product summary
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company name :
R&D Systems
product type :
antibody
product name :
Rat TrkA Antibody
catalog :
AF1056
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section
more info or order :
citations: 33
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 2e
Wang R, Cao X, Kulej K, Liu W, Ma T, MacDonald M, et al. Uncovering BRD4 hyperphosphorylation associated with cellular transformation in NUT midline carcinoma. Proc Natl Acad Sci U S A. 2017;114:E5352-E5361 pubmed publisher
Tanaka T, Isonishi A, Banja M, Yamamoto R, Sonobe M, Okuda Ashitaka E, et al. Dermal macrophages control tactile perception under physiological conditions via NGF signaling. Sci Rep. 2024;14:27192 pubmed publisher
Koui Y, Song S, Dong X, Mukouyama Y. Local keratinocyte-nociceptor interactions enhance obesity-mediated small fiber neuropathy via NGF-TrkA-PI3K signaling axis. bioRxiv. 2024;: pubmed publisher
Cameron B, Torres Hernandez L, Montague V, Lewis K, Smith H, Fox J, et al. Titin is a nucleolar protein in neurons. Res Sq. 2024;: pubmed publisher
Frezel N, Ranucci M, Foster E, Wende H, Pelczar P, Mendes R, et al. c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy. Cell Rep. 2023;42:112295 pubmed publisher
Albisetti G, Ganley R, Pietrafesa F, Werynska K, Magalhaes de Sousa M, Sipione R, et al. Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold. Neuron. 2023;111:92-105.e5 pubmed publisher
Bogdan D, Studholme K, DiBua A, Gordon C, Kanjiya M, Yu M, et al. FABP5 deletion in nociceptors augments endocannabinoid signaling and suppresses TRPV1 sensitization and inflammatory pain. Sci Rep. 2022;12:9241 pubmed publisher
Kanehisa K, Koga K, Maejima S, Shiraishi Y, Asai K, Shiratori Hayashi M, et al. Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch. Nat Commun. 2022;13:2367 pubmed publisher
Yang N, Isensee J, Neel D, Quadros A, Zhang H, Lauzadis J, et al. Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons. Nat Neurosci. 2022;25:168-179 pubmed publisher
Muzyka V, Badea T. Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification. Neural Dev. 2021;16:5 pubmed publisher
Landy M, Goyal M, Lai H. Nociceptor subtypes are born continuously over DRG development. Dev Biol. 2021;479:91-98 pubmed publisher
Nencini S, Morgan M, Thai J, Jobling A, Mazzone S, Ivanusic J. Piezo2 Knockdown Inhibits Noxious Mechanical Stimulation and NGF-Induced Sensitization in A-Delta Bone Afferent Neurons. Front Physiol. 2021;12:644929 pubmed publisher
Matsumoto K, Suenaga M, Mizutani Y, Matsui K, Yoshida A, Nakamoto T, et al. Role of transient receptor potential vanilloid subtype 2 in lower oesophageal sphincter in rat acid reflux oesophagitis. J Pharmacol Sci. 2021;146:125-135 pubmed publisher
Landy M, Goyal M, Casey K, Liu C, Lai H. Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation. Cell Rep. 2021;34:108913 pubmed publisher
Morgan M, Thai J, Trinh P, Habib M, Effendi K, Ivanusic J. ASIC3 inhibition modulates inflammation-induced changes in the activity and sensitivity of Aδ and C fiber sensory neurons that innervate bone. Mol Pain. 2020;16:1744806920975950 pubmed publisher
de Clauser L, Luiz A, Santana Varela S, Wood J, Sikandar S. Sensitization of Cutaneous Primary Afferents in Bone Cancer Revealed by In Vivo Calcium Imaging. Cancers (Basel). 2020;12: pubmed publisher
Roome R, Bourojeni F, Mona B, Rastegar Pouyani S, Blain R, Dumouchel A, et al. Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans. Cell Rep. 2020;33:108425 pubmed publisher
Faure L, Wang Y, Kastriti M, Fontanet P, Cheung K, Petitpré C, et al. Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates. Nat Commun. 2020;11:4175 pubmed publisher
Shaqura M, Li L, Mohamed D, Li X, Treskatsch S, Buhrmann C, et al. Neuronal aldosterone elicits a distinct genomic response in pain signaling molecules contributing to inflammatory pain. J Neuroinflammation. 2020;17:183 pubmed publisher
Wang Y, Wu H, Zelenin P, Fontanet P, Wanderoy S, Petitpré C, et al. Muscle-selective RUNX3 dependence of sensorimotor circuit development. Development. 2019;146: pubmed publisher
Wang Y, Wu H, Fontanet P, Codeluppi S, Akkuratova N, Petitpré C, et al. A cell fitness selection model for neuronal survival during development. Nat Commun. 2019;10:4137 pubmed publisher
Ding X, Wang H, Qian X, Han X, Yang L, Cao Y, et al. Panicle-Shaped Sympathetic Architecture in the Spleen Parenchyma Modulates Antibacterial Innate Immunity. Cell Rep. 2019;27:3799-3807.e3 pubmed publisher
Bersellini Farinotti A, Wigerblad G, Nascimento D, Bas D, Morado Urbina C, Nandakumar K, et al. Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons. J Exp Med. 2019;: pubmed publisher
Wiszniak S, Schwarz Q. Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration. BMC Neurosci. 2019;20:21 pubmed publisher
Bartesaghi L, Wang Y, Fontanet P, Wanderoy S, Berger F, Wu H, et al. PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis. Cell Rep. 2019;26:3484-3492.e4 pubmed publisher
Chen H, Hu B, Lv X, Zhu S, Zhen G, Wan M, et al. Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis. Nat Commun. 2019;10:181 pubmed publisher
Schaefer I, Prato V, Arcourt A, Taberner F, Lechner S. Differential modulation of voltage-gated sodium channels by nerve growth factor in three major subsets of TrkA-expressing nociceptors. Mol Pain. 2018;14:1744806918814640 pubmed publisher
Chakrabarti S, Pattison L, Singhal K, Hockley J, Callejo G, Smith E. Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner. Neuropharmacology. 2018;143:49-62 pubmed publisher
Tashima R, Koga K, Sekine M, Kanehisa K, Kohro Y, Tominaga K, et al. Optogenetic Activation of Non-Nociceptive Aβ Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats. Eneuro. 2018;5: pubmed publisher
Chartier S, Mitchell S, Majuta L, Mantyh P. The Changing Sensory and Sympathetic Innervation of the Young, Adult and Aging Mouse Femur. Neuroscience. 2018;387:178-190 pubmed publisher
Chartier S, Mitchell S, Majuta L, Mantyh P. Immunohistochemical localization of nerve growth factor, tropomyosin receptor kinase A, and p75 in the bone and articular cartilage of the mouse femur. Mol Pain. 2017;13:1744806917745465 pubmed publisher
Price E, Krasowska Zoladek A, Nanda K, Stachel S, Henze D. Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway. J Neurosci Methods. 2017;282:34-42 pubmed publisher
Usoskin D, Furlan A, Islam S, Abdo H, Lönnerberg P, Lou D, et al. Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nat Neurosci. 2015;18:145-53 pubmed publisher
product information
master code :
AF1056
SKU :
AF1056
product name :
Rat TrkA Antibody
unit size :
100 ug (also 25 ug)
description :
The Rat TrkA Antibody from R&D Systems is a goat polyclonal antibody to TrkA. This antibody reacts with human,mouse,rat,transgenic mouse,xenograft. The Rat TrkA Antibody has been validated for the following applications: Immunohistochemistry,ELISA Development (Capture),IHC-F,Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry-Frozen,Immunocytochemistry.
target :
TrkA
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant rat TrkA, Ala33-Pro418, Accession # P35739
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Rat,Transgenic Mouse,Xenograft
specificity :
Detects rat TrkA in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human TrkA and less than 1% cross-reactivity with recombinant mouse (rm) TrkB and rmTrkC is observed.
gene symbol :
NTRK1
top caption :
Detection of Rat TrkA antibody by Western Blot.
accessionNumbers :
P35739
applications :
Immunohistochemistry,ELISA Development (Capture),IHC-F,Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry-Frozen,Immunocytochemistry
USD :
499 USD
alt names :
DKFZp781I14186, EC 2.7.10, EC 2.7.10.1, MTChigh affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, neurotrophic tyrosine kinase, receptor, type 1, NTRK1, NTRK-1, p140-TrkA, TRK1-transforming tyrosine kinase protein, Trk-A, TRKAOncogene TRK, TRKTRK1, tyrosine kinase receptor A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.