This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
antibody
product name :
Mouse PDGF R alpha Antibody
catalog :
AF1062-SP
quantity :
25 ug
price :
135 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, neutralization, immunohistochemistry - frozen section
citations: 58
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 2a
Pu A, Mishra M, Dong Y, Ghorbanigazar S, Stephenson E, Rawji K, et al. The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination. J Neuroinflammation. 2020;17:220 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 2c
Du Z, Dong J, Li M, Zhang J, Bi J, Ren Y, et al. Overexpression of Platelet-Derived Growth Factor Receptor Α D842V Mutants Prevents Liver Regeneration and Chemically Induced Hepatocarcinogenesis via Inhibition of MET and EGFR. J Cancer. 2020;11:4614-4624 pubmed publisher
Sivaraj K, Jeong H, Dharmalingam B, Zeuschner D, Adams S, Potente M, et al. Regional specialization and fate specification of bone stromal cells in skeletal development. Cell Rep. 2021;36:109352 pubmed publisher
Mu W, Li S, Xu J, Guo X, Wu H, Chen Z, et al. Hypothalamic Rax+ tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice. Nat Commun. 2021;12:2288 pubmed publisher
Mészáros L, Riemenschneider M, Gassner H, Marxreiter F, von Horsten S, Hoffmann A, et al. Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy. Acta Neuropathol Commun. 2021;9:68 pubmed publisher
Yamakawa D, Katoh D, Kasahara K, Shiromizu T, Matsuyama M, Matsuda C, et al. Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis. Cell Rep. 2021;34:108817 pubmed publisher
Luo M, Yin Y, Li D, Tang W, Liu Y, Pan L, et al. Neuronal activity-dependent myelin repair promotes motor function recovery after contusion spinal cord injury. Brain Res Bull. 2021;166:73-81 pubmed publisher
Jiang D, Christ S, Correa Gallegos D, Ramesh P, Kalgudde Gopal S, Wannemacher J, et al. Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin. Nat Commun. 2020;11:5653 pubmed publisher
Song K, Qing Y, Guo Q, Peden E, Chen C, Mitch W, et al. PDGFRA in vascular adventitial MSCs promotes neointima formation in arteriovenous fistula in chronic kidney disease. JCI Insight. 2020;5: pubmed publisher
Zhao L, Son J, Wang B, Tian Q, Chen Y, Liu X, et al. Retinoic acid signalling in fibro/adipogenic progenitors robustly enhances muscle regeneration. EBioMedicine. 2020;60:103020 pubmed publisher
Hong S, Yang M, Cho H, Park I, Bae H, Choe K, et al. Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi. Nat Commun. 2020;11:4102 pubmed publisher
Asega A, Menezes M, Trevisan Silva D, Cajado Carvalho D, Bertholim L, Oliveira A, et al. Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases. Sci Rep. 2020;10:12912 pubmed publisher
Kaji S, Maki T, Ueda J, Ishimoto T, Inoue Y, Yasuda K, et al. BCAS1-positive immature oligodendrocytes are affected by the α-synuclein-induced pathology of multiple system atrophy. Acta Neuropathol Commun. 2020;8:120 pubmed publisher
Davidson S, Efremova M, Riedel A, Mahata B, Pramanik J, Huuhtanen J, et al. Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth. Cell Rep. 2020;31:107628 pubmed publisher
Marsters C, Nesan D, Far R, Klenin N, Pittman Q, Kurrasch D. Embryonic microglia influence developing hypothalamic glial populations. J Neuroinflammation. 2020;17:146 pubmed publisher
Micali N, Kim S, Diaz Bustamante M, Stein O Brien G, Seo S, Shin J, et al. Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates. Cell Rep. 2020;31:107599 pubmed publisher
Camps J, Breuls N, Sifrim A, Giarratana N, Corvelyn M, Danti L, et al. Interstitial Cell Remodeling Promotes Aberrant Adipogenesis in Dystrophic Muscles. Cell Rep. 2020;31:107597 pubmed publisher
Bahar Halpern K, Massalha H, Zwick R, Moor A, Castillo Azofeifa D, Rozenberg M, et al. Lgr5+ telocytes are a signaling source at the intestinal villus tip. Nat Commun. 2020;11:1936 pubmed publisher
McCarthy N, Manieri E, Storm E, Saadatpour A, Luoma A, Kapoor V, et al. Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. Cell Stem Cell. 2020;: pubmed publisher
Wojahn I, Lüdtke T, Christoffels V, Trowe M, Kispert A. TBX2-positive cells represent a multi-potent mesenchymal progenitor pool in the developing lung. Respir Res. 2019;20:292 pubmed publisher
Grund A, Szaroszyk M, Korf Klingebiel M, Malek Mohammadi M, Trogisch F, Schrameck U, et al. TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation. EMBO Mol Med. 2019;11:e10018 pubmed publisher
Zhang X, Wang X, Yin H, Zhang L, Feng A, Zhang Q, et al. Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice. Cell Rep. 2019;28:792-803.e4 pubmed publisher
Wosczyna M, Konishi C, Perez Carbajal E, Wang T, Walsh R, Gan Q, et al. Mesenchymal Stromal Cells Are Required for Regeneration and Homeostatic Maintenance of Skeletal Muscle. Cell Rep. 2019;27:2029-2035.e5 pubmed publisher
Goldstein J, Tabebordbar M, Zhu K, Wang L, Messemer K, Peacker B, et al. In Situ Modification of Tissue Stem and Progenitor Cell Genomes. Cell Rep. 2019;27:1254-1264.e7 pubmed publisher
Hartley M, Banerji T, Tagge I, Kirkemo L, Chaudhary P, CALKINS E, et al. Myelin repair stimulated by CNS-selective thyroid hormone action. JCI Insight. 2019;4: pubmed publisher
Joshi P, Waterhouse P, Kasaian K, Fang H, Gulyaeva O, Sul H, et al. PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland. Nat Commun. 2019;10:1760 pubmed publisher
Han X, Wang Y, Pu W, Huang X, Qiu L, Li Y, et al. Lineage Tracing Reveals the Bipotency of SOX9+ Hepatocytes during Liver Regeneration. Stem Cell Reports. 2019;12:624-638 pubmed publisher
Guerrero Juarez C, Dedhia P, Jin S, Ruiz Vega R, Ma D, Liu Y, et al. Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds. Nat Commun. 2019;10:650 pubmed publisher
Lukjanenko L, Karaz S, Stuelsatz P, Gurriaran Rodriguez U, Michaud J, Dammone G, et al. Aging Disrupts Muscle Stem Cell Function by Impairing Matricellular WISP1 Secretion from Fibro-Adipogenic Progenitors. Cell Stem Cell. 2019;24:433-446.e7 pubmed publisher
Aran D, Looney A, Liu L, Wu E, Fong V, Hsu A, et al. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol. 2019;20:163-172 pubmed publisher
Oishi S, Harkins D, Kurniawan N, Kasherman M, Harris L, Zalucki O, et al. Heterozygosity for Nuclear Factor One X in mice models features of Malan syndrome. EBioMedicine. 2019;39:388-400 pubmed publisher
Carr M, Toma J, Johnston A, Steadman P, Yuzwa S, Mahmud N, et al. Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration. Cell Stem Cell. 2019;24:240-256.e9 pubmed publisher
Kretzschmar K, Post Y, Bannier Hélaouët M, Mattiotti A, Drost J, Basak O, et al. Profiling proliferative cells and their progeny in damaged murine hearts. Proc Natl Acad Sci U S A. 2018;115:E12245-E12254 pubmed publisher
Juban G, Saclier M, Yacoub Youssef H, Kernou A, Arnold L, Boisson C, et al. AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy. Cell Rep. 2018;25:2163-2176.e6 pubmed publisher
Jensen S, Michaels N, Ilyntskyy S, Keough M, Kovalchuk O, Yong V. Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1?. Cell Rep. 2018;24:3167-3179 pubmed publisher
Kato K, Diéguez Hurtado R, Park D, Hong S, Kato Azuma S, Adams S, et al. Pulmonary pericytes regulate lung morphogenesis. Nat Commun. 2018;9:2448 pubmed publisher
Maden M, Brant J, Rubiano A, Sandoval A, Simmons C, Mitchell R, et al. Perfect chronic skeletal muscle regeneration in adult spiny mice, Acomys cahirinus. Sci Rep. 2018;8:8920 pubmed publisher
Kim S, Akindehin S, Kwon H, Son Y, Saha A, Jung Y, et al. Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice. Sci Rep. 2018;8:8856 pubmed publisher
Collins L, Hill D, Brunjes P. Myelination of the developing lateral olfactory tract and anterior commissure. J Comp Neurol. 2018;526:1843-1858 pubmed publisher
Tanabe S, Yamashita T. B-1a lymphocytes promote oligodendrogenesis during brain development. Nat Neurosci. 2018;21:506-516 pubmed publisher
Yu W, Hill W, Robson S, Zeidel M. Role of P2X4 Receptor in Mouse Voiding Function. Sci Rep. 2018;8:1838 pubmed publisher
Mitew S, Gobius I, Fenlon L, McDougall S, Hawkes D, Xing Y, et al. Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner. Nat Commun. 2018;9:306 pubmed publisher
Begolly S, Olschowka J, Love T, Williams J, O Banion M. Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion. Glia. 2018;66:846-861 pubmed publisher
Chen Y, Zhen W, Guo T, Zhao Y, Liu A, Rubio J, et al. Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination. PLoS ONE. 2017;12:e0189380 pubmed publisher
Lu H, Zhang C, Song N, Lu C, Tong L, Huang X, et al. Colonic PDGFRα Overexpression Accompanied Forkhead Transcription Factor FOXO3 Up-Regulation in STZ-Induced Diabetic Mice. Cell Physiol Biochem. 2017;43:158-171 pubmed publisher
Ha S, Lee M, Kurahashi M, Wei L, Jorgensen B, Park C, et al. Transcriptome analysis of PDGFRα+ cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFRα+ cell hyperplasia. PLoS ONE. 2017;12:e0182265 pubmed publisher
Aghajanian H, Cho Y, Rizer N, Wang Q, Li L, Degenhardt K, et al. Pdgfr? functions in endothelial-derived cells to regulate neural crest cells and the development of the great arteries. Dis Model Mech. 2017;10:1101-1108 pubmed publisher
Gonzalez D, Contreras O, Rebolledo D, Espinoza J, van Zundert B, Brandan E. ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers. PLoS ONE. 2017;12:e0177649 pubmed publisher
Guo Q, Minnier J, Burchard J, Chiotti K, Spellman P, Schedin P. Physiologically activated mammary fibroblasts promote postpartum mammary cancer. JCI Insight. 2017;2:e89206 pubmed publisher
Guimarães Camboa N, Cattaneo P, Sun Y, Moore Morris T, Gu Y, Dalton N, et al. Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell. 2017;20:345-359.e5 pubmed publisher
Matoba K, Muramatsu R, Yamashita T. Leptin sustains spontaneous remyelination in the adult central nervous system. Sci Rep. 2017;7:40397 pubmed publisher
Lin J, Khan M, Zapiec B, Mombaerts P. Efficient derivation of extraembryonic endoderm stem cell lines from mouse postimplantation embryos. Sci Rep. 2016;6:39457 pubmed publisher
Frank D, Peng T, Zepp J, Snitow M, Vincent T, Penkala I, et al. Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell Rep. 2016;17:2312-2325 pubmed publisher
Fu J, Wiraja C, Chong R, Xu C, Wang D. Real-time and non-invasive monitoring of embryonic stem cell survival during the development of embryoid bodies with smart nanosensor. Acta Biomater. 2017;49:358-367 pubmed publisher
Oishi S, Zalucki O, Premarathne S, Wood S, Piper M. USP9X deletion elevates the density of oligodendrocytes within the postnatal dentate gyrus. Neurogenesis (Austin). 2016;3:e1235524 pubmed
Noda K, Kitami M, Kitami K, Kaku M, Komatsu Y. Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development. Proc Natl Acad Sci U S A. 2016;113:E2589-97 pubmed publisher
Tagge I, O Connor A, Chaudhary P, Pollaro J, BERLOW Y, Chalupsky M, et al. Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model. PLoS ONE. 2016;11:e0152480 pubmed publisher
Shin J, Lee S, Kim Y, Kim I, Kim Y, Kyeong D, et al. AHNAK deficiency promotes browning and lipolysis in mice via increased responsiveness to ?-adrenergic signalling. Sci Rep. 2016;6:23426 pubmed publisher
product information
brand :
R&D Systems
master code :
AF1062
SKU :
AF1062-SP
product name :
Mouse PDGF R alpha Antibody
description :
The Mouse PDGF R alpha Antibody from R&D Systems is a goat polyclonal antibody to PDGFR alpha. This antibody reacts with mouse. The Mouse PDGF R alpha Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Neutralization.
target :
PDGFR alpha
category :
Primary Antibodies
unit size :
25 ug
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse PDGF R alpha , Leu25-Glu524 (Asp65Glu, Gly439Ala, Thr440Ala), Accession # P26618
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Mouse
specificity :
Detects mouse PDGF R alpha in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human (rh) PDGF R alpha , rhPDGF R beta , and recombinant mouse PDGF R beta is observed.
gene symbol :
PDGFRA
endotoxin note :
<0.10 EU per 1 µg of the antibody by the LAL method.
accessionNumbers :
P26618
applications :
Western Blot, Immunohistochemistry, Neutralization
USD 2021 :
129
USD 2022 :
135 USD
alt name :
alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a, CD140a antigen, EC 2.7.10, EC 2.7.10.1, MGC74795, PDGFR alpha, PDGFR2, PDGFRA, PDGFRA/BCR fusion, PDGF-R-alpha, platelet-derived growth factor receptor, alpha polypeptide, rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein, RHEPDGFRA
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.