Mouse IL-1 alpha /IL-1F1 Antibody | R&D Systems AF-400-NA product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse IL-1 alpha /IL-1F1 Antibody

catalog :

AF-400-NA

quantity :

100 ug (also 25 ug)

price :

509 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 17

Reference
Zhong X, Wu H, Zhang W, Shi Y, Gwack Y, Xue H, et al. Distinct RORγt-dependent Th17 immune responses are required for autoimmune pathogenesis and protection against bacterial infection. Cell Rep. 2024;43:114951 pubmed publisher
Lorenzo Mart xed n L, H xfc bscher T, Bowler A, Broguiere N, Langer J, Tillard L, et al. Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo. Nature. 2024;629:450-457 pubmed publisher
Maeder C, Speer T, Wirth A, Boeckel J, Fatima S, Shahzad K, et al. Membrane-bound Interleukin-1α mediates leukocyte adhesion during atherogenesis. Front Immunol. 2023;14:1252384 pubmed publisher
Millar F, Pennycuick A, Muir M, Quintanilla A, Hari P, Freyer E, et al. Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer. Cell Rep. 2022;41:111596 pubmed publisher
Bretheau F, Castellanos Molina A, B xe9 langer D, Kusik M, Mailhot B, Boisvert A, et al. The alarmin interleukin-1α triggers secondary degeneration through reactive astrocytes and endothelium after spinal cord injury. Nat Commun. 2022;13:5786 pubmed publisher
Hoyle C, Green J, Allan S, Brough D, Lemarchand E. Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages. Immunology. 2022;165:460-480 pubmed publisher
Matsunami A, Mizuno Kamiya M, Kawaki H, Takayama E, Ueno K, Ando M, et al. Augmented secretion of IL-1α from mouse oral squamous cell carcinoma (OSCC) vcells caused by serum deprivation and hypoxia promotes immune suppressive activity of mesenchymal stromal cells. J Oral Biosci. 2021;63:284-291 pubmed publisher
Tsuchiya K, Hosojima S, Hara H, Kushiyama H, Mahib M, Kinoshita T, et al. Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes. Cell Rep. 2021;34:108887 pubmed publisher
Melchor S, Hatter J, Castillo É, Saunders C, Byrnes K, Sanders I, et al. T. gondii infection induces IL-1R dependent chronic cachexia and perivascular fibrosis in the liver and skeletal muscle. Sci Rep. 2020;10:15724 pubmed publisher
Shukla S, Markov S, Attri K, Vernucci E, King R, Dasgupta A, et al. Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia. Cancer Lett. 2020;484:29-39 pubmed publisher
Speir M, Nowell C, Chen A, O Donnell J, Shamie I, Lakin P, et al. Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation. Nat Immunol. 2020;21:54-64 pubmed publisher
Zhou H, Slominski R, Seymour L, Bell M, Dave P, Atumonye J, et al. Ex vivo culture of mouse skin activates an interleukin 1 alpha-dependent inflammatory response. Exp Dermatol. 2020;29:102-106 pubmed publisher
Tapia V, Daniels M, Palazón Riquelme P, Dewhurst M, Luheshi N, Rivers Auty J, et al. The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes. J Biol Chem. 2019;294:8325-8335 pubmed publisher
Ubil E, Caskey L, Holtzhausen A, Hunter D, Story C, Earp H. Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J Clin Invest. 2018;128:2356-2369 pubmed publisher
Zhong J, Peng L, Wang B, Zhang H, Li S, Yang R, et al. Tacrolimus interacts with voriconazole to reduce the severity of fungal keratitis by suppressing IFN-related inflammatory responses and concomitant FK506 and voriconazole treatment suppresses fungal keratitis. Mol Vis. 2018;24:187-200 pubmed
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product information

master code :

AF-400-NA

SKU :

AF-400-NA

product name :

Mouse IL-1 alpha /IL-1F1 Antibody

unit size :

100 ug (also 25 ug)

description :

The Mouse IL-1 alpha /IL-1F1 Antibody from R&D Systems is a goat polyclonal antibody to IL-1 alpha/IL-1F1. This antibody reacts with mouse,transgenic mouse. The Mouse IL-1 alpha /IL-1F1 Antibody has been validated for the following applications: Immunohistochemistry,Neutralization,Bioassay,Western Blot,Functional Assay,Immunohistochemistry-Frozen,Immunocytochemistry.

target :

IL-1 alpha/IL-1F1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

E. coli -derived recombinant mouse IL-1 alpha /IL-1F1, Ser6-Ser161, Accession # Q62161

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Mouse,Transgenic Mouse

specificity :

Detects mouse IL-1 alpha /IL-1F1 in direct ELISAs and Western blots. In direct ELISAs, approximately 25% cross-reactivity with recombinant rat IL-1 alpha and recombinant cotton rat IL-1 alpha is observed and less than 1% cross-reactivity with recombinant human IL-1 alpha is observed.

gene symbol :

IL1A

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Recombinant Mouse and Rat IL-1a/IL-1F1 antibody by Western Blot.

accessionNumbers :

Q62161

applications :

Immunohistochemistry,Neutralization,Bioassay,Western Blot,Functional Assay,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

509 USD

alt names :

BAF, Hematopoietin-1, IL1, IL1 alpha, IL-1 alpha, IL1A, IL-1A, IL1-ALPHA, IL1F1, IL-1F1, IL1F1hematopoietin-1, interleukin 1, alpha, interleukin-1 alpha, LAF, LEM, preinterleukin 1 alpha, pro-interleukin-1-alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage