product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Mouse PDGF R alpha Antibody
catalog :
AF1062
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
citations: 248
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - free floating section; mouse; 1:500; loading ...; fig 3d
  • immunocytochemistry; mouse; 1:500; loading ...; fig 2e
O Shea T, Ao Y, Wang S, Wollenberg A, Kim J, Ramos Espinoza R, et al. Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice. Nat Commun. 2022;13:5702 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 4h
  • western blot; mouse; 1:500; loading ...; fig 2f
Ha S, Jorgensen B, Wei L, Jin B, Kim M, Poudrier S, et al. Metalloendopeptidase ADAM-like Decysin 1 (ADAMDEC1) in Colonic Subepithelial PDGFRα+ Cells Is a New Marker for Inflammatory Bowel Disease. Int J Mol Sci. 2022;23: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig e5a
Fischer A, Wannemacher J, Christ S, Koopmans T, Kadri S, Zhao J, et al. Neutrophils direct preexisting matrix to initiate repair in damaged tissues. Nat Immunol. 2022;23:518-531 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2b
Xu J, Li Z, Tower R, Negri S, Wang Y, Meyers C, et al. NGF-p75 signaling coordinates skeletal cell migration during bone repair. Sci Adv. 2022;8:eabl5716 pubmed publisher
  • immunocytochemistry; mouse; 1:400; fig 2h
Pantasis S, Friemel J, Brütsch S, Hu Z, Krautbauer S, Liebisch G, et al. Vertebrate lonesome kinase modulates the hepatocyte secretome to prevent perivascular liver fibrosis and inflammation. J Cell Sci. 2022;135: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig 1u, s1b
Aberle T, Piefke S, Hillg xe4 rtner S, Tamm E, Wegner M, K xfc spert M. Transcription factor Zfp276 drives oligodendroglial differentiation and myelination by switching off the progenitor cell program. Nucleic Acids Res. 2022;50:1951-1968 pubmed publisher
  • immunohistochemistry; mouse; 1:300; loading ...
Zhang X, Liu Y, Hong X, Li X, Meshul C, Moore C, et al. NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety. Nat Commun. 2021;12:5740 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; fig 4o
Takanezawa Y, Tanabe S, Kato D, Ozeki R, Komoda M, Suzuki T, et al. Microglial ASD-related genes are involved in oligodendrocyte differentiation. Sci Rep. 2021;11:17825 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...
Quijada P, Trembley M, Misra A, Myers J, Baker C, Pérez Hernández M, et al. Coordination of endothelial cell positioning and fate specification by the epicardium. Nat Commun. 2021;12:4155 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 3c
Talley M, Nardini D, Shabbir N, Ehrman L, Prada C, Waclaw R. Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon. Front Cell Dev Biol. 2021;9:673995 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 1a
Kimura K, Ramirez K, Nguyen T, Yamashiro Y, Sada A, Yanagisawa H. Contribution of PDGFRα-positive cells in maintenance and injury responses in mouse large vessels. Sci Rep. 2021;11:8683 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 3e
Mu W, Li S, Xu J, Guo X, Wu H, Chen Z, et al. Hypothalamic Rax+ tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice. Nat Commun. 2021;12:2288 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 2h
  • western blot; mouse; loading ...; fig 7f
Sherafat A, Pfeiffer F, Reiss A, Wood W, Nishiyama A. Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor. Nat Commun. 2021;12:2265 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3h
Kastenschmidt J, Coulis G, Farahat P, Pham P, Rios R, Cristal T, et al. A stromal progenitor and ILC2 niche promotes muscle eosinophilia and fibrosis-associated gene expression. Cell Rep. 2021;35:108997 pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig 1
Moore K, Fulmer D, Guo L, Koren N, Glover J, Moore R, et al. PDGFRα: Expression and Function during Mitral Valve Morphogenesis. J Cardiovasc Dev Dis. 2021;8: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3a
Ichinose M, Suzuki N, Wang T, Wright J, Lannagan T, Vrbanac L, et al. Stromal DLK1 promotes proliferation and inhibits differentiation of the intestinal epithelium during development. Am J Physiol Gastrointest Liver Physiol. 2021;320:G506-G520 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 3d
Zhang S, Wang Y, Xu J, Kim B, Deng W, Guo F. HIFα Regulates Developmental Myelination Independent of Autocrine Wnt Signaling. J Neurosci. 2021;41:251-268 pubmed publisher
Spurgin S, Nguimtsop A, Chaudhry F, Michki S, Salvador J, Iruela Arispe M, et al. Spatiotemporal dynamics of primary and motile cilia throughout lung development. bioRxiv. 2024;: pubmed publisher
Duncan G, Ingram S, Emberley K, Hill J, Cordano C, Abdelhak A, et al. Remyelination protects neurons from DLK-mediated neurodegeneration. Nat Commun. 2024;15:9148 pubmed publisher
Pan Y, Hysinger J, Yal xe7 x131 n B, Lennon J, Byun Y, Raghavan P, et al. Nf1 mutation disrupts activity-dependent oligodendroglial plasticity and motor learning in mice. Nat Neurosci. 2024;27:1555-1564 pubmed publisher
Arreguin A, Shao Z, Colognato H. Dmd mdx mice have defective oligodendrogenesis, delayed myelin compaction and persistent hypomyelination. Dis Model Mech. 2024;17: pubmed publisher
Vishlaghi N, Guo L, Griswold Wheeler D, Sun Y, Booker C, Crossley J, et al. Vegfc-expressing cells form heterotopic bone after musculoskeletal injury. Cell Rep. 2024;43:114049 pubmed publisher
Halder S, Sapkota A, Milner R. β1 integrins play a critical role maintaining vascular integrity in the hypoxic spinal cord, particularly in white matter. Acta Neuropathol Commun. 2024;12:45 pubmed publisher
Lai A, Almanza D, Ribeiro J, Hill M, Mandrozos M, Koletar M, et al. Obesity Facilitates Sex-Specific Improvement In Cognition And Neuronal Function In A Rat Model Of Alzheimer's Disease. bioRxiv. 2024;: pubmed publisher
Shumliakivska M, Lux xe1 n G, Hemmerling I, Scheller M, Li X, M xfc ller Tidow C, et al. DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts. Nat Commun. 2024;15:606 pubmed publisher
Zhang D, Ruan J, Peng S, Li J, Hu X, Zhang Y, et al. Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling. Nat Neurosci. 2024;27:232-248 pubmed publisher
Nguyen L, Aprico A, Nwoke E, Walsh A, Blades F, Avneri R, et al. Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS. J Neuroinflammation. 2023;20:253 pubmed publisher
Tripathi A, Rai N, Perles A, Jones C, Dutta R. Dicer deficiency in microglia leads to accelerated demyelination and failed remyelination. bioRxiv. 2023;: pubmed publisher
Duncan G, Ingram S, Emberley K, Hill J, Cordano C, Abdelhak A, et al. Remyelination protects neurons from DLK-mediated neurodegeneration. bioRxiv. 2023;: pubmed publisher
He S, Guo Z, Zhou M, Wang H, Zhang Z, Shi M, et al. Spatial-temporal proliferation of hepatocytes during pregnancy revealed by genetic lineage tracing. Cell Stem Cell. 2023;30:1549-1558.e5 pubmed publisher
Talley M, Nardini D, Ehrman L, Lu Q, Waclaw R. Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon. Neural Dev. 2023;18:5 pubmed publisher
Bowers S, Meng Q, Kuwabara Y, Huo J, Minerath R, York A, et al. Col1a2-Deleted Mice Have Defective Type I Collagen and Secondary Reactive Cardiac Fibrosis with Altered Hypertrophic Dynamics. Cells. 2023;12: pubmed publisher
Odell I, Agrawal K, Sefik E, Odell A, Caves E, Kirkiles Smith N, et al. IL-6 trans-signaling in a humanized mouse model of scleroderma. Proc Natl Acad Sci U S A. 2023;120:e2306965120 pubmed publisher
Kahng J, Xavier A, Ferro A, Auguste Y, Cheadle L. Integrated high-confidence and high-throughput approaches for quantifying synapse engulfment by oligodendrocyte precursor cells. bioRxiv. 2023;: pubmed publisher
Whisler J, Shahreza S, Schlegelmilch K, Ege N, Javanmardi Y, Malandrino A, et al. Emergent mechanical control of vascular morphogenesis. Sci Adv. 2023;9:eadg9781 pubmed publisher
Tsutsumi R, Ueberheide B, Liang F, Neel B, Sakai R, Saito Y. Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation. bioRxiv. 2023;: pubmed publisher
Cabrera Cabrera F, Tull H, Capuana R, Kasvandik S, Timmusk T, Koppel I. Cell type-specific labeling of newly synthesized proteins by puromycin inactivation. J Biol Chem. 2023;299:105129 pubmed publisher
Halder S, Milner R. Spinal Cord Blood Vessels in Aged Mice Show Greater Levels of Hypoxia-Induced Vascular Disruption and Microglial Activation. Int J Mol Sci. 2023;24: pubmed publisher
Rusu B, Kukreja B, Wu T, Dan S, Feng M, Kalish B. Single-Nucleus Profiling Identifies Accelerated Oligodendrocyte Precursor Cell Senescence in a Mouse Model of Down Syndrome. Eneuro. 2023;10: pubmed publisher
Huycke T, Miyazaki H, H xe4 kkinen T, Srivastava V, Barruet E, McGinnis C, et al. Patterning and folding of intestinal villi by active mesenchymal dewetting. bioRxiv. 2023;: pubmed publisher
Stec M, Su Q, Adler C, Zhang L, Golann D, Khan N, et al. A cellular and molecular spatial atlas of dystrophic muscle. Proc Natl Acad Sci U S A. 2023;120:e2221249120 pubmed publisher
Hu Y, Ding X, Yang G, Liang X, Feng L, Sun Y, et al. Analysis of the influences of social isolation on cognition and the therapeutic potential of deep brain stimulation in a mouse model. Front Psychiatry. 2023;14:1186073 pubmed publisher
Waldhauser V, Baroti T, Fr xf6 b F, Wegner M. PBAF Subunit Pbrm1 Selectively Influences the Transition from Progenitors to Pre-Myelinating Cells during Oligodendrocyte Development. Cells. 2023;12: pubmed publisher
Norris A, Appu A, Johnson C, Zhou L, McKellar D, Renault M, et al. Hedgehog signaling via its ligand DHH acts as cell fate determinant during skeletal muscle regeneration. Nat Commun. 2023;14:3766 pubmed publisher
Sun L, Zhang X, Wu S, Liu Y, Guerrero Juarez C, Liu W, et al. Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration. Cell Rep. 2023;42:112647 pubmed publisher
Wu J, Jing X, Du Q, Sun X, Holgersson K, Gao J, et al. Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI-1-TGF-β-myoCAF-Dependent Mechanism. Adv Sci (Weinh). 2023;10:e2301505 pubmed publisher
Alber A, Marquez H, Ma L, Kwong G, Thapa B, Villacorta Martin C, et al. Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme. Nat Commun. 2023;14:3488 pubmed publisher
Kalgudde Gopal S, Dai R, Stefanska A, Ansari M, Zhao J, Ramesh P, et al. Wound infiltrating adipocytes are not myofibroblasts. Nat Commun. 2023;14:3020 pubmed publisher
Wang K, Papadopoulos N, Hamidi A, Lennartsson J, Heldin C. SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation. BMC Mol Cell Biol. 2023;24:19 pubmed publisher
Menges L, Giesen J, Yilmaz K, Mergia E, F xfc chtbauer A, F xfc chtbauer E, et al. It takes two to tango: cardiac fibroblast-derived NO-induced cGMP enters cardiac myocytes and increases cAMP by inhibiting PDE3. Commun Biol. 2023;6:504 pubmed publisher
Chaen T, Kurosawa T, Kishi K, Kaji N, Ikemoto Uezumi M, Uezumi A, et al. Transcriptome analysis of mesenchymal stromal cells of the large and small intestinal smooth muscle layers reveals a unique gastrontestinal stromal signature. Biochem Biophys Rep. 2023;34:101478 pubmed publisher
Wei H, Wu X, Withrow J, Cuevas Diaz Duran R, Singh S, Chaboub L, et al. Glial progenitor heterogeneity and key regulators revealed by single-cell RNA sequencing provide insight to regeneration in spinal cord injury. Cell Rep. 2023;42:112486 pubmed publisher
Tsuchikawa Y, Kamei N, Sanada Y, Nakamae T, Harada T, Imaizumi K, et al. Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System. Neural Plast. 2023;2023:8938674 pubmed publisher
Fu C, Chin Young B, Park G, Guzm xe1 n Seda M, Laudier D, Han W. WNT7A suppresses adipogenesis of skeletal muscle mesenchymal stem cells and fatty infiltration through the alternative Wnt-Rho-YAP/TAZ signaling axis. Stem Cell Reports. 2023;18:999-1014 pubmed publisher
Xing Y, Poh J, Chuang B, Moradi K, Mitew S, Richardson W, et al. High-efficiency pharmacogenetic ablation of oligodendrocyte progenitor cells in the adult mouse CNS. Cell Rep Methods. 2023;3:100414 pubmed publisher
Kolaj A, Zahr S, Wang B, Krawec T, Kazan H, Yang G, et al. The P-body protein 4E-T represses translation to regulate the balance between cell genesis and establishment of the postnatal NSC pool. Cell Rep. 2023;42:112242 pubmed publisher
Br xfc tsch S, Madzharova E, Pantasis S, W xfc stemann T, Gurri S, Steenbock H, et al. Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome. Cell Mol Life Sci. 2023;80:89 pubmed publisher
Lemmetyinen T, Viitala E, Wartiovaara L, Kaprio T, Hagstr xf6 m J, Haglund C, et al. Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth. Dis Model Mech. 2023;16: pubmed publisher
Liu Q, Li C, Deng B, Gao P, Wang L, Li Y, et al. Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development. Cell Rep. 2023;42:112166 pubmed publisher
Hoeft K, Schaefer G, Kim H, Schumacher D, Bleckwehl T, Long Q, et al. Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner. Cell Rep. 2023;42:112131 pubmed publisher
Mohr M, Li S, Trouten A, Stairley R, Roddy P, Liu C, et al. Cardiomyocyte-fibroblast interaction regulates ferroptosis and fibrosis after myocardial injury. bioRxiv. 2023;: pubmed publisher
Manieri E, Tie G, Seruggia D, Madha S, Maglieri A, Huang K, et al. Defining the structure, signals, and cellular elements of the gastric mesenchymal niche. bioRxiv. 2023;: pubmed publisher
Jacobsen N, Morton A, Segal S. Angiogenesis precedes myogenesis during regeneration following biopsy injury of skeletal muscle. Skelet Muscle. 2023;13:3 pubmed publisher
Pan L, Trimarco A, Zhang A, Fujimori K, Urade Y, Sun L, et al. Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination. elife. 2023;12: pubmed publisher
Li Z, Chen K, Shao Q, Lu H, Zhang X, Pu Y, et al. Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16 pubmed publisher
Hong X, Jian Y, Ding S, Zhou J, Zheng X, Zhang H, et al. Kir4.1 channel activation in NG2 glia contributes to remyelination in ischemic stroke. EBioMedicine. 2023;87:104406 pubmed publisher
Legouez L, Le Dieu Lugon B, Feillet S, Riou G, Yeddou M, Plouchart T, et al. Effects of MgSO4 Alone or Associated with 4-PBA on Behavior and White Matter Integrity in a Mouse Model of Cerebral Palsy: A Sex- and Time-Dependent Study. Int J Mol Sci. 2022;23: pubmed publisher
Pagani C, Bancroft A, Tower R, Livingston N, Sun Y, Hong J, et al. Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization. Sci Adv. 2022;8:eabq6152 pubmed publisher
Sesillo F, Rajesh V, Wong M, Durán P, Rudell J, Rundio C, et al. Muscle stem cells and fibro-adipogenic progenitors in female pelvic floor muscle regeneration following birth injury. NPJ Regen Med. 2022;7:72 pubmed publisher
Liu X, Zhao L, Gao Y, Chen Y, Tian Q, Son J, et al. AMP-activated protein kinase inhibition in fibro-adipogenic progenitors impairs muscle regeneration and increases fibrosis. J Cachexia Sarcopenia Muscle. 2022;: pubmed publisher
Meyer G, Thomopoulos S, Abu Amer Y, Shen K. Tenotomy-induced muscle atrophy is sex-specific and independent of NFκB. elife. 2022;11: pubmed publisher
Dai Z, Li J, Li Y, Wang R, Yan H, Xiong Z, et al. Role of pericytes in the development of cerebral cavernous malformations. iScience. 2022;25:105642 pubmed publisher
Cattaneo P, Hayes M, Baumgarten N, Hecker D, Peruzzo S, Aslan G, et al. DOT1L regulates chamber-specific transcriptional networks during cardiogenesis and mediates postnatal cell cycle withdrawal. Nat Commun. 2022;13:7444 pubmed publisher
Ono K, Gotoh H, Nomura T, Morita T, Baba O, Matsumoto M, et al. Ultrastructural characteristics of oligodendrocyte precursor cells in the early postnatal mouse optic nerve observed by serial block-face scanning electron microscopy. PLoS ONE. 2022;17:e0278118 pubmed publisher
Yamakawa D, Tsuboi J, Kasahara K, Matsuda C, Nishimura Y, Kodama T, et al. Cilia-Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury. Adv Sci (Weinh). 2022;10:e2202632 pubmed publisher
Bernhardt C, Sock E, Fr xf6 b F, Hillg xe4 rtner S, Nemer M, Wegner M. KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF. Nucleic Acids Res. 2022;50:11509-11528 pubmed publisher
Alonso P xe9 rez J, Carrasco Rozas A, Borrell Pages M, Fern xe1 ndez Sim xf3 n E, Pi xf1 ol Jurado P, Badimon L, et al. Nintedanib Reduces Muscle Fibrosis and Improves Muscle Function of the Alpha-Sarcoglycan-Deficient Mice. Biomedicines. 2022;10: pubmed publisher
Kaya T, Mattugini N, Liu L, Ji H, Cantuti Castelvetri L, Wu J, et al. CD8+ T cells induce interferon-responsive oligodendrocytes and microglia in white matter aging. Nat Neurosci. 2022;25:1446-1457 pubmed publisher
Hammers D. NOX4 inhibition promotes the remodeling of dystrophic muscle. JCI Insight. 2022;7: pubmed publisher
Ennerfelt H, Frost E, Shapiro D, Holliday C, Zengeler K, Voithofer G, et al. SYK coordinates neuroprotective microglial responses in neurodegenerative disease. Cell. 2022;185:4135-4152.e22 pubmed publisher
Nicholson M, Wood R, Gonsalvez D, Hannan A, Fletcher J, Xiao J, et al. Remodelling of myelinated axons and oligodendrocyte differentiation is stimulated by environmental enrichment in the young adult brain. Eur J Neurosci. 2022;56:6099-6114 pubmed publisher
Sobecki M, Chen J, Krzywinska E, Nagarajan S, Fan Z, Nelius E, et al. Vaccination-based immunotherapy to target profibrotic cells in liver and lung. Cell Stem Cell. 2022;29:1459-1474.e9 pubmed publisher
Khalaj K, Figueira R, Antounians L, Gandhi S, Wales M, Montalva L, et al. Treatment with Amniotic Fluid Stem Cell Extracellular Vesicles Promotes Fetal Lung Branching and Cell Differentiation at Canalicular and Saccular Stages in Experimental Pulmonary Hypoplasia Secondary to Congenital Diaphragmatic Hernia. Stem Cells Transl Med. 2022;11:1089-1102 pubmed publisher
Caramello A, Galichet C, Sopena M, Lovell Badge R, Rizzoti K. The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX. Dev Neurobiol. 2022;82:565-580 pubmed publisher
Li Y, Li C, Liu Q, Wang L, Bao A, Jung J, et al. Loss of Acta2 in cardiac fibroblasts does not prevent the myofibroblast differentiation or affect the cardiac repair after myocardial infarction. J Mol Cell Cardiol. 2022;171:117-132 pubmed publisher
Lee I, Noguera Ortega E, Xiao Z, Todd L, Scholler J, Song D, et al. Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74. Clin Cancer Res. 2022;28:5330-5342 pubmed publisher
Palikuqi B, Rispal J, Reyes E, Vaka D, Boffelli D, Klein O. Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury. Cell Stem Cell. 2022;29:1262-1272.e5 pubmed publisher
Beiter R, Rivet Noor C, Merchak A, Bai R, Johanson D, Slogar E, et al. Evidence for oligodendrocyte progenitor cell heterogeneity in the adult mouse brain. Sci Rep. 2022;12:12921 pubmed publisher
Hong J, Jeong Y, Heo W. The Neurotrophic Receptor Tyrosine Kinase in MEC-mPFC Neurons Contributes to Remote Memory Consolidation. J Neurosci. 2022;42:6605-19 pubmed publisher
Hamed A, Kunz D, El Hamamy I, Trinh Q, Subedar O, Richards L, et al. A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours. Nat Commun. 2022;13:4178 pubmed publisher
Burl R, Rondini E, Wei H, Pique Regi R, Granneman J. Deconstructing cold-induced brown adipocyte neogenesis in mice. elife. 2022;11: pubmed publisher
Liu Y, Guerrero Juarez C, Xiao F, Shettigar N, Ramos R, Kuan C, et al. Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state. Dev Cell. 2022;57:1758-1775.e7 pubmed publisher
Fernandez Castaneda A, Lu P, Geraghty A, Song E, Lee M, WOOD J, et al. Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation. Cell. 2022;185:2452-2468.e16 pubmed publisher
Fung C, Zhou S, Zhu H, Wei X, Wu Z, Wu A. Cell fate determining molecular switches and signaling pathways in Pax7-expressing somitic mesoderm. Cell Discov. 2022;8:61 pubmed publisher
Marguet F, Brosolo M, Friocourt G, Sauvestre F, Marcorelles P, Lesueur C, et al. Oligodendrocyte lineage is severely affected in human alcohol-exposed foetuses. Acta Neuropathol Commun. 2022;10:74 pubmed publisher
Ha S, Jin B, Jorgensen B, Zogg H, Wei L, Singh R, et al. Transcriptome profiling of subepithelial PDGFRα cells in colonic mucosa reveals several cell-selective markers. PLoS ONE. 2022;17:e0261743 pubmed publisher
Jacob J, Di Carlo S, Stzepourginski I, Lepelletier A, Ndiaye P, Varet H, et al. PDGFRα-induced stromal maturation is required to restrain postnatal intestinal epithelial stemness and promote defense mechanisms. Cell Stem Cell. 2022;29:856-868.e5 pubmed publisher
Ghorbani S, Jelinek E, Jain R, Buehner B, Li C, Lozinski B, et al. Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination. Nat Commun. 2022;13:2445 pubmed publisher
KNOWLES J, Xu H, Soane C, Batra A, Saucedo T, Frost E, et al. Maladaptive myelination promotes generalized epilepsy progression. Nat Neurosci. 2022;25:596-606 pubmed publisher
Zhang Y, Manouchehri Doulabi E, Herre M, Cedervall J, Qiao Q, Miao Z, et al. Platelet-Derived PDGFB Promotes Recruitment of Cancer-Associated Fibroblasts, Deposition of Extracellular Matrix and Tgfβ Signaling in the Tumor Microenvironment. Cancers (Basel). 2022;14: pubmed publisher
Potluri T, Taylor M, Stulberg J, Lieber R, Zhao H, Bulun S. An estrogen-sensitive fibroblast population drives abdominal muscle fibrosis in an inguinal hernia mouse model. JCI Insight. 2022;7: pubmed publisher
Ma X, Yang S, Zheng S, Yan H, Gu H, Wang F, et al. Inhibition of RIPK1 by ZJU-37 promotes oligodendrocyte progenitor proliferation and remyelination via NF-κB pathway. Cell Death Discov. 2022;8:147 pubmed publisher
Saclier M, Angelini G, Bonfanti C, Mura G, Temponi G, Messina G. Selective ablation of Nfix in macrophages attenuates muscular dystrophy by inhibiting fibro-adipogenic progenitor-dependent fibrosis. J Pathol. 2022;257:352-366 pubmed publisher
Ma X, Zhu X, Xiao Y, Gu H, Zheng S, Li L, et al. Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing. Nat Commun. 2022;13:1225 pubmed publisher
Long J, Leinroth A, Liao Y, Ren Y, Mirando A, Nguyen T, et al. Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development. elife. 2022;11: pubmed publisher
Bugg D, Bailey L, Bretherton R, Beach K, Reichardt I, Robeson K, et al. MBNL1 drives dynamic transitions between fibroblasts and myofibroblasts in cardiac wound healing. Cell Stem Cell. 2022;29:419-433.e10 pubmed publisher
Celorrio M, Shumilov K, Payne C, Vadivelu S, Friess S. Acute minocycline administration reduces brain injury and improves long-term functional outcomes after delayed hypoxemia following traumatic brain injury. Acta Neuropathol Commun. 2022;10:10 pubmed publisher
Fernandez Castaneda A, Lu P, Geraghty A, Song E, Lee M, WOOD J, et al. Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain. bioRxiv. 2022;: pubmed publisher
Liu Y, Castaño D, Girolamo F, Trigueros Motos L, Bae H, Neo S, et al. Loss of ABCA8B decreases myelination by reducing oligodendrocyte precursor cells in mice. J Lipid Res. 2022;63:100147 pubmed publisher
Eitner F, Richter B, Schw xe4 nen S, Szaroszyk M, Vogt I, Grund A, et al. Comprehensive Expression Analysis of Cardiac Fibroblast Growth Factor 23 in Health and Pressure-induced Cardiac Hypertrophy. Front Cell Dev Biol. 2021;9:791479 pubmed publisher
Misra A, Baker C, Pritchett E, Burgos Villar K, Ashton J, Small E. Characterizing Neonatal Heart Maturation, Regeneration, and Scar Resolution Using Spatial Transcriptomics. J Cardiovasc Dev Dis. 2021;9: pubmed publisher
Méndez Solís O, Bendjennat M, Naipauer J, Theodoridis P, Ho J, Verdun R, et al. Kaposi's sarcoma herpesvirus activates the hypoxia response to usurp HIF2α-dependent translation initiation for replication and oncogenesis. Cell Rep. 2021;37:110144 pubmed publisher
Tang J, Liang X, Dou X, Qi Y, Yang C, Luo Y, et al. Exercise rather than fluoxetine promotes oligodendrocyte differentiation and myelination in the hippocampus in a male mouse model of depression. Transl Psychiatry. 2021;11:622 pubmed publisher
Reyes Nicolás V, Allaire J, Alfonso A, Pupo Gómez D, Pomerleau V, Giroux V, et al. Altered Mucus Barrier Integrity and Increased Susceptibility to Colitis in Mice upon Loss of Telocyte Bone Morphogenetic Protein Signalling. Cells. 2021;10: pubmed publisher
Li Y, Ao J, Huang X, Lu H, Fu H, Song N, et al. Involvement of PAR2 in platelet-derived growth factor receptor-α-positive cell proliferation in the colon of diabetic mice. Physiol Rep. 2021;9:e15099 pubmed publisher
Nabeebaccus A, Verma S, Zoccarato A, Emanuelli G, Santos C, Streckfuss B xf6 meke K, et al. Cardiomyocyte protein O-GlcNAcylation is regulated by GFAT1 not GFAT2. Biochem Biophys Res Commun. 2021;583:121-127 pubmed publisher
Progatzky F, Shapiro M, Chng S, García Cassani B, Classon C, Sevgi S, et al. Regulation of intestinal immunity and tissue repair by enteric glia. Nature. 2021;599:125-130 pubmed publisher
Cohen N, Massalha H, Ben Moshe S, Egozi A, Rozenberg M, Bahar Halpern K, et al. Spatial gene expression maps of the intestinal lymphoid follicle and associated epithelium identify zonated expression programs. PLoS Biol. 2021;19:e3001214 pubmed publisher
Wang Y, Zhang Y, Zhang S, Kim B, Hull V, Xu J, et al. PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination. Cell Rep. 2021;37:109695 pubmed publisher
Shin H, Kawai H. Sensitive timing of undifferentiation in oligodendrocyte progenitor cells and their enhanced maturation in primary visual cortex of binocularly enucleated mice. PLoS ONE. 2021;16:e0257395 pubmed publisher
Lee K, Park S, Choi P, Ryoo S, Lee H, Peri L, et al. Molecular and functional characterization of detrusor PDGFRα positive cells in spinal cord injury-induced detrusor overactivity. Sci Rep. 2021;11:16268 pubmed publisher
Cordero Espinoza L, Dowbaj A, Kohler T, Strauss B, Sarlidou O, Belenguer G, et al. Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation. Cell Stem Cell. 2021;28:1907-1921.e8 pubmed publisher
Shin H, Kawai H. Visual deprivation induces transient upregulation of oligodendrocyte progenitor cells in the subcortical white matter of mouse visual cortex. IBRO Neurosci Rep. 2021;11:29-41 pubmed publisher
De I, Maklakova V, Litscher S, Boyd M, Klemm L, Wang Z, et al. Microglial responses to CSF1 overexpression do not promote the expansion of other glial lineages. J Neuroinflammation. 2021;18:162 pubmed publisher
Sivaraj K, Jeong H, Dharmalingam B, Zeuschner D, Adams S, Potente M, et al. Regional specialization and fate specification of bone stromal cells in skeletal development. Cell Rep. 2021;36:109352 pubmed publisher
Walker J, Flynn L, Hamilton D. Lineage tracing of Foxd1-expressing embryonic progenitors to assess the role of divergent embryonic lineages on adult dermal fibroblast function. FASEB Bioadv. 2021;3:541-557 pubmed publisher
Thulabandu V, Nehila T, Ferguson J, ATIT R. Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development. Dev Biol. 2021;478:25-40 pubmed publisher
Schüler S, Kirkpatrick J, Schmidt M, Santinha D, Koch P, Di Sanzo S, et al. Extensive remodeling of the extracellular matrix during aging contributes to age-dependent impairments of muscle stem cell functionality. Cell Rep. 2021;35:109223 pubmed publisher
Hara T, Chanoch Myers R, Mathewson N, Myskiw C, Atta L, Bussema L, et al. Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. Cancer Cell. 2021;39:779-792.e11 pubmed publisher
Waisman A, Norris A, Elias Costa M, Kopinke D. Automatic and unbiased segmentation and quantification of myofibers in skeletal muscle. Sci Rep. 2021;11:11793 pubmed publisher
Pfeiffer F, Sherafat A, Nishiyama A. The Impact of Fixation on the Detection of Oligodendrocyte Precursor Cell Morphology and Vascular Associations. Cells. 2021;10: pubmed publisher
Pan Y, Hysinger J, Barron T, Schindler N, Cobb O, Guo X, et al. NF1 mutation drives neuronal activity-dependent initiation of optic glioma. Nature. 2021;594:277-282 pubmed publisher
Contreras O, Córdova Casanova A, Brandan E. PDGF-PDGFR network differentially regulates the fate, migration, proliferation, and cell cycle progression of myogenic cells. Cell Signal. 2021;84:110036 pubmed publisher
Hara A, Kato K, Ishihara T, Kobayashi H, Asai N, Mii S, et al. Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity. Genes Cells. 2021;26:495-512 pubmed publisher
Wosczyna M, Perez Carbajal E, Wagner M, Paredes S, Konishi C, Liu L, et al. Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells. Cell Stem Cell. 2021;28:1323-1334.e8 pubmed publisher
Dittrich G, Froese N, Wang X, Kroeger H, Wang H, Szaroszyk M, et al. Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis. Basic Res Cardiol. 2021;116:26 pubmed publisher
Mészáros L, Riemenschneider M, Gassner H, Marxreiter F, von Horsten S, Hoffmann A, et al. Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy. Acta Neuropathol Commun. 2021;9:68 pubmed publisher
Angueira A, Sakers A, Holman C, Cheng L, Arbocco M, Shamsi F, et al. Defining the lineage of thermogenic perivascular adipose tissue. Nat Metab. 2021;3:469-484 pubmed publisher
Hiroshige T, Uemura K, Hirashima S, Hino K, Togo A, Ohta K, et al. Identification of PDGFRα-positive interstitial cells in the distal segment of the murine vas deferens. Sci Rep. 2021;11:7553 pubmed publisher
Choi S, Zhang B, Ma S, Gonzalez Celeiro M, Stein D, Jin X, et al. Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence. Nature. 2021;592:428-432 pubmed publisher
Talley M, Nardini D, Qin S, Prada C, Ehrman L, Waclaw R. A role for sustained MAPK activity in the mouse ventral telencephalon. Dev Biol. 2021;476:137-147 pubmed publisher
Yamakawa D, Katoh D, Kasahara K, Shiromizu T, Matsuyama M, Matsuda C, et al. Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis. Cell Rep. 2021;34:108817 pubmed publisher
Boshans L, Soh H, Wood W, Nolan T, Mandoiu I, Yanagawa Y, et al. Direct reprogramming of oligodendrocyte precursor cells into GABAergic inhibitory neurons by a single homeodomain transcription factor Dlx2. Sci Rep. 2021;11:3552 pubmed publisher
Matthews B, Novak S, Sbrana F, Funnell J, Cao Y, Buckels E, et al. Heterogeneity of murine periosteum progenitors involved in fracture healing. elife. 2021;10: pubmed publisher
Giuliani G, Vumbaca S, Fuoco C, Gargioli C, Giorda E, Massacci G, et al. SCA-1 micro-heterogeneity in the fate decision of dystrophic fibro/adipogenic progenitors. Cell Death Dis. 2021;12:122 pubmed publisher
Takase H, Hamanaka G, Ohtomo R, Park J, Chung K, Gelman I, et al. Roles of A-kinase Anchor Protein 12 in Astrocyte and Oligodendrocyte Precursor Cell in Postnatal Corpus Callosum. Stem Cell Rev Rep. 2021;17:1446-1455 pubmed publisher
Cullen C, Pepper R, Clutterbuck M, Pitman K, Oorschot V, Auderset L, et al. Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain. Cell Rep. 2021;34:108641 pubmed publisher
Br xfc gger M, Valenta T, Fazilaty H, Hausmann G, Basler K. Distinct populations of crypt-associated fibroblasts act as signaling hubs to control colon homeostasis. PLoS Biol. 2020;18:e3001032 pubmed publisher
Auderset L, Pitman K, Cullen C, Pepper R, Taylor B, Foa L, et al. Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Is a Negative Regulator of Oligodendrocyte Progenitor Cell Differentiation in the Adult Mouse Brain. Front Cell Dev Biol. 2020;8:564351 pubmed publisher
Jin X, Simmons S, Guo A, Shetty A, Ko M, Nguyen L, et al. In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes. Science. 2020;370: pubmed publisher
Floriddia E, Lourenco T, Zhang S, van Bruggen D, Hilscher M, Kukanja P, et al. Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury. Nat Commun. 2020;11:5860 pubmed publisher
Luo M, Yin Y, Li D, Tang W, Liu Y, Pan L, et al. Neuronal activity-dependent myelin repair promotes motor function recovery after contusion spinal cord injury. Brain Res Bull. 2021;166:73-81 pubmed publisher
Jiang D, Christ S, Correa Gallegos D, Ramesh P, Kalgudde Gopal S, Wannemacher J, et al. Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin. Nat Commun. 2020;11:5653 pubmed publisher
Aung K, Akiyama K, Kunitomo M, Mun A, Tosa I, Nguyen H, et al. Aging-Affected MSC Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model. Int J Mol Sci. 2020;21: pubmed publisher
Li L, Xiang S, Wang B, Lin H, Cao G, Alexander P, et al. Dead muscle tissue promotes dystrophic calcification by lowering circulating TGF-β1 level. Bone Joint Res. 2020;9:742-750 pubmed publisher
Medved J, Wood W, Van Heyst M, Sherafat A, Song J, Sakya S, et al. Novel guanidine compounds inhibit platelet-derived growth factor receptor alpha transcription and oligodendrocyte precursor cell proliferation. Glia. 2021;69:792-811 pubmed publisher
Song K, Qing Y, Guo Q, Peden E, Chen C, Mitch W, et al. PDGFRA in vascular adventitial MSCs promotes neointima formation in arteriovenous fistula in chronic kidney disease. JCI Insight. 2020;5: pubmed publisher
Phan Q, Fine G, Salz L, Herrera G, Wildman B, Driskell I, et al. Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds. elife. 2020;9: pubmed publisher
Zhao L, Son J, Wang B, Tian Q, Chen Y, Liu X, et al. Retinoic acid signalling in fibro/adipogenic progenitors robustly enhances muscle regeneration. EBioMedicine. 2020;60:103020 pubmed publisher
Ogino H, Nakajima T, Hirota Y, Toriuchi K, Aoyama M, Nakajima K, et al. The Secreted Glycoprotein Reelin Suppresses the Proliferation and Regulates the Distribution of Oligodendrocyte Progenitor Cells in the Embryonic Neocortex. J Neurosci. 2020;40:7625-7636 pubmed publisher
Hong S, Yang M, Cho H, Park I, Bae H, Choe K, et al. Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi. Nat Commun. 2020;11:4102 pubmed publisher
Abbasi S, Sinha S, Labit E, Rosin N, Yoon G, Rahmani W, et al. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing. Cell Stem Cell. 2020;27:396-412.e6 pubmed publisher
Asega A, Menezes M, Trevisan Silva D, Cajado Carvalho D, Bertholim L, Oliveira A, et al. Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases. Sci Rep. 2020;10:12912 pubmed publisher
Kaji S, Maki T, Ueda J, Ishimoto T, Inoue Y, Yasuda K, et al. BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy. Acta Neuropathol Commun. 2020;8:120 pubmed publisher
Pu A, Mishra M, Dong Y, Ghorbanigazar S, Stephenson E, Rawji K, et al. The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination. J Neuroinflammation. 2020;17:220 pubmed publisher
Shwartz Y, Gonzalez Celeiro M, Chen C, Pasolli H, Sheu S, Fan S, et al. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells. Cell. 2020;: pubmed publisher
Elitt M, Barbar L, Shick H, Powers B, Maeno Hikichi Y, Madhavan M, et al. Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease. Nature. 2020;585:397-403 pubmed publisher
de la Fuente A, Queiroz R, Ghosh T, McMurran C, Cubillos J, Bergles D, et al. Changes in the Oligodendrocyte Progenitor Cell Proteome with Ageing. Mol Cell Proteomics. 2020;19:1281-1302 pubmed publisher
Contreras O, Soliman H, Theret M, Rossi F, Brandan E. TGF-β-driven downregulation of the transcription factor TCF7L2 affects Wnt/β-catenin signaling in PDGFRα+ fibroblasts. J Cell Sci. 2020;133: pubmed publisher
Davidson S, Efremova M, Riedel A, Mahata B, Pramanik J, Huuhtanen J, et al. Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth. Cell Rep. 2020;31:107628 pubmed publisher
Grainger N, Freeman R, Shonnard C, Drumm B, Koh S, Ward S, et al. Identification and classification of interstitial cells in the mouse renal pelvis. J Physiol. 2020;598:3283-3307 pubmed publisher
Marsters C, Nesan D, Far R, Klenin N, Pittman Q, Kurrasch D. Embryonic microglia influence developing hypothalamic glial populations. J Neuroinflammation. 2020;17:146 pubmed publisher
Micali N, Kim S, Diaz Bustamante M, Stein O Brien G, Seo S, Shin J, et al. Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates. Cell Rep. 2020;31:107599 pubmed publisher
Camps J, Breuls N, Sifrim A, Giarratana N, Corvelyn M, Danti L, et al. Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles. Cell Rep. 2020;31:107597 pubmed publisher
Biltz N, Collins K, Shen K, Schwartz K, Harris C, Meyer G. Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction. J Physiol. 2020;598:2669-2683 pubmed publisher
Toma J, Karamboulas K, Carr M, Kolaj A, Yuzwa S, Mahmud N, et al. Peripheral Nerve Single-Cell Analysis Identifies Mesenchymal Ligands that Promote Axonal Growth. Eneuro. 2020;7: pubmed publisher
Bahar Halpern K, Massalha H, Zwick R, Moor A, Castillo Azofeifa D, Rozenberg M, et al. Lgr5+ telocytes are a signaling source at the intestinal villus tip. Nat Commun. 2020;11:1936 pubmed publisher
Fiore L, Takata N, Acosta S, Ma W, Pandit T, Oxendine M, et al. Optic vesicle morphogenesis requires primary cilia. Dev Biol. 2020;462:119-128 pubmed publisher
Chitu V, Biundo F, Shlager G, Park E, Wang P, Gulinello M, et al. Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling. Cell Rep. 2020;30:3004-3019.e5 pubmed publisher
Kurahashi M, Kito Y, Baker S, Jennings L, Dowers J, Koh S, et al. A novel postsynaptic signal pathway of sympathetic neural regulation of murine colonic motility. FASEB J. 2020;34:5563-5577 pubmed publisher
McCarthy N, Manieri E, Storm E, Saadatpour A, Luoma A, Kapoor V, et al. Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. Cell Stem Cell. 2020;: pubmed publisher
Rawji K, Young A, Ghosh T, Michaels N, Mirzaei R, Kappen J, et al. Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system. Acta Neuropathol. 2020;139:893-909 pubmed publisher
Reggio A, Rosina M, Krahmer N, Palma A, Petrilli L, Maiolatesi G, et al. Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration. Life Sci Alliance. 2020;3: pubmed publisher
Pu W, Han X, He L, Li Y, Huang X, Zhang M, et al. A genetic system for tissue-specific inhibition of cell proliferation. Development. 2020;147: pubmed publisher
Xu H, Dzhashiashvili Y, Shah A, Kunjamma R, Weng Y, Elbaz B, et al. m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination. Neuron. 2020;105:293-309.e5 pubmed publisher
Morrison V, Smith V, Huang J. Retinoic Acid Is Required for Oligodendrocyte Precursor Cell Production and Differentiation in the Postnatal Mouse Corpus Callosum. Eneuro. 2020;7: pubmed publisher
Wojahn I, Lüdtke T, Christoffels V, Trowe M, Kispert A. TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung. Respir Res. 2019;20:292 pubmed publisher
HWANG C, Marini S, Huber A, Stepien D, Sorkin M, Loder S, et al. Mesenchymal VEGFA induces aberrant differentiation in heterotopic ossification. Bone Res. 2019;7:36 pubmed publisher
Hilgendorf K, Johnson C, Mezger A, Rice S, Norris A, Demeter J, et al. Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. Cell. 2019;179:1289-1305.e21 pubmed publisher
Steadman P, Xia F, Ahmed M, Mocle A, Penning A, Geraghty A, et al. Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice. Neuron. 2020;105:150-164.e6 pubmed publisher
Fernandez Castaneda A, Chappell M, Rosen D, Seki S, Beiter R, Johanson D, et al. The active contribution of OPCs to neuroinflammation is mediated by LRP1. Acta Neuropathol. 2020;139:365-382 pubmed publisher
Grund A, Szaroszyk M, Korf Klingebiel M, Malek Mohammadi M, Trogisch F, Schrameck U, et al. TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation. EMBO Mol Med. 2019;11:e10018 pubmed publisher
Contreras O, Cruz Soca M, Theret M, Soliman H, Tung L, Groppa E, et al. Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro-adipogenic progenitors. J Cell Sci. 2019;132: pubmed publisher
Zhang X, Wang X, Yin H, Zhang L, Feng A, Zhang Q, et al. Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice. Cell Rep. 2019;28:792-803.e4 pubmed publisher
Scharf G, Kilian K, Cordero J, Wang Y, Grund A, Hofmann M, et al. Inactivation of Sox9 in fibroblasts reduces cardiac fibrosis and inflammation. JCI Insight. 2019;5: pubmed publisher
Welc S, Flores I, Wehling Henricks M, Ramos J, Wang Y, Bertoni C, et al. Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy. Nat Commun. 2019;10:2788 pubmed publisher
Eaton A, Clayton D, Ruiz W, Griffiths S, RUBIO M, Apodaca G. Expansion and Contraction of the Umbrella Cell Apical Junctional Ring in Response to Bladder Filling and Voiding. Mol Biol Cell. 2019;:mbcE19020115 pubmed publisher
Hogarth M, Defour A, LAZARSKI C, Gallardo E, Diaz Manera J, Partridge T, et al. Fibroadipogenic progenitors are responsible for muscle loss in limb girdle muscular dystrophy 2B. Nat Commun. 2019;10:2430 pubmed publisher
Wang X, Matthews B, Yu J, Novak S, Grcevic D, Sanjay A, et al. PDGF Modulates BMP2-Induced Osteogenesis in Periosteal Progenitor Cells. JBMR Plus. 2019;3:e10127 pubmed publisher
Geraghty A, Gibson E, Ghanem R, Greene J, Ocampo A, Goldstein A, et al. Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment. Neuron. 2019;: pubmed publisher
Wosczyna M, Konishi C, Perez Carbajal E, Wang T, Walsh R, Gan Q, et al. Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle. Cell Rep. 2019;27:2029-2035.e5 pubmed publisher
Changarathil G, Ramirez K, Isoda H, Sada A, Yanagisawa H. Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis. PLoS ONE. 2019;14:e0215908 pubmed publisher
Hamaguchi M, Muramatsu R, Fujimura H, Mochizuki H, Kataoka H, Yamashita T. Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system. elife. 2019;8: pubmed publisher
Mahlakõiv T, Flamar A, Johnston L, Moriyama S, Putzel G, Bryce P, et al. Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33. Sci Immunol. 2019;4: pubmed publisher
Bryniarski A, Meyer G. Brown Fat Promotes Muscle Growth During Regeneration. J Orthop Res. 2019;37:1817-1826 pubmed publisher
Govier Cole A, Wood R, Fletcher J, Gonsalvez D, Merlo D, Cate H, et al. Inhibiting Bone Morphogenetic Protein 4 Type I Receptor Signaling Promotes Remyelination by Potentiating Oligodendrocyte Differentiation. Eneuro. 2019;6: pubmed publisher
Goldstein J, Tabebordbar M, Zhu K, Wang L, Messemer K, Peacker B, et al. In Situ Modification of Tissue Stem and Progenitor Cell Genomes. Cell Rep. 2019;27:1254-1264.e7 pubmed publisher
Hartley M, Banerji T, Tagge I, Kirkemo L, Chaudhary P, CALKINS E, et al. Myelin repair stimulated by CNS-selective thyroid hormone action. JCI Insight. 2019;4: pubmed publisher
Joshi P, Waterhouse P, Kasaian K, Fang H, Gulyaeva O, Sul H, et al. PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland. Nat Commun. 2019;10:1760 pubmed publisher
Shen Q, Yu S, Zhang Y, Zhou Z, Zhu Z, Pan Q, et al. Characterization of porcine extraembryonic endoderm cells. Cell Prolif. 2019;52:e12591 pubmed publisher
Han X, Wang Y, Pu W, Huang X, Qiu L, Li Y, et al. Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration. Stem Cell Reports. 2019;12:624-638 pubmed publisher
Guerrero Juarez C, Dedhia P, Jin S, Ruiz Vega R, Ma D, Liu Y, et al. Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds. Nat Commun. 2019;10:650 pubmed publisher
Lüdtke T, Rudat C, Kurz J, Häfner R, Greulich F, Wojahn I, et al. Mesothelial mobilization in the developing lung and heart differs in timing, quantity, and pathway dependency. Am J Physiol Lung Cell Mol Physiol. 2019;316:L767-L783 pubmed publisher
Lukjanenko L, Karaz S, Stuelsatz P, Gurriaran Rodriguez U, Michaud J, Dammone G, et al. Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors. Cell Stem Cell. 2019;24:433-446.e7 pubmed publisher
Park J, Ivey M, Deana Y, Riggsbee K, Sörensen E, Schwabl V, et al. The Tcf21 lineage constitutes the lung lipofibroblast population. Am J Physiol Lung Cell Mol Physiol. 2019;316:L872-L885 pubmed publisher
Aran D, Looney A, Liu L, Wu E, Fong V, Hsu A, et al. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol. 2019;20:163-172 pubmed publisher
Mouton A, Ma Y, Rivera Gonzalez O, Daseke M, Flynn E, Freeman T, et al. Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesis. Basic Res Cardiol. 2019;114:6 pubmed publisher
Kretzschmar K, Post Y, Bannier Hélaouët M, Mattiotti A, Drost J, Basak O, et al. Profiling proliferative cells and their progeny in damaged murine hearts. Proc Natl Acad Sci U S A. 2018;115:E12245-E12254 pubmed publisher
Gibson E, Nagaraja S, Ocampo A, Tam L, Wood L, Pallegar P, et al. Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment. Cell. 2019;176:43-55.e13 pubmed publisher
Oishi S, Harkins D, Kurniawan N, Kasherman M, Harris L, Zalucki O, et al. Heterozygosity for Nuclear Factor One X in mice models features of Malan syndrome. EBioMedicine. 2019;39:388-400 pubmed publisher
Carr M, Toma J, Johnston A, Steadman P, Yuzwa S, Mahmud N, et al. Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration. Cell Stem Cell. 2019;24:240-256.e9 pubmed publisher
Juban G, Saclier M, Yacoub Youssef H, Kernou A, Arnold L, Boisson C, et al. AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy. Cell Rep. 2018;25:2163-2176.e6 pubmed publisher
Jensen S, Michaels N, Ilyntskyy S, Keough M, Kovalchuk O, Yong V. Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1?. Cell Rep. 2018;24:3167-3179 pubmed publisher
Fletcher J, Wood R, Nguyen J, Norman E, Jun C, Prawdiuk A, et al. Targeting TrkB with a Brain-Derived Neurotrophic Factor Mimetic Promotes Myelin Repair in the Brain. J Neurosci. 2018;38:7088-7099 pubmed publisher
Kato K, Diéguez Hurtado R, Park D, Hong S, Kato Azuma S, Adams S, et al. Pulmonary pericytes regulate lung morphogenesis. Nat Commun. 2018;9:2448 pubmed publisher
Maden M, Brant J, Rubiano A, Sandoval A, Simmons C, Mitchell R, et al. Perfect chronic skeletal muscle regeneration in adult spiny mice, Acomys cahirinus. Sci Rep. 2018;8:8920 pubmed publisher
Kim S, Akindehin S, Kwon H, Son Y, Saha A, Jung Y, et al. Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice. Sci Rep. 2018;8:8856 pubmed publisher
Collins L, Hill D, Brunjes P. Myelination of the developing lateral olfactory tract and anterior commissure. J Comp Neurol. 2018;526:1843-1858 pubmed publisher
Tanabe S, Yamashita T. B-1a lymphocytes promote oligodendrogenesis during brain development. Nat Neurosci. 2018;21:506-516 pubmed publisher
Yu W, Hill W, Robson S, Zeidel M. Role of P2X4 Receptor in Mouse Voiding Function. Sci Rep. 2018;8:1838 pubmed publisher
Mitew S, Gobius I, Fenlon L, McDougall S, Hawkes D, Xing Y, et al. Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner. Nat Commun. 2018;9:306 pubmed publisher
Begolly S, Olschowka J, Love T, Williams J, O Banion M. Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion. Glia. 2018;66:846-861 pubmed publisher
Chen Y, Zhen W, Guo T, Zhao Y, Liu A, Rubio J, et al. Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination. PLoS ONE. 2017;12:e0189380 pubmed publisher
Lu H, Zhang C, Song N, Lu C, Tong L, Huang X, et al. Colonic PDGFRα Overexpression Accompanied Forkhead Transcription Factor FOXO3 Up-Regulation in STZ-Induced Diabetic Mice. Cell Physiol Biochem. 2017;43:158-171 pubmed publisher
Ha S, Lee M, Kurahashi M, Wei L, Jorgensen B, Park C, et al. Transcriptome analysis of PDGFRα+ cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFRα+ cell hyperplasia. PLoS ONE. 2017;12:e0182265 pubmed publisher
Su E, Cao C, Fredriksson L, Nilsson I, Stefanitsch C, Stevenson T, et al. Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke. Acta Neuropathol. 2017;134:585-604 pubmed publisher
Aghajanian H, Cho Y, Rizer N, Wang Q, Li L, Degenhardt K, et al. Pdgfr? functions in endothelial-derived cells to regulate neural crest cells and the development of the great arteries. Dis Model Mech. 2017;10:1101-1108 pubmed publisher
Gonzalez D, Contreras O, Rebolledo D, Espinoza J, van Zundert B, Brandan E. ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers. PLoS ONE. 2017;12:e0177649 pubmed publisher
Guo Q, Minnier J, Burchard J, Chiotti K, Spellman P, Schedin P. Physiologically activated mammary fibroblasts promote postpartum mammary cancer. JCI Insight. 2017;2:e89206 pubmed publisher
Guimarães Camboa N, Cattaneo P, Sun Y, Moore Morris T, Gu Y, Dalton N, et al. Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell. 2017;20:345-359.e5 pubmed publisher
Matoba K, Muramatsu R, Yamashita T. Leptin sustains spontaneous remyelination in the adult central nervous system. Sci Rep. 2017;7:40397 pubmed publisher
Lin J, Khan M, Zapiec B, Mombaerts P. Efficient derivation of extraembryonic endoderm stem cell lines from mouse postimplantation embryos. Sci Rep. 2016;6:39457 pubmed publisher
Frank D, Peng T, Zepp J, Snitow M, Vincent T, Penkala I, et al. Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell Rep. 2016;17:2312-2325 pubmed publisher
Fu J, Wiraja C, Chong R, Xu C, Wang D. Real-time and non-invasive monitoring of embryonic stem cell survival during the development of embryoid bodies with smart nanosensor. Acta Biomater. 2017;49:358-367 pubmed publisher
Oishi S, Zalucki O, Premarathne S, Wood S, Piper M. USP9X deletion elevates the density of oligodendrocytes within the postnatal dentate gyrus. Neurogenesis (Austin). 2016;3:e1235524 pubmed
Noda K, Kitami M, Kitami K, Kaku M, Komatsu Y. Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development. Proc Natl Acad Sci U S A. 2016;113:E2589-97 pubmed publisher
Tagge I, O Connor A, Chaudhary P, Pollaro J, BERLOW Y, Chalupsky M, et al. Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model. PLoS ONE. 2016;11:e0152480 pubmed publisher
Shin J, Lee S, Kim Y, Kim I, Kim Y, Kyeong D, et al. AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to ?-adrenergic signalling. Sci Rep. 2016;6:23426 pubmed publisher
product information
brand :
R&D Systems
master code :
AF1062
SKU :
AF1062
product name :
Mouse PDGF R alpha Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Mouse PDGF R alpha Antibody from R&D Systems is a goat polyclonal antibody to PDGFR alpha. This antibody reacts with human,mouse,primate - cercopithecus aethiops (african green monkey),rat,transgenic mouse,transgenic rat,xenograft. The Mouse PDGF R alpha Antibody has been validated for the following applications: Immunohistochemistry,Immunocytochemistry,Flow Cytometry,Immunohistochemistry-Frozen,Bioassay,IHC/IF,IHC frozen fixed,Immunoprecipitation,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunofluorescence,Immunocytochemistry/ Immunofluorescence.
target :
PDGF R alpha
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, Immunohistochemistry 5-15 ug/mL, Neutralization 0.2 - 1.6 ug/mL
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse PDGF R alpha , Leu25-Glu524 (Asp65Glu, Gly439Ala, Thr440Ala), Accession # P26618
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Primate - Cercopithecus aethiops (African Green Monkey),Rat,Transgenic Mouse,Transgenic Rat,Xenograft
specificity :
Detects mouse PDGF R alpha in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) PDGF R alpha , rhPDGF R▀, and recombinant mouse PDGF R▀ is observed.
gene symbol :
PDGFRA
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Detection of Mouse PDGF Ra antibody by Western Blot.
accessionNumbers :
P26618
applications :
Bioassay,ICC-IF,IHC/IF,IHC frozen fixed,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunofluorescence,Immunocytochemistry,Immunocytochemistry/ Immunofluorescence
USD :
499 USD
alt names :
alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a, CD140a antigen, EC 2.7.10, EC 2.7.10.1, MGC74795, PDGFR alpha, PDGFR2, PDGFRA, PDGFRA/BCR fusion, PDGF-R-alpha, platelet-derived growth factor receptor, alpha polypeptide, rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein, RHEPDGFRA
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.