Human/Mouse/Rat RAGE Antibody | R&D Systems AF1179 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse/Rat RAGE Antibody

catalog :

AF1179

quantity :

100 ug (also 25 ug)

price :

479 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; loading ...; fig 1f	MacLean M, Juranek J, Cuddapah S, López Díez R, Ruiz H, Hu J, et al. Microglia RAGE exacerbates the progression of neurodegeneration within the SOD1G93A murine model of amyotrophic lateral sclerosis in a sex-dependent manner. J Neuroinflammation. 2021;18:139 pubmed publisher
	Monteiro C, Miarka L, Perea García M, Priego N, García Gómez P, Álvaro Espinosa L, et al. Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism. Nat Med. 2022;28:752-765 pubmed publisher
	Li M, Ong C, Langou xeb t Astri xe9 C, Tan L, Verma A, Yang Y, et al. Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE. elife. 2022;11: pubmed publisher
	Navel V, Malecaze J, Belville C, Choltus H, Henrioux F, Dutheil F, et al. Dysregulation of Receptor for Advanced Glycation End Products (RAGE) Expression as a Biomarker of Keratoconus. Dis Markers. 2022;2022:1543742 pubmed publisher
	Kitaura A, Nishinaka T, Hamasaki S, Hatipoglu O, Wake H, Nishibori M, et al. Advanced glycation end-products reduce lipopolysaccharide uptake by macrophages. PLoS ONE. 2021;16:e0245957 pubmed publisher
	Nishioku T, Kubo T, Kamada T, Okamoto K, Tsukuba T, Uto T, et al. (-)-Epigallocatechin-3-gallate inhibits RANKL-induced osteoclastogenesis via downregulation of NFATc1 and suppression of HO-1-HMGB1-RAGE pathway. Biomed Res. 2020;41:269-277 pubmed publisher
	Choltus H, Lavergne M, Belville C, Gallot D, Minet Quinard R, Durif J, et al. Occurrence of a RAGE-Mediated Inflammatory Response in Human Fetal Membranes. Front Physiol. 2020;11:581 pubmed publisher
	Zeng F, Liu Y, Huang W, Qing H, Kadowaki T, Kashiwazaki H, et al. Receptor for advanced glycation end products up-regulation in cerebral endothelial cells mediates cerebrovascular-related amyloid β accumulation after Porphyromonas gingivalis infection. J Neurochem. 2021;158:724-736 pubmed publisher
	Zhou L, Chen X, Lu M, Wu Q, Yuan Q, Hu C, et al. Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria. Kidney Int. 2019;95:830-845 pubmed publisher
	Sanders K, Delker D, Huecksteadt T, Beck E, Wuren T, Chen Y, et al. RAGE is a Critical Mediator of Pulmonary Oxidative Stress, Alveolar Macrophage Activation and Emphysema in Response to Cigarette Smoke. Sci Rep. 2019;9:231 pubmed publisher
	Wolf L, Herr C, Niederstraßer J, Beisswenger C, Bals R. Receptor for advanced glycation endproducts (RAGE) maintains pulmonary structure and regulates the response to cigarette smoke. PLoS ONE. 2017;12:e0180092 pubmed publisher

product information

brand :

R&D Systems

master code :

AF1179

SKU :

AF1179

product name :

Human/Mouse/Rat RAGE Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human/Mouse/Rat RAGE Antibody from R&D Systems is a goat polyclonal antibody to AGER. This antibody reacts with avian - chicken,human,mouse,rabbit,rat. The Human/Mouse/Rat RAGE Antibody has been validated for the following applications: Western Blot,Electrophysiology,Flow Cytometry,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,Blockade of Receptor-ligand Interaction.

target :

RAGE/AGER

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.1-1 ug/mL, Immunohistochemistry 5-15 ug/mL, Blockade of Receptor-ligand Interaction

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse RAGE, Gln24-Ala342, Accession # O35444

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Avian - Chicken,Human,Mouse,Rabbit,Rat

specificity :

Detects human, mouse, and rat RAGE in Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant canine RAGE is observed.

gene symbol :

Ager

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Human RAGE antibody by Western Blot.

accessionNumbers :

O35444

applications :

Blockade of Receptor-ligand Interaction,Electrophysiology,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry

USD :

479 USD

alt names :

advanced glycosylation end product-specific receptor, AGER, RAGE isoform delta, RAGE isoform sRAGE-delta, Receptor for advanced glycosylation end products, receptor for advanced glycosylation end-products, SCARJ1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage