product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse Cathepsin D Antibody
catalog :
AF1029
quantity :
100 ug (also 25 ug)
price :
519 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 41
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 6a
Reifschneider A, Robinson S, van Lengerich B, Gnörich J, Logan T, Heindl S, et al. Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. EMBO J. 2022;41:e109108 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 6h
Takahashi K, Nakamura S, Otsu W, Shimazawa M, Hara H. Progranulin deficiency in Iba-1+ myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation. J Neuroinflammation. 2021;18:164 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 3a
Frew J, Nygaard H. Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice. Acta Neuropathol Commun. 2021;9:57 pubmed publisher
Ford N, Benedeck R, Mattoon M, Peterson J, Mesler A, Veniaminova N, et al. Hair follicles modulate skin barrier function. bioRxiv. 2024;: pubmed publisher
Takahashi H, Bhagwagar S, Nies S, Ye H, Han X, Chiasseu M, et al. Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase. Nat Commun. 2024;15:1434 pubmed publisher
He Y, Kaya I, Shariatgorji R, Lundkvist J, Wahlberg L, Nilsson A, et al. Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents. Nat Commun. 2023;14:5804 pubmed publisher
Ebrahimi Samani S, Kaartinen M. Increased Osteoclastogenesis in Absence of TG2 Is Reversed by Transglutaminase Inhibition-Evidence for the Role for TG1 in Osteoclast Formation. Cells. 2023;12: pubmed publisher
Feng T, Minevich G, Liu P, Qin H, Wozniak G, Pham J, et al. AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b-/-Grn-/- mice. iScience. 2023;26:107247 pubmed publisher
Zhang T, Pang W, Feng T, Guo J, Wu K, Nunez Santos M, et al. TMEM106B regulates microglial proliferation and survival in response to demyelination. Sci Adv. 2023;9:eadd2676 pubmed publisher
Davis S, Cook A, Hall J, Voskobiynyk Y, Carullo N, Boyle N, et al. Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations. Acta Neuropathol Commun. 2023;11:70 pubmed publisher
DU H, Yang C, Nana A, Seeley W, Smolka M, Hu F. Progranulin inhibits phospholipase sPLA2-IIA to control neuroinflammation. bioRxiv. 2023;: pubmed publisher
Yu J, Yang X, Zheng J, Sgobio C, Sun L, Cai H. Deficiency of Perry syndrome-associated p150Glued in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities. NPJ Parkinsons Dis. 2023;9:35 pubmed publisher
Tunganuntarat J, Kanjanasirirat P, Khumpanied T, Benjaskulluecha S, Wongprom B, Palaga T, et al. BORC complex specific components and Kinesin-1 mediate autophagy evasion by the autophagy-resistant Mycobacterium tuberculosis Beijing strain. Sci Rep. 2023;13:1663 pubmed publisher
Pedram K, Laqtom N, Shon D, Di Spiezio A, Riley N, Saftig P, et al. Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals. Proc Natl Acad Sci U S A. 2022;119:e2117105119 pubmed publisher
Xie Y, Naseri N, Fels J, Kharel P, Na Y, Lane D, et al. Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models. Nat Commun. 2022;13:4918 pubmed publisher
Ratto E, Chowdhury S, Siefert N, Schneider M, Wittmann M, Helm D, et al. Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly. Nat Commun. 2022;13:4848 pubmed publisher
Santos M, Paushter D, Zhang T, Wu X, Feng T, Lou J, et al. Progranulin-derived granulin E and lysosome membrane protein CD68 interact to reciprocally regulate their protein homeostasis. J Biol Chem. 2022;298:102348 pubmed publisher
Jung H, Lee S, Lim S, Choi H, Choi Y, Kim M, et al. Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein. Nat Med. 2022;28:1802-1812 pubmed publisher
Barutta F, Bellini S, Kimura S, Hase K, Corbetta B, Corbelli A, et al. Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy. Autophagy. 2022;:1-20 pubmed publisher
Skop xe1 l A, K xe9 ki T, T xf3 th P, Cs xf3 ka B, Koscs xf3 B, N xe9 meth Z, et al. Cathepsin D interacts with adenosine A2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signaling. J Biol Chem. 2022;298:101888 pubmed publisher
Feng T, Luan L, Katz I, Ullah M, Van Deerlin V, Trojanowski J, et al. TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss. Acta Neuropathol Commun. 2022;10:33 pubmed publisher
Uehara K, Koyanagi Aoi M, Koide T, Itoh T, Aoi T. Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids. Stem Cell Reports. 2022;17:820-834 pubmed publisher
Sun J, Liu Y, Hao X, Lin W, Su W, Chiang E, et al. LAMTOR1 inhibition of TRPML1-dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function. EMBO J. 2022;41:e108119 pubmed publisher
Takahashi K, Nakamura S, Shimazawa M, Hara H. Retinal Degeneration and Microglial Dynamics in Mature Progranulin-Deficient Mice. Int J Mol Sci. 2021;22: pubmed publisher
Pescosolido M, Ouyang Q, Liu J, Morrow E. Loss of Christianson Syndrome Na+/H+ Exchanger 6 (NHE6) Causes Abnormal Endosome Maturation and Trafficking Underlying Lysosome Dysfunction in Neurons. J Neurosci. 2021;41:9235-9256 pubmed publisher
Davis S, Roth J, Aljabi Q, Hakim A, Savell K, Day J, et al. Delivering progranulin to neuronal lysosomes protects against excitotoxicity. J Biol Chem. 2021;:100993 pubmed publisher
DU H, Wong M, Zhang T, Santos M, Hsu C, Zhang J, et al. A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses. Life Sci Alliance. 2021;4: pubmed publisher
Alcaraz L, Mallavialle A, David T, Derocq D, Delolme F, Dieryckx C, et al. A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment. Theranostics. 2021;11:6173-6192 pubmed publisher
Lee J, Kim J, Noh S, Lee H, Lee S, Mun J, et al. Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis. Nature. 2020;: pubmed publisher
Ketterer S, Mitschke J, Ketscher A, Schlimpert M, Reichardt W, Baeuerle N, et al. Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling. Nat Commun. 2020;11:5133 pubmed publisher
Huang M, Modeste E, Dammer E, Merino P, Taylor G, Duong D, et al. Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations. Acta Neuropathol Commun. 2020;8:163 pubmed publisher
Feng T, Mai S, Roscoe J, Sheng R, Ullah M, Zhang J, et al. Loss of TMEM106B and PGRN leads to severe lysosomal abnormalities and neurodegeneration in mice. EMBO Rep. 2020;21:e50219 pubmed publisher
Ziros P, Renaud C, Chartoumpekis D, Bongiovanni M, Habeos I, Liao X, et al. Mice Hypomorphic for Keap1, a Negative Regulator of the Nrf2 Antioxidant Response, Show Age-Dependent Diffuse Goiter with Elevated Thyrotropin Levels. Thyroid. 2021;31:23-35 pubmed publisher
Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed publisher
Shao Q, Yang M, Liang C, Ma L, Zhang W, Jiang Z, et al. C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis. Autophagy. 2019;:1-16 pubmed publisher
Atiskova Y, Bartsch S, Danyukova T, Becker E, Hagel C, Storch S, et al. Mice deficient in the lysosomal enzyme palmitoyl-protein thioesterase 1 (PPT1) display a complex retinal phenotype. Sci Rep. 2019;9:14185 pubmed publisher
Koenig U, Robenek H, Barresi C, Brandstetter M, Resch G, Groger M, et al. Cell death induced autophagy contributes to terminal differentiation of skin and skin appendages. Autophagy. 2020;16:932-945 pubmed publisher
Kishimoto A, Kimura S, Nio Kobayashi J, Takahashi Iwanaga H, Park A, Iwanaga T. Histochemical characteristics of regressing vessels in the hyaloid vascular system of neonatal mice: Novel implication for vascular atrophy. Exp Eye Res. 2018;172:1-9 pubmed publisher
Walenbergh S, Houben T, Rensen S, Bieghs V, Hendrikx T, van Gorp P, et al. Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention. Sci Rep. 2016;6:38278 pubmed publisher
Kretzer N, Theisen D, Tussiwand R, Briseño C, Grajales Reyes G, Wu X, et al. RAB43 facilitates cross-presentation of cell-associated antigens by CD8?+ dendritic cells. J Exp Med. 2016;213:2871-2883 pubmed
Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, et al. A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Sci Adv. 2016;2:e1601167 pubmed publisher
product information
master code :
AF1029
SKU :
AF1029
product name :
Mouse Cathepsin D Antibody
unit size :
100 ug (also 25 ug)
description :
The Mouse Cathepsin D Antibody from R&D Systems is a goat polyclonal antibody to Cathepsin D. This antibody reacts with human,mouse,rat,transgenic mouse. The Mouse Cathepsin D Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunoprecipitation,Functional Assay,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Immunocytochemistry/ Immunofluorescence.
target :
Cathepsin D
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse Cathepsin D, Ile21-Leu410, Accession # Q3UCD9
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Transgenic Mouse
specificity :
Detects mouse Cathepsin D in direct ELISAs and Western blots.
gene symbol :
CTSD
top caption :
Detection of Mouse Cathepsin D antibody by Western Blot.
accessionNumbers :
Q3UCD9
applications :
Western Blot,Immunohistochemistry,Immunoprecipitation,Functional Assay,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Immunocytochemistry/ Immunofluorescence
USD :
519 USD
alt names :
cathepsin D, cathepsin D (lysosomal aspartyl protease), CPSD, CTSD, EC 3.4.23, EC 3.4.23.5, lysosomal aspartyl peptidase, lysosomal aspartyl protease, MGC2311, neuronal 10
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.