Mouse CCL2/JE/MCP-1 Antibody | R&D Systems AF-479-NA product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse CCL2/JE/MCP-1 Antibody

catalog :

AF-479-NA

quantity :

100 ug (also 25 ug)

price :

519 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, dot blot

more info or order :

R&D Systems product webpage

citations: 18

Reference
de Souza S, Rosario Claudio J, Sim J, Inyang K, Dagenais A, Monahan K, et al. Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response. Brain Behav Immun. 2024;116:193-202 pubmed publisher
Hong J, Son M, Sin J, Kim H, Chung D. Nanoparticles of Lactiplantibacillus plantarum K8 Reduce Staphylococcus aureus Respiratory Infection and Tumor Necrosis Factor Alpha- and Interferon Gamma-Induced Lung Inflammation. Nutrients. 2023;15: pubmed publisher
Ye Q, Jo J, Wang C, Oh H, Choy T, Kim K, et al. Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a NO-CCL2-CCR2 pathway. bioRxiv. 2023;: pubmed publisher
Komori T, Morikawa Y. Essential roles of the cytokine oncostatin M in crosstalk between muscle fibers and immune cells in skeletal muscle after aerobic exercise. J Biol Chem. 2022;298:102686 pubmed publisher
Asano H, Hasegawa Ishii S, Arae K, Obara A, Laumet G, Dantzer R, et al. Infiltration of peripheral immune cells into the olfactory bulb in a mouse model of acute nasal inflammation. J Neuroimmunol. 2022;368:577897 pubmed publisher
Suresh M, Yalamanchili G, Rao T, Aktay S, Kralovich A, Shah Y, et al. Hypoxia-inducible factor (HIF)-1α-induced regulation of lung injury in pulmonary aspiration is mediated through NF-kB. FASEB Bioadv. 2022;4:309-328 pubmed publisher
Wang L, Lan J, Tang J, Luo N. MCP-1 targeting: Shutting off an engine for tumor development. Oncol Lett. 2022;23:26 pubmed publisher
Bellomo A, Mondor I, Spinelli L, Lagueyrie M, Stewart B, Brouilly N, et al. Reticular Fibroblasts Expressing the Transcription Factor WT1 Define a Stromal Niche that Maintains and Replenishes Splenic Red Pulp Macrophages. Immunity. 2020;53:127-142.e7 pubmed publisher
Sui A, Chen X, Demetriades A, Shen J, Cai Y, Yao Y, et al. Inhibiting NF-κB Signaling Activation Reduces Retinal Neovascularization by Promoting a Polarization Shift in Macrophages. Invest Ophthalmol Vis Sci. 2020;61:4 pubmed publisher
Zhang X, Li J, Luo S, Wang M, Huang Q, Deng Z, et al. IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation. Arterioscler Thromb Vasc Biol. 2020;40:597-610 pubmed publisher
Colijn S, Muthukumar V, Xie J, Gao S, Griffin C. Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis. Dis Model Mech. 2020;13: pubmed publisher
Gasparitsch M, Schieber A, Schaubeck T, Keller U, Cattaruzza M, Lange Sperandio B. Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy. PLoS ONE. 2019;14:e0226675 pubmed publisher
Sun C, Li X, Guo E, Li N, Zhou B, Lu H, et al. MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis. Oncogene. 2019;: pubmed publisher
He J, Song Y, Li G, Xiao P, Liu Y, Xue Y, et al. Fbxw7 increases CCL2/7 in CX3CR1hi macrophages to promote intestinal inflammation. J Clin Invest. 2019;129:3877-3893 pubmed publisher
Karlen S, Miller E, Wang X, Levine E, Zawadzki R, Burns M. Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration. J Neuroinflammation. 2018;15:344 pubmed publisher
Chen H, Ambadapadi S, Wakefield D, Bartee M, Yaron J, Zhang L, et al. Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection. Sci Rep. 2018;8:13433 pubmed publisher
Zou A, Magee N, Deng F, Lehn S, Zhong C, Zhang Y. Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis. J Biol Chem. 2018;293:8656-8671 pubmed publisher
Cerri C, Genovesi S, Allegra M, Pistillo F, Püntener U, Guglielmotti A, et al. The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation. J Neurosci. 2016;36:3777-88 pubmed publisher

product information

brand :

R&D Systems

master code :

AF-479-NA

SKU :

AF-479-NA

product name :

Mouse CCL2/JE/MCP-1 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Mouse CCL2/JE/MCP-1 Antibody from R&D Systems is a goat polyclonal antibody to CCL2/JE/MCP-1. This antibody reacts with human,mouse,rat,transgenic mouse. The Mouse CCL2/JE/MCP-1 Antibody has been validated for the following applications: Western Blot,Neutralization,In vivo assay,Bioassay,ELISA Development,ELISA Development (Capture),Luminex Development,Flow Cytometry,Dot Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,ELISA Capture (Matched Antibody Pair).

target :

CCL2/JE/MCP-1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.1 ug/mL, Neutralization 0.5-2.5 ug/mL, ELISA Capture (Matched Antibody Pair) 0.2-0.8 ug/mL

host :

Goat

immunogen :

E. coli -derived recombinant mouse CCL2/JE/MCP-1, Gln24-Arg96, Accession # Q5SVU3

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat,Transgenic Mouse

specificity :

Detects mouse CCL2/JE/MCP-1 in ELISAs and Western blots.

gene symbol :

Ccl2

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Recombinant Mouse CCL2/JE/MCP-1 antibody by Western Blot.

accessionNumbers :

Q5SVU3

applications :

ELISA Capture (Matched Antibody Pair),Bioassay,ELISA Development,ELISA Development (Capture),Luminex Development,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Dot Blot,In vivo assay,Neutralization,Immunocytochemistry

USD :

519 USD

alt names :

C-C motif chemokine ligand 2, CCL2, GDCF-2, HC11, HSMCR30, MCAF, Mcp1, MCP-1, SCYA2, SMC-CF

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage