| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry - paraffin section; mouse; loading ...; fig 5l
- western blot; mouse; loading ...; fig 1b, 3b
| Jin Y, Liu Y, Xu L, Xu J, Xiong Y, Peng Y, et al. Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis. Cell Death Dis. 2022;13:512 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4e
| Simpson D, Pang J, Weir A, Kong I, Fritsch M, Rashidi M, et al. Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity. 2022;55:423-441.e9 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2h
| xd8 stergaard J, Jha J, Sharma A, Dai A, Choi J, de Haan J, et al. Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease. Clin Sci (Lond). 2022;136:167-180 pubmed publisher |
- western blot; mouse; loading ...; fig 1d
| Ma M, Li G, Qi M, Jiang W, Zhou R. Inhibition of the Inflammasome Activity of NLRP3 Attenuates HDM-Induced Allergic Asthma. Front Immunol. 2021;12:718779 pubmed publisher |
- immunohistochemistry; mouse; 1:200; loading ...; fig 3e
| Zou Y, Bhat O, Yuan X, Li G, Huang D, Guo Y, et al. Release and Actions of Inflammatory Exosomes in Pulmonary Emphysema: Potential Therapeutic Target of Acupuncture. J Inflamm Res. 2021;14:3501-3521 pubmed publisher |
- immunohistochemistry; human; loading ...; fig 1g
- western blot; human; loading ...; fig 1c
| Chen Q, Liu X, Wang D, Zheng J, Chen L, Xie Q, et al. Periodontal Inflammation-Triggered by Periodontal Ligament Stem Cell Pyroptosis Exacerbates Periodontitis. Front Cell Dev Biol. 2021;9:663037 pubmed publisher |
- immunohistochemistry - paraffin section; rat; 1:200; loading ...; fig 3i
- western blot; rat; 1:2000; loading ...; fig 5k
| Wu M, Ma Y, Chen X, Liang N, Qu S, Chen H. Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency. Dis Model Mech. 2021;14: pubmed publisher |
- western blot; mouse; loading ...; fig 5a
| Li J, Zhang H, Dong Y, Wang X, Wang G. Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice. Front Physiol. 2021;12:628122 pubmed publisher |
| Yao Q, Wen J, Chen S, Wang Y, Wen X, Wang X, et al. Shuangdan Jiedu Decoction improved LPS-induced acute lung injury by regulating both cGAS-STING pathway and inflammasome. J Ethnopharmacol. 2025;336:118661 pubmed publisher |
| Li D, Yang Q, Luo J, Xu Y, Li J, Tao L. Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation. Cell Discov. 2024;10:112 pubmed publisher |
| Zhang Z, Zhan Z, Jiang M, Wang X, Quan S, Wu Y, et al. Casting NETs on Psoriasis: The modulation of inflammatory feedback targeting IL-36/IL-36R axis. Int Immunopharmacol. 2024;142:113190 pubmed publisher |
| Nabukhotna K, Kordus S, Shupe J, Cano Rodr xed guez R, Smith A, Bohannon J, et al. Purified CDT toxins and a clean deletion within the CDT locus provide novel insights into the contribution of binary toxin in cellular inflammation and Clostridioides difficile infection. PLoS Pathog. 2024;20:e1012568 pubmed publisher |
| Liu W, Yang H, Xu Q, Lee J, Sun J, Xue S, et al. Role of MYO1F in neutrophil and macrophage recruitment and pro-inflammatory cytokine production in Aspergillus fumigatus keratitis. Int Immunopharmacol. 2024;142:113094 pubmed publisher |
| Song M, Deng M, Peng Z, Dai F, Wang Y, Shu W, et al. Granulocyte colony-stimulating factor mediates bone loss via the activation of IL-1β/JNK signaling pathway in murine Staphylococcus aureus-induced osteomyelitis. Int Immunopharmacol. 2024;141:112959 pubmed publisher |
| Wang M, Flaswinkel H, Joshi A, Napoli M, Masgrau Alsina S, Kamper J, et al. Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation. Nat Commun. 2024;15:6438 pubmed publisher |
| Sun Y, Lu Y, Liu L, Saaoud F, Shao Y, Xu K, et al. Caspase-4/11 promotes hyperlipidemia and chronic kidney disease-accelerated vascular inflammation by enhancing trained immunity. JCI Insight. 2024;9: pubmed publisher |
| Yow S, Rosli S, Hutchinson P, Chen K. Differential signalling requirements for RIPK1-dependent pyroptosis in neutrophils and macrophages. Cell Death Dis. 2024;15:479 pubmed publisher |
| Kang H, Choi S, Kim J, Oh S, Kim S, Lee M. ER-to-lysosome Ca2+ refilling followed by K+ efflux-coupled store-operated Ca2+ entry in inflammasome activation and metabolic inflammation. elife. 2024;12: pubmed publisher |
| Redmer T, Raigel M, Sternberg C, Ziegler R, Probst C, Lindner D, et al. JUN mediates the senescence associated secretory phenotype and immune cell recruitment to prevent prostate cancer progression. Mol Cancer. 2024;23:114 pubmed publisher |
| Ge X, Han H, Désert R, Das S, Song Z, Komakula S, et al. A Protein Complex of Liver Origin Activates a Pro-inflammatory Program That Drives Hepatic and Intestinal Injury in Alcohol-Associated Liver Disease. Cell Mol Gastroenterol Hepatol. 2024;18:101362 pubmed publisher |
| Tran H, Kratina T, Coutansais A, Michalek D, Hogan B, Lawlor K, et al. RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation. Cell Death Differ. 2024;31:662-671 pubmed publisher |
| Li Y, Wu C, Lee J, Ning Q, Lim J, Eoh H, et al. Hepatitis B virus e antigen induces atypical metabolism and differentially regulates programmed cell deaths of macrophages. PLoS Pathog. 2024;20:e1012079 pubmed publisher |
| Zhan Z, Zhang Z, Sun R, Wu Y, Nan J, Lian L. A therapeutic strategy of parthenolide in improving imiquimod-induced psoriasis-like skin inflammation targeting IL-36/NETs through skin transdermal therapeutic system. Int Immunopharmacol. 2024;131:111824 pubmed publisher |
| Cao F, Chen G, Xu Y, Wang X, Tang X, Zhang W, et al. METTL14 contributes to acute lung injury by stabilizing NLRP3 expression in an IGF2BP2-dependent manner. Cell Death Dis. 2024;15:43 pubmed publisher |
| Lee S, Yun S, Yang H, Lee N, Kim Y, Lee S, et al. Guarea microcarpa C. DC. extract inhibits NLRP3 inflammasome by suppressing its ATPase activity. J Ethnopharmacol. 2024;323:117711 pubmed publisher |
| Cho E, Mun S, Kim H, Ham Y, Gil W, Yang C. Colon-targeted S100A8/A9-specific peptide systems ameliorate colitis and colitis-associated colorectal cancer in mouse models. Acta Pharmacol Sin. 2024;45:581-593 pubmed publisher |
| Exconde P, Hernandez Chavez C, Bourne C, Richards R, Bray M, Lopez J, et al. The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases. Cell Rep. 2023;42:113581 pubmed publisher |
| McCrory C, Verma J, Tucey T, Turner R, Weerasinghe H, Beilharz T, et al. The short-chain fatty acid crotonate reduces invasive growth and immune escape of Candida albicans by regulating hyphal gene expression. MBio. 2023;14:e0260523 pubmed publisher |
| Caronni N, La Terza F, Vittoria F, Barbiera G, Mezzanzanica L, Cuzzola V, et al. IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer. Nature. 2023;623:415-422 pubmed publisher |
| Meibers H, Warrick K, Vonhandorf A, Vallez C, Kawarizadeh K, Saha I, et al. Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells. Cell Rep. 2023;42:113180 pubmed publisher |
| Wong M, Juan E, Chelluri S, Wang P, Pahmeier F, Castillo Rojas B, et al. The Inflammasome Pathway is Activated by Dengue Virus Non-structural Protein 1 and is Protective During Dengue Virus Infection. bioRxiv. 2023;: pubmed publisher |
| Shosha E, Shahror R, Morris C, Xu Z, Lucas R, McGee Lawrence M, et al. The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury. Cell Death Dis. 2023;14:621 pubmed publisher |
| Baldrighi M, Doreth C, Li Y, Zhao X, Warner E, Chenoweth H, et al. PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models. J Clin Invest. 2023;133: pubmed publisher |
| Liu D, Huang Y. Protocol for in vivo and in vitro activation of NLRP3 inflammasome in mice using monosodium urate. STAR Protoc. 2023;4:102554 pubmed publisher |
| Liu H, Zhang L, Liu Z, Lin J, He X, Wu S, et al. Galectin-3 as TREM2 upstream factor contributes to lung ischemia-reperfusion injury by regulating macrophage polarization. iScience. 2023;26:107496 pubmed publisher |
| Sin R, Sotogaku N, Ohnishi Y, Shuto T, Kuroiwa M, Kawahara Y, et al. Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments. Brain Behav Immun. 2023;114:173-186 pubmed publisher |
| Diskin C, Day E, Henry x, Toller Kawahisa J, O Neill L. 4-Octyl Itaconate and Dimethyl Fumarate Induce Secretion of the Anti-Inflammatory Protein Annexin A1 via NRF2. J Immunol. 2023;211:1032-1041 pubmed publisher |
| Rondeaux J, Groussard D, Renet S, Tardif V, Dumesnil A, Chu A, et al. Ezh2 emerges as an epigenetic checkpoint regulator during monocyte differentiation limiting cardiac dysfunction post-MI. Nat Commun. 2023;14:4461 pubmed publisher |
| Bai Y, Min R, Chen P, Mei S, Deng F, Zheng Z, et al. Disulfiram blocks inflammatory TLR4 signaling by targeting MD-2. Proc Natl Acad Sci U S A. 2023;120:e2306399120 pubmed publisher |
| Mutti V, Carini G, Filippini A, Castrezzati S, Giugno L, Gennarelli M, et al. LRRK2 Kinase Inhibition Attenuates Neuroinflammation and Cytotoxicity in Animal Models of Alzheimer's and Parkinson's Disease-Related Neuroinflammation. Cells. 2023;12: pubmed publisher |
| Wang B, Ma Y, Li S, Yao H, Gu M, Liu Y, et al. GSDMD in peripheral myeloid cells regulates microglial immune training and neuroinflammation in Parkinson's disease. Acta Pharm Sin B. 2023;13:2663-2679 pubmed publisher |
| Lentini G, Fam xe0 A, De Gaetano G, Coppolino F, Mahjoub A, Ryan L, et al. Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation. Cell Rep Med. 2023;4:101098 pubmed publisher |
| Hou Y, He H, Ma M, Zhou R. Apilimod activates the NLRP3 inflammasome through lysosome-mediated mitochondrial damage. Front Immunol. 2023;14:1128700 pubmed publisher |
| Leem Y, Kim D, Park J, Kim H. Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and α-synuclein oligomerization in a subacute MPTP mouse model of Parkinson's disease. Sci Rep. 2023;13:8783 pubmed publisher |
| Fang L, Ohashi K, Hayakawa S, Ogawa H, Otaka N, Kawanishi H, et al. Adipolin protects against renal injury via PPARα-dependent reduction of inflammasome activation. iScience. 2023;26:106591 pubmed publisher |
| Zhang Z, Song J, Kwon S, Wang Z, Park S, Piao X, et al. Pirfenidone Inhibits Alveolar Bone Loss in Ligature-Induced Periodontitis by Suppressing the NF-κB Signaling Pathway in Mice. Int J Mol Sci. 2023;24: pubmed publisher |
| Green J, El Sharkawy L, Roth S, Zhu J, Cao J, Leach A, et al. Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome. iScience. 2023;26:106758 pubmed publisher |
| Weerasinghe H, Simm C, Djajawi T, Tedja I, Lo T, Simpson D, et al. Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response. Cell Rep. 2023;42:112522 pubmed publisher |
| Foster S, Dutton A, Yerzhan A, March L, Barry K, Seehus C, et al. A Preliminary Study of Mild Heat Stress on Inflammasome Activation in Murine Macrophages. Cells. 2023;12: pubmed publisher |
| Ren M, Chen J, Xu H, Li W, Wang T, Chi Z, et al. Ergolide covalently binds NLRP3 and inhibits NLRP3 inflammasome-mediated pyroptosis. Int Immunopharmacol. 2023;120:110292 pubmed publisher |
| Liu L, Feng L, Gao J, Hu J, Li A, Zhu Y, et al. Parthenolide targets NLRP3 to treat inflammasome-related diseases. Int Immunopharmacol. 2023;119:110229 pubmed publisher |
| Huang L, Anas M, Xu J, Zhou B, Toth P, Krishnan Y, et al. Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury. elife. 2023;12: pubmed publisher |
| Siopi E, Galerne M, Rivagorda M, Saha S, Moigneu C, Moriceau S, et al. Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice. Mol Psychiatry. 2023;28:3002-3012 pubmed publisher |
| Kang J, Lee S, Seok J, Kim D, Ma G, Park J, et al. Novel Activity of ODZ10117, a STAT3 Inhibitor, for Regulation of NLRP3 Inflammasome Activation. Int J Mol Sci. 2023;24: pubmed publisher |
| Ta A, Ricci Azevedo R, Vasudevan S, Wright S, Kumari P, Havira M, et al. A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3. Nat Commun. 2023;14:2035 pubmed publisher |
| Lee S, Kang J, Sim E, Jung Y, Kim J, Hillman P, et al. Cornus officinalis Seed Extract Inhibits AIM2-Inflammasome Activation and Attenuates Imiquimod-Induced Psoriasis-like Skin Inflammation. Int J Mol Sci. 2023;24: pubmed publisher |
| Jeon Y, Chow S, Stuart I, Weir A, Yeung A, Hale C, et al. FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins. Life Sci Alliance. 2023;6: pubmed publisher |
| Bollenbecker S, Heitman K, Czaya B, Easter M, Hirsch M, Vang S, et al. Phosphate induces inflammation and exacerbates injury from cigarette smoke in the bronchial epithelium. Sci Rep. 2023;13:4898 pubmed publisher |
| Li J, Lin Q, Shao X, Li S, Zhu X, Wu J, et al. HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome. Cell Death Dis. 2023;14:200 pubmed publisher |
| Lin T, Jiang C, Sheng L, Wan L, Fan W, Li J, et al. Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5'-monophosphate-activated protein kinase/heme oxygenase-1 pathway. Neural Regen Res. 2023;18:2067-2074 pubmed publisher |
| Chen Y, Pu J, Li X, Lian L, Ge C, Liu Z, et al. Aim2 Deficiency Ameliorates Lacrimal Gland Destruction and Corneal Epithelium Defects in an Experimental Dry Eye Model. Invest Ophthalmol Vis Sci. 2023;64:26 pubmed publisher |
| Hooftman A, Peace C, Ryan D, Day E, Yang M, McGettrick A, et al. Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Nature. 2023;615:490-498 pubmed publisher |
| Zhong W, Zhang J, Duan J, Zhang C, Ma S, Li Y, et al. TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury. J Transl Med. 2023;21:179 pubmed publisher |
| Xu H, Chen J, Chen P, Li W, Shao J, Hong S, et al. Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases. Acta Pharm Sin B. 2023;13:678-693 pubmed publisher |
| Jang A, Lee H, Hong J, Kim Y, Park J. Ethanol extract of Chrysanthemum zawadskii inhibits the NLRP3 inflammasome by suppressing ASC oligomerization in macrophages. Exp Ther Med. 2023;25:128 pubmed publisher |
| Huang Y, Guo Y, Zhou Y, Huang Q, Ru Y, Luo Y, et al. Tivantinib alleviates inflammatory diseases by directly targeting NLRP3. iScience. 2023;26:106062 pubmed publisher |
| Filippini A, Salvi V, Dattilo V, Magri C, Castrezzati S, Veerhuis R, et al. LRRK2 Kinase Inhibition Attenuates Astrocytic Activation in Response to Amyloid β1-42 Fibrils. Biomolecules. 2023;13: pubmed publisher |
| Exconde P, Hernandez Chavez C, Bray M, Lopez J, Srivastava T, Egan M, et al. The tetrapeptide sequence of IL-1β regulates its recruitment and activation by inflammatory caspases. bioRxiv. 2023;: pubmed publisher |
| Wang Y, Sadike D, Huang B, Li P, Wu Q, Jiang N, et al. Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-κB pathway in LPC-induced demyelination. J Neuroinflammation. 2023;20:41 pubmed publisher |
| Shu X, Wei C, Tu W, Zhong K, Qi S, Wang A, et al. Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome. Cell Rep. 2023;42:112133 pubmed publisher |
| Wang F, Zhang M, Yuan M, Xia Z, Yang F, Zhang S, et al. A novel sorbicillinoid compound as a potent anti-inflammation agent through inducing NLRP3 protein degradation. Br J Pharmacol. 2023;180:1930-1948 pubmed publisher |
| Hendawy N, Salaheldin T, Abuelezz S. PCSK9 Inhibition Reduces Depressive like Behavior in CUMS-Exposed Rats: Highlights on HMGB1/RAGE/TLR4 Pathway, NLRP3 Inflammasome Complex and IDO-1. J Neuroimmune Pharmacol. 2023;18:195-207 pubmed publisher |
| Zhao W, Cao Y, Chen Y, Chen Y, Wang T, Li L, et al. NLRP3 Regulates Mandibular Healing through Interaction with UCHL5 in MSCs. Int J Biol Sci. 2023;19:936-949 pubmed publisher |
| Ramadan A, Cao Z, Gadjeva M, Zaidi T, Rathinam V, Panjwani N. The NLRP3 Inflammasome Is Required for Protection Against Pseudomonas Keratitis. Invest Ophthalmol Vis Sci. 2023;64:11 pubmed publisher |
| Amrute J, Luo X, Penna V, Bredemeyer A, Yamawaki T, Yang S, et al. Targeting Immune-Fibroblast Crosstalk in Myocardial Infarction and Cardiac Fibrosis. Res Sq. 2023;: pubmed publisher |
| Lin G, Li N, Li D, Chen L, Deng H, Wang S, et al. Carnosic acid inhibits NLRP3 inflammasome activation by targeting both priming and assembly steps. Int Immunopharmacol. 2023;116:109819 pubmed publisher |
| Reynolds M, Hong H, Michmerhuizen B, Lawrence A, Zhang L, Knight J, et al. Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation. Sci Adv. 2023;9:eade8701 pubmed publisher |
| Peng Z, Tan X, Xie L, Li Z, Zhou S, Li Y. PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation. iScience. 2023;26:105909 pubmed publisher |
| Gonz xe1 lez Cofrade L, P Green J, Cuadrado I, Amesty x, Oramas Royo S, David Brough -, et al. Phenolic and quinone methide nor-triterpenes as selective NLRP3 inflammasome inhibitors. Bioorg Chem. 2023;132:106362 pubmed publisher |
| Meyers A, Wang Z, Han W, Zhao Q, Zabalawi M, Duan L, et al. Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation. Cell Rep. 2023;42:111941 pubmed publisher |
| Xu H, Li W, Hong S, Shao J, Chen J, Chattipakorn N, et al. Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3-driven diseases in mice. Acta Pharmacol Sin. 2023;44:1252-1261 pubmed publisher |
| Vainchtein I, Alsema A, Dubbelaar M, Grit C, Vinet J, van Weering H, et al. Characterizing microglial gene expression in a model of secondary progressive multiple sclerosis. Glia. 2023;71:588-601 pubmed publisher |
| Zhu Y, Zhang H, Mao H, Zhong S, Huang Y, Chen S, et al. FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system. Cell Death Differ. 2023;30:168-183 pubmed publisher |
| Lee G, Ahn H, Yun J, Park J, Lee E, Oh S, et al. JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation. Sci Rep. 2022;12:22484 pubmed publisher |
| Kim J, Kim H, Kim M, Jang S, Cho E, Mun S, et al. Colon-Targeted eNAMPT-Specific Peptide Systems for Treatment of DSS-Induced Acute and Chronic Colitis in Mouse. Antioxidants (Basel). 2022;11: pubmed publisher |
| Juin S, Pushpakumar S, Tyagi S, Sen U. Glucosidase inhibitor, Nimbidiol ameliorates renal fibrosis and dysfunction in type-1 diabetes. Sci Rep. 2022;12:21707 pubmed publisher |
| Branco L, Amaral M, Boekhoff H, de Lima A, Farias I, Lage S, et al. Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1β secretion. Cell Death Dis. 2022;13:1029 pubmed publisher |
| Oh C, Li L, Verma A, Reuven A, Miao E, Bliska J, et al. Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins. Cell Rep. 2022;41:111688 pubmed publisher |
| Wu Y, Mo S, Chen I, Hsieh F, Hsieh S, Zhang J, et al. Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells. Sci Adv. 2022;8:eabn9912 pubmed publisher |
| Mangan M, Gorki F, Krause K, Heinz A, Pankow A, Ebert T, et al. Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever. PLoS Biol. 2022;20:e3001351 pubmed publisher |
| Sun T, Xie R, He H, Xie Q, Zhao X, Kang G, et al. Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35. Front Immunol. 2022;13:1019365 pubmed publisher |
| Ahn H, Lee G, Han B, Lee S, Lee G. Maltol, a Natural Flavor Enhancer, Inhibits NLRP3 and Non-Canonical Inflammasome Activation. Antioxidants (Basel). 2022;11: pubmed publisher |
| Kim S, Shin M, Kim S. Lipocalin 2 activates the NLRP3 inflammasome via LPS‑induced NF‑κB signaling and plays a role as a pro‑inflammatory regulator in murine macrophages. Mol Med Rep. 2022;26: pubmed publisher |
| Tsutsuki H, Zhang T, Yahiro K, Toyomoto T, Sawa T. Non-canonical inflammasome activation analysis in a mouse model of Citrobacter rodentium infection. STAR Protoc. 2022;3:101741 pubmed publisher |
| Lin Q, Zhang D, Zhang J, Luo W, Xu Z, Yao J, et al. Identification of lncRNA DLEU2 as a potential diagnostic biomarker and anti-inflammatory target for ulcerative colitis. Front Pharmacol. 2022;13:991448 pubmed publisher |
| Sharma P, Karnam K, Mahale A, Sedmaki K, Krishna Venuganti V, Kulkarni O. HDAC5 RNA interference ameliorates acute renal injury by upregulating KLF2 and inhibiting NALP3 expression in a mouse model of oxalate nephropathy. Int Immunopharmacol. 2022;112:109264 pubmed publisher |
| Cohen H, Baram N, Fridman C, Edry Botzer L, Salomon D, Gerlic M. Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors. elife. 2022;11: pubmed publisher |
| Abdelrahman A, Bunch K, Sandow P, Cheng P, Caldwell R, Caldwell R. Systemic Administration of Pegylated Arginase-1 Attenuates the Progression of Diabetic Retinopathy. Cells. 2022;11: pubmed publisher |
| Duhalde Vega M, Olivera D, Gast xe3 o Davanzo G, Bertullo M, Noya V, Fabiano de Souza G, et al. PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical β-coronavirus disease. Sci Adv. 2022;8:eabn6545 pubmed publisher |
| de Castro Silva I, Bianchi A, Deshpande N, Sharma P, Mehra S, Garrido V, et al. Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study. elife. 2022;11: pubmed publisher |
| Ruwanpura S, McLeod L, Dousha L, Seow H, West A, West A, et al. Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema. Proc Natl Acad Sci U S A. 2022;119:e2201494119 pubmed publisher |
| Lee J, Kim S, Choi G, Yi E, Park H, Choi W, et al. Sweet taste receptor agonists attenuate macrophage IL-1β expression and eosinophilic inflammation linked to autophagy deficiency in myeloid cells. Clin Transl Med. 2022;12:e1021 pubmed publisher |
| Yuan C, Ai K, Xiang M, Xie C, Zhao M, Wu M, et al. Novel 1-hydroxy phenothiazinium-based derivative protects against bacterial sepsis by inhibiting AAK1-mediated LPS internalization and caspase-11 signaling. Cell Death Dis. 2022;13:722 pubmed publisher |
| Feriotti C, S xe1 Pessoa J, Calder xf3 n Gonz xe1 lez R, Gu L, Morris B, Sugisawa R, et al. Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity. Cell Rep. 2022;40:111167 pubmed publisher |
| Shi H, Zhu Y, Xing C, Li S, Bao Z, Lei L, et al. An injectable thermosensitive hydrogel for dual delivery of diclofenac and Avastin® to effectively suppress inflammatory corneal neovascularization. Int J Pharm. 2022;625:122081 pubmed publisher |
| Dong A, Yang Y, Jiang S, Yao X, Qi D, Mao C, et al. Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson's disease. Acta Pharmacol Sin. 2022;: pubmed publisher |
| López Rodríguez A, Decouty Perez C, Farr xe9 Alins V, Palomino Antol xed n A, Narros Fern xe1 ndez P, Egea J. Activation of NLRP3 Is Required for a Functional and Beneficial Microglia Response after Brain Trauma. Pharmaceutics. 2022;14: pubmed publisher |
| Han J, Kim Y, Yu H, Park J, Kim Y, Park S, et al. Safety and Efficacy of Intratympanic Alpha-Lipoic Acid Injection in a Mouse Model of Noise-Induced Hearing Loss. Antioxidants (Basel). 2022;11: pubmed publisher |
| Dong X, Limjunyawong N, Sypek E, Wang G, Ortines R, Youn C, et al. Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022;55:1645-1662.e7 pubmed publisher |
| Ma J, Lee E, Yoon S, Min H, Oh J, Hwang I, et al. Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model. EBioMedicine. 2022;82:104184 pubmed publisher |
| Zhou H, Shen X, Yan C, Xiong W, Ma Z, Tan Z, et al. Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage. Stem Cell Res Ther. 2022;13:322 pubmed publisher |
| Peng Z, Duan M, Tang Y, Wu J, Zhao K, Zhong Y, et al. Impaired interferon-γ signaling promotes the development of silicosis. iScience. 2022;25:104647 pubmed publisher |
| Chen W, Chen S, Yan C, Zhang Y, Zhang R, Chen M, et al. Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion. Nat Immunol. 2022;: pubmed publisher |
| Dong H, Zhao B, Chen J, Liu Z, Li X, Li L, et al. Mitochondrial calcium uniporter promotes phagocytosis-dependent activation of the NLRP3 inflammasome. Proc Natl Acad Sci U S A. 2022;119:e2123247119 pubmed publisher |
| Yu W, Wang Z, Yu X, Zhao Y, Xie Z, Zhang K, et al. Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters. Nat Commun. 2022;13:3544 pubmed publisher |
| Liu S, Wang S, Gu R, Che N, Wang J, Cheng J, et al. The XPO1 Inhibitor KPT-8602 Ameliorates Parkinson's Disease by Inhibiting the NF-κB/NLRP3 Pathway. Front Pharmacol. 2022;13:847605 pubmed publisher |
| Di Carlo S, H xe4 cker G, Gentle I. GM-CSF suppresses antioxidant signaling and drives IL-1β secretion through NRF2 downregulation. EMBO Rep. 2022;23:e54226 pubmed publisher |
| Tengesdal I, Li S, Powers N, May M, Neff C, Joosten L, et al. Activation of Host-NLRP3 Inflammasome in Myeloid Cells Dictates Response to Anti-PD-1 Therapy in Metastatic Breast Cancers. Pharmaceuticals (Basel). 2022;15: pubmed publisher |
| Zhang Q, Liu W, Wang H, Zhou H, Bulek K, Chen X, et al. TH17 cells promote CNS inflammation by sensing danger signals via Mincle. Nat Commun. 2022;13:2406 pubmed publisher |
| Zhou L, Yang S, Zou X. Farrerol Alleviates Myocardial Ischemia/Reperfusion Injury by Targeting Macrophages and NLRP3. Front Pharmacol. 2022;13:879232 pubmed publisher |
| Billingham L, Stoolman J, Vasan K, Rodriguez A, Poor T, Szibor M, et al. Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation. Nat Immunol. 2022;23:692-704 pubmed publisher |
| Jung E, Suh K, Han J, Kim H, Kang H, Choi W, et al. Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway. Aging Cell. 2022;21:e13623 pubmed publisher |
| Li F, Lin L, He Y, Sun G, Dong D, Wu B. BMAL1 regulates Propionibacterium acnes-induced skin inflammation via REV-ERBα in mice. Int J Biol Sci. 2022;18:2597-2608 pubmed publisher |
| Li P, Kurata Y, Taufiq F, Kuwabara M, Ninomiya H, Higaki K, et al. Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes. Mol Biol Rep. 2022;49:5939-5952 pubmed publisher |
| Tsutsuki H, Zhang T, Yahiro K, Ono K, Fujiwara Y, Iyoda S, et al. Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection. iScience. 2022;25:104050 pubmed publisher |
| Molnár K, Nógrádi B, Kristóf R, Mészáros A, Pajer K, Siklos L, et al. Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury. J Neuroinflammation. 2022;19:68 pubmed publisher |
| Rego C, Francisco A, Boeno C, Paloschi M, Lopes J, Silva M, et al. Inflammasome NLRP3 activation induced by Convulxin, a C-type lectin-like isolated from Crotalus durissus terrificus snake venom. Sci Rep. 2022;12:4706 pubmed publisher |
| Czaya B, Heitman K, Campos I, Yanucil C, Kentrup D, Westbrook D, et al. Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling. elife. 2022;11: pubmed publisher |
| Mohamed M, Gupta K, Goldufsky J, Roy R, Callaghan L, Wetzel D, et al. CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT. Nat Commun. 2022;13:1295 pubmed publisher |
| Li C, Lin H, He H, Ma M, Jiang W, Zhou R. Inhibition of the NLRP3 Inflammasome Activation by Manoalide Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis. Front Cell Dev Biol. 2022;10:822236 pubmed publisher |
| Lin H, Yang M, Li C, Lin B, Deng X, He H, et al. An RRx-001 Analogue With Potent Anti-NLRP3 Inflammasome Activity but Without High-Energy Nitro Functional Groups. Front Pharmacol. 2022;13:822833 pubmed publisher |
| Eislmayr K, Bestehorn A, Morelli L, Borroni M, Walle L, Lamkanfi M, et al. Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection. Sci Adv. 2022;8:eabj7293 pubmed publisher |
| Zhang T, Zhao J, Liu T, Cheng W, Wang Y, Ding S, et al. A novel mechanism for NLRP3 inflammasome activation. Metabol Open. 2022;13:100166 pubmed publisher |
| Wang Y, Liu T, Shen C, Lin S, Hung C, Hsu L, et al. K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy. Cell Rep. 2022;38:110354 pubmed publisher |
| Jiao Y, Nan J, Mu B, Zhang Y, Zhou N, Yang S, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022;232:114194 pubmed publisher |
| Hoyle C, Green J, Allan S, Brough D, Lemarchand E. Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages. Immunology. 2022;165:460-480 pubmed publisher |
| Romero A, Dongil P, Valencia I, Vallejo S, Hip xf3 lito Luengo x, D xed az Araya G, et al. Pharmacological Blockade of NLRP3 Inflammasome/IL-1β-Positive Loop Mitigates Endothelial Cell Senescence and Dysfunction. Aging Dis. 2022;13:284-297 pubmed publisher |
| Xu T, Yu W, Fang H, Wang Z, Chi Z, Guo X, et al. Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation. Cell Death Differ. 2022;29:1582-1595 pubmed publisher |
| Toth K, Lénárt N, Berki P, Fekete R, Szabadits E, Pósfai B, et al. The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner. PLoS Biol. 2022;20:e3001526 pubmed publisher |
| Wang S, Jing K, Wu H, Li X, Yang C, Li T, et al. Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy. Oxid Med Cell Longev. 2022;2022:2812493 pubmed publisher |
| Li Y, Zhu Y, Feng S, Ishida Y, Chiu T, Saito T, et al. Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3. Cell Rep. 2022;38:110284 pubmed publisher |
| Murthy S, Baruah S, Bowen J, Keck K, Wagner B, Buettner G, et al. TREM-1 is required for enhanced OpZ-induced superoxide generation following priming. J Leukoc Biol. 2022;112:457-473 pubmed publisher |
| Szab xf3 D, Tod P, G xf6 l xf6 ncs xe9 r F, Rom xe1 n V, Lendvai B, Otrokocsi L, et al. Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway. Brain Behav Immun. 2022;101:318-332 pubmed publisher |
| Williams N, Ryan D, Costa A, Mills E, Jedrychowski M, Cloonan S, et al. Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages. J Biol Chem. 2022;298:101501 pubmed publisher |
| Yuan K, Zheng J, Shen X, Wu Y, Han Y, Jin X, et al. Sensory nerves promote corneal inflammation resolution via CGRP mediated transformation of macrophages to the M2 phenotype through the PI3K/AKT signaling pathway. Int Immunopharmacol. 2022;102:108426 pubmed publisher |
| Munoz M, Fletcher E, Skinner O, Jurczyluk J, Kristianto E, Hodson M, et al. Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages. elife. 2021;10: pubmed publisher |
| Tian Y, Li P, Wu Z, Deng Q, Pan B, Stringer K, et al. Citrullinated Histone H3 Mediates Sepsis-Induced Lung Injury Through Activating Caspase-1 Dependent Inflammasome Pathway. Front Immunol. 2021;12:761345 pubmed publisher |
| Zhang J, Mai C, Xiong Y, Lin Z, Jie Y, Mai J, et al. The Causal Role of Magnesium Deficiency in the Neuroinflammation, Pain Hypersensitivity and Memory/Emotional Deficits in Ovariectomized and Aged Female Mice. J Inflamm Res. 2021;14:6633-6656 pubmed publisher |
| Chowdhury D, Gardner J, Satpati A, Nookala S, Mukundan S, Porollo A, et al. Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity. Front Immunol. 2021;12:755961 pubmed publisher |
| Kodji X, Kee Z, McKenna R, de Sousa Valente J, Ravenscroft H, McMillan H, et al. Evidence That a TRPA1-Mediated Murine Model of Temporomandibular Joint Pain Involves NLRP3 Inflammasome Activation. Pharmaceuticals (Basel). 2021;14: pubmed publisher |
| Dong X, Chen L. Protocol for measuring NLRC4 inflammasome activation and pyroptosis in murine bone-marrow-derived macrophages. STAR Protoc. 2021;2:100894 pubmed publisher |
| Wei Z, Zhan X, Ding K, Xu G, Shi W, Ren L, et al. Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo. Front Pharmacol. 2021;12:750815 pubmed publisher |
| Liu B, Li X, Yu H, Shi X, Zhou Y, Alvarez S, et al. Therapeutic potential of garlic chive-derived vesicle-like nanoparticles in NLRP3 inflammasome-mediated inflammatory diseases. Theranostics. 2021;11:9311-9330 pubmed publisher |
| Chen P, Bai Q, Wu Y, Zeng Q, Song X, Guo Y, et al. The Essential Oil of Artemisia argyi H.Lév. and Vaniot Attenuates NLRP3 Inflammasome Activation in THP-1 Cells. Front Pharmacol. 2021;12:712907 pubmed publisher |
| Ahn H, Lee H, Lee G, Park J, Sung H, Lee E, et al. Parabens disrupt non-canonical inflammasome activation. Int Immunopharmacol. 2021;101:108196 pubmed publisher |
| Wen B, Dang Y, Wu S, Huang Y, Ma K, Xu Y, et al. Antiatherosclerotic effect of dehydrocorydaline on ApoE-/- mice: inhibition of macrophage inflammation. Acta Pharmacol Sin. 2021;: pubmed publisher |
| Jiang S, Maphis N, Binder J, Chisholm D, Weston L, DURAN W, et al. Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway. Cell Rep. 2021;36:109720 pubmed publisher |
| Tang Y, Kline K, Zhong X, Xiao Y, Lian H, Peng J, et al. Chronic colitis upregulates microRNAs suppressing brain-derived neurotrophic factor in the adult heart. PLoS ONE. 2021;16:e0257280 pubmed publisher |
| Xiong S, Zhang L, Richner J, Class J, Rehman J, Malik A. Interleukin-1RA Mitigates SARS-CoV-2-Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice. Arterioscler Thromb Vasc Biol. 2021;41:2773-2785 pubmed publisher |
| Stackowicz J, Gaudenzio N, Serhan N, Conde E, Godon O, Marichal T, et al. Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome. J Exp Med. 2021;218: pubmed publisher |
| Reimers D, Vallejo Muñoz M, Casarejos M, Jimenez Escrig A, Gonzalo Gobernado R, Bazán E. Immunohistochemical Study of ASC Expression and Distribution in the Hippocampus of an Aged Murine Model of Alzheimer's Disease. Int J Mol Sci. 2021;22: pubmed publisher |
| Li X, Zhang X, Xia J, Zhang L, Chen B, Lian G, et al. Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance. Cell Rep. 2021;36:109607 pubmed publisher |
| Ortiz Romero P, González Simón A, Egea G, Perez Jurado L, Campuzano V. Co-Treatment With Verapamil and Curcumin Attenuates the Behavioral Alterations Observed in Williams-Beuren Syndrome Mice by Regulation of MAPK Pathway and Microglia Overexpression. Front Pharmacol. 2021;12:670785 pubmed publisher |
| Liu J, Jiang M, Jin Q, Wu Y, Cui Z, Cui B, et al. Modulation of HMGB1 Release in APAP-Induced Liver Injury: A Possible Strategy of Chikusetsusaponin V Targeting NETs Formation. Front Pharmacol. 2021;12:723881 pubmed publisher |
| Ahn H, Lee G, Kim J, Park J, Kang S, Yoon S, et al. NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation. Cells. 2021;10: pubmed publisher |
| Wu X, Lv J, Zhang S, Yi X, Xu Z, Zhi Y, et al. ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome. Acta Pharmacol Sin. 2021;: pubmed publisher |
| Rastogi S, Ellinwood S, Augenstreich J, Mayer Barber K, Briken V. Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF. PLoS Pathog. 2021;17:e1009712 pubmed publisher |
| Nizami S, Millar V, Arunasalam K, Zarganes Tzitzikas T, Brough D, Tresadern G, et al. A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation. Sci Rep. 2021;11:15319 pubmed publisher |
| Ali M, Gupta M, Wani A, Sharma A, Abdullaha M, Kour D, et al. IIIM-941, a Stilbene Derivative Inhibits NLRP3 Inflammasome Activation by Inducing Autophagy. Front Pharmacol. 2021;12:695712 pubmed publisher |
| Kozma M, M xe9 sz xe1 ros x, Ny xfa l T xf3 th x, Moln xe1 r K, Costea L, Hern xe1 di Z, et al. Cerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals. Int J Mol Sci. 2021;22: pubmed publisher |
| Lin C, Shen Y, Chang C, Guo X, Young Y, Lai T, et al. Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation. Nat Commun. 2021;12:3878 pubmed publisher |
| Wang X, Shi J, Li Z, Li L, Zhang R, Bai Y, et al. An 8-Hydroxy-Quinoline Derivative Protects Against Lipopolysaccharide-Induced Lethality in Endotoxemia by Inhibiting HMGB1-Mediated Caspase-11 Signaling. Front Pharmacol. 2021;12:673818 pubmed publisher |
| Timblin G, Tharp K, Ford B, Winchester J, Wang J, Zhu S, et al. Mitohormesis reprogrammes macrophage metabolism to enforce tolerance. Nat Metab. 2021;3:618-635 pubmed publisher |
| Ratitong B, Marshall M, Pearlman E. β-Glucan-stimulated neutrophil secretion of IL-1α is independent of GSDMD and mediated through extracellular vesicles. Cell Rep. 2021;35:109139 pubmed publisher |
| Tomita T, Mukhopadhyay D, Han B, Yakubu R, Tu V, Mayoral J, et al. Toxoplasma gondii Matrix Antigen 1 Is a Secreted Immunomodulatory Effector. MBio. 2021;12: pubmed publisher |
| Vijayaraj S, Feltham R, Rashidi M, Frank D, Liu Z, Simpson D, et al. The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation. Nat Commun. 2021;12:2713 pubmed publisher |
| Flis E, Barber G, Nulty C, Keogh B, McGuirk P, Anand A, et al. Identification of TLR2 Signalling Mechanisms Which Contribute to Barrett's and Oesophageal Adenocarcinoma Disease Progression. Cancers (Basel). 2021;13: pubmed publisher |
| Xia S, Zhang Z, Magupalli V, Pablo J, Dong Y, Vora S, et al. Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. 2021;593:607-611 pubmed publisher |
| Wang X, Li Z, Bai Y, Zhang R, Meng R, Chen F, et al. A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis. Cell Death Dis. 2021;12:402 pubmed publisher |
| Zhou B, Abbott D. Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases. Cell Rep. 2021;35:108998 pubmed publisher |
| Zhang C, Yue H, Sun P, Hua L, Liang S, Ou Y, et al. Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities. Eur J Med Chem. 2021;219:113417 pubmed publisher |
| Skerni x161 kyt x117 J, Karazijait x117 E, Lu x10d i x16b nait x117 A, Su x17e ied x117 lien x117 E. OmpA Protein-Deficient Acinetobacter baumannii Outer Membrane Vesicles Trigger Reduced Inflammatory Response. Pathogens. 2021;10: pubmed publisher |
| Shimada A, Hasegawa Ishii S. Increased cytokine expression in the choroid plexus stroma and epithelium in response to endotoxin-induced systemic inflammation in mice. Toxicol Rep. 2021;8:520-528 pubmed publisher |
| Lee M, Lee Y, Wu D, Pae M. Luteolin inhibits NLRP3 inflammasome activation via blocking ASC oligomerization. J Nutr Biochem. 2021;92:108614 pubmed publisher |
| Li Z, Cao Y, Li Y, Zhao Y, Chen X. Vaccine delivery alerts innate immune systems for more immunogenic vaccination. JCI Insight. 2021;6: pubmed publisher |
| Martini H, Lefevre L, Sayir S, Itier R, Maggiorani D, Dutaur M, et al. Selective Cardiomyocyte Oxidative Stress Leads to Bystander Senescence of Cardiac Stromal Cells. Int J Mol Sci. 2021;22: pubmed publisher |
| Starobova H, Monteleone M, Adolphe C, Batoon L, Sandrock C, Tay B, et al. Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. J Exp Med. 2021;218: pubmed publisher |
| Mishima Y, Osaki T, Shimada A, Kamiya S, Hasegawa Ishii S. Sex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice. Sci Rep. 2021;11:4640 pubmed publisher |
| Li Y, Chen X, Jin R, Chen L, Dang M, Cao H, et al. Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs. Sci Adv. 2021;7: pubmed publisher |
| Chen X, Liu B, Li X, An T, Zhou Y, Li G, et al. Identification of anti-inflammatory vesicle-like nanoparticles in honey. J Extracell Vesicles. 2021;10:e12069 pubmed publisher |
| Dong X, Hu X, Bao Y, Li G, Yang X, Slauch J, et al. Brd4 regulates NLRC4 inflammasome activation by facilitating IRF8-mediated transcription of Naips. J Cell Biol. 2021;220: pubmed publisher |
| Shi Y, Lv Q, Zheng M, Sun H, Shi F. NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages. Int Immunopharmacol. 2021;92:107358 pubmed publisher |
| Estfanous S, Krause K, Anne M, Eltobgy M, Caution K, Abu Khweek A, et al. Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo. Sci Rep. 2021;11:855 pubmed publisher |
| Tsu B, Beierschmitt C, Ryan A, Agarwal R, Mitchell P, Daugherty M. Diverse viral proteases activate the NLRP1 inflammasome. elife. 2021;10: pubmed publisher |
| Chen Y, Yang Q, Lv C, Chen Y, Zhao W, Li W, et al. NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation. Cell Prolif. 2021;54:e12973 pubmed publisher |
| Farré Alins V, Narros Fernández P, Palomino Antolin A, Decouty Pérez C, López Rodríguez A, Parada E, et al. Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux. Antioxidants (Basel). 2020;9: pubmed publisher |
| Xu G, Fu S, Zhan X, Wang Z, Zhang P, Shi W, et al. Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90. JCI Insight. 2021;6: pubmed publisher |
| Lin Q, Li S, Jiang N, Jin H, Shao X, Zhu X, et al. Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy. Autophagy. 2021;17:2975-2990 pubmed publisher |
| Nógrádi B, Nyúl Tóth Á, Kozma M, Molnár K, Patai R, Siklos L, et al. Upregulation of Nucleotide-Binding Oligomerization Domain-, LRR- and Pyrin Domain-Containing Protein 3 in Motoneurons Following Peripheral Nerve Injury in Mice. Front Pharmacol. 2020;11:584184 pubmed publisher |
| Lef xe8 vre L, Iacovoni J, Martini H, Belli xe8 re J, Maggiorani D, Dutaur M, et al. Kidney inflammaging is promoted by CCR2+ macrophages and tissue-derived micro-environmental factors. Cell Mol Life Sci. 2021;78:3485-3501 pubmed publisher |
| Nilsson J, Hörnberg M, Schmidt Christensen A, Linde K, Nilsson M, Carlus M, et al. NKT cells promote both type 1 and type 2 inflammatory responses in a mouse model of liver fibrosis. Sci Rep. 2020;10:21778 pubmed publisher |
| Morshed N, Ralvenius W, Nott A, Watson L, Rodriguez F, Akay L, et al. Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration. Mol Syst Biol. 2020;16:e9819 pubmed publisher |
| Havira M, Ta A, Kumari P, Wang C, Russo A, Ruan J, et al. Shiga toxin suppresses noncanonical inflammasome responses to cytosolic LPS. Sci Immunol. 2020;5: pubmed publisher |
| Wang W, Hu D, Feng Y, Wu C, Song Y, Liu W, et al. Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome. BMC Biol. 2020;18:182 pubmed publisher |
| Green J, Swanton T, Morris L, El Sharkawy L, Cook J, Yu S, et al. LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation. elife. 2020;9: pubmed publisher |
| Sweet D, Vasudevan N, Fan L, Booth C, Keerthy K, Liao X, et al. Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation. Nat Commun. 2020;11:5872 pubmed publisher |
| Duan Y, Zhang L, Angosto Bazarra D, Pelegrin P, Nunez G, He Y. RACK1 Mediates NLRP3 Inflammasome Activation by Promoting NLRP3 Active Conformation and Inflammasome Assembly. Cell Rep. 2020;33:108405 pubmed publisher |
| Kim J, Mun S, Cho E, Kim D, Son W, Jeon H, et al. Toxoplasma gondii GRA9 Regulates the Activation of NLRP3 Inflammasome to Exert Anti-Septic Effects in Mice. Int J Mol Sci. 2020;21: pubmed publisher |
| Kajino Sakamoto R, Fujishita T, Taketo M, Aoki M. Synthetic lethality between MyD88 loss and mutations in Wnt/β-catenin pathway in intestinal tumor epithelial cells. Oncogene. 2021;40:408-420 pubmed publisher |
| Ahn H, Lee G. Riboflavin, vitamin B2, attenuates NLRP3, NLRC4, AIM2, and non-canonical inflammasomes by the inhibition of caspase-1 activity. Sci Rep. 2020;10:19091 pubmed publisher |
| Matsuoka T, Yoshimatsu G, Sakata N, Kawakami R, Tanaka T, Yamada T, et al. Inhibition of NLRP3 inflammasome by MCC950 improves the metabolic outcome of islet transplantation by suppressing IL-1β and islet cellular death. Sci Rep. 2020;10:17920 pubmed publisher |
| Ming S, Zeng L, Guo Y, Zhang S, Li G, Ma Y, et al. The Human-Specific STING Agonist G10 Activates Type I Interferon and the NLRP3 Inflammasome in Porcine Cells. Front Immunol. 2020;11:575818 pubmed publisher |
| Guey B, Bodnar Wachtel M, Drouillard A, Eberhardt A, Pratviel M, Goutagny N, et al. Inflammasome Deletion Promotes Anti-tumor NK Cell Function in an IL-1/IL-18 Independent Way in Murine Invasive Breast Cancer. Front Oncol. 2020;10:1683 pubmed publisher |
| Kong X, Liao Y, Zhou L, Zhang Y, Cheng J, Yuan Z, et al. Hematopoietic Cell Kinase (HCK) Is Essential for NLRP3 Inflammasome Activation and Lipopolysaccharide-Induced Inflammatory Response In Vivo. Front Pharmacol. 2020;11:581011 pubmed publisher |
| Kim Y, Kwak M, Lee B, Shin J, Aum S, Park I, et al. Secretory autophagy machinery and vesicular trafficking are involved in HMGB1 secretion. Autophagy. 2020;:1-18 pubmed publisher |
| Guo H, Ting J. Inflammasome Assays In Vitro and in Mouse Models. Curr Protoc Immunol. 2020;131:e107 pubmed publisher |
| Zhao Q, Bi Y, Guo J, Liu Y, Zhong J, Pan L, et al. Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation. Acta Pharmacol Sin. 2021;42:975-986 pubmed publisher |
| Magupalli V, Negro R, Tian Y, Hauenstein A, Di Caprio G, Skillern W, et al. HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science. 2020;369: pubmed publisher |
| Volchuk A, Ye A, Chi L, Steinberg B, Goldenberg N. Indirect regulation of HMGB1 release by gasdermin D. Nat Commun. 2020;11:4561 pubmed publisher |
| Deo P, Chow S, Han M, Speir M, Huang C, Schittenhelm R, et al. Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation. Nat Microbiol. 2020;5:1418-1427 pubmed publisher |
| Rui W, Li S, Xiao H, Xiao M, Shi J. Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/caspase-1/GSDMD Pathway in MPTP Induced Mice Model of Parkinson's Disease. Int J Neuropsychopharmacol. 2020;23:762-73 pubmed publisher |
| Tucey T, Verma J, Olivier F, Lo T, Robertson A, Naderer T, et al. Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection. PLoS Pathog. 2020;16:e1008695 pubmed publisher |
| Sneezum L, Eislmayr K, Dworak H, Sedlyarov V, Le Heron A, Ebner F, et al. Context-Dependent IL-1 mRNA-Destabilization by TTP Prevents Dysregulation of Immune Homeostasis Under Steady State Conditions. Front Immunol. 2020;11:1398 pubmed publisher |
| Templin A, Mellati M, Meier D, Esser N, Hogan M, Castillo J, et al. Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro. Diabetologia. 2020;63:2385-2395 pubmed publisher |
| von Herrmann K, Anderson F, Martinez E, Young A, Havrda M. Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice. J Neuroinflammation. 2020;17:213 pubmed publisher |
| Park Y, Remmers E, Lee W, Ombrello A, Chung L, Shilei Z, et al. Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis. Nat Immunol. 2020;21:857-867 pubmed publisher |
| Bulek K, Zhao J, Liao Y, Rana N, Corridoni D, Antanaviciute A, et al. Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis. J Clin Invest. 2020;130:4218-4234 pubmed publisher |
| Jang A, Kang M, Shin J, Kwon S, Park J, Ahn J, et al. Unveiling the Crucial Role of Type IV Secretion System and Motility of Helicobacter pylori in IL-1β Production via NLRP3 Inflammasome Activation in Neutrophils. Front Immunol. 2020;11:1121 pubmed publisher |
| Mailhot B, Christin M, Tessandier N, Sotoudeh C, Bretheau F, Turmel R, et al. Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases. J Exp Med. 2020;217: pubmed publisher |
| Ipseiz N, Pickering R, Rosas M, Tyrrell V, Davies L, Orr S, et al. Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway. EMBO J. 2020;39:e103454 pubmed publisher |
| Hoyle C, Redondo Castro E, Cook J, Tzeng T, Allan S, Brough D, et al. Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture. Immunology. 2020;161:39-52 pubmed publisher |
| Huang Y, Wang H, Hao Y, Lin H, Dong M, Ye J, et al. Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. Nat Cell Biol. 2020;22:716-727 pubmed publisher |
| Heilig R, Dilucca M, Boucher D, Chen K, Hancz D, Demarco B, et al. Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD. Life Sci Alliance. 2020;3: pubmed publisher |
| Xiong S, Hong Z, Huang L, Tsukasaki Y, Nepal S, Di A, et al. IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury. J Clin Invest. 2020;130:3684-3698 pubmed publisher |
| Wang Y, Li H, Li F. ELMO2 association with Gαi2 regulates pancreatic cancer cell chemotaxis and metastasis. Peerj. 2020;8:e8910 pubmed publisher |
| Donado C, Cao A, Simmons D, Croker B, Brennan P, Brenner M. A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling. Cell Rep. 2020;31:107466 pubmed publisher |
| Cao F, Tian X, Li Z, Lv Y, Han J, Zhuang R, et al. Suppression of NLRP3 Inflammasome by Erythropoietin via the EPOR/JAK2/STAT3 Pathway Contributes to Attenuation of Acute Lung Injury in Mice. Front Pharmacol. 2020;11:306 pubmed publisher |
| Tozaki Saitoh H, Sasaki I, Yamashita T, Hosoi M, Kato T, Tsuda M. Involvement of exchange protein directly activated by cAMP and tumor progression locus 2 in IL-1β production in microglial cells following activation of β-adrenergic receptors. J Pharmacol Sci. 2020;143:133-140 pubmed publisher |
| Hamarsheh S, Osswald L, Saller B, Unger S, De Feo D, Vinnakota J, et al. Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation. Nat Commun. 2020;11:1659 pubmed publisher |
| Li Q, Cao Y, Dang C, Han B, Han R, Ma H, et al. Inhibition of double-strand DNA-sensing cGAS ameliorates brain injury after ischemic stroke. EMBO Mol Med. 2020;12:e11002 pubmed publisher |
| Kim B, Kim B, Kook Y, Kim B. Mycobacterium abscessus infection leads to enhanced production of type 1 interferon and NLRP3 inflammasome activation in murine macrophages via mitochondrial oxidative stress. PLoS Pathog. 2020;16:e1008294 pubmed publisher |
| Nakata R, Nakamura Y, Hosomi S, Okuda H, Nishida Y, Sugita N, et al. Slco2a1 deficiency exacerbates experimental colitis via inflammasome activation in macrophages: a possible mechanism of chronic enteropathy associated with SLCO2A1 gene. Sci Rep. 2020;10:4883 pubmed publisher |
| Subbarao S, Sanchez Garrido J, Krishnan N, Shenoy A, Robertson B. Genetic and pharmacological inhibition of inflammasomes reduces the survival of Mycobacterium tuberculosis strains in macrophages. Sci Rep. 2020;10:3709 pubmed publisher |
| Zasłona Z, Flis E, Wilk M, Carroll R, Palsson McDermott E, Hughes M, et al. Caspase-11 promotes allergic airway inflammation. Nat Commun. 2020;11:1055 pubmed publisher |
| das Gupta K, Shakespear M, Curson J, Murthy A, Iyer A, Hodson M, et al. Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2. Cell Rep. 2020;30:2712-2728.e8 pubmed publisher |
| Muri J, Thut H, Feng Q, Kopf M. Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip. elife. 2020;9: pubmed publisher |
| Liu B, Lu Y, Chen X, Muthuraj P, Li X, Pattabiraman M, et al. Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice. Nutrients. 2020;12: pubmed publisher |
| Wooff Y, Fernando N, Wong J, Dietrich C, Aggio Bruce R, Chu Tan J, et al. Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration. Sci Rep. 2020;10:2263 pubmed publisher |
| He M, Chiang H, Luo H, Zheng Z, Qiao Q, Wang L, et al. An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance. Cell Metab. 2020;31:580-591.e5 pubmed publisher |
| Fox D, Mathur A, Xue Y, Liu Y, Tan W, Feng S, et al. Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome. Nat Commun. 2020;11:760 pubmed publisher |
| Cohen H, Baram N, Edry Botzer L, Munitz A, Salomon D, Gerlic M. Vibrio pore-forming leukocidin activates pyroptotic cell death via the NLRP3 inflammasome. Emerg Microbes Infect. 2020;9:278-290 pubmed publisher |
| Wang J, Liu H, Xie G, Cai W, Xu J. Identification of hub genes and key pathways of dietary advanced glycation end products‑induced non‑alcoholic fatty liver disease by bioinformatics analysis and animal experiments. Mol Med Rep. 2020;21:685-694 pubmed publisher |
| Tripathi H, Peng H, Donahue R, Chelvarajan L, Gottipati A, Levitan B, et al. Isolation Methods for Human CD34 Subsets Using Fluorescent and Magnetic Activated Cell Sorting: an In Vivo Comparative Study. Stem Cell Rev Rep. 2020;16:413-423 pubmed publisher |
| Kim J, Ahn H, Yu S, Ahn J, Ko H, Kweon M, et al. IκBζ controls NLRP3 inflammasome activation via upregulation of the Nlrp3 gene. Cytokine. 2020;127:154983 pubmed publisher |
| Rao Z, Chen X, Wu J, Xiao M, Zhang J, Wang B, et al. Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination. Front Immunol. 2019;10:2783 pubmed publisher |
| Bhatta A, Atianand M, Jiang Z, Crabtree J, Blin J, Fitzgerald K. A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome. J Immunol. 2020;204:428-437 pubmed publisher |
| Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, et al. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019;10:5681 pubmed publisher |
| Speir M, Nowell C, Chen A, O Donnell J, Shamie I, Lakin P, et al. Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation. Nat Immunol. 2020;21:54-64 pubmed publisher |
| Di Gioia M, Spreafico R, Springstead J, Mendelson M, Joehanes R, Levy D, et al. Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation. Nat Immunol. 2020;21:42-53 pubmed publisher |
| Harding C, Pytte C, Page K, Ryberg K, Normand E, Remigio G, et al. Mold inhalation causes innate immune activation, neural, cognitive and emotional dysfunction. Brain Behav Immun. 2020;87:218-228 pubmed publisher |
| Aires I, Madeira M, Boia R, Rodrigues Neves A, Martins J, Ambrósio A, et al. Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice. Sci Rep. 2019;9:17207 pubmed publisher |
| Yoshizaki T, Itoh S, Yamaguchi S, Numata T, Nambu A, Kimura N, et al. IL-25 exacerbates autoimmune aortitis in IL-1 receptor antagonist-deficient mice. Sci Rep. 2019;9:17067 pubmed publisher |
| Jo S, Bae J, Kim S, Lee J, Jeong J, Moon J. PF-04620110, a Potent Antidiabetic Agent, Suppresses Fatty Acid-Induced NLRP3 Inflammasome Activation in Macrophages. Diabetes Metab J. 2019;43:683-699 pubmed publisher |
| Nnah I, Lee C, Wessling Resnick M. Iron potentiates microglial interleukin-1β secretion induced by amyloid-β. J Neurochem. 2020;154:177-189 pubmed publisher |
| Kim J, Kim W, Ha K, Han E, Park W, Yang S, et al. Perivascular Stem Cells Suppress Inflammasome Activation during Inflammatory Responses in Macrophages. Int J Stem Cells. 2019;12:419-429 pubmed publisher |
| Krause K, Daily K, Estfanous S, Hamilton K, Badr A, Abu Khweek A, et al. Caspase-11 counteracts mitochondrial ROS-mediated clearance of Staphylococcus aureus in macrophages. EMBO Rep. 2019;20:e48109 pubmed publisher |
| Chen Y, Wang H, Shen J, Deng R, Yao X, Guo Q, et al. Gasdermin D Drives the Nonexosomal Secretion of Galectin-3, an Insulin Signal Antagonist. J Immunol. 2019;203:2712-2723 pubmed publisher |
| Hughes M, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch M, et al. Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation. Cell Rep. 2019;29:151-161.e5 pubmed publisher |
| Bonnardel J, T Jonck W, Gaublomme D, Browaeys R, Scott C, Martens L, et al. Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche. Immunity. 2019;51:638-654.e9 pubmed publisher |
| Deng M, Guo H, Tam J, Johnson B, Brickey W, New J, et al. Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR. J Exp Med. 2019;216:2838-2853 pubmed publisher |
| Wang P, Qi X, Xu G, Liu J, Guo J, Li X, et al. CCL28 promotes locomotor recovery after spinal cord injury via recruiting regulatory T cells. Aging (Albany NY). 2019;11:7402-7415 pubmed publisher |
| Lipinski S, Pfeuffer S, Arnold P, Treitz C, Aden K, Ebsen H, et al. Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles. EMBO J. 2019;38:e101266 pubmed publisher |
| Samir P, Kesavardhana S, Patmore D, Gingras S, Malireddi R, Karki R, et al. DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature. 2019;573:590-594 pubmed publisher |
| Akula M, Ibrahim M, Ivarsson E, Khan O, Kumar I, Erlandsson M, et al. Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions. Nat Commun. 2019;10:3975 pubmed publisher |
| Chen R, Zhu S, Zeng L, Wang Q, Sheng Y, Zhou B, et al. AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis. Front Immunol. 2019;10:1904 pubmed publisher |
| Cho S, Hong K, Jeong J, Lee M, Choi A, Stout Delgado H, et al. DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis. Cells. 2019;8: pubmed publisher |
| Kimball A, Davis F, denDekker A, Joshi A, Schaller M, Bermick J, et al. The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair. Immunity. 2019;51:258-271.e5 pubmed publisher |
| Mian Wu -, Zhang M, Ma Y, Liu F, Chen S, Lu J, et al. Chaetocin attenuates gout in mice through inhibiting HIF-1α and NLRP3 inflammasome-dependent IL-1β secretion in macrophages. Arch Biochem Biophys. 2019;: pubmed publisher |
| Lin Q, Li S, Jiang N, Shao X, Zhang M, Jin H, et al. PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation. Redox Biol. 2019;26:101254 pubmed publisher |
| Shikano S, Gon Y, Maruoka S, Shimizu T, Kozu Y, Iida Y, et al. Increased extracellular vesicle miRNA-466 family in the bronchoalveolar lavage fluid as a precipitating factor of ARDS. BMC Pulm Med. 2019;19:110 pubmed publisher |
| Rashidi M, Simpson D, Hempel A, Frank D, Petrie E, Vince A, et al. The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release. J Immunol. 2019;: pubmed publisher |
| Spalinger M, Schmidt T, Schwarzfischer M, Hering L, Atrott K, Lang S, et al. Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner. J Clin Invest. 2019;129:2527-2541 pubmed publisher |
| Carpentier S, Ni M, Duggan J, James R, Cookson B, Hamerman J. The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1. Sci Signal. 2019;12: pubmed publisher |
| Segovia M, Russo S, Jeldres M, Mahmoud Y, Perez V, Duhalde M, et al. Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation. Cancer Cell. 2019;35:767-781.e6 pubmed publisher |
| Phillips E, Lorch A, Durkes A, Goergen C. Early pathological characterization of murine dissecting abdominal aortic aneurysms. APL Bioeng. 2018;2:046106 pubmed publisher |
| Da Costa L, Outlioua A, Anginot A, Akarid K, Arnoult D. RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux. Cell Death Dis. 2019;10:346 pubmed publisher |
| Ojcius D, Jafari A, Yeruva L, Schindler C, Abdul Sater A. Dicer regulates activation of the NLRP3 inflammasome. PLoS ONE. 2019;14:e0215689 pubmed publisher |
| Meng R, Gu L, Lu Y, Zhao K, Wu J, Wang H, et al. High mobility group box 1 enables bacterial lipids to trigger receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis and apoptosis in mice. J Biol Chem. 2019;294:8872-8884 pubmed publisher |
| Ahn H, Han B, Kim J, Kang S, Kim P, Jang K, et al. Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression. J Ginseng Res. 2019;43:291-299 pubmed publisher |
| Bae J, Jo S, Kim S, Lee J, Jeong J, Kang J, et al. Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes. Cells. 2019;8: pubmed publisher |
| Ilyas G, Cingolani F, Zhao E, Tanaka K, Czaja M. Decreased Macrophage Autophagy Promotes Liver Injury and Inflammation from Alcohol. Alcohol Clin Exp Res. 2019;43:1403-1413 pubmed publisher |
| Zhang P, Cao L, Zhou R, Yang X, Wu M. The lncRNA Neat1 promotes activation of inflammasomes in macrophages. Nat Commun. 2019;10:1495 pubmed publisher |
| Tapia V, Daniels M, Palazón Riquelme P, Dewhurst M, Luheshi N, Rivers Auty J, et al. The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes. J Biol Chem. 2019;294:8325-8335 pubmed publisher |
| Li X, Deng M, Petrucelli A, Zhu C, Mo J, Zhang L, et al. Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon. Immunity. 2019;50:591-599.e6 pubmed publisher |
| Chen Y, Wu T, Li H, Li X, Li Q, Zhu X, et al. Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation. Front Aging Neurosci. 2019;11:44 pubmed publisher |
| Liao Y, Hussain T, Liu C, Cui Y, Wang J, Yao J, et al. Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation. Front Immunol. 2019;10:268 pubmed publisher |
| Chung I, OuYang C, Yuan S, Lin H, Huang K, Wu P, et al. Pretreatment with a Heat-Killed Probiotic Modulates the NLRP3 Inflammasome and Attenuates Colitis-Associated Colorectal Cancer in Mice. Nutrients. 2019;11: pubmed publisher |
| Lee J, Jung E, Heur M. Injury induces endothelial to mesenchymal transition in the mouse corneal endothelium in vivo via FGF2. Mol Vis. 2019;25:22-34 pubmed |
| Ren G, Zhang X, Xiao Y, Zhang W, Wang Y, Ma W, et al. ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination. EMBO J. 2019;38: pubmed publisher |
| Murakami T, Ruengsinpinya L, Nakamura E, Takahata Y, Hata K, Okae H, et al. Cutting Edge: G Protein Subunit β 1 Negatively Regulates NLRP3 Inflammasome Activation. J Immunol. 2019;202:1942-1947 pubmed publisher |
| Morita Takemura S, Nakahara K, Hasegawa Ishii S, Isonishi A, Tatsumi K, Okuda H, et al. Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance. J Neuroinflammation. 2019;16:39 pubmed publisher |
| Erlich Z, Shlomovitz I, Edry Botzer L, Cohen H, Frank D, Wang H, et al. Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model. Nat Immunol. 2019;20:397-406 pubmed publisher |
| Hwang W, Lan H, Cheng W, Huang S, Yang M. Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer. J Hematol Oncol. 2019;12:10 pubmed publisher |
| Cui H, Banerjee S, Guo S, Xie N, Ge J, Jiang D, et al. Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury. JCI Insight. 2019;4: pubmed publisher |
| Gunaratna R, Santos A, Luo L, Nagi C, Lambertz I, Spier M, et al. Dynamic role of the codon 72 p53 single-nucleotide polymorphism in mammary tumorigenesis in a humanized mouse model. Oncogene. 2019;38:3535-3550 pubmed publisher |
| Kurundkar D, Kurundkar A, Bone N, Becker E, Liu W, Chacko B, et al. SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury. JCI Insight. 2019;4: pubmed publisher |
| Widmann C, Gandin C, Petit Paitel A, Lazdunski M, Heurteaux C. The Traditional Chinese Medicine MLC901 inhibits inflammation processes after focal cerebral ischemia. Sci Rep. 2018;8:18062 pubmed publisher |
| Kaplanov I, Carmi Y, Kornetsky R, Shemesh A, Shurin G, Shurin M, et al. Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation. Proc Natl Acad Sci U S A. 2019;116:1361-1369 pubmed publisher |
| Mathur A, Feng S, Hayward J, Ngo C, Fox D, Atmosukarto I, et al. A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome. Nat Microbiol. 2019;4:362-374 pubmed publisher |
| Vince J, De Nardo D, Gao W, Vince A, Hall C, McArthur K, et al. The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation. Cell Rep. 2018;25:2339-2353.e4 pubmed publisher |
| Koch B, Barugahare A, Lo T, Huang C, Schittenhelm R, Powell D, et al. A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling. Cell Rep. 2018;25:2244-2258.e7 pubmed publisher |
| Sharma D, Malik A, Guy C, Vogel P, Kanneganti T. TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy. J Clin Invest. 2019;129:150-162 pubmed publisher |
| Kasper L, König A, Koenig P, Gresnigt M, Westman J, Drummond R, et al. The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nat Commun. 2018;9:4260 pubmed publisher |
| Wang S, Lin Y, Yuan X, Li F, Guo L, Wu B. REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis. Nat Commun. 2018;9:4246 pubmed publisher |
| Benjamin J, Moore D, Bennett C, Van Der Meer R, Royce A, Loveland R, et al. Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality. J Immunol. 2018;201:2873-2878 pubmed publisher |
| Zhang Z, Shao X, Jiang N, Mou S, Gu L, Li S, et al. Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury. Cell Death Dis. 2018;9:983 pubmed publisher |
| Chen Y, He X, Yuan X, Hong J, Bhat O, Li G, et al. NLRP3 Inflammasome Formation and Activation in Nonalcoholic Steatohepatitis: Therapeutic Target for Antimetabolic Syndrome Remedy FTZ. Oxid Med Cell Longev. 2018;2018:2901871 pubmed publisher |
| Monteleone M, Stanley A, Chen K, Brown D, Bezbradica J, von Pein J, et al. Interleukin-1? Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion. Cell Rep. 2018;24:1425-1433 pubmed publisher |
| Marchetti C, Swartzwelter B, Koenders M, Azam T, Tengesdal I, Powers N, et al. NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis. Arthritis Res Ther. 2018;20:169 pubmed publisher |
| Thygesen S, Takizawa K, Robertson A, Sester D, Stacey K. Compromised NLRP3 and AIM2 inflammasome function in autoimmune NZB/W F1 mouse macrophages. Immunol Cell Biol. 2019;97:17-28 pubmed publisher |
| Shahid M, Lee M, Yeon A, Cho E, Sairam V, Valdiviez L, et al. Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis. Sci Rep. 2018;8:10859 pubmed publisher |
| He H, Jiang H, Chen Y, Ye J, Wang A, Wang C, et al. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat Commun. 2018;9:2550 pubmed publisher |
| Lee E, Hwang I, Park S, Hong S, Hwang B, Cho Y, et al. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell Death Differ. 2019;26:213-228 pubmed publisher |
| Kwak S, Koppula S, In E, Sun X, Kim Y, Kim M, et al. Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation. Mediators Inflamm. 2018;2018:6054069 pubmed publisher |
| Coleman L, Maile R, Jones S, Cairns B, Crews F. HMGB1/IL-1β complexes in plasma microvesicles modulate immune responses to burn injury. PLoS ONE. 2018;13:e0195335 pubmed publisher |
| Kim Y, Koppula S, Shim D, In E, Kwak S, Kim M, et al. Inhibitory Effect and Mechanism of Arctium lappa Extract on NLRP3 Inflammasome Activation. Evid Based Complement Alternat Med. 2018;2018:6346734 pubmed publisher |
| Cochain C, Vafadarnejad E, Arampatzi P, Pelisek J, Winkels H, Ley K, et al. Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis. Circ Res. 2018;122:1661-1674 pubmed publisher |
| Huang Y, Jiang H, Chen Y, Wang X, Yang Y, Tao J, et al. Tranilast directly targets NLRP3 to treat inflammasome-driven diseases. EMBO Mol Med. 2018;10: pubmed publisher |
| Chu L, Indramohan M, Ratsimandresy R, Gangopadhyay A, Morris E, Monack D, et al. The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Nat Commun. 2018;9:996 pubmed publisher |
| Zhuang W, Wang C, Shi X, Qiu S, Zhang S, Xu B, et al. MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss. Int J Mol Med. 2018;41:3448-3456 pubmed publisher |
| Carroll R, Zasłona Z, Galván Peña S, Koppe E, Sévin D, Angiari S, et al. An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation. J Biol Chem. 2018;293:5509-5521 pubmed publisher |
| Santos J, Dick M, Lagrange B, Degrandi D, Pfeffer K, Yamamoto M, et al. LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation. EMBO J. 2018;37: pubmed publisher |
| Boucher D, Monteleone M, Coll R, Chen K, Ross C, Teo J, et al. Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. J Exp Med. 2018;215:827-840 pubmed publisher |
| Kuriakose T, Zheng M, Neale G, Kanneganti T. IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection. J Immunol. 2018;200:1489-1495 pubmed publisher |
| Ross J, Queme L, Lamb J, Green K, Jankowski M. Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury. Biol Sex Differ. 2018;9:2 pubmed publisher |
| Zenke K, Muroi M, Tanamoto K. AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner. Cell Signal. 2018;43:32-39 pubmed publisher |
| Cheng K, Xiong S, Ye Z, Hong Z, Di A, Tsang K, et al. Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest. 2017;127:4124-4135 pubmed publisher |
| Ghosh S, Wallerath C, Covarrubias S, Hornung V, Carpenter S, Fitzgerald K. The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression. J Immunol. 2017;199:3249-3260 pubmed publisher |
| Rivera J, Noueihed B, Madaan A, Lahaie I, Pan J, Belik J, et al. Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina. J Neuroinflammation. 2017;14:181 pubmed publisher |
| Albalawi F, Lu W, Beckel J, Lim J, McCaughey S, Mitchell C. The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Front Cell Neurosci. 2017;11:227 pubmed publisher |
| Nakanishi H, Kawashima Y, Kurima K, Chae J, Ross A, Pinto Patarroyo G, et al. NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy. Proc Natl Acad Sci U S A. 2017;114:E7766-E7775 pubmed publisher |
| McDonough E, Barrett C, Parang B, Mittal M, Smith J, Bradley A, et al. MTG16 is a tumor suppressor in colitis-associated carcinoma. JCI Insight. 2017;2: pubmed publisher |
| Brawek B, Liang Y, Savitska D, Li K, Fomin Thunemann N, Kovalchuk Y, et al. A new approach for ratiometric in vivo calcium imaging of microglia. Sci Rep. 2017;7:6030 pubmed publisher |
| Yoon S, Kovalenko A, Bogdanov K, Wallach D. MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation. Immunity. 2017;47:51-65.e7 pubmed publisher |
| Wu T, Zhang J, Geng M, Tang S, Zhang W, Shu J. Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling. Sci Rep. 2017;7:4117 pubmed publisher |
| Domingo Fernández R, Coll R, Kearney J, Breit S, O Neill L. The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1? transcription and activate the NLRP3 inflammasome. J Biol Chem. 2017;292:12077-12087 pubmed publisher |
| Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson J, Tye H, et al. Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. J Exp Med. 2017;214:1737-1752 pubmed publisher |
| Zhu Q, Kanneganti T. Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1?. J Immunol. 2017;198:4210-4215 pubmed publisher |
| Ahn H, Jeon E, Kim J, Kang S, Yoon S, Ko H, et al. Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production. Sci Rep. 2017;7:1314 pubmed publisher |
| Kanamori Y, Murakami M, Sugiyama M, Hashimoto O, Matsui T, Funaba M. Interleukin-1? (IL-1?) transcriptionally activates hepcidin by inducing CCAAT enhancer-binding protein ? (C/EBP?) expression in hepatocytes. J Biol Chem. 2017;292:10275-10287 pubmed publisher |
| Freeman L, Guo H, David C, Brickey W, JHA S, Ting J. NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes. J Exp Med. 2017;214:1351-1370 pubmed publisher |
| Choo M, Sano Y, Kim C, Yasuda K, Li X, Lin X, et al. TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects. J Exp Med. 2017;214:1297-1311 pubmed publisher |
| Zhong Z, Zhai Y, Bu P, Shah S, Qiao L. Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice. Nat Commun. 2017;8:15004 pubmed publisher |
| Youssef H, Stashenko P. Interleukin-1 and estrogen protect against disseminating dentoalveolar infections. Int J Oral Sci. 2017;9:16-23 pubmed publisher |
| Moriwaki K, Balaji S, Bertin J, Gough P, Chan F. Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair. Cell Rep. 2017;18:2441-2451 pubmed publisher |
| Domiciano T, Wakita D, Jones H, Crother T, Verri W, Arditi M, et al. Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis. Sci Rep. 2017;7:41539 pubmed publisher |
| Tsugita M, Morimoto N, Tashiro M, Kinoshita K, Nakayama M. SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation. Cell Rep. 2017;18:1298-1311 pubmed publisher |
| Tufanlı Ö, Telkoparan Akillilar P, Acosta Alvear D, Kocatürk B, Onat U, Hamid S, et al. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A. 2017;114:E1395-E1404 pubmed publisher |
| Koh H, Kim Y, Kim J, Yun J, Jang K, Yang C. Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα. PLoS Pathog. 2017;13:e1006126 pubmed publisher |
| Haldar S, Dru C, Mishra R, Tripathi M, Duong F, Angara B, et al. Histone deacetylase inhibitors mediate DNA damage repair in ameliorating hemorrhagic cystitis. Sci Rep. 2016;6:39257 pubmed publisher |
| Chavarria Smith J, Mitchell P, Ho A, Daugherty M, Vance R. Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation. PLoS Pathog. 2016;12:e1006052 pubmed publisher |
| Mittal M, Tiruppathi C, Nepal S, Zhao Y, Grzych D, Soni D, et al. TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury. Proc Natl Acad Sci U S A. 2016;113:E8151-E8158 pubmed |
| Leaf I, Nakagawa S, Johnson B, Cha J, Mittelsteadt K, Guckian K, et al. Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury. J Clin Invest. 2017;127:321-334 pubmed publisher |
| Pereira M, Tourlomousis P, Wright J, P Monie T, Bryant C. CARD9 negatively regulates NLRP3-induced IL-1? production on Salmonella infection of macrophages. Nat Commun. 2016;7:12874 pubmed publisher |
| Lund A, Wagner M, Fankhauser M, Steinskog E, Broggi M, Spranger S, et al. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. J Clin Invest. 2016;126:3389-402 pubmed publisher |
| Myles I, Zhao M, Nardone G, Olano L, Reckhow J, Saleem D, et al. CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells. J Leukoc Biol. 2017;101:307-320 pubmed publisher |
| Cader M, Boroviak K, Zhang Q, Assadi G, Kempster S, Sewell G, et al. C13orf31 (FAMIN) is a central regulator of immunometabolic function. Nat Immunol. 2016;17:1046-56 pubmed publisher |
| Braverman J, Sogi K, Benjamin D, Nomura D, Stanley S. HIF-1? Is an Essential Mediator of IFN-?-Dependent Immunity to Mycobacterium tuberculosis. J Immunol. 2016;197:1287-97 pubmed publisher |
| Stein R, Kapplusch F, Heymann M, Russ S, Staroske W, Hedrich C, et al. Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division. J Biol Chem. 2016;291:18419-29 pubmed publisher |
| Meng N, Xia M, Lu Y, Wang M, Boini K, Li P, et al. Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma J. infection. Oncotarget. 2016;7:39316-39331 pubmed publisher |
| Park Y, Wood G, Kastner D, Chae J. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol. 2016;17:914-21 pubmed publisher |
| Du R, Tan J, Sun X, Lu M, Ding J, Hu G. Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression. Int J Neuropsychopharmacol. 2016;19: pubmed publisher |
| Wang X, Shaw D, Sakhon O, Snyder G, Sundberg E, Santambrogio L, et al. The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation. Infect Immun. 2016;84:1796-1805 pubmed publisher |
| Marty Roix R, Vladimer G, Pouliot K, Weng D, Buglione Corbett R, West K, et al. Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants. J Biol Chem. 2016;291:1123-36 pubmed publisher |
