang I, Harten I, Gebe J, Chan C, Omer M, et al. Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity. Cell Rep. 2020;31:107818 pubmed publisher
Svensson M, Andersson E, Manouchehrian O, Yang Y, Deierborg T. Voluntary running does not reduce neuroinflammation or improve non-cognitive behavior in the 5xFAD mouse model of Alzheimer's disease. Sci Rep. 2020;10:1346 pubmed publisher
Douglas G, Mehta V, Zen A, Akoumianakis I, Goel A, Rashbrook V, et al. A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction. Cardiovasc Res. 2019;: pubmed publisher
Siew J, Chen H, Chen H, Chen H, Chen C, Soong B, et al. Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease. Nat Commun. 2019;10:3473 pubmed publisher
Iwanaga T, Nio Kobayashi J, Takahashi Iwanaga H. Bush-like integrin filament networks associated with hyaloid vasculature in murine neonate eyes. Biomed Res. 2019;40:79-85 pubmed publisher
García Domínguez I, Veselá K, García Revilla J, Carrillo Jimenez A, Roca Ceballos M, Santiago M, et al. Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson's Disease. Front Cell Neurosci. 2018;12:398 pubmed publisher
Alawieh A, Andersen M, Adkins D, Tomlinson S. Acute Complement Inhibition Potentiates Neurorehabilitation and Enhances tPA-Mediated Neuroprotection. J Neurosci. 2018;38:6527-6545 pubmed publisher
Kishimoto A, Kimura S, Nio Kobayashi J, Takahashi Iwanaga H, Park A, Iwanaga T. Histochemical characteristics of regressing vessels in the hyaloid vascular system of neonatal mice: Novel implication for vascular atrophy. Exp Eye Res. 2018;172:1-9 pubmed publisher
Alawieh A, Langley E, Weber S, Adkins D, Tomlinson S. Identifying the Role of Complement in Triggering Neuroinflammation after Traumatic Brain Injury. J Neurosci. 2018;38:2519-2532 pubmed publisher
Knights A, Yik J, Mat Jusoh H, Norton L, Funnell A, Pearson R, et al. Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3). J Biol Chem. 2016;291:16048-58 pubmed publisher
product information
master code :
AF1197
SKU :
AF1197
product name :
Human/Mouse/Rat Galectin-3 Antibody
unit size :
100 ug (also 25 ug)
description :
The Human/Mouse/Rat Galectin-3 Antibody from R&D Systems is a goat polyclonal antibody to Galectin-3. This antibody reacts with human,mouse,rat,transgenic mouse,xenograft. The Human/Mouse/Rat Galectin-3 Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Immunocytochemistry,IFC,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Simple Western.
target :
Galectin-3
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
E. coli -derived recombinant mouse Galectin-3, Ala2-Ile264, Accession # NP_034835
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Rat,Transgenic Mouse,Xenograft
specificity :
Detects human, mouse, and rat Galectin-3 in Western blots. Detects mouse Galectin-3 in direct ELISAs. In direct ELISAs, approximately 20% cross-reactivity with recombinant human (rh) Galectin-3 is observed and less than 1% cross-reactivity with recombinant mouse (rm) Galectin-4 and rmGalectin-9 is observed.
gene symbol :
LGALS3
top caption :
Detection of Mouse Galectin-3 antibody by Western Blot.
accessionNumbers :
NP_034835
applications :
Immunohistochemistry,Immunocytochemistry,IFC,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Simple Western
USD :
509 USD
alt names :
AGE-R3, Carbohydrate-binding protein 35, CBP 35,35 kDa lectin, CBP35, Gal-3, GAL3, galactin-3, Galactose-specific lectin 3, Galactoside-binding protein, GALBPCBP35, galectin-3, Galectin3, GALIG, IgE-binding protein, L29, L31, L-31, Laminin-binding protein, Lectin L-29, lectin, galactoside-binding, soluble, 3, LGALS2, LGALS3, Mac-2, Mac-2 antigen, MAC2GAL3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.