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company name :
R&D Systems
product type :
antibody
product name :
Mouse IL-6 Antibody
catalog :
AF-406-NA
quantity :
100 ug (also 25 ug)
price :
509 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 27
Reference
Turkkahraman H, Flanagan S, Zhu T, Akel N, Marino S, Ortega Gonzalez D, et al. Sclerostin antibody corrects periodontal disease in type 2 diabetic mice. JCI Insight. 2024;9: pubmed publisher
Zhou X, Hao H, Chen Y, Cao W, Zhu Z, Ni Y, et al. Covalently grafted human serum albumin coating mitigates the foreign body response against silicone implants in mice. Bioact Mater. 2024;34:482-493 pubmed publisher
Liu W, Yalcınkaya M, Maestre I, Olszewska M, Ampomah P, Heimlich J, et al. Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis. Nat Cardiovasc Res. 2023;2:572-586 pubmed publisher
Shang M, Ni L, Shan X, Cui Y, Hu P, Ji Z, et al. MTHFD2 reprograms macrophage polarization by inhibiting PTEN. Cell Rep. 2023;42:112481 pubmed publisher
Jiang A, Wang B, Wang S, Zhao K, Wu H, Yan K, et al. The study of direct and indirect effects of radiofrequency ablation on tumor microenvironment in liver tumor animal model. BMC Cancer. 2022;22:663 pubmed publisher
Petrosino J, Longenecker J, Angell C, Hinger S, Martens C, Accornero F. CCN2 participates in overload-induced skeletal muscle hypertrophy. Matrix Biol. 2022;106:1-11 pubmed publisher
Gerlach B, Ampomah P, Yurdagul A, Liu C, Lauring M, Wang X, et al. Efferocytosis induces macrophage proliferation to help resolve tissue injury. Cell Metab. 2021;33:2445-2463.e8 pubmed publisher
Oelze B, Elger K, Schadzek P, Burmeister L, Hamm A, Laggies S, et al. The inflammatory signalling mediator TAK1 mediates lymphocyte recruitment to lipopolysaccharide-activated murine mesenchymal stem cells through interleukin-6. Mol Cell Biochem. 2021;476:3655-3670 pubmed publisher
Vaught D, Merkel A, Lynch C, Edwards J, Tantawy M, Hilliard T, et al. EphA2 Is a Clinically Relevant Target for Breast Cancer Bone Metastatic Disease. JBMR Plus. 2021;5:e10465 pubmed publisher
Tamura K, Goto Inoue N, Miyata K, Furuichi Y, Fujii N, Manabe Y. Effect of treatment with conditioned media derived from C2C12 myotube on adipogenesis and lipolysis in 3T3-L1 adipocytes. PLoS ONE. 2020;15:e0237095 pubmed publisher
Clark K, Hewett D, Panagopoulos V, Plakhova N, Opperman K, Bradey A, et al. Targeted Disruption of Bone Marrow Stromal Cell-Derived Gremlin1 Limits Multiple Myeloma Disease Progression In Vivo. Cancers (Basel). 2020;12: pubmed publisher
Zuccolo E, Badi I, Scavello F, Gambuzza I, Mancinelli L, Macr xec F, et al. The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification. Int J Mol Sci. 2020;21: pubmed publisher
Hans C, Sharma N, Dev R, Blain J, Tonniges J, Agarwal G. DAPT, a potent Notch inhibitor regresses actively growing abdominal aortic aneurysm via divergent pathways. Clin Sci (Lond). 2020;134:1555-1572 pubmed publisher
Wang J, Liu H, Xie G, Cai W, Xu J. Identification of hub genes and key pathways of dietary advanced glycation end products‑induced non‑alcoholic fatty liver disease by bioinformatics analysis and animal experiments. Mol Med Rep. 2020;21:685-694 pubmed publisher
Jia C, Keasey M, Malone H, Lovins C, Hagg T. Vitronectin mitigates stroke-increased neurogenesis only in female mice and through FAK-regulated IL-6. Exp Neurol. 2020;323:113088 pubmed publisher
Tominaga T, Ma S, Saitou K, Suzuki K. Glucose Ingestion Inhibits Endurance Exercise-Induced IL-6 Producing Macrophage Infiltration in Mice Muscle. Nutrients. 2019;11: pubmed publisher
Pajer K, Bellák T, Redl H, Nogradi A. Neuroectodermal stem cells grafted into the injured spinal cord induce both axonal regeneration and morphological restoration via multiple mechanisms. J Neurotrauma. 2019;: pubmed publisher
Sul O, Rajasekaran M, Park H, Suh J, Choi H. MicroRNA-29b Enhances Osteoclast Survival by Targeting BCL-2-Modifying Factor after Lipopolysaccharide Stimulation. Oxid Med Cell Longev. 2019;2019:6018180 pubmed publisher
Jhun J, Lee S, Kim S, Ryu J, Kwon J, Na H, et al. RIPK1 inhibition attenuates experimental autoimmune arthritis via suppression of osteoclastogenesis. J Transl Med. 2019;17:84 pubmed publisher
Su W, Zhang T, Jiang C, Wang W. Clemastine Alleviates Depressive-Like Behavior Through Reversing the Imbalance of Microglia-Related Pro-inflammatory State in Mouse Hippocampus. Front Cell Neurosci. 2018;12:412 pubmed publisher
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Xu L, Liu T, Wang L, Li L, Wu Y, Li C, et al. 3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation. Oxid Med Cell Longev. 2018;2018:3271617 pubmed publisher
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product information
brand :
R&D Systems
master code :
AF-406-NA
SKU :
AF-406-NA
product name :
Mouse IL-6 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Mouse IL-6 Antibody from R&D Systems is a goat polyclonal antibody to IL-6. This antibody reacts with human,mouse,rabbit. The Mouse IL-6 Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,ELISA Development (Capture),Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry.
target :
IL-6
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.5 ug/mL, Immunohistochemistry 5-15 ug/mL, Neutralization 0.01-0.03 ug/mL, Immunocytochemistry 5-15 ug/mL
host :
Goat
immunogen :
E. coli -derived recombinant mouse IL-6, Phe25-Thr211, Accession # P08505
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Rabbit
specificity :
Detects mouse IL-6 in direct ELISAs and Western blots. In direct ELISAs, approximately 100% cross-reactivity with recombinant rat IL-6 and recombinant cotton rat IL-6 is observed and less than 15% cross-reactivity with recombinant human IL-6 is observed.
gene symbol :
IL6
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Detection of Mouse IL-6 antibody by Western Blot.
accessionNumbers :
P08505
applications :
ELISA Development (Capture),Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry
USD :
509 USD
alt names :
B-cell differentiation factor, B-cell stimulatory factor 2, BSF2, BSF-2, CDF, CTL differentiation factor, HSF, hybridoma growth factor, IFNB2, IFN-beta-2, IL6, IL-6, Interferon beta-2, interleukin 6 (interferon, beta 2), interleukin BSF-2, interleukin-6, MGI-2A
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.