Human/Mouse Dkk-1 Antibody | R&D Systems AF1096 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse Dkk-1 Antibody

catalog :

AF1096

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, neutralization, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 9

Reference
Sung E, Dozmorov M, Song S, Aung T, Park M, Sime P, et al. Ablation of LRP6 in alpha-smooth muscle actin-expressing cells abrogates lung inflammation and fibrosis upon bleomycin-induced lung injury. bioRxiv. 2024;: pubmed publisher
Hsu Y, Chang C, Hsieh C, Huang Y, Shih Y, Chang H, et al. Dickkopf-1 Acts as a Profibrotic Mediator in Progressive Chronic Kidney Disease. Int J Mol Sci. 2023;24: pubmed publisher
Yu D, Zhang S, Ma C, Huang S, Xu L, Liang J, et al. CCL3 in the bone marrow microenvironment causes bone loss and bone marrow adiposity in aged mice. JCI Insight. 2023;8: pubmed publisher
Won J, Choi J, Jun J. CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation. Nat Commun. 2022;13:3117 pubmed publisher
Kim H, Jang S, Lee Y. The m6A(m)-independent role of FTO in regulating WNT signaling pathways. Life Sci Alliance. 2022;5: pubmed publisher
Amadei G, Lau K, De Jonghe J, Gantner C, Sozen B, Chan C, et al. Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro. Dev Cell. 2021;56:366-382.e9 pubmed publisher
Claveria Cabello A, Colyn L, Uriarte I, Latasa M, Arechederra M, Herranz J, et al. Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis. Cancers (Basel). 2020;12: pubmed publisher
Jumpertz S, Hennes T, Asare Y, Schütz A, Bernhagen J. CSN5/JAB1 suppresses the WNT inhibitor DKK1 in colorectal cancer cells. Cell Signal. 2017;34:38-46 pubmed publisher
Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, et al. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nat Commun. 2016;7:13602 pubmed publisher

product information

master code :

AF1096

SKU :

AF1096

product name :

Human/Mouse Dkk-1 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human/Mouse Dkk-1 Antibody from R&D Systems is a goat polyclonal antibody to Dkk-1. This antibody reacts with avian - chicken,human,mouse,transgenic mouse. The Human/Mouse Dkk-1 Antibody has been validated for the following applications: Neutralization,Western Blot,Bioassay,ELISA Development,Immunodepletion,Neutralizing,Immunohistochemistry,Immunohistochemistry-Paraffin,Blockade of Receptor-ligand Interaction,Knockout Validated.

target :

Dkk-1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Dkk-1, Thr32-His266, Accession # O94907

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Avian - Chicken,Human,Mouse,Transgenic Mouse

specificity :

Detects human and mouse Dkk-1 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) Dkk-2, and rhDkk-4 is observed.

gene symbol :

DKK1

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

Antibody validation :

Knockout/Knockdown

top caption :

Detection of Human Dkk-1 antibody by Western Blot.

accessionNumbers :

O94907

applications :

Neutralization,Western Blot,Bioassay,ELISA Development,Immunodepletion,Neutralizing,Immunohistochemistry,Immunohistochemistry-Paraffin,Blockade of Receptor-ligand Interaction,Knockout Validated

USD :

489 USD

alt names :

dickkopf (Xenopus laevis) homolog 1, dickkopf homolog 1 (Xenopus laevis), dickkopf related protein-1, Dickkopf-1, dickkopf-related protein 1, Dkk1, DKK-1, hDkk-1, SKdickkopf-1 like

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage