Rat TNF-alpha Antibody | R&D Systems AF-510-NA product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Rat TNF-alpha Antibody

catalog :

AF-510-NA

quantity :

100 ug (also 25 ug)

price :

509 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

rat

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 28

Reference
Tang H, Zhang X, Hao X, Dou H, Zou C, Zhou Y, et al. Hepatocyte growth factor-modified hair follicle stem cells ameliorate cerebral ischemia/reperfusion injury in rats. Stem Cell Res Ther. 2023;14:25 pubmed publisher
Nagayach A, Bhaskar R, Patro I. Microglia activation and inflammation in hippocampus attenuates memory and mood functions during experimentally induced diabetes in rat. J Chem Neuroanat. 2022;125:102160 pubmed publisher
Li Q, Chen S, Liu J, Yao P, Duan Y, Li Y, et al. Neuroinflammation in the anterior cingulate cortex: the potential supraspinal mechanism underlying the mirror-image pain following motor fiber injury. J Neuroinflammation. 2022;19:162 pubmed publisher
Xu T, Li X, Guo Y, Uhlin E, Holmberg L, Mitra S, et al. Multiple therapeutic effects of human neural stem cells derived from induced pluripotent stem cells in a rat model of post-traumatic syringomyelia. EBioMedicine. 2022;77:103882 pubmed publisher
Cheng F, Liu J, Guo Z, Li S, Chen J, Tu C, et al. Angiotensin-(1-7) ameliorates high glucose-induced vascular endothelial injury through suppressing chloride channel 3. Bioengineered. 2022;13:4100-4111 pubmed publisher
Wang Z, Xia Y, Wu Z, Kang S, Zhang J, Liu P, et al. Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer's disease pathology in a mouse model. Prog Neurobiol. 2022;209:102212 pubmed publisher
Balzano T, Leone P, Ivaylova G, Castro M, Reyes L, Ramón C, et al. Rifaximin Prevents T-Lymphocytes and Macrophages Infiltration in Cerebellum and Restores Motor Incoordination in Rats with Mild Liver Damage. Biomedicines. 2021;9: pubmed publisher
Malaguarnera M, Balzano T, Castro M, Llansola M, Felipo V. The Dual Role of the GABAA Receptor in Peripheral Inflammation and Neuroinflammation: A Study in Hyperammonemic Rats. Int J Mol Sci. 2021;22: pubmed publisher
Koizumi M, Asano S, Furukawa A, Hayashi Y, Hitomi S, Shibuta I, et al. P2X3 receptor upregulation in trigeminal ganglion neurons through TNFα production in macrophages contributes to trigeminal neuropathic pain in rats. J Headache Pain. 2021;22:31 pubmed publisher
Fern xe1 ndez Arjona M, Le xf3 n Rodr xed guez A, L xf3 pez xc1 valos M, Grondona J. Microglia activated by microbial neuraminidase contributes to ependymal cell death. Fluids Barriers CNS. 2021;18:15 pubmed publisher
Liu Y, Fu H, Wu Y, Nie B, Liu F, Wang T, et al. Elamipretide (SS-31) Improves Functional Connectivity in Hippocampus and Other Related Regions Following Prolonged Neuroinflammation Induced by Lipopolysaccharide in Aged Rats. Front Aging Neurosci. 2021;13:600484 pubmed publisher
Wang Z, Xia Y, Liu P, Liu X, Edgington Mitchell L, Lei K, et al. ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease. Prog Neurobiol. 2021;202:102032 pubmed publisher
Ren S, Breuillaud L, Yao W, Yin T, Norris K, Zehntner S, et al. TNF-α-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2R47H rats. J Biol Chem. 2021;296:100089 pubmed publisher
Guimarães N, Alves D, Vilela W, de Souza Ferreira E, Gomes B, Ott D, et al. Mitochondrial pyruvate carrier as a key regulator of fever and neuroinflammation. Brain Behav Immun. 2021;92:90-101 pubmed publisher
Shi Y, Sun C, Ge W, Du Y, Hu N. Circular RNA VMA21 ameliorates sepsis-associated acute kidney injury by regulating miR-9-3p/SMG1/inflammation axis and oxidative stress. J Cell Mol Med. 2020;24:11397-11408 pubmed publisher
Ren S, Yao W, Tambini M, Yin T, Norris K, D ADAMIO L. Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels. elife. 2020;9: pubmed publisher
Liang C, Shaw S, Ko Y, Huang Y, Lee T. Effect of amniotic fluid stem cell transplantation on the recovery of bladder dysfunction in spinal cord-injured rats. Sci Rep. 2020;10:10030 pubmed publisher
Kim J, Park H, Lee J, Kang T. CDDO-Me Inhibits Microglial Activation and Monocyte Infiltration by Abrogating NFκB- and p38 MAPK-Mediated Signaling Pathways Following Status Epilepticus. Cells. 2020;9: pubmed publisher
Kim M, Park H, Choi S, Kong M, Kim J, Kang T. CDDO-Me Attenuates Vasogenic Edema and Astroglial Death by Regulating NF-κB p65 Phosphorylations and Nrf2 Expression Following Status Epilepticus. Int J Mol Sci. 2019;20: pubmed publisher
Wang Z, Xiang J, Liu X, Yu S, Manfredsson F, Sandoval I, et al. Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease. Cell Rep. 2019;28:655-669.e5 pubmed publisher
Malaguarnera M, Llansola M, Balzano T, Gómez Giménez B, Antúnez Muñoz C, Martínez Alarcón N, et al. Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors. Front Pharmacol. 2019;10:132 pubmed publisher
Lai H, Lu C, Wong C, Lin B, Chan S, Kuo C, et al. Baicalein attenuates neuropathic pain and improves sciatic nerve function recovery in rats with partial sciatic nerve transection. J Chin Med Assoc. 2018;81:955-963 pubmed publisher
Zhao Y, Pan Y, Tang M, Lin W. Blocking p38 Signaling Reduces the Activation of Pro-inflammatory Cytokines and the Phosphorylation of p38 in the Habenula and Reverses Depressive-Like Behaviors Induced by Neuroinflammation. Front Pharmacol. 2018;9:511 pubmed publisher
Ma L, Jiang Y, Dong Y, Gao J, Du B, Liu D. Anti-TNF-alpha antibody attenuates subarachnoid hemorrhage-induced apoptosis in the hypothalamus by inhibiting the activation of Erk. Neuropsychiatr Dis Treat. 2018;14:525-536 pubmed publisher
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product information

master code :

AF-510-NA

SKU :

AF-510-NA

product name :

Rat TNF-alpha Antibody

unit size :

100 ug (also 25 ug)

description :

The Rat TNF-alpha Antibody from R&D Systems is a goat polyclonal antibody to TNF-alpha. This antibody reacts with rat,transgenic rat. The Rat TNF-alpha Antibody has been validated for the following applications: Neutralization,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry.

target :

TNF-alpha

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

E. coli -derived recombinant rat TNF-alpha , Leu80-Leu235, Accession # P16599

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Rat,Transgenic Rat

specificity :

Detects rat TNF-alpha in direct ELISAs and Western blots. In Western blots, approximately 25% cross-reactivity with recombinant porcine TNF-alpha is observed and less than 1% cross-reactivity with recombinant human (rh) TNF┐▀, rhTNF sRI, and rhTNF sRII is observed. In direct ELISAs, approximately 40% cross-reactivity with recombinant canine TNF-alpha , recombinant feline TNF-alpha , and recombinant rhesus macaque TNF-alpha is observed. Neutralizes the biological activity of rat TNF-alpha . This antibody will also neutralize the biological activity of murine TNF-alpha , but weak neutralization of rhTNF-alpha and no neutralization of rhTNF┐▀ was observed.

gene symbol :

TNF

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Cytotoxicity Induced by TNF-a and Neutralization by Rat TNF-a Antibody.

accessionNumbers :

P16599

applications :

Immunohistochemistry,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

509 USD

alt names :

APC1 protein, Cachectin, Cachetin, DIF, TNF, TNF, monocyte-derived, TNF-a, TNFA, TNFalpha, TNF-alphacachectin, TNFATNF, macrophage-derived, TNFG1F, TNFSF1A, TNFSF2, TNFSF2TNF superfamily, member 2, tumor necrosis factor, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage