product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse TROP-2 Antibody
catalog :
AF1122
quantity :
100 ug (also 25 ug)
price :
489 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 18
Reference
Li D, Zhan Y, Wang N, Tang F, Lee C, Bayshtok G, et al. ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer. Sci Adv. 2023;9:eadc9446 pubmed publisher
x160 vec J, x160 x165 astn xe1 M, Jane x10d kov xe1 L, Hr x10d kul xe1 k D, Vojt x11b chov xe1 M, Onhajzer J, et al. TROP2 Represents a Negative Prognostic Factor in Colorectal Adenocarcinoma and Its Expression Is Associated with Features of Epithelial-Mesenchymal Transition and Invasiveness. Cancers (Basel). 2022;14: pubmed publisher
Silva J, Alkan F, Ramalho S, Snieckute G, Prekovic S, Garcia A, et al. Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation. Nat Commun. 2022;13:4492 pubmed publisher
Abu El Maaty M, Terzic J, Keime C, Rovito D, Lutzing R, Yanushko D, et al. Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression. Sci Adv. 2022;8:eabo2295 pubmed publisher
Laporte E, Hermans F, De Vriendt S, Vennekens A, Lambrechts D, Nys C, et al. Decoding the activated stem cell phenotype of the neonatally maturing pituitary. elife. 2022;11: pubmed publisher
Lee S, Jang B, Min J, Contreras Panta E, Presentation K, Delgado A, et al. Up-regulation of Aquaporin 5 Defines Spasmolytic Polypeptide-Expressing Metaplasia and Progression to Incomplete Intestinal Metaplasia. Cell Mol Gastroenterol Hepatol. 2022;13:199-217 pubmed publisher
Abu El Maaty M, Grelet E, Keime C, Rerra A, Gantzer J, Emprou C, et al. Single-cell analyses unravel cell type-specific responses to a vitamin D analog in prostatic precancerous lesions. Sci Adv. 2021;7: pubmed publisher
Mevel R, Steiner I, Mason S, Galbraith L, Patel R, Fadlullah M, et al. RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development. elife. 2020;9: pubmed publisher
Riera K, Jang B, Min J, Roland J, Yang Q, Fesmire W, et al. Trop2 is upregulated in the transition to dysplasia in the metaplastic gastric mucosa. J Pathol. 2020;251:336-347 pubmed publisher
Aros C, Paul M, Pantoja C, Bisht B, Meneses L, Vijayaraj P, et al. High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis. Cell Rep. 2020;30:2055-2064.e5 pubmed publisher
Wang Y, Chiang I, Ohara T, Fujii S, Cheng J, Muegge B, et al. Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells. Cell. 2019;179:1144-1159.e15 pubmed publisher
Mahiddine K, Blaisdell A, Ma S, Créquer Grandhomme A, Lowell C, Erlebacher A. Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils. J Clin Invest. 2020;130:389-403 pubmed publisher
Crowell P, Fox J, Hashimoto T, Diaz J, Navarro H, Henry G, et al. Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate. Cell Rep. 2019;28:1499-1510.e6 pubmed publisher
Lynch T, Anderson P, Rotti P, Tyler S, Crooke A, Choi S, et al. Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell. 2018;22:653-667.e5 pubmed publisher
Yui S, Azzolin L, Maimets M, Pedersen M, Fordham R, Hansen S, et al. YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration. Cell Stem Cell. 2018;22:35-49.e7 pubmed publisher
Anderson P, Lynch T, Engelhardt J. Multipotent Myoepithelial Progenitor Cells Are Born Early during Airway Submucosal Gland Development. Am J Respir Cell Mol Biol. 2017;56:716-726 pubmed publisher
Hokke S, Puelles V, Armitage J, Fong K, Bertram J, Cullen McEwen L. Maternal Fat Feeding Augments Offspring Nephron Endowment in Mice. PLoS ONE. 2016;11:e0161578 pubmed publisher
Lokody I, Francis J, Gardiner J, Erler J, Swain A. Pten Regulates Epithelial Cytodifferentiation during Prostate Development. PLoS ONE. 2015;10:e0129470 pubmed publisher
product information
master code :
AF1122
SKU :
AF1122
product name :
Mouse TROP-2 Antibody
unit size :
100 ug (also 25 ug)
description :
The Mouse TROP-2 Antibody from R&D Systems is a goat polyclonal antibody to TROP-2. This antibody reacts with mouse,transgenic mouse. The Mouse TROP-2 Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,CyTOF-ready.
target :
TROP-2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse TROP-2, Ser82-Thr268, Accession # Q8BGV3
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Mouse,Transgenic Mouse
specificity :
Detects mouse TROP-2 in direct ELISAs and Western blots. In direct ELISAs, less than 30% cross-reactivity with recombinant human TROP-2 is observed.
gene symbol :
TACSTD2
top caption :
Detection of TROP-2 antibody in mIMCD-3 Mouse Cell Line antibody by Flow Cytometry.
accessionNumbers :
Q8BGV3
applications :
Western Blot,Immunohistochemistry,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,CyTOF-ready
USD :
489 USD
alt names :
Cell surface glycoprotein Trop-2, EGP1, EGP-1, epithelial glycoprotein-1, GA733-1, GA733-1GP50, gastrointestinal tumor-associated antigen GA7331, gp50, M1S1cell surface glycoprotein TROP2, Membrane component chromosome 1 surface marker 1, membrane component, chromosome 1, surface marker 1, Pancreatic carcinoma marker protein GA733-1, pancreatic carcinoma marker protein GA7331,40kD glycoprotein, identified by monoclonal GA733, T16, TACSTD2, TROP2, TROP2GA7331, tumor-associated calcium signal transducer 2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.