Human ErbB2/Her2 Antibody | R&D Systems AF1129 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human ErbB2/Her2 Antibody

catalog :

AF1129

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

R&D Systems product webpage

citations: 8

Reference
Wignarajah S, Chianella I, Tothill I. Development of Electrochemical Immunosensors for HER-1 and HER-2 Analysis in Serum for Breast Cancer Patients. Biosensors (Basel). 2023;13: pubmed publisher
Paul D, Stern O, Vallis Y, Dhillon J, Buchanan A, McMahon H. Cell surface protein aggregation triggers endocytosis to maintain plasma membrane proteostasis. Nat Commun. 2023;14:947 pubmed publisher
Nikitina A, Lipatova A, Goncharov A, Kliuchnikova A, Pyatnitskiy M, Kuznetsova K, et al. Multiomic Profiling Identified EGF Receptor Signaling as a Potential Inhibitor of Type I Interferon Response in Models of Oncolytic Therapy by Vesicular Stomatitis Virus. Int J Mol Sci. 2022;23: pubmed publisher
Luan H, Bailey T, Clubb R, Mohapatra B, Bhat A, Chakraborty S, et al. CHIP/STUB1 Ubiquitin Ligase Functions as a Negative Regulator of ErbB2 by Promoting Its Early Post-Biosynthesis Degradation. Cancers (Basel). 2021;13: pubmed publisher
Joh D, Heggestad J, Zhang S, Anderson G, Bhattacharyya J, Wardell S, et al. Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates. NPJ Breast Cancer. 2021;7:85 pubmed publisher
Zhang J, Nguyen L, Hickey R, Walters N, Wang X, Kwak K, et al. Immunomagnetic sequential ultrafiltration (iSUF) platform for enrichment and purification of extracellular vesicles from biofluids. Sci Rep. 2021;11:8034 pubmed publisher
Zhang J, Liu S, Li Q, Shi Y, Wu Y, Liu F, et al. The deubiquitylase USP2 maintains ErbB2 abundance via counteracting endocytic degradation and represents a therapeutic target in ErbB2-positive breast cancer. Cell Death Differ. 2020;27:2710-2725 pubmed publisher
Li X, Nelson C, Nair R, Hazlehurst L, Moroni T, Martínez Acedo P, et al. Stable and Potent Selenomab-Drug Conjugates. Cell Chem Biol. 2017;24:433-442.e6 pubmed publisher

product information

master code :

AF1129

SKU :

AF1129

product name :

Human ErbB2/Her2 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human ErbB2/Her2 Antibody from R&D Systems is a goat polyclonal antibody to ErbB2/Her2. This antibody reacts with human. The Human ErbB2/Her2 Antibody has been validated for the following applications: ELISA Development,Flow Cytometry,Immunoprecipitation,Western Blot,ELISA Capture,Immunocytochemistry,Immunohistochemistry,Inhibition of Cell Growth,CyTOF-ready.

target :

ErbB2/Her2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human ErbB2/Her2, Thr23-Thr652, Accession # P04626

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human

specificity :

Detects human ErbB2/Her2 in direct ELISAs and Western blots. In direct ELISAs, less than 20% cross-reactivity with recombinant mouse ErbB2 is observed and less than 5% cross-reactivity with recombinant human (rh) ErbB3, rhErbB4, and rhEGF R is observed.

gene symbol :

ERBB2

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

ErbB2/Her2 antibody in Human Breast Cancer Tissue by Immunohistochemistry (IHC-P).

accessionNumbers :

P04626

applications :

ELISA Development,Flow Cytometry,Immunoprecipitation,Western Blot,ELISA Capture,Immunocytochemistry,Immunohistochemistry,Inhibition of Cell Growth,CyTOF-ready

USD :

499 USD

alt names :

CD340, CD340 antigen, c-erb B2/neu protein, EC 2.7.10, EGFR2, HER2, HER-2, HER2EC 2.7.10.1, herstatin, Metastatic lymph node gene 19 protein, MLN 19, MLN19, Neu Oncogene, NEUHER-2/neu, neuroblastoma/glioblastoma derived oncogene homolog, NGL, NGLTKR1, p185erbB2, Proto-oncogene c-ErbB-2, Proto-oncogene Neu, receptor tyrosine-protein kinase erbB-2, TKR1, Tyrosine kinase-type cell surface receptor HER2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/glioblastoma derived oncogene homolog), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomaderived oncogene homolog (avian)

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage