product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse CXCL10/IP-10/CRG-2 Antibody
catalog :
AF-466-NA
quantity :
100 ug (also 25 ug)
price :
519 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments
more info or order :
R&D Systems product webpage
citations: 27
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; mouse; fig 7c
Liang Z, He P, Han Y, Yun C. Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPA5-Dependent Signaling. Cell Mol Gastroenterol Hepatol. 2022;14:129-150 pubmed publisher
Licht Murava A, Meadows S, Palaguachi F, Song S, Jackvony S, Bram Y, et al. Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines. Sci Adv. 2023;9:eade1282 pubmed publisher
Wang S, Kuai Y, Lin S, Li L, Gu Q, Zhang X, et al. NF-κB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer. BMC Med. 2023;21:115 pubmed publisher
Haffner Luntzer M, Weber B, Morioka K, Lackner I, Fischer V, Bahney C, et al. Altered early immune response after fracture and traumatic brain injury. Front Immunol. 2023;14:1074207 pubmed publisher
B xfc low J, Renz N, Haffner Luntzer M, Fischer V, Schoppa A, Tuckermann J, et al. Complement receptor C5aR1 on osteoblasts regulates osteoclastogenesis in experimental postmenopausal osteoporosis. Front Endocrinol (Lausanne). 2022;13:1016057 pubmed publisher
Chryplewicz A, Scotton J, Tichet M, Zomer A, Shchors K, Joyce J, et al. Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity. Cancer Cell. 2022;40:1111-1127.e9 pubmed publisher
Perdigoto A, Deng S, Du K, Kuchroo M, Burkhardt D, Tong A, et al. Immune cells and their inflammatory mediators modify β cells and cause checkpoint inhibitor-induced diabetes. JCI Insight. 2022;7: pubmed publisher
Igarashi N, Miyata K, Loo T, Chiba M, Hanyu A, Nishio M, et al. Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells. Nat Commun. 2022;13:4157 pubmed publisher
Jie X, Chen Y, Zhao Y, Yang X, Xu Y, Wang J, et al. Targeting KDM4C enhances CD8+ T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer. J Immunother Cancer. 2022;10: pubmed publisher
Somebang K, Rudolph J, Imhof I, Li L, Niemi E, Shigenaga J, et al. CCR2 deficiency alters activation of microglia subsets in traumatic brain injury. Cell Rep. 2021;36:109727 pubmed publisher
Javeed N, Her T, Brown M, Vanderboom P, Rakshit K, Egan A, et al. Pro-inflammatory β cell small extracellular vesicles induce β cell failure through activation of the CXCL10/CXCR3 axis in diabetes. Cell Rep. 2021;36:109613 pubmed publisher
Anastasiou M, Newton G, Kaur K, Carrillo Salinas F, Smolgovsky S, Bayer A, et al. Endothelial STING controls T cell transmigration in an IFNI-dependent manner. JCI Insight. 2021;6: pubmed publisher
Wang J, Zhang Y, Xiao Y, Yuan X, Li P, Wang X, et al. Boosting immune surveillance by low-dose PI3K inhibitor facilitates early intervention of breast cancer. Am J Cancer Res. 2021;11:2005-2024 pubmed
Guldner I, Wang Q, Yang L, Golomb S, Zhao Z, Lopez J, et al. CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10. Cell. 2020;183:1234-1248.e25 pubmed publisher
Sorrentino G, Rezakhani S, Yıldız E, Nuciforo S, Heim M, Lutolf M, et al. Mechano-modulatory synthetic niches for liver organoid derivation. Nat Commun. 2020;11:3416 pubmed publisher
McKinsey G, Lizama C, Keown Lang A, Niu A, Santander N, Larpthaveesarp A, et al. A new genetic strategy for targeting microglia in development and disease. elife. 2020;9: pubmed publisher
Chen Y, Tsai C, Cheng Y, Nieh S, Yeh T, Chen C, et al. Impacts of Intralipid on Nanodrug Abraxane Therapy and on the Innate Immune System. Sci Rep. 2020;10:2838 pubmed publisher
Li L, Shirkey M, Zhang T, Xiong Y, Piao W, Saxena V, et al. The lymph node stromal laminin α5 shapes alloimmunity. J Clin Invest. 2020;130:2602-2619 pubmed publisher
Trittel S, Chambers B, Heise U, Guzman C, Riese P. Key features and homing properties of NK cells in the liver are shaped by activated iNKT cells. Sci Rep. 2019;9:16362 pubmed publisher
Zang J, Ye J, Zhang C, Sha M, Gao J. Senescent hepatocytes enhance natural killer cell activity via the CXCL-10/CXCR3 axis. Exp Ther Med. 2019;18:3845-3852 pubmed publisher
Chen M, Reed R, Lane A. Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense. Cell Stem Cell. 2019;25:501-513.e5 pubmed publisher
Hiyari S, Green E, Pan C, Lari S, Davar M, Davis R, et al. Genomewide Association Study Identifies Cxcl Family Members as Partial Mediators of LPS-Induced Periodontitis. J Bone Miner Res. 2018;33:1450-1463 pubmed publisher
Muramatsu M, Gao L, Peresie J, Balderman B, Akakura S, Gelman I. SSeCKS/AKAP12 scaffolding functions suppress B16F10-induced peritoneal metastasis by attenuating CXCL9/10 secretion by resident fibroblasts. Oncotarget. 2017;8:70281-70298 pubmed publisher
Thaney V, O Neill A, Hoefer M, Maung R, Sanchez A, Kaul M. IFNβ Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury. Sci Rep. 2017;7:46514 pubmed publisher
Li X, Yao Q, Liu H, Jin Q, Xu B, Zhang S, et al. Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease. J Cell Mol Med. 2017;21:2370-2385 pubmed publisher
Okuneva O, Li Z, Körber I, Tegelberg S, Joensuu T, Tian L, et al. Brain inflammation is accompanied by peripheral inflammation in Cstb -/- mice, a model for progressive myoclonus epilepsy. J Neuroinflammation. 2016;13:298 pubmed
Dai Z, Xing L, Cerise J, Wang E, Jabbari A, de Jong A, et al. CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata. J Immunol. 2016;197:1089-99 pubmed publisher
product information
brand :
R&D Systems
master code :
AF-466-NA
SKU :
AF-466-NA
product name :
Mouse CXCL10/IP-10/CRG-2 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Mouse CXCL10/IP-10/CRG-2 Antibody from R&D Systems is a goat polyclonal antibody to CXCL10/IP-10/CRG-2. This antibody reacts with mouse,rat. The Mouse CXCL10/IP-10/CRG-2 Antibody has been validated for the following applications: Immunohistochemistry,Tissue Culture,Flow Cytometry,Western Blot,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry.
target :
CXCL10/IP-10/CRG-2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Neutralization 5-25 ug/mL
host :
Goat
immunogen :
E. coli -derived recombinant mouse CXCL10/IP-10/CRG-2, Ile22-Pro98, Accession # P17515
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Mouse,Rat
specificity :
Detects mouse CXCL10/IP-10/CRG-2 in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant human CXCL10 is observed.
gene symbol :
Cxcl10
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Detection of Mouse CXCL10/IP-10/CRG-2 antibody by Western Blot.
accessionNumbers :
P17515
applications :
Tissue Culture,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry,Functional Assay
USD :
519 USD
alt names :
C7, chemokine (C-X-C motif) ligand 10, crg-2, CRG2, gIP-10, IFI10, INP10, IP-10, mob-1, SCYB10
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.