product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Phospho-EGFR (Y1173) Antibody
catalog :
AF1095
quantity :
50 ug (also 25 ug)
price :
399 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 7
Reference
Grozdani x107 M, Soboti x10d B, Biasizzo M, Sever T, Vidmar R, Vizovi x161 ek M, et al. Cathepsin L-mediated EGFR cleavage affects intracellular signalling pathways in cancer. Biol Chem. 2023;: pubmed publisher
Pardo Pastor C, Rosenblatt J. Piezo1 activates noncanonical EGFR endocytosis and signaling. Sci Adv. 2023;9:eadi1328 pubmed publisher
Volman Y, Hefetz R, Galun E, Rachmilewitz J. DNA damage alters EGFR signaling and reprograms cellular response via Mre-11. Sci Rep. 2022;12:5760 pubmed publisher
Bahl S, Ling H, Acharige N, Santos Barriopedro I, Pflum M, Seto E. EGFR phosphorylates HDAC1 to regulate its expression and anti-apoptotic function. Cell Death Dis. 2021;12:469 pubmed publisher
Vijayaraghavan S, Lipfert L, Chevalier K, Bushey B, Henley B, Lenhart R, et al. Amivantamab (JNJ-61186372), an Fc Enhanced EGFR/cMet Bispecific Antibody, Induces Receptor Downmodulation and Antitumor Activity by Monocyte/Macrophage Trogocytosis. Mol Cancer Ther. 2020;19:2044-2056 pubmed publisher
Harikrishnan K, Joshi O, Madangirikar S, Balasubramanian N. Cell Derived Matrix Fibulin-1 Associates With Epidermal Growth Factor Receptor to Inhibit Its Activation, Localization and Function in Lung Cancer Calu-1 Cells. Front Cell Dev Biol. 2020;8:522 pubmed publisher
Kefaloyianni E, Muthu M, Kaeppler J, Sun X, Sabbisetti V, Chalaris A, et al. ADAM17 substrate release in proximal tubule drives kidney fibrosis. JCI Insight. 2016;1: pubmed publisher
product information
master code :
AF1095
SKU :
AF1095
product name :
Human Phospho-EGFR (Y1173) Antibody
unit size :
50 ug (also 25 ug)
description :
The Human Phospho-EGFR (Y1173) Antibody from R&D Systems is a rabbit polyclonal antibody to EGFR. This antibody reacts with human,mouse. The Human Phospho-EGFR (Y1173) Antibody has been validated for the following applications: Western Blot,Immunocytochemistry,Immunohistochemistry,Flow Cytometry,Simple Western,Immunoprecipitation,Immunohistochemistry-Paraffin,Intracellular Staining by Flow Cytometry,CyTOF-ready.
target :
EGFR
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Phosphopeptide containing human EGFR Y1173 site
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse
specificity :
Detects human EGFR when phosphorylated at Y1173 in Western blots.
gene symbol :
EGFR
top caption :
Detection of Human Phospho-EGFR (Y1173) antibody by Western Blot.
applications :
Flow Cytometry,Western Blot,Simple Western,Immunohistochemistry,Immunoprecipitation,Immunohistochemistry-Paraffin,Intracellular Staining by Flow Cytometry,Immunocytochemistry,CyTOF-ready
USD :
399 USD
alt names :
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EC 2.7.10, EC 2.7.10.1, EGF R, epidermal growth factor receptor, epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b)oncogene homolog), ErbB, ErbB1, ERBB1PIG61, HER1, HER-1, mENA, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.