Human Cathepsin D Antibody | R&D Systems AF1014 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Cathepsin D Antibody

catalog :

AF1014

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 21

Reference
Cardoso M, Hall M, Burgoyne T, Falé P, Storm T, Escrevente C, et al. Impaired Lysosome Reformation in Chloroquine-Treated Retinal Pigment Epithelial Cells. Invest Ophthalmol Vis Sci. 2023;64:10 pubmed publisher
Idera A, Sharkey L, Kurauchi Y, Kadoyama K, Paulson H, Katsuki H, et al. Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways. J Pharmacol Sci. 2023;152:182-192 pubmed publisher
Ercan H, Resch U, Hsu F, Mitulovic G, Bileck A, Gerner C, et al. A Practical and Analytical Comparative Study of Gel-Based Top-Down and Gel-Free Bottom-Up Proteomics Including Unbiased Proteoform Detection. Cells. 2023;12: pubmed publisher
Kovalyova Y, Bak D, Gordon E, Fung C, Shuman J, Cover T, et al. An infection-induced oxidation site regulates legumain processing and tumor growth. Nat Chem Biol. 2022;18:698-705 pubmed publisher
Espinosa R, Gutiérrez K, Rios J, Ormeño F, Yantén L, Galaz Davison P, et al. Palmitic and Stearic Acids Inhibit Chaperone-Mediated Autophagy (CMA) in POMC-like Neurons In Vitro. Cells. 2022;11: pubmed publisher
Vargas G, Cort xe9 s O, Arias Mu xf1 oz E, Hern xe1 ndez S, Cerda Troncoso C, Hern xe1 ndez L, et al. Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival. Front Cell Dev Biol. 2022;10:743287 pubmed publisher
Devireddy S, Ferguson S. Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo. J Cell Biol. 2022;221: pubmed publisher
van der Beek J, de Heus C, Liv N, Klumperman J. Quantitative correlative microscopy reveals the ultrastructural distribution of endogenous endosomal proteins. J Cell Biol. 2022;221: pubmed publisher
Benedetti L. Optogenetic Tools for Manipulating Protein Subcellular Localization and Intracellular Signaling at Organelle Contact Sites. Curr Protoc. 2021;1:e71 pubmed publisher
Ferdoushi A, Li X, Griffin N, Faulkner S, Jamaluddin M, Gao F, et al. Schwann Cell Stimulation of Pancreatic Cancer Cells: A Proteomic Analysis. Front Oncol. 2020;10:1601 pubmed publisher
Dissanayake K, Nõmm M, Lättekivi F, Ressaissi Y, Godakumara K, Lavrits A, et al. Individually cultured bovine embryos produce extracellular vesicles that have the potential to be used as non-invasive embryo quality markers. Theriogenology. 2020;149:104-116 pubmed publisher
Frew J, Baradaran Heravi A, Balgi A, Wu X, Yan T, Arns S, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Mol Neurodegener. 2020;15:21 pubmed publisher
Kakimoto Y, Sasaki A, Niioka M, Kawabe N, Osawa M. Myocardial cathepsin D is downregulated in sudden cardiac death. PLoS ONE. 2020;15:e0230375 pubmed publisher
DE Campos C, Zhu Y, Sepetov N, Romanov S, Bruins L, Shi C, et al. Identification of PIKfyve kinase as a target in multiple myeloma. Haematologica. 2020;105:1641-1649 pubmed publisher
Ishii S, Matsuura A, Itakura E. Identification of a factor controlling lysosomal homeostasis using a novel lysosomal trafficking probe. Sci Rep. 2019;9:11635 pubmed publisher
Brahmer A, Neuberger E, Esch Heisser L, Haller N, Jorgensen M, Baek R, et al. Platelets, endothelial cells and leukocytes contribute to the exercise-triggered release of extracellular vesicles into the circulation. J Extracell Vesicles. 2019;8:1615820 pubmed publisher
Gao X, De Mazière A, Iaea D, Arthur C, Klumperman J, Ciferri C, et al. Visualizing the cellular route of entry of a cystine-knot peptide with Xfect transfection reagent by electron microscopy. Sci Rep. 2019;9:6907 pubmed publisher
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Cui Y, Carosi J, Yang Z, Ariotti N, Kerr M, Parton R, et al. Retromer has a selective function in cargo sorting via endosome transport carriers. J Cell Biol. 2019;218:615-631 pubmed publisher
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product information

brand :

R&D Systems

master code :

AF1014

SKU :

AF1014

product name :

Human Cathepsin D Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human Cathepsin D Antibody from R&D Systems is a goat polyclonal antibody to Cathepsin D. This antibody reacts with canine,gerbil,human,mouse,xenograft. The Human Cathepsin D Antibody has been validated for the following applications: Western Blot,Immunoprecipitation,Electron Microscopy,Microarray,Immunohistochemistry-Frozen,Immunocytochemistry,Immunohistochemistry,Simple Western.

target :

Cathepsin D

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Simple Western 50 ug/mL, Immunohistochemistry 5-15 ug/mL, Immunoprecipitation 25 ug/mL

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Cathepsin D, Leu21-Leu412, Accession # P07339

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Canine,Gerbil,Human,Mouse

specificity :

Detects human Cathepsin D in direct ELISAs and Western blots. In direct ELISAs, approximately 20% cross-reactivity with recombinant mouse (rm) Cathepsin D is observed.

gene symbol :

CTSD

top caption :

Detection of Human Cathepsin D antibody by Western Blot.

accessionNumbers :

P07339

applications :

Immunohistochemistry,Simple Western,Immunoprecipitation,Western Blot,Immunohistochemistry-Frozen,Electron Microscopy,Microarray,Immunocytochemistry

USD :

499 USD

alt names :

cathepsin D, cathepsin D (lysosomal aspartyl protease), CPSD, CTSD, EC 3.4.23, EC 3.4.23.5, lysosomal aspartyl peptidase, lysosomal aspartyl protease, MGC2311, neuronal 10

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage